Total laboratory automation can help eliminate the laboratory as a factor in emergency department length of stay.

abstract：:Four cases of acute myelofibrosis are contrasted to three cases of acute megakaryocytic leukemia. The cases were clinically indistinguishable. Light microscopic examination of hematoxylin and eosin-stained bone marrow biopsy specimens from the cases of acute myelofibrosis showed a trilinear proliferation of mature and...

journal_title：American journal of clinical pathology

authors： Hruban RH,Kuhajda FP,Mann RB

更新日期：1987-11-01 00:00:00

abstract：:In a child with renal failure and oliguria due to hyperoxaluria myelophthisis developed as a result of extensive bone-marrow replacement with calcium oxalate crystals and an accompanying fibrous proliferations. The histopathology associated with this metabolic disorder was demonstrated in posterior iliac crest bone-ma...

journal_title：American journal of clinical pathology

authors： McKenna RW,Dehner LP

更新日期：1976-12-01 00:00:00

abstract：:In five patients with eosinophilia and myeloproliferative disorders, the IgE levels were normal, and immune complexes were not detected. In contrast, in six patients with reactive eosinophilia accompanying immunologic diseases, the IgE levels were elevated in five, and immune complexes were elevated in two. Five of si...

journal_title：American journal of clinical pathology

authors： Crowley JP,Myers TJ

更新日期：1983-03-01 00:00:00

abstract：:The May-Hegglin anomaly is one of the rare forms of heriditary thrombocytopenia. Since fewer than 100 cases of May-Hegglin anomaly have been described to date, major controversies regarding the adequacy of hemostasis in vivo and abnormalities of platelet function in vitro continue to prevail. This report describes the...

journal_title：American journal of clinical pathology

authors： Hamilton RW,Shaikh BS,Ottie JN,Storch AE,Saleem A,White JG

更新日期：1980-11-01 00:00:00

abstract：OBJECTIVES:To compare next-generation sequencing (NGS) platforms with mutation-specific analysis platforms in a clinical setting, in terms of sensitivity, mutation specificity, costs, capacity, and ease of use. METHODS:We analyzed 25 formalin-fixed, paraffin-embedded lung cancer samples of different size and tumor per...

journal_title：American journal of clinical pathology

authors： Hinrichs JW,van Blokland WT,Moons MJ,Radersma RD,Radersma-van Loon JH,de Voijs CM,Rappel SB,Koudijs MJ,Besselink NJ,Willems SM,de Weger RA

更新日期：2015-04-01 00:00:00

abstract：:Three cases of microcystic adenomas of the pancreas with special reference to multicentric origin are described. The gross features and light microscopic findings were consistent with those described as being microcystic adenomas, but in two cases the gross examination and gelatin-embedded giant slices revealed multip...

journal_title：American journal of clinical pathology

authors： Kim YI,Seo JW,Suh JS,Lee KU,Choe KJ

更新日期：1990-08-01 00:00:00

abstract：:Pulmonary alveolar proteinosis (PAP) is an uncommon disease in which alveoli are progressively filled with surfactant-related material. Although a definitive diagnosis is usually made by an open lung biopsy, bronchoalveolar lavage (BAL) cytology may play a decisive role in the clinical work-up of these patients, and, ...

journal_title：American journal of clinical pathology

authors： Burkhalter A,Silverman JF,Hopkins MB 3rd,Geisinger KR

更新日期：1996-10-01 00:00:00

abstract：:Lymphocyte subpopulations in the intestinal tissues of seven patients with acquired immunodeficiency syndrome (AIDS) or AIDS-related complex (ARC) were studied by immunohistologic technics at two different locations, the small bowel and the rectum. Intraepithelial and lamina propria lymphocyte subsets stained with mon...

journal_title：American journal of clinical pathology

authors： Ellakany S,Whiteside TL,Schade RR,van Thiel DH

更新日期：1987-03-01 00:00:00

abstract：:A test for the detection of antibodies to HTLV-III is available and will be widely used to screen donated blood to prevent transfusion-associated acquired immunodeficiency syndrome (AIDS). Based upon the sensitivity and specificity, the authors calculated the expected predictive values for different groups of asymptom...

journal_title：American journal of clinical pathology

authors： Sivak SL,Wormser GP

更新日期：1986-06-01 00:00:00

abstract：:In a computerized case registry, containing 220 cases of sinus histiocytosis with massive lymphadenopathy (SHML), 23 patients were identified with clinical or routine laboratory findings suggestive or diagnostic of immune dysfunction. We divided the abnormalities into hematologic autoantibodies (nine patients), glomer...

