Expression of the Leu-8 antigen by B-cell lymphomas.

Abstract:

:The Leu-8 antigen is found on the surface of many hematologic cells, including many T- and B-lymphocytes. With the use of a frozen-section immunoperoxidase technic, 152 B-cell non-Hodgkin's lymphomas were examined for Leu-8 expression. Of these lymphomas, 53% expressed Leu-8. Subclassification of the lymphomas with the use of the International Working Formulation showed that most small lymphocytic, intermediate lymphocytic, and diffuse large cell lymphomas and about half of diffuse small cleaved, diffuse mixed, and follicular lymphomas expressed Leu-8. In contrast, all 17 cases of small noncleaved cell (Burkitt's) lymphoma and 9 of 10 cases of multiple myeloma/plasmacytoma were Leu-8 negative. These results indicate that Leu-8 is expressed on a wide variety of B-cell lymphomas and that differences in Leu-8 expression may be useful in the diagnostic separation of small lymphocytic lymphoma with plasmacytoid features from multiple myeloma/plasmacytoma, and diffuse large cell lymphoma from Burkitt's lymphoma.

journal_name

Am J Clin Pathol

authors

Michie SA,Garcia CF,Strickler JG,Dailey MO,Rouse RV,Warnke RA

doi

10.1093/ajcp/88.4.486

subject

Has Abstract

pub_date

1987-10-01 00:00:00

pages

486-90

issue

4

eissn

0002-9173

issn

1943-7722

journal_volume

88

pub_type

杂志文章
  • Immunohistochemical detection of hepatitis C antigen by monoclonal antibody TORDJI-22 compared with PCR viral detection.

    abstract::We sought to determine the sensitivity and specificity of immunohistochemistry using the TORDJI-22 MoAb (BioGenex, San Ramon, Calif), which is specific for the C-100 protein of the hepatitis C virus, compared with reverse transcriptase-polymerase chain reaction (RT-PCR) of tissue for viral RNA. RT-PCR had been perform...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/110.1.32

    authors: Brody RI,Eng S,Melamed J,Mizrachi H,Schneider RJ,Tobias H,Teperman LW,Theise ND

    更新日期:1998-07-01 00:00:00

  • Restrictive Transfusion Strategy and Clinical Decision Support Practices for Reducing RBC Transfusion Overuse.

    abstract:OBJECTIVES:Assess support for the effectiveness of two separate practices, restrictive transfusion strategy and computerized physician order entry/clinical decision support (CPOE/CDS) tools, in decreasing RBC transfusions in adult surgical and nonsurgical patients. METHODS:Following the Centers for Disease Control and...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz070

    authors: Derzon JH,Clarke N,Alford A,Gross I,Shander A,Thurer R

    更新日期:2019-10-07 00:00:00

  • Histopathologic findings of duodenal biopsy specimens in HIV-infected patients with and without diarrhea and malabsorption.

    abstract::The significance of the human immunodeficiency virus (HIV) in the small intestinal lamina propria in patients with the acquired immune deficiency syndrome or conditions related to that syndrome who have chronic diarrhea and malabsorption is unclear. To investigate this issue, upper endoscopy (after a 12- to 16-hour fa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.1.21

    authors: Ehrenpreis ED,Patterson BK,Brainer JA,Yokoo H,Rademaker AW,Glogowski W,Noskin GA,Craig RM

    更新日期:1992-01-01 00:00:00

  • Can We Identify Nephrogenic Adenoma in Urine Cytology Specimens? A Study Evaluating Previously Described Cytomorphologic Features in Correlation With PAX8 Immunohistochemical Staining Results.

    abstract:OBJECTIVES:The aim of this study is to determine if the diagnosis of nephrogenic adenoma (NA) can be made on cytologic criteria alone and if pair box gene transcription factor 8 (PAX8) is useful in the diagnosis of NA in daily cytology practice. METHODS:Cytologic features of NA previously described in a literature wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw006

    authors: McCroskey Z,Pambuccian SE,Wojcik EM,Barkan GA

    更新日期:2016-03-01 00:00:00

  • Detection of Naegleria fowleri, Acanthamoeba spp, and Balamuthia mandrillaris in Formalin-Fixed, Paraffin-Embedded Tissues by Real-Time Multiplex Polymerase Chain Reaction.

    abstract:OBJECTIVES:Pathogenic free-living amebae (FLAs) cause skin, ocular, and central nervous system (CNS) infections with significant morbidity and mortality. Diagnosis of FLA infections by pathologic examination of tissue sections can be aided using molecular assays. This study investigated the performance characteristics ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz103

    authors: Norgan AP,Sloan LM,Pritt BS

    更新日期:2019-11-04 00:00:00

  • Immunoglobulin inclusions in non-Hodgkin's lymphomas.

