Hidden mastocytosis in acute myeloid leukemia with t(8;21)(q22;q22).

Abstract:

OBJECTIVES:To assess the frequency of systemic mastocytosis (SM) in a large series of acute myeloid leukemia (AML) with t(8;21)(q22;q22). METHODS:We retrospectively characterized 40 bone marrow aspirate smears and biopsy specimens from patients with AML with t(8;21) for the presence of SM. Cases were assessed for mast cell morphology and immunohistochemistry, as well as KIT exon 8 and 17 mutational assessment by reverse transcription polymerase chain reaction. RESULTS:Four patients met criteria for SM, 1 met criteria for myelomastocytic leukemia, and 8 demonstrated the benign finding of mast cell hyperplasia. CONCLUSIONS:We recommend examining all cases of AML with t(8;21) for the presence of SM via morphology, immunophenotyping, and KIT mutational analysis studies.

journal_name

Am J Clin Pathol

authors

Johnson RC,Savage NM,Chiang T,Gotlib JR,Cherry AM,Arber DA,George TI

doi

10.1309/AJCP1Q0YSXEAHNKK

subject

Has Abstract

pub_date

2013-10-01 00:00:00

pages

525-35

issue

4

eissn

0002-9173

issn

1943-7722

pii

140/4/525

journal_volume

140

pub_type

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