Abstract:
OBJECTIVES:To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). METHODS:We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. RESULTS:Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. CONCLUSIONS:We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Johnson RC,Savage NM,Chiang T,Gotlib JR,Cherry AM,Arber DA,George TIdoi
10.1309/AJCP1Q0YSXEAHNKKsubject
Has Abstractpub_date
2013-10-01 00:00:00pages
525-35issue
4eissn
0002-9173issn
1943-7722pii
140/4/525journal_volume
140pub_type
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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doi:
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
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