    abstract::The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin's lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG (k) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/69.1.306

    authors: van den Tweel JG,Taylor CR,Parker JW,Lukes RJ

    更新日期:1978-03-01 00:00:00

  • Comparison of the clinic microscopy laboratory with the cytopathology laboratory in the detection of malignant cells in body fluids.

    abstract::The clinical microscopy (fluids) laboratory evaluates almost every body fluid that is obtained in the hospital. Because the fluids laboratory functions at all hours, it is often the first laboratory to receive a body fluid. In addition to its primary purpose of quantitating categories of cells, the medical technologis...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.4.439

    authors: Ben-Ezra J,Stastny JF,Harris AC,Bork L,Frable WJ

    更新日期:1994-10-01 00:00:00

  • Encephalitozoon (Septata) intestinalis: cytologic, histologic, and electron microscopic features of a systemic intestinal pathogen.

    abstract::Encephalitozoon (Septata) intestinalis affects AIDS patients with CD4 counts <100/microL, causing intestinal and disseminated disease. It must be distinguished from the more common intestinal microsporidian, Enterocytozoon bieneusi, and from other microsporidia of extraintestinal tissues, such as Encephalitozoon helle...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.5.606

    authors: Chu P,West AB

    更新日期:1996-11-01 00:00:00

  • DNA analysis (ploidy) of molar pregnancies with image analysis on paraffin tissue sections.

    abstract::Hydatidiform moles can be subclassified based on their ploidy. In general, complete moles are diploid, and partial moles are triploid. The standard method for the determination of DNA content is flow cytometric analysis. In this study, the authors investigated whether static cytometric analysis with the CAS 200 Image ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.4.451

    authors: Barclay ID,Dabbagh L,Babiak J,Poppema S

    更新日期:1993-10-01 00:00:00

  • Extranodal Natural Killer/T-Cell Lymphoma in Children and Adolescents: A Report of 17 Cases in China.

    abstract:OBJECTIVES:To investigate the clinicopathologic features of extranodal natural killer/T-cell lymphoma (ENKTL) not preceded by another Epstein-Barr virus (EBV)-related disorder in children and adolescents. METHODS:A series of 17 cases of ENKTL not preceded by another EBV-related disorder in children and adolescents in ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqv010

    authors: Huang Y,Xie J,Ding Y,Zhou X

    更新日期:2016-01-01 00:00:00

  • The utility of BRAF V600E mutation-specific antibody VE1 for the diagnosis of hairy cell leukemia.

    abstract:OBJECTIVES:BRAF V600E mutation is characteristic of hairy cell leukemia (HCL). A V600E mutation-specific antibody, VE1, has been recently developed. We studied the diagnostic utility of this antibody in HCL and compared it with other B-cell neoplasms. METHODS:VE1 activity was assessed using immunohistochemistry in 90 ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQLQ89VXTVWKN

    authors: Uppal G,Ly V,Wang ZX,Bajaj R,Solomides CC,Banks PM,Medeiros LJ,Peiper SC,Gong JZ

    更新日期:2015-01-01 00:00:00

  • Squamous metaplasia of the prostate. An immunohistochemical study.

    abstract::Immunoperoxidase strains for prostate-specific antigen (PSA), prostatic acid phosphatase (PAcP), epithelial membrane antigen (EMA), and cytokeratins (MAK 6 and CK-KES) were performed on 1 case of squamous cell carcinoma of the prostate and on 13 cases of squamous metaplasia of prostatic epithelium in an effort to demo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.5.597

    authors: Lager DJ,Goeken JA,Kemp JD,Robinson RA

    更新日期:1988-11-01 00:00:00

  • Epithelial cell atypia in bronchoalveolar lavage specimens from lung transplant recipients.

    abstract::In lung transplant recipients, bronchoalveolar lavage (BAL) is mainly performed to detect infectious agents. However, in addition to microorganisms, epithelial cell atypia may be identified, and determination of its significance is necessary. Specimens obtained at BAL in lung and heart-lung transplant recipients (LTRs...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/112.2.204

    authors: Ohori NP

    更新日期:1999-08-01 00:00:00

  • The proliferative cell fraction in cytology specimens. A study of human esophageal carcinoma.

