Relationship of pathologic factors to efficacy of sorafenib treatment in patients with metastatic clear cell renal cell carcinoma.


OBJECTIVES:To evaluate the predictive value of growth patterns in patients undergoing sorafenib treatment for metastatic clear cell renal cell carcinomas (CCRCCs). METHODS:Forty-eight patients were analyzed, each of whom underwent nephrectomy and received sorafenib treatment for metastatic CCRCC. Progression-free survival (PFS) was predicted using pathologic parameters, including pathologic stage, Fuhrman nuclear grade (FNG), the presence of a sarcomatoid component, lymphovascular invasion, tumor necrosis, and growth pattern. RESULTS:Three (6%) patients showed partial response, 20 (42%) patients showed stable disease, and 25 (52%) patients showed progressive disease. Univariate analyses demonstrated that FNG, the presence of a sarcomatoid component, tumor necrosis, and growth pattern were significantly associated with PFS. In the multivariate analysis, growth pattern was the only parameter that was significantly and independently predictive of PFS. CONCLUSIONS:As a novel histologic prognostic parameter, growth pattern may be useful for predicting response to sorafenib treatment.


Am J Clin Pathol


Araki H,Tsuzuki T,Kimura T,Tanaka K,Yamada S,Sassa N,Yoshino Y,Hattori R,Gotoh M




Has Abstract


2015-04-01 00:00:00














  • Successful triage of suspected hantavirus cardiopulmonary syndrome by peripheral blood smear review: a decade of experience in an endemic region.

    abstract:OBJECTIVES:In 2001, the University of New Mexico Hospitals implemented a rapid screening tool for the triage of suspected hantavirus cardiopulmonary syndrome based on peripheral blood smear morphology. Five criteria guided clinical decisions: thrombocytopenia, hemoconcentration, granulocytic left shift, absence of toxi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Dvorscak L,Czuchlewski DR

    更新日期:2014-08-01 00:00:00

  • Immunoreactivity of paraffin-embedded normal tissues and mesenchymal tumors for smooth muscle myosin.

    abstract::Immunohistochemical study of smooth muscle myosin, a protein distinct from skeletal, cardiac, or nonmyogenous myosins in paraffin-embedded normal tissues and benign and malignant mesenchymal tumors revealed its strong expression in normal smooth muscle, capillary endothelium, and pericytes. All benign smooth muscle tu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Donner L,de Lanerolle P,Costa J

    更新日期:1983-11-01 00:00:00

  • Prevalence of non-A,non-B hepatitis/hepatitis C virus antibody in human immunoglobulins.

    abstract::Human intravenous immunoglobulins prepared by the cold ethanol fractionation technique of Cohn are considered safe with respect to infectivity. However, there have been several instances of transmission of both hepatitis B and non-A,non-B hepatitis viruses after administration of intravenous immunoglobulins. To determ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Dodd LG,McBride JH,Gitnick GL,Howanitz PJ,Rodgerson DO

    更新日期:1992-01-01 00:00:00

  • bcl-2 expression by multicolor flow cytometric analysis assists in the diagnosis of follicular lymphoma in lymph node and bone marrow.

    abstract::The expression of bcl-2, CD10, and CD20 was examined by multicolor flow cytometry in 78 samples including lymph node or other tissue biopsy specimens containing follicular lymphoma (FL; n = 17), reactive hyperplasia (RH; n = 28), or other malignant lymphomas (n = 20), as well as bone marrow aspirates (n = 13). The pre...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Cook JR,Craig FE,Swerdlow SH

    更新日期:2003-01-01 00:00:00

  • Audit of Use and Overuse of Serum Protein Immunofixation Electrophoresis and Serum Free Light Chain Assay in Tertiary Health Care: A Case for Algorithmic Testing to Optimize Laboratory Utilization.