journal_title：American journal of clinical pathology

authors： Foucar E,Rosai J,Dorfman RF,Eyman JM

更新日期：1984-11-01 00:00:00

abstract：:A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocyt...

journal_title：American journal of clinical pathology

authors： Rosenfeld CS,Nichols G,Bodensteiner DC

更新日期：1987-04-01 00:00:00

abstract：:Human papillomaviruses (HPVs) are associated with benign and malignant neoplasms of the cervix. One of the criteria for their etiologic role requires an assessment of whether virtually all or only a small fraction of lesions contain viral genomes. DNA preparations from colposcopically directed punch biopsies of cervic...

journal_title：American journal of clinical pathology

authors： Tham KM,Chow VT,Singh P,Tock EP,Ching KC,Lim-Tan SK,Sng IT,Bernard HU

更新日期：1991-05-01 00:00:00

abstract：:In 1985 Harvard Medical School initiated an experimental curriculum that incorporated many of the recommendations of the report on the General Professional Education of the Physician (GPEP). Key features are problem-based small group tutorials that emphasize active learning, with increased independent study time and a...

journal_title：American journal of clinical pathology

authors： Colvin RB,Wetzel MS

更新日期：1989-10-01 00:00:00

abstract：:The effect of blood transfusion on DNA profiles of an individual is a significant issue in the forensic context. In the present study, the effects of blood transfusion in 5 recipients were studied by performing restriction fragment length polymorphism and polymerase chain reaction HLA-DQA1 and Polymarker (LDLR, GYPA, ...

journal_title：American journal of clinical pathology

authors： Giroti RI,Biswas R,Mukherjee K

更新日期：2002-09-01 00:00:00

abstract：:HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas. However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity. In ...

journal_title：American journal of clinical pathology

authors： Chan OT,Chen ZM,Chung F,Kawachi K,Phan DC,Himmelfarb E,Lin F,Perry A,Wang HL

更新日期：2010-12-01 00:00:00

abstract：:Following normalization of blood glucose levels, a marked change in the MCV and in the calculated hematocrit was observed in five patients with transient severe hyperglycemia. The addition of varied concentrations of glucose to blood samples from healthy volunteers and from patients with microcytic, macrocytic, and no...

journal_title：American journal of clinical pathology

authors： Holt JT,DeWandler MJ,Arvan DA

更新日期：1982-05-01 00:00:00

abstract：OBJECTIVES:To investigate the prognostic utility of multifocal extraprostatic extension (EPE) on biochemical recurrence after radical prostatectomy. METHODS:We conducted retrospective analysis of biochemical recurrence and prognostic pathologic variables in 673 men with stage pT3a/pT3b prostate cancer from 2000 to 201...

journal_title：American journal of clinical pathology

authors： Farchoukh L,Laframboise WA,Nelson JB,Bastacky S,Parwani AV,Dhir R

更新日期：2020-03-09 00:00:00

abstract：:The authors have examined the sensitivity and detection efficiency of the three peroxidase methods that currently have the widest application in diagnostic immunohistochemistry: the peroxidase-antiperoxidase (PAP), the avidin-biotin complex (ABC), and the labeled avidin-biotin (LAB) methods. Sensitivity was evaluated ...

journal_title：American journal of clinical pathology

authors： Elias JM,Margiotta M,Gaborc D

更新日期：1989-07-01 00:00:00

abstract：:An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers. Of the small cell carcinomas (SCC), 69 out of 99 (70%) cases stained with the anti-serum. Maltreated biopsies s...

journal_title：American journal of clinical pathology

authors： Bergh J,Esscher T,Steinholtz L,Nilsson K,Påhlman S

更新日期：1985-07-01 00:00:00

abstract：:Prostate-specific antigen (PSA) is a sensitive and specific serum marker for monitoring disease activity in men with prostatic carcinoma. Despite reports of elevation of levels of this analyte in men with benign prostatic hyperplasia, no information is available correlating the serum levels with the actual prostatic a...

journal_title：American journal of clinical pathology

authors： Brawer MK,Rennels MA,Nagle RB,Schifman R,Gaines JA

更新日期：1989-12-01 00:00:00

abstract：:Mean nuclear areas (MNA) were calculated morphometrically in ten cases of well-differentiated adenocarcinoma, ten cases of atypical alveolar cuboidal cell hyperplasia (AAH), and five cases of alveolar cuboidal cell hyperplasia (AH) and were compared with each other. In cases of adenocarcinoma, the MNA were significant...

