Forty Postmortem Examinations in COVID-19 Patients.

Abstract:

OBJECTIVES:Although diffuse alveolar damage, a subtype of acute lung injury (ALI), is the most common microscopic pattern in coronavirus disease 2019 (COVID-19), other pathologic patterns have been described. The aim of the study was to review autopsies from COVID-19 decedents to evaluate the spectrum of pathology and correlate the results with clinical, laboratory, and radiologic findings. METHODS:A comprehensive and quantitative review from 40 postmortem examinations was performed. The microscopic patterns were categorized as follows: "major" when present in more than 50% of cases and "novel" if rarely or not previously described and unexpected clinically. RESULTS:Three major pulmonary patterns were identified: ALI in 29 (73%) of 40, intravascular fibrin or platelet-rich aggregates (IFPAs) in 36 (90%) of 40, and vascular congestion and hemangiomatosis-like change (VCHL) in 20 (50%) of 40. The absence of ALI (non-ALI) was novel and seen in 11 (27%) of 40. Compared with ALI decedents, those with non-ALI had a shorter hospitalization course (P = .02), chest radiographs with no or minimal consolidation (P = .01), and no pathologically confirmed cause of death (9/11). All non-ALI had VCHL and IFPAs, and clinically most had cardiac arrest. CONCLUSIONS:Two distinct pulmonary phenotypic patterns-ALI and non-ALI-were noted. Non-ALI represents a rarely described phenotype. The cause of death in non-ALI is most likely COVID-19 related but requires additional corroboration.

journal_name

Am J Clin Pathol

authors

De Michele S,Sun Y,Yilmaz MM,Katsyv I,Salvatore M,Dzierba AL,Marboe CC,Brodie D,Patel NM,Garcia CK,Saqi A

doi

10.1093/ajcp/aqaa156

subject

Has Abstract

pub_date

2020-11-04 00:00:00

pages

748-760

issue

6

eissn

0002-9173

issn

1943-7722

pii

5900519

journal_volume

154

pub_type

杂志文章
  • Heterogenous expression of endothelial cell markers in infantile hemangioendothelioma. Immunohistochemical study of two solitary cases and one multiple one.

    abstract::Three cases of infantile hemangioendothelioma were immunohistochemically studied with the use of antibodies against von Willebrand factor (vWF), Ulex europaeus I lectin (UEA I), vimentin, thrombomodulin (TM), and actin, as endothelial cell (EC) markers. Because of a broad variety of histologic features, the growth pat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.6.673

    authors: Yasunaga C,Sueishi K,Ohgami H,Suita S,Kawanami T

    更新日期:1989-06-01 00:00:00

  • Lectin binding activity in appendiceal mucocele.

    abstract::In order to further clarify the histologic criteria and prognostic measurement of appendiceal adenoma and well differentiated adenocarcinoma, lectin binding activity in 31 cases of appendiceal mucocele (6 hyperplasias, 16 adenomas and 9 adenocarcinomas) was studied using an immunoperoxidase staining method. An additio...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.4.481

    authors: Kim CW,Kim YI

    更新日期:1988-04-01 00:00:00

  • Secondary CD5+ diffuse large B-cell lymphoma not associated with transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (Richter syndrome).

    abstract::Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression durin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP58FETFGLCKKW

    authors: Maeshima AM,Taniguchi H,Nomoto J,Maruyama D,Kim SW,Watanabe T,Kobayashi Y,Tobinai K,Matsuno Y

    更新日期:2009-03-01 00:00:00

  • Expression of the Leu-8 antigen by B-cell lymphomas.

    abstract::The Leu-8 antigen is found on the surface of many hematologic cells, including many T- and B-lymphocytes. With the use of a frozen-section immunoperoxidase technic, 152 B-cell non-Hodgkin's lymphomas were examined for Leu-8 expression. Of these lymphomas, 53% expressed Leu-8. Subclassification of the lymphomas with th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.4.486

    authors: Michie SA,Garcia CF,Strickler JG,Dailey MO,Rouse RV,Warnke RA

    更新日期:1987-10-01 00:00:00

  • An acute myeloproliferative disorder characterized by myelofibrosis and blast cells that express phenotypic properties associated with multiple hematopoietic lineages.

    abstract::The authors investigated the blast cells obtained from two patients with acute myelofibrosis with the use of recently developed immunochemical and ultrastructural markers. They intended to examine the expression of megakaryoblastic, erythroblastic, myeloblastic, and monoblastic properties in these cells. Respectively,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/83.1.114

    authors: Schreeder MT,Prchal JT,Parmley RT,Carroll AJ,Gewirtz AM,Hoffman R

    更新日期:1985-01-01 00:00:00

  • Tartrate-resistant acid phosphatase as an immunohistochemical marker for inflammatory macrophages.

