Intratumoral DNA content variability. A study of non-small cell lung cancer.

abstract：:Reference values for hematologic parameters are determined using data from patient populations of a whole year. As a consequence, the authors are not dependent on a limited selected population and can determine reference values for all age and sex groups. It turns out that from the possible compilation technics the ga...

journal_title：American journal of clinical pathology

authors： Swaanenburg JC,Rutten WP,Holdrinet AC,van Strik R

更新日期：1987-08-01 00:00:00

abstract：:Chronic myeloproliferative diseases (MPDs) are not associated with consistent cytogenetic or molecular abnormalities. Demonstration of clonal cell growth by analysis of X-chromosome inactivation (XCI) patterns in females provides a promising tool for diagnosis. However, this technique can be complicated by excessive l...

journal_title：American journal of clinical pathology

authors： Mitterbauer G,Winkler K,Gisslinger H,Geissler K,Lechner K,Mannhalter C

更新日期：1999-07-01 00:00:00

abstract：:Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the pa...

journal_title：American journal of clinical pathology

authors： Sosler SD,Behzad O,Garratty G,Lee CL,Postoway N,Khomo O

更新日期：1985-09-01 00:00:00

abstract：OBJECTIVES:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR...

journal_title：American journal of clinical pathology

authors： Seo AN,Park HJ,Lee HS,Park JO,Chang HE,Nam KH,Choe G,Park KU

更新日期：2014-09-01 00:00:00

abstract：:Chicken pox, although common, is rarely associated with autoimmune hemolytic anemia. Reported here is the case of an 8-year-old boy who was found to have cold agglutinin disease and severe anemia several days after he contracted chicken pox. The cold agglutinin appeared to be a polyclonal immunoglobulin M antibody wit...

journal_title：American journal of clinical pathology

authors： Friedman HD,Dracker RA

更新日期：1992-01-01 00:00:00

abstract：:S-100 protein was detected in a small number of human peripheral T-lymphocytes by a direct immunoperoxidase method with the use of monospecific antibody to S-100 protein. Complemented-mediated lysis using monoclonal antibodies revealed that the S-100+ T-lymphocytes bore OKT3, OKT8, and OKT11 antigens but not OKT4, OKM...

journal_title：American journal of clinical pathology

authors： Takahashi K,Isobe T,Ohtsuki Y,Sonobe H,Yamaguchi H,Akagi T

更新日期：1985-01-01 00:00:00

abstract：:Uterine tumors with histologic resemblances to ovarian sex-cord tumors were encountered in 14 women in the fourth to sixth decades of life, most of whom had abnormal vaginal bleeding and enlarged uteri suggesting leiomyomas. The tumors in six cases (Group I) were identical to one or another form of well-recognized end...

journal_title：American journal of clinical pathology

authors： Clement PB,Scully RE

更新日期：1976-09-01 00:00:00

abstract：:A case of congenital Pelger-Hüet anomaly of the peripheral blood cells is described. Electronmicroscopic examination of the blood cells revealed nuclear bridges and appendices in the polymorphonuclear leukocytes. The number of cytoplasmic granules was diminished, but the size of the secondary granules was markedly inc...

journal_title：American journal of clinical pathology

authors： Djaldetti M,Weiss S,Gafter U

更新日期：1976-06-01 00:00:00

abstract：:Overexpression and amplification of the HER-2 oncogene in patients with breast cancer has correlated with early onset of metastasis, resistance to hormonal therapy and some forms of chemotherapy, and shortened survival. Therefore, evaluation of this putative prognostic or predictive factor seems critical. Because diff...

journal_title：American journal of clinical pathology

authors： Gancberg D,Lespagnard L,Rouas G,Paesmans M,Piccart M,Di Leo A,Nogaret JM,Hertens D,Verhest A,Larsimont D

更新日期：2000-05-01 00:00:00

abstract：:An acquired circulating inhibitor to Factor VIII:C was found in a 27-year-old postpartum woman who presented with ecchymoses and hematomas. Postpartum Factor VIII:C inhibitors can clinically manifest with signs and symptoms not unlike those in a classic hemophiliac. The natural history of this inhibitor is typically o...

journal_title：American journal of clinical pathology

authors： Shitamoto BS,Leslie KO,Galloway WB

更新日期：1982-11-01 00:00:00

abstract：:It has been shown that the monoclonal antibody Ki-67 reacts with a nuclear antigen that is expressed only by proliferating cells. The feasibility of using image analysis to quantitate Ki-67 staining (proliferation index [PI]) of epithelial ovarian cancers was investigated. The PI was determined in 50 advanced-stage pr...