    abstract:OBJECTIVES:Overuse of laboratory tests is a persistent issue. We examined the use and overuse of serum immunofixation electrophoresis and serum free light chain assays to develop an algorithm for optimizing utilization. METHODS:A retrospective review of all tests, for investigation of monoclonal gammopathies, for all ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Heaton C,Vyas SG,Singh G

    更新日期:2016-04-01 00:00:00

  • Fixation time does not affect expression of HER2/neu: a pilot study.

    abstract::It is said that HER2/neu expression by immunohistochemical analysis varies with the time of fixation. The purpose of this pilot study was to determine the impact of the length of fixation in 10% buffered formalin on the expression of HER2/neu by immunohistochemical analysis. We studied tissue samples from 10 invasive ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Ibarra JA,Rogers LW

    更新日期:2010-10-01 00:00:00

  • Mesothelin expression in pancreatic mucinous cysts.

    abstract:OBJECTIVES:Mesothelin (MSLN) is a differentiation antigen found to be overexpressed in intraductal papillary mucinous neoplasms (IPMNs) and is a potential treatment target in pancreatic ductal adenocarcinoma. METHODS:From institutional archives, 114 cases of resected pancreatic mucinous cysts were identified, includin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Frank R,Li S,Ahmad NA,Sepulveda AR,Jhala NC

    更新日期:2014-09-01 00:00:00

  • Platelet function, ultrastructure, and survival in the May-Hegglin anomaly.

    abstract::The May-Hegglin anomaly is one of the rare forms of heriditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Hamilton RW,Shaikh BS,Ottie JN,Storch AE,Saleem A,White JG

    更新日期:1980-11-01 00:00:00

  • Mesothelial Cysts.

    abstract:OBJECTIVES:Peritoneal mesothelial cysts have been reported under various terms, including benign cystic mesothelioma, usually in the form of case reports/series, whereas extraperitoneal cases are rarely reported. Our objective was to report the detailed characteristics of cystic lesions of the serosal cavities. METHOD...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Karpathiou G,Casteillo F,Dridi M,Peoc'h M

    更新日期:2020-12-01 00:00:00

  • The use of cell line standards to reduce HER-2/neu assay variation in multiple European cancer centers and the potential of automated image analysis to provide for more accurate cut points for predicting clinical response to trastuzumab.

    abstract::Immunohistochemical analysis, the most efficient way of assaying for HER-2/neu overexpression in patients with invasive breast cancer, is subject to variation in sensitivity and evaluation when used in multiple laboratories. Cell lines with differing but constant levels of HER-2/neu expression have been advocated as s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Rhodes A,Borthwick D,Sykes R,Al-Sam S,Paradiso A

    更新日期:2004-07-01 00:00:00

  • Adrenocortical cytopathology.

    abstract::Cytopathologic smears and/or imprints of human adrenal cortex (9 cases) and its disorders were examined, including adrenocortical nodule (3 cases), adrenocortical adenoma (23 cases), carcinoma (8 cases), and renal cell carcinoma (6 cases). Immunocytochemistry directed against 3 beta-hydroxysteroid dehydrogenase and ad...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Sasano H,Shizawa S,Nagura H

    更新日期:1995-08-01 00:00:00

  • CD5+ follicle center lymphoma. Immunophenotyping detects a unique subset of "floral" follicular lymphoma.

    abstract::The "floral" variant of follicle center lymphoma (FCL) may be confused with progressive transformation of germinal centers or lymphocyte predominance Hodgkin lymphoma. Immunohistochemistry and gene rearrangement studies are usually sufficient to differentiate among these entities. We present 11 cases of floral FCL tha...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Tiesinga JJ,Wu CD,Inghirami G

    更新日期:2000-12-01 00:00:00

  • Theory of network planning for laboratory research and development.

    abstract::Critical Path Method (CPM) and Program Evaluation and Review Technique (PERT) are quantitative network planning strategies that facilitate management of projects with many interrelated activities. They determine the minimum time necessary to complete a project and identify which activities are critical to achieving th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Kost GJ

