Aberrant expression of CD7 in myeloblasts is highly associated with de novo acute myeloid leukemias with FLT3/ITD mutation.

Abstract:

:Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT3/ITD) mutation-positive de novo AML may represent a distinctive subgroup of AML. We analyzed the clinical and pathologic features of 15 cases of de novo AML with normal cytogenetics and with the FLT3/ITD mutation. In comparison with patients with AML without the FLT3/ITD mutation, patients with FLT3/ITD+ AML are relatively younger, more often have marked peripheral leukocytosis with a higher number of circulating blasts at initial examination, more often have minimal differentiation morphologic features, more frequently have abnormal CD7 coexpression, and have poorer outcome. Close association of aberrant CD7 expression and FLT3/ITD mutation in the myeloblasts of FLT3/ITD+ AML suggests that FLT3/ITD- mediated leukemic transformation occurs in the more early stage of myeloid progenitor cells.

journal_name

Am J Clin Pathol

authors

Rausei-Mills V,Chang KL,Gaal KK,Weiss LM,Huang Q

doi

10.1309/NRTX9AKXHR5JBT93

subject

Has Abstract

pub_date

2008-04-01 00:00:00

pages

624-9

issue

4

eissn

0002-9173

issn

1943-7722

pii

36172625408184M3

journal_volume

129

pub_type

杂志文章
  • Improving quality of patient care in an emergency department: a laboratory perspective.

    abstract::The purpose of our study was to improve the quality of care in an emergency department (ED) as measured by length of stay (LOS), total turnaround time (TAT) for laboratory result reporting, and the blood culture contamination rate. Data were included for patients who had at least 1 of 5 laboratory tests performed as p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DGXYTH0VNTTQRQHD

    authors: Sheppard C,Franks N,Nolte F,Fantz C

    更新日期:2008-10-01 00:00:00

  • Phenotypic heterogeneity of B cells in patients with chronic lymphocytic leukemia/small lymphocytic lymphoma.

    abstract::Although some studies have examined the expression of aberrant markers such as CD2, CD7, CD10, CD13, CD33, and CD34 on B cells in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a uniform multiparametric analysis of the frequency of expression of these markers using stringent criteria is lacking. By...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/4AGU-T3LK-EURD-7T7K

    authors: Kampalath B,Barcos MP,Stewart C

    更新日期:2003-06-01 00:00:00

  • ABO blood type and longevity.

    abstract::To assess the observation that blood type B might be a marker for longevity, we reviewed the records and determined the ABO blood types of all patients who died in our hospital in 2004. Age was stratified by decade of death, and linear regressions were calculated by ABO percentage. ABO survival curves were compared. I...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPMIHJ6L3RPHZX

    authors: Brecher ME,Hay SN

    更新日期:2011-01-01 00:00:00

  • Immune hemolytic anemia associated with probenecid.

    abstract::Upon hospital admission a patient was found to have severe anemia and a strongly positive direct antiglobulin test (DAT). The patient was taking probenecid periodically for gout. An antibody was detected in the patient's serum that only reacted with red blood cells (RBCs) when probenecid was added. Eluates from the pa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.3.391

    authors: Sosler SD,Behzad O,Garratty G,Lee CL,Postoway N,Khomo O

    更新日期:1985-09-01 00:00:00

  • Micronema deletrix meningoencephalitis in an adult man.

    abstract::This is apparently the second report of a case of human meningoencephalitis caused by the nematode Micronema deletrix. The patient had severe granulomatous meningoencephalitis with numerous foci of hemorrhage and encephalomalacia. Numerous adult female and larval M. deletrix were in the brain. The organisms probably i...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.4.640

    authors: Shadduck JA,Ubelaker J,Telford VQ

    更新日期:1979-10-01 00:00:00

  • Percutaneous ultrasound-guided needle biopsy of hepatic mass lesions using a cytohistologic approach. Comparison of two needle types.

    abstract::This study compared the ability to diagnose and accurately classify hepatic mass lesions by ultrasound-guided biopsy using two different needle types: a 20 gauge needle that yielded primarily cytologic material and an 18 gauge automated core biopsy needle. Slides prepared from each of the needle types were separately ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/104.5.583

    authors: Dusenbery D,Ferris JV,Thaete FL,Carr BI

    更新日期:1995-11-01 00:00:00

  • Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs.

