Relationship of pathologic factors to efficacy of sorafenib treatment in patients with metastatic clear cell renal cell carcinoma.

Abstract:

OBJECTIVES:To evaluate the predictive value of growth patterns in patients undergoing sorafenib treatment for metastatic clear cell renal cell carcinomas (CCRCCs). METHODS:Forty-eight patients were analyzed, each of whom underwent nephrectomy and received sorafenib treatment for metastatic CCRCC. Progression-free survival (PFS) was predicted using pathologic parameters, including pathologic stage, Fuhrman nuclear grade (FNG), the presence of a sarcomatoid component, lymphovascular invasion, tumor necrosis, and growth pattern. RESULTS:Three (6%) patients showed partial response, 20 (42%) patients showed stable disease, and 25 (52%) patients showed progressive disease. Univariate analyses demonstrated that FNG, the presence of a sarcomatoid component, tumor necrosis, and growth pattern were significantly associated with PFS. In the multivariate analysis, growth pattern was the only parameter that was significantly and independently predictive of PFS. CONCLUSIONS:As a novel histologic prognostic parameter, growth pattern may be useful for predicting response to sorafenib treatment.

journal_name

Am J Clin Pathol

authors

Araki H,Tsuzuki T,Kimura T,Tanaka K,Yamada S,Sassa N,Yoshino Y,Hattori R,Gotoh M

doi

10.1309/AJCPM8RJ2ECAWOGQ

subject

Has Abstract

pub_date

2015-04-01 00:00:00

pages

492-9

issue

4

eissn

0002-9173

issn

1943-7722

pii

143/4/492

journal_volume

143

pub_type

杂志文章
  • The equivocally amplified HER2 FISH result on breast core biopsy: indications for further sampling do affect patient management.

    abstract::To our knowledge, there are no universally accepted, evidence-based guidelines for how to resolve the HER2 status of tumors demonstrating equivocal amplification. The present study was based on 17 breast core biopsy specimens demonstrating invasive carcinoma with equivocal HER2 amplification, defined as an HER2/chromo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/KFKDNK8CENVN24VU

    authors: Striebel JM,Bhargava R,Horbinski C,Surti U,Dabbs DJ

    更新日期:2008-03-01 00:00:00

  • Steatohepatitis-Like Changes in Hepatocellular Adenoma.

    abstract:OBJECTIVES:Our aim was to investigate the frequency of steatohepatitic morphology in hepatocellular adenoma (HCA) and correlate with its clinical parameters and risk factors underlying nonalcoholic fatty liver disease (NAFLD) or nonalcoholic steatohepatitis (NASH). METHODS:We examined a series of 41 liver resection sp...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa075

    authors: Liu Y,Zen Y,Yeh MM

    更新日期:2020-09-08 00:00:00

  • Infections caused by Actinomyces viscosus.

    abstract::Two cases of Actinomyces viscosus infection of the lungs were seen in nonimmunosuppressed patients. One patient had a peripheral actinomycotic lung mass resembling a tumor. Both patients responded to a long course of penicillin therapy. Reports of A. viscosus infections are rare, although the organism colonizes the mo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.1.113

    authors: Eng RH,Corrado ML,Cleri D,Cherubin C,Goldstein EJ

    更新日期:1981-01-01 00:00:00

  • Quality assurance of histopathologic diagnoses: a prospective audit of three thousand cases.

    abstract::The purpose of this study was to examine a system of quality assurance in which microscopic slides from all surgical cases were subject to peer review before completion of the final pathology report. Three thousand surgical pathology cases were evaluated and the diagnoses entered on preliminary diagnosis sheets. Micro...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.4.487

    authors: Whitehead ME,Fitzwater JE,Lindley SK,Kern SB,Ulirsch RC,Winecoff WF 3rd

    更新日期:1984-04-01 00:00:00

  • Detection of chromosome 11q13 breakpoints by interphase fluorescence in situ hybridization. A useful ancillary method for the diagnosis of mantle cell lymphoma.

    abstract::We assessed cytologic specimens from 11 mantle cell lymphomas (MCLs) and 32 other B-cell non-Hodgkin lymphomas (NHLs) for 11q13 breakpoints using a 2-color fluorescence in situ hybridization (FISH) assay that uses an 11q13 probe centered on the CCND1 gene and a centromeric chromosome 11 probe (CEP11). The number of nu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/69EJ-RFM5-E976-BUTP

    authors: Katz RL,Caraway NP,Gu J,Jiang F,Pasco-Miller LA,Glassman AB,Luthra R,Hayes KJ,Romaguera JE,Cabanillas FF,Medeiros LJ