    更新日期:1983-03-01 00:00:00

  • Laboratory prediction of the carrier state in hemophilia B: role of replication of assays.

    abstract::The authors studied the effect of averaging replicated assays of Factor IX coagulation activity and Factor IX antigen on each plasma specimen in improving the ability to detect carriers of hemophilia B. The improvement resulting from this procedure is particularly marked in tests depending on the linear regression of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Lipworth L,Tiarks CY,Rice CA,Pechet L

    更新日期:1979-12-01 00:00:00

  • The blood counts and lactate dehydrogenase levels in thrombotic thrombocytopenic purpura (TTP).

    abstract::The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Crowley JP,Metzger JB,L'Europa RA

    更新日期:1983-11-01 00:00:00

  • Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis.

    abstract::A teenage male, with Goodpasture's syndrome and serum antiglomerular basement membrane (anti-GBM) antibodies, had a focal proliferative glomerulonephritis with crescents. Immunofluorescence microscopy of his glomeruli using anti-IgG antibodies demonstrated both intense linear GBM staining, and granular subepithelial s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Jennette JC,Lamanna RW,Burnette JP,Wilkman AS,Iskander SS

    更新日期:1982-09-01 00:00:00

  • The diagnostic value of the serum lactic dehydrogenase determination in the evaluation of unexplained thrombocytosis.

    abstract::Thrombocytosis may reflect a primary myeloproliferative disorder or be a secondary reaction to other pathologic processes. Patients with persistent unexplained thrombocytosis meeting criteria of primary thrombocythemia had elevated levels of serum lactic dehydrogenase, whereas comparable patients with secondary thromb...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Budman DR,Lackner H,Berczeller P,Silber R

    更新日期:1981-06-01 00:00:00

  • Detection of cytomegalovirus antibodies in serum using the TranSTAT-CMV and CMV Scan assays.

    abstract::Two hundred serum samples were tested with two assays for rapid detection of cytomegalovirus (CMV) antibodies. The assays were CMV Scan, a two-step latex particle agglutination assay for CMV IgG and IgM antibodies, and TranSTAT-CMV, a newly available six-step solid-phase enzyme immunoassay for CMV IgG antibodies. Comp...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Roseff SD,Campos JM

    更新日期:1993-05-01 00:00:00

  • Fluorescence in situ hybridization analysis of trisomy 12 in ovarian tumors.

    abstract::Conventional cytogenetic studies have suggested that trisomy 12 may be a characteristic nonrandom numerical chromosome anomaly in benign ovarian tumors, particularly sex cord-stromal tumors. To confirm this finding, and to avoid possible culture artifact introduced during cytogenetic analysis, the authors performed fl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Persons DL,Hartmann LC,Herath JF,Keeney GL,Jenkins RB

    更新日期:1994-12-01 00:00:00

  • erb-b2 amplification by fluorescence in situ hybridization in breast cancer specimens read as 2+ in immunohistochemical analysis.

    abstract::We conducted this study to ascertain the prevalence of erb-b2 gene amplification in breast cancer specimens read as 2+ in immunohistochemical analysis. Slides from patients with metastatic or recurrent breast cancer were eligible for fluorescent in situ hybridization (FISH) study if they were read as 2+ immunohistoche...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Lan C,Liu JM,Liu TW,Hsu DH,Liang S,Chen JR,Peng JW

    更新日期:2005-07-01 00:00:00

  • Chemokines and their receptors: roles in specific clinical conditions and measurement in the clinical laboratory.

    abstract::Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Locati M,Bonecchi R,Corsi MM

    更新日期:2005-06-01 00:00:00

  • The data warehouse as a foundation for population-based reference intervals.