    abstract::Human serum contains 2 isoforms of type-5 tartrate-resistant acid phosphatase (TRACP): 5a and 5b. TRACP-5b is osteoclastic. Our goal was to determine if serum TRACP-5a could originate from inflammatory macrophages (MPhi). We stained 246 paraffin-embedded tissue samples for TRACP using monoclonal antibody 9C5 (mab9C5) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DGEA9BE2VE5VCFYH

    authors: Janckila AJ,Slone SP,Lear SC,Martin A,Yam LT

    更新日期:2007-04-01 00:00:00

  • Management by objectives for the academic medical center.

    abstract::Management by Objectives (MBO) is results-oriented, participatory management, which is appropriate for the current era of keen competition for resources. MBO was installed in the author's institution in clinical laboratory divisions meeting prerequisites and fit the system to the local management environment. The resu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.6.738

    authors: Kost GJ

    更新日期:1986-12-01 00:00:00

  • Mimics of cutaneous lymphoma: report of the 2011 Society for Hematopathology/European Association for Haematopathology workshop.

    abstract::The Society for Hematopathology and European Association for Haematopathology workshop, from October 27 to 29, 2011, in Los Angeles, CA, exhibited many exemplary skin biopsy specimens with interesting inflammatory changes mimicking features of cutaneous lymphoma. This article reviews features observed in cutaneous lym...

    journal_title:American journal of clinical pathology

    pub_type: 共识发展会议,杂志文章

    doi:10.1309/AJCPX4BXTP2QBRKO

    authors: Sarantopoulos GP,Palla B,Said J,Kinney MC,Swerdlow SM,Willemze R,Binder SW

    更新日期:2013-04-01 00:00:00

  • Lymphomatoid papulosis. Characterization of skin infiltrates by monoclonal antibodies.

    abstract::Cryostat sections from fully developed papular lesions of lymphomatoid papulosis (histologic subtype A or B) have been examined by immunoenzymatic staining with 24 monoclonal antibodies against lymphoid cells and their subsets. The lesions demonstrated essentially identical cellular compositions and consisted of T-lym...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.5.587

    authors: Ralfkiaer E,Stein H,Wantzin GL,Thomsen K,Ralfkiaer N,Mason DY

    更新日期:1985-11-01 00:00:00

  • Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus infection and in patients with idiopathic thrombocytopenic purpura. A morphometric, immunohistochemical, and ultrastructural study.

    abstract::A morphometric and immunohistochemical study was performed to assess the spleen's alterations in patients with autoimmune thrombocytopenia and in drug abusers with thrombocytopenia (DAT) related to human immunodeficiency virus (HIV) infection. A total of 34 patients were included in the study: 20 DAT patients and 14 w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.6.633

    authors: Marti M,Feliu E,Campo E,Palacin A,Berga L,Casals FJ,Urbano Ispizua A,Cardesa A,Rozman C

    更新日期:1993-12-01 00:00:00

  • Endocrine aspects of exocrine cancer of the pancreas. Their patterns and suggested biologic significance.

    abstract::Nine human exocrine pancreatic adenocarcinomas were examined by serial sectioning and double- and triple-labeled immunohistochemical techniques with antibodies against chromogranin A, insulin, islet amyloid polypeptide, glucagon, somatostatin, pancreatic polypeptide, serotonin, pancreastatin, and neuron-specific enola...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.3.223

    authors: Pour PM,Permert J,Mogaki M,Fujii H,Kazakoff K

    更新日期:1993-09-01 00:00:00

  • Detection of DNA abnormalities by flow cytometry in cells from cerebrospinal fluid.

    abstract::To evaluate the diagnostic utility of flow cytometry (FCM) as compared to cytology, DNA and RNA content of cells were measured in 233 samples of cerebrospinal fluid (CSF) from 147 patients with solid tumors or lymphomas and 17 controls with nonmalignant disorders. All control specimens were normal. Twenty-eight sample...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.5.570

    authors: Cibas ES,Malkin MG,Posner JB,Melamed MR

    更新日期:1987-11-01 00:00:00

  • High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera.