    更新日期:2000-08-01 00:00:00

  • Transfusion-related acute lung injury: past, present, and future.

    abstract::Noncardiogenic pulmonary edema caused by transfusion has been observed for almost 60 years. Today, we know this entity as transfusion-related acute lung injury (TRALI). TRALI is an uncommon but potentially fatal adverse reaction to transfusion of plasma-containing blood components. It is typified by dyspnea, cough, hy...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/D3F7BXH466AE3G0P

    authors: Cherry T,Steciuk M,Reddy VV,Marques MB

    更新日期:2008-02-01 00:00:00

  • Immunohistochemical expression of angiogenesis-related markers in oral squamous cell carcinomas with multiple metastatic lymph nodes.

    abstract::The aim of this study was to evaluate the histopathologic features and the expression of angiogenesis-related markers in primary tumors and metastatic lymph nodes of oral squamous cell carcinomas (SCCs) with multiple lymph node involvement in comparison with oral SCCs without nodal metastasis. The protein levels of th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/JD3D-HGCD-GAUN-1R0J

    authors: Nikitakis NG,Rivera H,Lopes MA,Siavash H,Reynolds MA,Ord RA,Sauk JJ

    更新日期:2003-04-01 00:00:00

  • Apolipoprotein A-I-derived amyloid in atherosclerosis. Its association with plasma levels of apolipoprotein A-I and cholesterol.

    abstract::Wild-type apolipoprotein A-I (apo A-I)-derived amyloid commonly occurs in atherosclerotic plaques. To clarify apo A-I amyloid formation, plasma levels of apo A-I and cholesterol were related to the presence of amyloid in atherosclerotic plaques in 15 patients with peripheral atherosclerosis, subjected to arterial reco...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/PJE6-X9E5-LX6K-NELY

    authors: Mucchiano GI,Jonasson L,Häggqvist B,Einarsson E,Westermark P

    更新日期:2001-02-01 00:00:00

  • Comparison of an enzyme immunoassay to an indirect fluorescent immunoassay for the detection of antinuclear antibodies.

    abstract::The standard method for detecting antinuclear antibodies (ANAs) is by immunofluorescence assay (IFA), a method that is labor intensive and subjective. In an attempt to overcome these limitations, several commercial enzyme immunoassays (EIAs) have been developed. We report the results of our evaluation of the ANA Micro...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/111.4.503

    authors: Reisner BS,DiBlasi J,Goel N

    更新日期:1999-04-01 00:00:00

  • Quality control in clinical chemistry: the two-sample plot and improvement of laboratory performance.

    abstract::A two-sample plot is often used to display test results in clinical chemistry external quality control programs. The use of control materials at different concentrations calls for a re-evaluation of the two-sample plot. A modification of the two-sample plot is presented. The axes of the graph are graduated in units of...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.1.91

    authors: Elion-Gerritzen WE

    更新日期:1977-01-01 00:00:00

  • Native-valve endocarditis caused by Staphylococcus epidermidis. A histologically confirmed case.

    abstract::Staphylococcus epidermidis is among the most common organisms isolated from blood cultures. Conversely, it is rarely a well-documented cause of natural-valve endocarditis. However, several authors have reported series of patients with the clinical picture of endocarditis and S. epidermidis bacteremia. Most of these ca...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.3.408

    authors: Littenberg B,Cooper B,Levitz R

    更新日期:1987-03-01 00:00:00

  • Detection of influenza A and B viruses with the Sofia analyzer: a novel, rapid immunofluorescence-based in vitro diagnostic device.

    abstract::This report describes the clinical evaluation of a novel fluorescent immunoassay (FIA), Sofia Influenza A+B FIA (Quidel, San Diego, CA), for the rapid detection and differentiation of influenza A and B viruses. A total of 2,047 subjects provided nasal swabs and nasopharyngeal swabs or aspirates. The overall sensitivit...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1309/AJCP7ZTLJCP3LLMA

    authors: Lewandrowski K,Tamerius J,Menegus M,Olivo PD,Lollar R,Lee-Lewandrowski E

    更新日期:2013-05-01 00:00:00

  • Essential thrombocythemia with acquired von Willebrand's disease.

    abstract::Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.102

    authors: Raman BK,Sawdyk M,Saeed SM

    更新日期:1987-07-01 00:00:00

  • Altered expression, localization, and phosphorylation of epithelial junctional proteins in celiac disease.

    abstract::We aimed to study the expression and localization of the molecular components of enterocyte junctions in celiac disease together with the level of tyrosine phosphorylation, a phenomenon known to affect their cellular distribution and function, and to explore the influence of proinflammatory cytokines. Duodenal biopsy ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DTYR-A91G-8R0K-TM8M

    authors: Ciccocioppo R,Finamore A,Ara C,Di Sabatino A,Mengheri E,Corazza GR

    更新日期:2006-04-01 00:00:00

  • Consolidation of the North Shore-LIJ Health System anatomic pathology services: the challenge of subspecialization, operations, quality management, staffing, and education.

    abstract:OBJECTIVES:To describe our experience, both in meeting challenges and in reporting outcomes, of the consolidation of anatomic pathology services in the North Shore-LIJ Health System in February 2011. METHODS:We addressed issues of governance, personnel, physical plant, quality programming, connectivity, and education....