    abstract::The expression of human E-cadherin in normal tissues and in benign and malignant tumors of female genital organs was examined immunohistochemically with a monoclonal antibody, HECD-1, specific for human E-cadherin. The normal tissues included the ovary, fallopian tube, uterine endometrium, uterine cervix, and vagina. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/98.1.76

    authors: Inoue M,Ogawa H,Miyata M,Shiozaki H,Tanizawa O

    更新日期:1992-07-01 00:00:00

  • Diagnostic decision-making in anatomic pathology.

    abstract::In diagnostic pathology, decision-making skills are used to match the facts of a particular case to a diagnostic category. Ideally the diagnosis is established with "beyond a reasonable doubt" certainty, but substantial uncertainty orfrank diagnostic error can afflict the diagnostic process for a variety of reasons. M...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/YUCA-HMEE-BKQ5-BH5B

    authors: Foucar E

    更新日期:2001-12-01 00:00:00

  • Encephalitozoon (Septata) intestinalis: cytologic, histologic, and electron microscopic features of a systemic intestinal pathogen.

    abstract::Encephalitozoon (Septata) intestinalis affects AIDS patients with CD4 counts <100/microL, causing intestinal and disseminated disease. It must be distinguished from the more common intestinal microsporidian, Enterocytozoon bieneusi, and from other microsporidia of extraintestinal tissues, such as Encephalitozoon helle...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.5.606

    authors: Chu P,West AB

    更新日期:1996-11-01 00:00:00

  • Statin--a novel marker of nonproliferation. Expression in nonneoplastic lymphoid tissues and follicular lymphomas.

    abstract::Statin is a 57 kDa nuclear protein exclusively found in noncycling cells. Its expression in hematolymphoid cells had not been examined previously. The authors studied statin immunoreactivity in nonneoplastic lymphoid tissues from 26 lymph nodes, 3 tonsils, and 2 spleens. Statin was detected primarily in small lymphoid...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.4.421

    authors: Trudel MA,Oligny L,Caplan S,Caplan C,Schipper HM,Wang E

    更新日期:1994-04-01 00:00:00

  • Assessment of The Bethesda System for Reporting Thyroid Cytopathology.

    abstract:OBJECTIVES:Long-term follow-up is important for determining performance characteristics of thyroid fine-needle aspiration (FNA). METHODS:Histologic or 3 or more years of clinical follow-up was used to calculate performance characteristics of thyroid FNA before and after implementation of The Bethesda System for Report...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz076

    authors: Sauter JL,Lehrke H,Zhang X,Al Badri OT,Rodriguez-Gutierrez R,Delivanis DA,Singh Ospina N,Donegan D,Hamidi O,Iñiguez-Ariza N,Sharma A,Kittah NEN,Tamhane SU,Hurtado Andrade MD,Kotwal A,Jenkins SM,Spears G,Rivera M,Dean

    更新日期:2019-09-09 00:00:00

  • Elastosis and elastofibromatous change in the gastrointestinal tract: a clinicopathologic study of 13 cases and a review of the literature.

    abstract::We describe 13 cases in which the submucosa and muscularis mucosae of the gastrointestinal tract exhibited a focal or diffuse increase of elastin fibers. This elastosis or elastofibromatous change most commonly manifested as a colonic polyp and usually was found during screening colonoscopy. Gastric and small intestin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/LBGT-CG1Q-CD96-M3NF

    authors: Hobbs CM,Burch DM,Sobin LH

    更新日期:2004-08-01 00:00:00

  • Peliosis of the spleen.

    abstract::Peliosis of the spleen was found in 10 out of 1,200 cases autopsied from 1977 through 1980 in our laboratory. Eight such cases had no peliosis of the liver. Histologically, it was noticed that the parafollicular areas were the most common sites of the lesions, and this feature seemed to be important for the histologic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.6.708

    authors: Tada T,Wakabayashi T,Kishimoto H

    更新日期:1983-06-01 00:00:00

  • MUC4 expression increases progressively in pancreatic intraepithelial neoplasia.

    abstract::Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the colon. The apomucin ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/7Y7N-M1WM-R0YK-M2VA

    authors: Swartz MJ,Batra SK,Varshney GC,Hollingsworth MA,Yeo CJ,Cameron JL,Wilentz RE,Hruban RH,Argani P

    更新日期:2002-05-01 00:00:00

  • Infections caused by Actinomyces viscosus.

