Chemokines and their receptors: roles in specific clinical conditions and measurement in the clinical laboratory.

Abstract:

:Considerable progress has been achieved in our knowledge of the function of the chemokine system and in understanding its role in the pathophysiology of human diseases. This complex system, presently including approximately 50 cytokines and 20 receptors, coordinates leukocyte recruitment in a variety of human diseases, ranging from infectious and inflammatory diseases to cancer. A large body of literature has been published describing various assays for the measurement of chemokines in biologic fluids and tissues. We review information available on the role of chemokines in selected human diseases and provide examples of clinical situations in which chemokine determination might be of practical value, and we describe the currently available assays for their measurement.

journal_name

Am J Clin Pathol

authors

Locati M,Bonecchi R,Corsi MM

doi

10.1309/M6U4B8L6TNAK4G9L

subject

Has Abstract

pub_date

2005-06-01 00:00:00

pages

S82-95

eissn

0002-9173

issn

1943-7722

journal_volume

123 Suppl

pub_type

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