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPZHEYK8XF4FCK

    authors: Groppi DE,Alexis CE,Sugrue CF,Bevis CC,Bhuiya TA,Crawford JM

    更新日期:2013-07-01 00:00:00

  • Comparison of touch imprints with aspirate smears for evaluating bone marrow specimens.

    abstract::We compared the differential counts of normal and abnormal bone marrow from touch imprints with those from aspirate smears to determine whether the touch imprint was reliable for independent routine use in the examination of bone marrow and the classification of hematologic abnormalities. Normocellular bone marrow spe...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/111.6.753

    authors: Aboul-Nasr R,Estey EH,Kantarjian HM,Freireich EJ,Andreeff M,Johnson BJ,Albitar M

    更新日期:1999-06-01 00:00:00

  • A computer system for cytology in a private laboratory using a PDP 8/E minicomputer.

    abstract::A computer software package written in Dibol for a PDP 8/E computer is described that is designed for the needs of the cytology department of a moderate-sized private medical laboratory. Computerized accessioning of cases, report preparation and printing, historical filing, activity summary reports, and direct patient...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.4.421

    authors: Ashworth CT,McConnell TH,Ashworth RD,Nielsen CR,Sanford J

    更新日期:1979-04-01 00:00:00

  • Thymoma, atypical thymoma, and thymic carcinoma. A novel conceptual approach to the classification of thymic epithelial neoplasms.

    abstract::Primary thymic epithelial neoplasms have been the subject of much controversy in recent years owing to the difficulties posed by these tumors for precise histopathologic typing and prognostication. A number of classification schemes using different terminology have been proposed, none of which has satisfactorily manag...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/111.6.826

    authors: Suster S,Moran CA

    更新日期:1999-06-01 00:00:00

  • American Burkitt's lymphoma-hand-mirror variant. A detailed investigation of cytologic, ultrastructural, and immunologic features.

    abstract::Previous studies of patients with lymphoid malignancies have suggested a relationship between survival and the presence of more than 40% hard-mirror cells in the bone marrow. This report represents the first detailed study of a patient with American Burkitt's lymphoma with numerous hand-mirror cells in the bone marrow...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.6.937

    authors: Schumacher HR,Rainey T,Davidson L,Simon D,Strong M,Creegan WJ,Holloway ML,Stass SA

    更新日期:1978-12-01 00:00:00

  • B-Lymphoblastic Leukemia in Patients With Chronic Lymphocytic Leukemia: A Report of Four Cases.

    abstract:OBJECTIVES:B-lymphoblastic leukemia (B-LBL) arising in patients with chronic lymphocytic leukemia (CLL) is exceedingly rare and poorly characterized. METHODS:We describe four patients with CLL and concurrent or subsequent B-LBL diagnosed by morphologic, immunophenotypic, cytogenetic, and molecular analysis and reviewe...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPXE5VMONMVLZ0

    authors: Chakhachiro Z,Yin CC,Abruzzo LV,Aladily TN,Barron LL,Banks HE,Thomas DA,Keating M,Medeiros LJ,Huh YO

    更新日期:2015-08-01 00:00:00

  • Suppurative granulomatous lymphadenitis caused by corynebacterium ovis (pseudotuberculosis).

    abstract::A 30-year-old previously healthy man developed cervical adenopathy associated with mild constitutional symptoms. Corynebacterium ovis was isolated in pure culture from lymph node tissue on two separate occasions, and small gram positive organisms were identified in both lymph nodes with tissue gram stain. Histopatholo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.4.486

    authors: Goldberger AC,Lipsky BA,Plorde JJ

    更新日期:1981-10-01 00:00:00

  • Practical Diagnostic Approach to the Presence of Hyphae in Neuropathology Specimens With Three Illustrative Cases.