    abstract::We examined the occurrence of JAK2(V617F) and JAK2 exon 12 mutations in a clinical cohort of polycythemia vera (PV) in Taiwan. Of 22 patients with PV, 17 (77%) had the V617F mutation, and all 5 V617F-negative patients (23%) had the exon 12 mutation. We found 3 different exon 12 mutations: 3 N542-E543del, 1 F537-K539de...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPK7KGOWPHYWM0

    authors: Yeh YM,Chen YL,Cheng HY,Su WC,Chow NH,Chen TY,Ho CL

    更新日期:2010-08-01 00:00:00

  • Clinical and laboratory efficiency of rapid screening urine cultures by nephelometry.

    abstract::Urine cultures represent 40-50% of specimens processed by hospital clinical microbiology laboratories. An accurate rapid screening method to detect positive urine cultures could greatly improve laboratory efficiency. Three hundred eighty-two unselected urines were screened by nephelometry at 2, 4, and 5 hours of shaki...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.3.305

    authors: Heinz T,Pezzlo M,Thrupp L

    更新日期:1982-03-01 00:00:00

  • Nephroblastoma: multidrug-resistance P-glycoprotein expression in tumor cells and intratumoral capillary endothelial cells.

    abstract::The development of chemoresistance in a variety of cancers seems related to overexpression of the P-glycoprotein (P-gp) drug pump. Nephroblastoma, the most common malignant renal tumor of childhood, usually is responsive to treatment, and prognosis is favorable in most cases. However, the disease in a subset of patien...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/L44X-L5DN-1VHV-X30N

    authors: Camassei FD,Arancia G,Cianfriglia M,Bosman C,Francalanci P,Ravà L,Jenkner A,Donfrancesco A,Boldrini R

    更新日期:2002-03-01 00:00:00

  • Intratumoral DNA content variability. A study of non-small cell lung cancer.

    abstract::Twenty-eight resected primary non-small cell lung carcinomas were studied for intratumoral DNA variability by flow cytometry (FCM). Three separate tissue specimens from each resected tumor were divided equally for FCM analysis and histologic evaluation. FCM analysis also was performed on fine-needle aspirates (FNAs) f...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.3.311

    authors: Sara A,el-Naggar AK

    更新日期:1991-09-01 00:00:00

  • Predicting relapse of chronic myelogenous leukemia after allogeneic bone marrow transplantation by bcr-abl mRNA and DNA fingerprinting.

    abstract::Fourteen patients treated by allogeneic bone marrow transplantation for chronic myelogenous leukemia (CML) were evaluated by the polymerase chain reaction (PCR) for bcr-abl-specific transcripts. Nine patients were transplanted in the first chronic phase, three in the second chronic phase, and two in the accelerated ph...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/104.5.510

    authors: Okamoto R,Harano H,Matsuzaki M,Motomura S,Maruta A,Kodama F,Mohri H,Okubo T

    更新日期:1995-11-01 00:00:00

  • Performance characteristics of nested polymerase chain reaction vs real-time polymerase chain reaction methods for detecting Mycobacterium tuberculosis complex in paraffin-embedded human tissues.

    abstract:OBJECTIVES:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP2QZRH4ZNPRDD

    authors: Seo AN,Park HJ,Lee HS,Park JO,Chang HE,Nam KH,Choe G,Park KU

    更新日期:2014-09-01 00:00:00

  • The osseous manifestations of sinus histiocytosis with massive lymphadenopathy.

    abstract::The cases of five patients who had sinus histiocytosis with massive lymphadenopathy accompanied by osseous involvement by the disease are presented. Four of the five patients were children. The bone lesions were multiple in four cases and solitary in one. The long bones were most commonly involved (three patients); ot...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.2.131

    authors: Walker PD,Rosai J,Dorfman RF

    更新日期:1981-02-01 00:00:00

  • A double-blind comparative immunotypic study between two institutions phenotyping non-Hodgkin's lymphomas.

    abstract::To establish the feasibility of immunotyping specimens transported over great distance, the University of Arizona and the Cleveland Clinic exchanged 39 lymphoma cases (26 B-cell, 13 T-cell cases) via air express for phenotyping. They were exchanged with the use of glass slides with adherent snap-frozen sections. The m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.4.478

    authors: Grogan TM,Tubbs RR

    更新日期:1987-04-01 00:00:00

  • Hemolytic disease of the newborn due to anti-C and anti-G masquerading as anti-D.

    abstract::After several transfusions with D-negative blood, an O Rh-negative women was apparently sensitized to the C and D antigens. In her prenatal workup, it became evident that she had in fact not been sensitized to D but to G, which initially appeared as anti-D plus anti-C. This sensitization pattern is an unusual occurren...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.6.769

    authors: Yesus YW,Akhter JE

    更新日期:1985-12-01 00:00:00

  • The evaluation of estrogen receptor in primary breast carcinoma by computer-assisted image analysis.