journal_title：American journal of clinical pathology

authors： Jordan PA,Kerns BJ,Pence JC,Kohler MF,Bast RC Jr,Kinney RB,Berchuck A

更新日期：1993-06-01 00:00:00

abstract：Objectives:The aims were to evaluate breast cancer (BC) tumor-infiltrating lymphocytes (TILs) interobserver variability, heterogeneity, and the fidelity of scoring TILs in core needle biopsy (CNB). Methods:Matching CNB and two full-face sections (FFSs) of BC cases (n = 100) were independently reviewed by two pathologi...

journal_title：American journal of clinical pathology

authors： Khoury T,Peng X,Yan L,Wang D,Nagrale V

更新日期：2018-10-01 00:00:00

abstract：OBJECTIVES:Meningiomas usually can be readily diagnosed on H&E alone, although occasionally immunohistochemistry (IHC) confirmation is desirable. Studies exploring the diagnostic utility of either podoplanin (D2-40) or E-cadherin IHC in meningiomas have conflicted, and no studies exist in which the two IHCs have been u...

journal_title：American journal of clinical pathology

authors： Mrachek EK,Davis D,Kleinschmidt-DeMasters BK

更新日期：2015-12-01 00:00:00

abstract：:The prehospital environment has not been studied for point-of-care testing. Therefore, the authors' helicopter program evaluated the performance of the i-STAT Portable Clinical Analyzer, a rapid point-of-care, hand-held instrument. The primary aim of the study was to determine if the i-STAT Portable Clinical Analyzer ...

journal_title：American journal of clinical pathology

authors： Herr DM,Newton NC,Santrach PJ,Hankins DG,Burritt MF

更新日期：1995-10-01 00:00:00

abstract：OBJECTIVES:Pathogenic free-living amebae (FLAs) cause skin, ocular, and central nervous system (CNS) infections with significant morbidity and mortality. Diagnosis of FLA infections by pathologic examination of tissue sections can be aided using molecular assays. This study investigated the performance characteristics ...

journal_title：American journal of clinical pathology

authors： Norgan AP,Sloan LM,Pritt BS

更新日期：2019-11-04 00:00:00

abstract：:Although papillary forms of intraductal cancer are a common component of amny mammary cancers, invasive papillary cancer of the breast is relatively rare. Only 35 examples were encountered in the specimens obtained from 1603 women participating in a prospective randomized study of invasive mammary cancer. Contingency-...

journal_title：American journal of clinical pathology

authors： Fisher ER,Palekar AS,Redmond C,Barton B,Fisher B

更新日期：1980-03-01 00:00:00

abstract：:Delta checking is a laboratory information system (LIS)-based tool that detects patient and laboratory quality control errors. By using hemoglobin A1c (HbA1c) data, we developed a novel approach to summarizing and presenting patient Delta values to address limitations of current Delta check algorithms. Delta values we...

journal_title：American journal of clinical pathology

authors： Tran DV,Cembrowski GS,Lee T,Higgins TN

更新日期：2008-08-01 00:00:00

abstract：:The determination of tumor cell estrogen receptor (ER) expression status by immunohistochemical analysis has become standard practice, yet assay reproducibility has not been assessed adequately. By using a breast cancer tissue microarray, we examined interlaboratory variability in ER reporting. A 2-fold redundant tiss...

journal_title：American journal of clinical pathology

authors： Parker RL,Huntsman DG,Lesack DW,Cupples JB,Grant DR,Akbari M,Gilks CB

更新日期：2002-05-01 00:00:00

abstract：:To study the usefulness of calretinin as an immunohistochemistry marker in the diagnosis of cardiac myxoma (CM) and the origin of myxoma cells, we examined 24 CMs and 9 fetal hearts with immunohistochemical methods on formalin-fixed paraffin-embedded tissues. We compared 24 CMs with 10 mural thrombi, 6 jaw myxomas, an...

journal_title：American journal of clinical pathology

authors： Terracciano LM,Mhawech P,Suess K,D'Armiento M,Lehmann FS,Jundt G,Moch H,Sauter G,Mihatsch MJ

更新日期：2000-11-01 00:00:00

abstract：Objectives:Diagnosis of B-cell acute lymphoblastic leukemia (B-ALL) requires immunophenotypic evidence of B-lineage and absence of specific myeloid or T-lineage markers. Rare cases of otherwise typical B-ALL express myeloperoxidase (MPO) detectable by flow cytometry with an absence of other myeloid markers, but the cli...