    abstract:Objectives:Early and accurate diagnosis remains crucial in the therapeutic management of invasive central nervous system fungal infections. Different molds have intrinsic resistance to antifungal agents; thus, morphologic differentiation is helpful to clinicians. Methods:Using three examples, we present a guide on how...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/aqx144

    authors: Chavez JA,Brat DJ,Hunter SB,Velazquez Vega J,Guarner J

    更新日期:2018-01-29 00:00:00

  • Evaluation of methods of detecting terminal deoxynucleotidyl transferase in human hematologic malignancies. Comparison of immunofluorescence and enzymatic assays.

    abstract::Terminal transferase (TdT) activity and antigen have been measured in 267 specimens of human bone marrow and peripheral blood by using a biochemical assay for enzymatic activity and an immunofluorescence test for antigen. Oligo p(dA)50 and dGTP were used as reagents in the biochemical assay and either rabbit anti-calf...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.4.420

    authors: Cibull ML,Coleman MS,Nelson O,Hutton JJ,Gordon D,Bollum FJ

    更新日期:1982-04-01 00:00:00

  • Presence of t(8;21)(q22;q22) in myeloperoxidase-positive, myeloid surface antigen-negative acute myeloid leukemia.

    abstract::Although acute myeloid leukemias (AMLs) cytochemically negative for myeloperoxidase are now well recognized, myeloid surface antigen-negative AMLs are rare. The morphologic, cytochemical, immunologic, and cytogenetic or molecular features of such cases are described in four adults aged 19 to 60 years. All had AML with...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/107.1.68

    authors: Arber DA,Glackin C,Lowe G,Medeiros LJ,Slovak ML

    更新日期:1997-01-01 00:00:00

  • Pathologic findings from the national surgical adjuvant breast project (protocol no. 4). II. The significance of regional node histology other than sinus histiocytosis in invasive mammary cancer.

    abstract::The morphologic appearances of regional lymph nodes in radical mastectomy specimens obtained from 303 women entered into a prospective study of invasive breast cancer were categorized into patterns that have been considered to reflect immunologic function. An attempt was made to correlate these with 31 other histologi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.1.21

    authors: Fisher ER,Gregorio R,Redmond C,Dekker A,Fisher B

    更新日期:1976-01-01 00:00:00

  • Rat antikeratin monoclonal antibodies are specific for stratified squamous epithelia.

    abstract::Seven monoclonal antibodies of rat origin were generated against human epidermal keratins and were assayed by immunoblot and by immunoperoxidase staining of frozen sections from various human epithelial tissues. By immunoblotting, the antibodies recognized two different subsets of high molecular weight cytokeratin pol...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.3.315

    authors: Chin NW,Lai BT,Lanks KW

    更新日期:1988-03-01 00:00:00

  • The data warehouse as a foundation for population-based reference intervals.

    abstract::The volume of data contained in a data warehouse represents a potential resource to provide the basis for detailed and specific reference intervals. Routine chemistry panel testing data were derived from an outreach laboratory patient population of 438,180 people and then screened by multiple data filters to identify ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/W8J8-5AG4-WDG6-JGJ9

    authors: Bock BJ,Dolan CT,Miller GC,Fitter WF,Hartsell BD,Crowson AN,Sheehan WW,Williams JD

    更新日期:2003-11-01 00:00:00

  • Effects of physiologic variations in temperature on the rate of antibiotic-induced bacterial killing.

    abstract::The effects of physiologic temperature variations on antibiotic-induced killing of Escherichia coli, Pseudomonas aeruginosa, Streptococcus faecalis, and Streptococcus pneumoniae were studied. At concentrations less than or equal to four times the minimal bactericidal concentration, the activity of each of the antibiot...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.1.57

    authors: Mackowiak PA,Ruderman AE,Martin RM,Many WJ,Smith JW,Luby JP

    更新日期:1981-07-01 00:00:00

  • Inherited giant platelet disorders. Classification and literature review.

    abstract::Inherited giant platelet disorders are extremely rare. The aim of this article is to review the clinical and laboratory features of this heterogeneous group and to arrive at a working classification. We conducted our literature search using the National Library of Medicine database. A total of 12 clinical entities wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/FC4H-LM5V-VCW8-DNJU

    authors: Mhawech P,Saleem A

    更新日期:2000-02-01 00:00:00

  • DNA typing of the human MN and Ss blood group antigens in amniotic fluid and following massive transfusion.

    abstract::Although red blood cell (RBC) antigen typing by agglutination is generally useful, several situations exist where this approach is difficult or impossible. For example, following a massive transfusion, a patient's residual RBCs are mixed with transfused normal donor RBCs. In this case, typing by hemagglutination prima...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.3.353

    authors: Eshleman JR,Shakin-Eshleman SH,Church A,Kant JA,Spitalnik SL

    更新日期:1995-03-01 00:00:00