    abstract::Immunostaining of cell cycle-related antigens, especially Ki-67, DNA polymerase alpha, and proliferating cell nuclear antigen, has become an important method to assess the proliferative activity of tumors. These three nuclear antigens were studied by immunohistochemical analysis of cytologic smears. These smears were ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/98.2.161

    authors: Sasano H,Miyazaki S,Nishihira T,Sawai T,Nagura H

    更新日期:1992-08-01 00:00:00

  • A study of results generated using the Abbott LCx-GC assay fails to reveal a performance-based rationale for the 2002 level 1 recall.

    abstract::To establish the effect of a quality control failure on the performance of the LCx-GC nucleic-acid amplification assay for Neisseria gonorrhoeae (Abbott Laboratories, Abbott Park, IL) in the field, we conducted a retrospective analysis comparing the clinical and analytic performance of the recalled lots with those not...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/1LD8-LU7Y-FFW7-5WQA

    authors: Skeate RC,Wahi MM,Hanson KL,Cartwright CP

    更新日期:2005-06-01 00:00:00

  • Oxalosis. An unusual cause of myelophthisis in childhood.

    abstract::In a child with renal failure and oliguria due to hyperoxaluria myelophthisis developed as a result of extensive bone-marrow replacement with calcium oxalate crystals and an accompanying fibrous proliferations. The histopathology associated with this metabolic disorder was demonstrated in posterior iliac crest bone-ma...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/66.6.991

    authors: McKenna RW,Dehner LP

    更新日期:1976-12-01 00:00:00

  • Management by objectives for the academic medical center.

    abstract::Management by Objectives (MBO) is results-oriented, participatory management, which is appropriate for the current era of keen competition for resources. MBO was installed in the author's institution in clinical laboratory divisions meeting prerequisites and fit the system to the local management environment. The resu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.6.738

    authors: Kost GJ

    更新日期:1986-12-01 00:00:00

  • Expression of matrix metalloproteinase-2 related to lymph node metastasis of oral squamous cell carcinoma. A clinicopathologic study.

    abstract::To investigate the effect of matrix-degrading enzymes on the malignant potential of oral squamous cell carcinoma, the expression of matrix metalloproteinase-2 (MMP-2/72-kD gelatinase/type IV collagenase) in 46 patients who had neck surgery for oral cancer was studied immunohistochemically. In 20 of 26 patients (76.9%)...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/99.1.18

    authors: Kusukawa J,Sasaguri Y,Shima I,Kameyama T,Morimatsu M

    更新日期:1993-01-01 00:00:00

  • Molecular Genetic Landscape of Sclerosing Pneumocytomas.

    abstract:OBJECTIVES:Sclerosing pneumocytomas are rare pulmonary neoplasms that are typically benign. However, rare patients experience progressive disease, and therapy targeting specific genetic underpinnings could be an attractive therapeutic option. Recent studies have found recurrent AKT 1 mutations in sclerosing pneumocytom...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa136

    authors: Boland JM,Lee HE,Barr Fritcher EG,Voss JS,Jessen E,Davila JI,Kipp BR,Graham RP,Maleszewski JJ,Yi ES

    更新日期:2020-11-04 00:00:00

  • Spinal cord aspergillus invasion--complication of an aspergilloma.

    abstract::Acute paraplegia developed in a 53-year-old man with pulmonary aspergilloma because of contiguous extension of Aspergillus infection to the epidural and subdural spaces and spinal cord. Histopathologic findings of the spinal cord showed Aspergillus hyphae penetrating the myelin sheath and myelomalacia, predominantly i...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.6.763

    authors: Sheth NK,Varkey B,Wagner DK

    更新日期:1985-12-01 00:00:00

  • Predictive value of a screening test for antibodies to HTLV-III.

    abstract::A test for the detection of antibodies to HTLV-III is available and will be widely used to screen donated blood to prevent transfusion-associated acquired immunodeficiency syndrome (AIDS). Based upon the sensitivity and specificity, the authors calculated the expected predictive values for different groups of asymptom...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/85.6.700

    authors: Sivak SL,Wormser GP

    更新日期:1986-06-01 00:00:00

  • Malakoplakia of palatine tonsil.

    abstract::This paper's purpose is to document a case of unilateral tonsillar malakoplakia. Escherichia coli was repeatedly cultured from the lesion, and the isolate was studied by expert microbiologists who found no abnormalities in its biologic properties. The course of the lesion was followed by repeated punch biopsies before...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.3.390

    authors: Kalfayan B,Seager GM

    更新日期:1982-09-01 00:00:00

  • Laboratory measurements of the oral direct factor Xa inhibitor edoxaban: comparison of prothrombin time, activated partial thromboplastin time, and thrombin generation assay.

