Clinically relevant differences in prothrombin time and INR values related to blood sample collection in plastic vs glass tubes.

Abstract:

:We compared prothrombin times (PTs) and international normalized ratios (INRs) for blood samples drawn into plastic vs glass collection tubes. We collected 60 venous blood samples into 4.5-mL glass and 2 plastic tubes (2.7 and 3.5 mL). An additional 153 samples, including 63 from warfarin-anticoagulated patients, were collected only in glass and 2.7-mL plastic tubes. The PTs and INRs were determined following routine laboratory procedures. A subset of 35 frozen aliquot samples was analyzed with a different instrument-reagent combination. The PTs and INRs for samples in plastic tubes were significantly lower than for samples in glass tubes. The mean INR differences increased with INR magnitude from approximately -0.1 (INR, 1.5) to -0.7 (INR, 4.5). Of the plastic tube INRs, 50% were more than 10% lower than INRs from samples collected in glass tubes. Therapeutic monitoring based on plastic-tube INRs could result in higher doses of warfarin.

journal_name

Am J Clin Pathol

authors

Fiebig EW,Etzell JE,Ng VL

subject

Has Abstract

pub_date

2005-12-01 00:00:00

pages

902-9

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

124

pub_type

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