    abstract::The volume of data contained in a data warehouse represents a potential resource to provide the basis for detailed and specific reference intervals. Routine chemistry panel testing data were derived from an outreach laboratory patient population of 438,180 people and then screened by multiple data filters to identify ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Bock BJ,Dolan CT,Miller GC,Fitter WF,Hartsell BD,Crowson AN,Sheehan WW,Williams JD

    更新日期:2003-11-01 00:00:00

  • Optimization of plasma fluorogenic thrombin-generation assays.

    abstract::We optimized fluorogenic thrombin-generation assays with regard to sample volume, calibration, analytic corrections, and activation reagents. Lower sample volumes (40 vs 80 microL) were associated with better recovery of thrombin activity, lower interference due to absorbance of light, and higher total thrombin genera...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Chandler WL,Roshal M

    更新日期:2009-08-01 00:00:00

  • Cost analysis of point-of-care laboratory testing in a community hospital.

    abstract::Point-of-care testing (POCT) is a means of providing patient services more rapidly. Most evaluations of bedside laboratory testing devices have emphasized analytical performance in tertiary care settings. In contrast, the authors compare the operating cost of POCT for glucose and an electrolyte/glucose/blood urea nitr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Nosanchuk JS,Keefner R

    更新日期:1995-02-01 00:00:00

  • The relationship between MIB-1 proliferation index and outcome in pancreatic neuroendocrine tumors.

    abstract::The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Gentil Perret A,Mosnier JF,Buono JP,Berthelot P,Chipponi J,Balique JG,Cuilleret J,Dechelotte P,Boucheron S

    更新日期:1998-03-01 00:00:00

  • Hepatic ALECT-2 amyloidosis causing portal hypertension and recurrent variceal bleeding: a case report and review of the literature.

    abstract:OBJECTIVES:To examine laser microdissection and mass spectrometry (LMD-MS), which has emerged as a new tool to aid in typing amyloid proteins. RESULTS:ALECT-2 is a potential cause of hepatic amyloidosis best detected by LMD-MS. METHODS:One of the more recently reported proteins is ALECT-2 (leukocyte cell-derived chem...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Damlaj M,Amre R,Wong P,How J

    更新日期:2014-02-01 00:00:00

  • Immune hemolytic anemia associated with probenecid.

    abstract::Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the pa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Sosler SD,Behzad O,Garratty G,Lee CL,Postoway N,Khomo O

    更新日期:1985-09-01 00:00:00

  • Endometrial biopsy. Pathologic findings in 3,600 biopsies from selected patients.

    abstract::During a 14-year period (1959-1972), 3,600 endometrial suction biopsies were performed in the office for specific indications in selected patients. Three hundred seventy-seven biopsies (10.5%) revealed abnormal findings. Of these, 233 showed endometritis, 96 associated with necrotic decidual or placental tissue, or bo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Baitlon D,Hadley JO

    更新日期:1975-01-01 00:00:00

  • Evaluation of a new blood culture medium for mycobacteria.

    abstract::This study evaluates the sensitivity and detection time of a new radiometric broth (BACTEC 13A medium, Johnston Laboratories, Towson, MD) designed for direct blood culturing for Mycobacteria. A total of 1,848 blood specimens were cultured in parallel by a new method in which blood was directly inoculated into 13A medi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Strand CL,Epstein C,Verzosa S,Effatt E,Hormozi P,Siddiqi SH

    更新日期:1989-03-01 00:00:00

  • Clinical trial of a new disposable bleeding-time device.

    abstract::A new disposable bleeding time device (Hemalet) was tested in 20 normal individuals and 11 patients with various bleeding disorders. The results were compared with those of Simplate II. The mean bleeding time for normal individuals was 5.4 +/- 1.5 (mean +/- 1 SD) minutes by Hemalet and 5.8 +/- 1.4 (mean +/- 1 SD) minu...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章


    authors: Toomey KC,Kim HC,Kosmin M,Saidi P

    更新日期:1986-05-01 00:00:00