    abstract:OBJECTIVES:Edoxaban, an oral direct factor Xa inhibitor, does not require routine monitoring. However, assessment of the anticoagulant effects may be required in certain situations. METHODS:We investigated the effects of edoxaban on prothrombin time (PT), activated partial thromboplastin time (aPTT), and thrombin gene...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQ2NJD3PXFTUG

    authors: Morishima Y,Kamisato C

    更新日期:2015-02-01 00:00:00

  • Automated immunohistochemical estrogen receptor in fixed embedded breast carcinomas. Comparison with manual immunohistochemistry on frozen tissues.

    abstract::Estrogen receptor (ER) status of breast carcinomas determines prognosis and treatment. Biochemical ER assays are expensive and time-consuming and require fresh tumor. Immunohistochemical ER was assessed in 68 breast carcinomas, by an automated method using routinely processed formalin-fixed paraffin-embedded tissues, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.5.669

    authors: Cohen C,Unger ER,Sgoutas D,Bradley N,Chenggis M

    更新日期:1989-11-01 00:00:00

  • Evaluation of two commercially available nucleic acid hybridization assays for the detection and typing of human papillomavirus in clinical specimens.

    abstract::Southern blot (Oncor, Gaithersburg, MD) and dot blot (Life Technologies, Gaithersburg, MD) nucleic acid hybridization assays were compared for their ability to detect and type human papillomavirus (HPV) DNA in 50 cervical swab specimens and 11 biopsy specimens. Overall agreement between the two methods was 78.7%. With...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.1.21

    authors: Bartholoma NY,Adelson MD,Forbes BA

    更新日期:1991-01-01 00:00:00

  • Prognostic factors in primary mucinous breast carcinoma.

    abstract::Two hundred seven mucinous breast carcinomas were morphologically classified into two different groups: pure mucinous carcinomas consisting only of areas with small epithelial islands of solid tumor floating in abundant extracellular mucin, and mixed carcinomas where the tumor contains large areas of mucin, as well as...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.2.155

    authors: Rasmussen BB,Rose C,Christensen IB

    更新日期:1987-02-01 00:00:00

  • Proliferative activity in non-Hodgkin's lymphomas. A comparison of the bromodeoxyuridine labeling index with PCNA immunostaining and quantitative image analysis.

    abstract::Cellular proliferation is being evaluated as an independent prognostic indicator in a variety of tumors, including non-Hodgkin's lymphomas (NHL). Although the labeling index (LI), using either tritiated thymidine or monoclonal antibodies to bromodeoxyuridine, is considered to be the gold standard of cell kinetic measu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/99.6.668

    authors: Sebo TJ,Roche PC,Witzig TE,Kurtin PJ

    更新日期:1993-06-01 00:00:00

  • Subclinical hemolytic disease of the newborn due to anti-e.

    abstract::A case of subclinical hemolytic disease of the newborn resulting in reticulocytosis and positive direct and indirect antiglobulin tests in an infant both ABO- and Rh(D)-compatible with its mother is reported. The antibody was an IgG, non-complement-binding molecule present in low titer with a low avidity for the antig...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.1.76

    authors: Hanzlick RL,Senhauser DA

    更新日期:1979-07-01 00:00:00

  • The use of fine needle aspiration cytology for the distinction of pancreatic mucinous neoplasia.

    abstract::Cytology frequently has some role in preoperatively distinguishing pancreatic mucus-producing neoplasia (intraductal papillary mucinous neoplasms [IPMNs] and mucinous cystic neoplasms [MCNs]) from other pancreatic cysts. We evaluated all cytologic specimens at our institutions from resected pancreatic cystic lesions f...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/Y16QCXE3YGMXX19Q

    authors: Stelow EB,Shami VM,Abbott TE,Kahaleh M,Adams RB,Bauer TW,Debol SM,Abraham JM,Mallery S,Policarpio-Nicolas ML

    更新日期:2008-01-01 00:00:00

  • Phenotype of the hairy cells of leukemic reticuloendotheliosis defined by monoclonal antibodies.

    abstract::Hairy cell populations of greater than 90 purity were prepared from six samples obtained from four patients with leukemic reticuloendotheliosis (LRE). These then were analyzed for surface immunoglobulin (SIg) and antigens specified by a panel of monoclonal antibodies. The hairy cells from all patients displayed SIg an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.4.431

    authors: Janckila AJ,Stelzer GT,Wallace JH,Yam LT

    更新日期:1983-04-01 00:00:00