    abstract::Two cases of Actinomyces viscosus infection of the lungs were seen in nonimmunosuppressed patients. One patient had a peripheral actinomycotic lung mass resembling a tumor. Both patients responded to a long course of penicillin therapy. Reports of A. viscosus infections are rare, although the organism colonizes the mo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.1.113

    authors: Eng RH,Corrado ML,Cleri D,Cherubin C,Goldstein EJ

    更新日期:1981-01-01 00:00:00

  • Detection of human T-cell leukemia virus type I proviral sequences from fixed tissues of seropositive patients.

    abstract::Fixed lymphoma tissues from 11 patients seropositive for human T-cell leukemia virus type I (HTLV-I) antibodies were analyzed for proviral sequences by the polymerase chain reaction. Typical adult T-cell leukemia/lymphomas (ATLLs) from nine patients were positive for HTLV-I sequences. In contrast, one of two lymphomas...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.4.536

    authors: Shibata D,Tokunaga M,Sasaki N,Nanba K

    更新日期:1991-04-01 00:00:00

  • Steroid hormone receptor and COX-2 expression in chordoma.

    abstract::Reports of sex steroid receptor expression in chordoma suggest that these tumors may be responsive to hormone manipulation therapy. Immunohistochemical stains for estrogen receptor (ER)-alpha, ER-beta, progesterone receptor (PR), androgen receptor (AR), and cyclooxygenase 2 (COX-2), were performed on a tissue microarr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/8T2NPHLK5X5WQ3E7

    authors: Fasig JH,Dupont WD,Olson SJ,Lafleur BJ,Cates JM

    更新日期:2007-09-01 00:00:00

  • Intratumoral genetic heterogeneity in Barrett adenocarcinoma.

    abstract::In 10 cases of Barrett adenocarcinoma, samples from 8 tumor areas (including superficial and deep from peripheral and central areas) and a regional lymph node metastasis were studied for amplification of c-myc, c-erbB-2, and EGFR. We analyzed loss of heterozygosity (LOH) at 3 loci (APC, MCC, and RB) and 2 anonymous mi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/6XY8-FMM5-VVCJ-T3N0

    authors: Owonikoko T,Rees M,Gabbert HE,Sarbia M

    更新日期:2002-04-01 00:00:00

  • Lack of in vitro interaction between heparin and nitroglycerin.

    abstract::Nitroglycerin has been reported to reduce activated partial thromboplastin time (aPTT) values in patients treated with concurrent heparin and nitroglycerin. However, in vivo studies have yielded conflicting results. In this in vitro evaluation, nitroglycerin was added to samples of pooled plasma from normal volunteers...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.3.298

    authors: Barnes AD,Horn JR,Wittkowsky AK

    更新日期:1996-03-01 00:00:00

  • Increased numbers of lymphocytes with single class surface immunoglobulins in Hodgkin's disease.

    abstract::Lymphocyte populations with abnormal kappa/lambda ratios have been described previously in B-cell non-Hodgkin's lymphomas and in lymphoid hyperplasia. The authors studied 12 patients in whom lymph nodes diagnostic of Hodgkin's disease contained evidence of monoclonal lymphocyte proliferation. One patient subsequently ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.6.674

    authors: Bain GO,Bain VG

    更新日期:1984-12-01 00:00:00

  • Large colorectal adenomas. An approach to pathologic evaluation.

    abstract::Adenomatous polyps are common neoplastic lesions of the large intestine. The risk of carcinoma increases with polyp size. Small polyps are typically totally embedded for histologic examination, but no standard method for sampling large, grossly benign polyps has been established. We reviewed grossly noninvasive adenom...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/804U-LHU1-TJ00-UGAU

    authors: Euscher ED,Niemann TH,Lucas JG,Kurokawa AM,Frankel WL

    更新日期:2001-09-01 00:00:00

  • A Venn diagram model that allows triple-label immunophenotypic analysis of cells based upon double-label measurements.

    abstract::Using Venn diagrams derived from set theory, a mathematic model is presented that allows triple-label immunophenotypic analysis of cells based upon double-label measurements. Practical applications of this method are illustrated and discussed. Using this model, triple-label data concerning Leu-8 and Leu-9 (CD7) antige...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.1.73

    authors: Wood GS

    更新日期:1989-07-01 00:00:00

  • Strict vs lenient criteria for elution testing: comparison of yields between two tertiary care medical centers.