    abstract::A monoclonal antibody prepared against estrogen receptor has been shown to be specific and sensitive for the detection of estrogen receptor in human breast lesions by use of immunohistochemical methods. Two hundred selected cases of primary breast carcinoma were assayed for estrogen receptor content by biochemical and...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.3.233

    authors: Bacus S,Flowers JL,Press MF,Bacus JW,McCarty KS Jr

    更新日期:1988-09-01 00:00:00

  • Adenovirus in the gastrointestinal tracts of immunosuppressed patients.

    abstract::Adenovirus was cultured from various gastrointestinal sites and one lung specimen from seven immunosuppressed patients, four of whom were bone marrow transplant recipients. Histologic examination and in situ hybridization studies of the lung demonstrated adenovirus in the bronchial epithelium and alveolar lining cells...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.4.555

    authors: Strickler JG,Singleton TP,Copenhaver CM,Erice A,Snover DC

    更新日期:1992-04-01 00:00:00

  • Decreased T-lymphocytes in patients with mammary cancer.

    abstract::The levels of thymus-derived lymphocytes (T-cells) in samples of peripheral blood from 47 patients with carcinoma of the breast, 36 patients with benign mammary lesions, and 33 matched normal controls were determined. Results were analyzed with three statistical tests. It was found that the mean percentages of T-lymph...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.4.445

    authors: Keller SE,Ioachim HL,Pearse T,Siletti DM

    更新日期:1976-04-01 00:00:00

  • Percentage of tumor in prostatectomy specimens: a study of American Veterans.

    abstract::In this study, I have estimated the percentage of tumor by visual estimate in 447 prostatectomy specimens from American Veterans Affairs patients and related this measurement to overall survival. Although percentage of tumor was significantly related to the serum prostate-specific antigen level, tumor stage, and Gleas...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPX5MAMNMFE6FQ

    authors: Vollmer RT

    更新日期:2009-01-01 00:00:00

  • Rapid immunocytochemical analysis of acute leukemias.

    abstract::Immunophenotypic analysis of acute leukemias is time consuming and often requires flow cytometric analysis. A 1-hour alkaline phosphatase-labeled streptavidin-biotin immunocytochemical procedure was evaluated as an alternative. Seventeen cases of acute leukemia, including 10 acute lymphocytic (ALL) and 7 acute nonlymp...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.6.876

    authors: Hammer RD,Collins RD,Ebrahimi S,Casey TT

    更新日期:1992-06-01 00:00:00

  • Comparison of Papanicolaou's stain with the Gomori methenamine silver (GMS) stain for the cytodiagnosis of Pneumocystis carinii in bronchoalveolar lavage (BAL) fluid.

    abstract::The cytodiagnosis of Pneumocystis carinii (PC) in bronchoalveolar lavage (BAL) fluids has traditionally required a special stain such as Gomori's methenamine silver (GMS) stain. Recent reports indicate that identification of foamy alveolar casts (FACs) with Papanicolaou's (Pap) stain may provide a sensitive and less c...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.4.583

    authors: Schumann GB,Swensen JJ

    更新日期:1991-04-01 00:00:00

  • Improving patient safety by repeating (read-back) telephone reports of critical information.

    abstract::Reducing the rate of avoidable errors is crucial to patient safety. Telephone calls with misunderstood critical results constitute one area in which opportunities for improvement exist. The aviation industry has dealt with this issue by requiring pilots to repeat instructions received from the air traffic controller. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/9DYM-6R0T-M830-U95Q

    authors: Barenfanger J,Sautter RL,Lang DL,Collins SM,Hacek DM,Peterson LR

    更新日期:2004-06-01 00:00:00

  • Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy.

    abstract::This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregati...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPTE3K1SGAPOIZ

    authors: Paniccia R,Antonucci E,Maggini N,Romano E,Gori AM,Marcucci R,Prisco D,Abbate R

    更新日期:2009-06-01 00:00:00

  • Restrictive Transfusion Strategy and Clinical Decision Support Practices for Reducing RBC Transfusion Overuse.

    abstract:OBJECTIVES:Assess support for the effectiveness of two separate practices, restrictive transfusion strategy and computerized physician order entry/clinical decision support (CPOE/CDS) tools, in decreasing RBC transfusions in adult surgical and nonsurgical patients. METHODS:Following the Centers for Disease Control and...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz070

    authors: Derzon JH,Clarke N,Alford A,Gross I,Shander A,Thurer R

    更新日期:2019-10-07 00:00:00