journal_title：American journal of clinical pathology

authors： Oberley MJ,Li S,Orgel E,Phei Wee C,Hagiya A,O'Gorman MRG

更新日期：2017-04-01 00:00:00

abstract：:The performance of the Coulter STKS (Coulter, Hialeah, FL) was evaluated in a busy computerized teaching hospital laboratory. The STKS was compared with a Coulter S Plus IV and manually performed 400 white blood-cell differentials. The measured blood-count parameters (i.e., white blood cells [WBCs], red blood cells [R...

journal_title：American journal of clinical pathology

authors： Warner BA,Reardon DM

更新日期：1991-02-01 00:00:00

abstract：:We compared an automated quantitative heart-type fatty acid-binding protein (H-FABP) assay with other cardiac-marker assays to examine its usefulness as an early diagnostic marker of acute myocardial infarction (AMI). Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), myoglobin, and H-FAB...

journal_title：American journal of clinical pathology

authors： Kim Y,Kim H,Kim SY,Lee HK,Kwon HJ,Kim YG,Lee J,Kim HM,So BH

更新日期：2010-07-01 00:00:00

abstract：:Our aim was to study the possible association between oral lichen planus and chronic hepatitis C in patients from the state of Minas Gerais, Brazil. Two groups of patients were studied: group 1, 50 patients with oral lichen planus evaluated for the presence of chronic hepatitis C; and group 2, 215 patients with chroni...

journal_title：American journal of clinical pathology

authors： de Mattos Camargo Grossmann S,de Aguiar MC,Teixeira R,do Carmo MA

更新日期：2007-05-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT...

journal_title：American journal of clinical pathology

authors： Rausei-Mills V,Chang KL,Gaal KK,Weiss LM,Huang Q

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:Universal screening of upper tract urothelial carcinoma (UTUC) for Lynch syndrome by mismatch repair (MMR) protein immunohistochemistry (IHC) has been recommended by some investigators. Herein, we assess this recommendation retrospectively by simulating its performance on a retrospective, unselected cohort o...

journal_title：American journal of clinical pathology

authors： Gayhart MG,Johnson N,Paul A,Quillin JM,Hampton LJ,Idowu MO,Smith SC

更新日期：2020-11-04 00:00:00

abstract：:Thirty-five consecutive renal biopsy specimens were evaluated by light histology using paraffin and glycol methacrylate embedding. The clarity of the renal structures was found to be much better, and the renal lesions better defined, using glycol methyacrylate embedding. ...

journal_title：American journal of clinical pathology

authors： Agodoa LC,Striker GE,Chi E

更新日期：1975-11-01 00:00:00

abstract：:A man was hospitalized with bacteremic Achromobacter xylosoxidans type IIIa pneumonia. The authors are aware of no previously reported similar infections caused by this bacterium. A clinical cure was achieved with a combination of carbenicillin and kanamycin therapy. Microtiter susceptibility testing revealed that car...

journal_title：American journal of clinical pathology

authors： Dworzack DL,Murray CM,Hodges GR,Barnes WG

更新日期：1978-10-01 00:00:00

abstract：:Two hundred forty-three patients who had pathologically verified primary osteosarcomas of bone, treated at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute over a 24-year period, form the basis of this study. These cases provide a basis for comparison of those patients currentl...

journal_title：American journal of clinical pathology

authors： Uribe-Botero G,Russell WO,Sutow WW,Martin RG

更新日期：1977-05-01 00:00:00

abstract：:Location-guided screening in cervical cytology offers a potentially significant advance over routine manual screening. A prospective, 2-armed, masked clinical trial of the BD FocalPoint GS Imaging System using SurePath slides (BD Diagnostics-TriPath, Burlington, NC) compared routine manual screening and quality contro...

journal_title：American journal of clinical pathology

authors： Wilbur DC,Black-Schaffer WS,Luff RD,Abraham KP,Kemper C,Molina JT,Tench WD

更新日期：2009-11-01 00:00:00

abstract：:It has been suggested that kallikrein inhibition may predispose patients with the lupus inhibitor to thrombosis by interfering with the Factor XII-mediated activation of plasminogen. To further investigate this suggestion, the authors measured kallikrein inhibition in 19 patients with the lupus inhibitor. They found t...

journal_title：American journal of clinical pathology

authors： Killeen AA,Meyer KC,Vogt JM,Edson JR

更新日期：1987-08-01 00:00:00