journal_title：American journal of clinical pathology

authors： Kodama T,Biyajima S,Watanabe S,Shimosato Y

更新日期：1986-02-01 00:00:00

abstract：:The aim of this study was to evaluate the histopathologic features and the expression of angiogenesis-related markers in primary tumors and metastatic lymph nodes of oral squamous cell carcinomas (SCCs) with multiple lymph node involvement in comparison with oral SCCs without nodal metastasis. The protein levels of th...

journal_title：American journal of clinical pathology

authors： Nikitakis NG,Rivera H,Lopes MA,Siavash H,Reynolds MA,Ord RA,Sauk JJ

更新日期：2003-04-01 00:00:00

abstract：OBJECTIVES:Although diffuse alveolar damage, a subtype of acute lung injury (ALI), is the most common microscopic pattern in coronavirus disease 2019 (COVID-19), other pathologic patterns have been described. The aim of the study was to review autopsies from COVID-19 decedents to evaluate the spectrum of pathology and ...

journal_title：American journal of clinical pathology

authors： De Michele S,Sun Y,Yilmaz MM,Katsyv I,Salvatore M,Dzierba AL,Marboe CC,Brodie D,Patel NM,Garcia CK,Saqi A

更新日期：2020-11-04 00:00:00

abstract：OBJECTIVES:Serologic testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has experienced a changing landscape of available assays coupled with uncertainty surrounding performance characteristics. Studies are needed to directly compare multiple commercially available assays. METHODS:Residual serum ...

journal_title：American journal of clinical pathology

authors： Manthei DM,Whalen JF,Schroeder LF,Sinay AM,Li SH,Valdez R,Giacherio DA,Gherasim C

更新日期：2020-10-09 00:00:00

abstract：:Diffuse alveolar damage (DAD) is usually considered a generalized lung process. During five years the authors observed 83 patients with generalized DAD in 827 adult autopsies (10.1%) and 10 patients with identical, but localized, lesions. The authors propose the term regional alveolar damage (RAD) to designate localiz...

journal_title：American journal of clinical pathology

authors： Yazdy AM,Tomashefski JF Jr,Yagan R,Kleinerman J

更新日期：1989-07-01 00:00:00

abstract：:S-100 protein was detected in a small number of human peripheral T-lymphocytes by a direct immunoperoxidase method with the use of monospecific antibody to S-100 protein. Complemented-mediated lysis using monoclonal antibodies revealed that the S-100+ T-lymphocytes bore OKT3, OKT8, and OKT11 antigens but not OKT4, OKM...

journal_title：American journal of clinical pathology

authors： Takahashi K,Isobe T,Ohtsuki Y,Sonobe H,Yamaguchi H,Akagi T

更新日期：1985-01-01 00:00:00

abstract：:Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings wi...

journal_title：American journal of clinical pathology

authors： Sutton B,Davion S,Feldman M,Siziopikou K,Mendelson E,Sullivan M

更新日期：2012-12-01 00:00:00

abstract：:Bronchoalveolar lavage (BAL) is a minimally invasive method possibly representing a diagnostic tool in the evaluation of interstitial lung diseases (ILDs) of different causes. We first describe herein the morphologic, histochemical, and immunohistochemical features of previously unreported eosinophilic globular deposi...

journal_title：American journal of clinical pathology

authors： Rossi G,Andreani A,Morandi P,Marchioni A,Corradini P,Cappiello G,Bortolotti M,Qosja A,Manzini C,Ferri C,Richeldi L,Cavazza A

更新日期：2008-12-01 00:00:00

abstract：:We describe 35 peripheral lymph nodes classified as mantle cell/marginal zone B-cell hyperplasia with clear cells using morphologic and immunologic findings. For the purpose of this study, we obtained clinical follow-up information and performed immunoglobulin gene rearrangement studies on paraffin sections by polymer...

journal_title：American journal of clinical pathology

authors： Hunt JP,Chan JA,Samoszuk M,Brynes RK,Hernandez AM,Bass R,Weisenburger DD,Müller-Hermelink K,Nathwani BN

更新日期：2001-10-01 00:00:00

abstract：:To evaluate the diagnostic utility of flow cytometry (FCM) as compared to cytology, DNA and RNA content of cells were measured in 233 samples of cerebrospinal fluid (CSF) from 147 patients with solid tumors or lymphomas and 17 controls with nonmalignant disorders. All control specimens were normal. Twenty-eight sample...

journal_title：American journal of clinical pathology

authors： Cibas ES,Malkin MG,Posner JB,Melamed MR

更新日期：1987-11-01 00:00:00