    abstract::In this study, 2 patient populations, using different elution strategies, were compared to evaluate eluate yields under more and less restrictive conditions. An informative eluate was defined as one in which an antibody that could be clinically significant was detected in the eluate but was not detectable in the plasm...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPRVDCKI5CE2CH

    authors: Veeraputhiran MK,Pesek GA,Blackall DP

    更新日期:2011-09-01 00:00:00

  • Telangiectatic oncocytoma: a previously undescribed variant of renal oncocytoma.

    abstract:OBJECTIVES:To identify, describe, and investigate the clinical, radiologic, and pathologic features of 8 cases of telangiectatic oncocytoma. METHODS:Fifty-three consecutive renal oncocytomas were reviewed for the telangiectatic pathologic features that were subsequently correlated with the demographic, clinical, and r...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP9HDXYB2WYYJX

    authors: Xiao GQ,Ko HB,Unger P

    更新日期:2013-07-01 00:00:00

  • The "diff-if". Use of microcomputer analysis to triage blood specimens for microscopic examination.

    abstract::Increasingly, all automated blood counts are not accompanied by a microscopic white blood cell differential. A popular strategy is to obtain a manual differential if any part of the automated blood count and differential is outside specified limits (the "diff-if" strategy). The authors compared two sets of criteria to...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.2.163

    authors: McClure S,Bates JE,Harrison R,Gilmer PR,Bessman JD

    更新日期:1988-08-01 00:00:00

  • The data warehouse as a foundation for population-based reference intervals.

    abstract::The volume of data contained in a data warehouse represents a potential resource to provide the basis for detailed and specific reference intervals. Routine chemistry panel testing data were derived from an outreach laboratory patient population of 438,180 people and then screened by multiple data filters to identify ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/W8J8-5AG4-WDG6-JGJ9

    authors: Bock BJ,Dolan CT,Miller GC,Fitter WF,Hartsell BD,Crowson AN,Sheehan WW,Williams JD

    更新日期:2003-11-01 00:00:00

  • Medullary thyroid cancer. An immunohistochemical and humoral study using six separate antigens.

    abstract::The authors investigated the humoral and tissue expression of six antigens associated with medullary thyroid cancer (MTC): calcitonin (CT), calcitonin gene-related peptide (CGRP), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), somatostatin (SRIF), and thyroglobulin (TG). The antigens were studied in th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.3.300

    authors: Pacini F,Basolo F,Elisei R,Fugazzola L,Cola A,Pinchera A

    更新日期:1991-03-01 00:00:00

  • Humoral and cellular studies of eosinophils in reactive and myeloproliferative syndromes with marked eosinophilia.

    abstract::In five patients with eosinophilia and myeloproliferative disorders, the IgE levels were normal, and immune complexes were not detected. In contrast, in six patients with reactive eosinophilia accompanying immunologic diseases, the IgE levels were elevated in five, and immune complexes were elevated in two. Five of si...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.3.301

    authors: Crowley JP,Myers TJ

    更新日期:1983-03-01 00:00:00

  • Spectrophotometric detection of RT-PCR-amplified BCR/ABL fusion transcripts. A survey performed on archival hematologic slides.

    abstract::We describe a method of spectrophotometric detection of BCR/ABL chimeric sequences amplified by multiplex reverse transcriptase-polymerase chain reaction (RT-PCR), enabling the use of archival hematologic slides as RNA sources. Multiplex PCR amplified b3a2, b2a2, and e1a2 break points of the BCR/ABL translocation and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/108.4.383

    authors: Attadia V,Alosi M,Improta S,Zagonel V,Martinazzo G,Carbone A,Pinto A

    更新日期:1997-10-01 00:00:00

  • Real-Time Clinical Decision Support Decreases Inappropriate Plasma Transfusion.

    abstract:Objectives:To curtail inappropriate plasma transfusions, we instituted clinical decision support as an alert upon order entry if the patient's recent international normalized ratio (INR) was 1.7 or less. Methods:The alert was suppressed for massive transfusion and within operative or apheresis settings. The plasma ord...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqx061

    authors: Shah N,Baker SA,Spain D,Shieh L,Shepard J,Hadhazy E,Maggio P,Goodnough LT

    更新日期:2017-08-01 00:00:00