Does the size matter?: Prostate weight does not predict PSA recurrence after radical prostatectomy.

Abstract:

:Previous studies suggest that low prostate weight is a significant negative prognostic factor for prostate cancer. In the current study, the data for 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical and pathologic parameters. These included age, preoperative prostate-specific antigen (PSA) level, PSA recurrence, pathologic stage, Gleason grade, extraprostatic extension, positive surgical margins, tumor volume, associated high-grade prostatic intraepithelial neoplasia, perineural invasion, and lymph node metastasis. Potential associations were probed by using Cox regression model analysis. A significant positive correlation was found between prostate weight and increasing patient age or increasing preoperative PSA level. There was no significant independent association between prostate weight and any of the other variables examined. No association was found between prostate weight and PSA recurrence. Although increasing prostate weight correlates with increased patient age and higher preoperative PSA level, it does not independently predict postoperative cancer recurrence.

journal_name

Am J Clin Pathol

authors

Davidson DD,Koch MO,Lin H,Jones TD,Biermann K,Cheng L

doi

10.1309/AJCPPHGXDI94SGAC

subject

Has Abstract

pub_date

2010-04-01 00:00:00

pages

662-8

issue

4

eissn

0002-9173

issn

1943-7722

pii

133/4/662

journal_volume

133

pub_type

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