Abstract:
:Characteristically, mantle cell lymphoma (MCL) expresses surface immunoglobulin (sIg), CD19, CD20, and CD5 and lacks CD10 and CD23. Rare CD5-MCL variants have been described. This report describes a case of leukemic MCL with morphologically and immunophenotypically distinct classic MCL and blastoid-variant MCL (BV-MCL) components. The classic MCL had typical morphologic features and immunophenotype (kappa sIg light chain-restricted and CD5+; CD10- and CD23-). The BV-MCL had larger nuclei and open chromatin; these cells also were kappa sIg light chain-restricted; however, they were CD10+ and CD5-. Fluorescence in situ hybridization studies demonstrated cyclin D1-immunoglobulin heavy chain gene fusion in both components; the bone marrow biopsy cellularity was replaced by CD10+ and cyclin D1+ and CD5-BV-MCL. This case illustrates the phenotypic heterogeneity of MCL and underscores the need for histopathologic correlation and, in some instances, ancillary genetic studies to accurately classify B-cell lymphomas.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Morice WG,Hodnefield JM,Kurtin PJ,Hanson CAdoi
10.1309/UD2C-6JVP-WHXQ-Q217subject
Has Abstractpub_date
2004-07-01 00:00:00pages
122-7issue
1eissn
0002-9173issn
1943-7722journal_volume
122pub_type
杂志文章abstract::During a 14-year period (1959-1972), 3,600 endometrial suction biopsies were performed in the office for specific indications in selected patients. Three hundred seventy-seven biopsies (10.5%) revealed abnormal findings. Of these, 233 showed endometritis, 96 associated with necrotic decidual or placental tissue, or bo...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/63.3.9
更新日期:1975-01-01 00:00:00
abstract::Cellular and humoral immunity combine to determine the outcome following exposure to hepatitis virus and are implicated in the proposed pathogenetic mechanism for acute and chronic hepatitis. Although antibody to HBsAg is found in virtually all following recovery from hepatitis B, a cell-mediated response to HBsAg can...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
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abstract::Abbreviated pretransfusion testing, although permitted by American Association of Blood Banks Standards for unimmunized patients, is not widely practiced. Concerns remain about optimal antibody screening methods, antibodies missed by deleting the antiglobulin crossmatch, and cost-effectiveness. The authors prospective...
journal_title:American journal of clinical pathology
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更新日期:1990-10-01 00:00:00
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:1998-02-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1980-04-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:2013-10-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1988-04-01 00:00:00
abstract::The effect of changes in cytology laboratory costs, including the costs of new technologies, on the cost-effectiveness of cervical cancer prevention has not been studied. Using University of Iowa laboratory detection rates and costs, a decision model determined the cost-effectiveness of the laboratory with and without...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/111.2.259
更新日期:1999-02-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1995-04-01 00:00:00
abstract::Session 1 of the 2007 Workshop of the Society for Hematopathology/European Association for Haematopathology focused on chronic myelogenous leukemia, BCR-ABL1+ (CML). CML is a myeloproliferative neoplasm arising at the level of a pluripotent stem cell and consistently associated with the BCR-ABL1 fusion gene. CML most ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:2009-08-01 00:00:00
abstract::A 30-year-old previously healthy man developed cervical adenopathy associated with mild constitutional symptoms. Corynebacterium ovis was isolated in pure culture from lymph node tissue on two separate occasions, and small gram positive organisms were identified in both lymph nodes with tissue gram stain. Histopatholo...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/76.4.486
更新日期:1981-10-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/66.2.376
更新日期:1976-08-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/101.4.475
更新日期:1994-04-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/63.6.895
更新日期:1975-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2006-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2012-01-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1990-11-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1994-01-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1984-03-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
更新日期:1978-09-01 00:00:00
abstract::We noticed almost routine disparate results in margin lengths when colorectal specimens are measured in vivo by the surgeon and in vitro by the pathologist. We studied 26 sigmoid and rectum specimens to document the amount of organ shrinkage after surgical removal and fixation. Each specimen had a 5.0-cm segment at ea...
journal_title:American journal of clinical pathology
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更新日期:1999-03-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1986-01-01 00:00:00
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更新日期:2004-04-01 00:00:00
abstract::Fourteen patients treated by allogeneic bone marrow transplantation for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr-abl-specific transcripts. Nine patients were transplanted in the first chronic phase, three in the second chronic phase, and two in the accelerated ph...
journal_title:American journal of clinical pathology
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更新日期:1995-11-01 00:00:00