Strict vs lenient criteria for elution testing: comparison of yields between two tertiary care medical centers.

Abstract:

:In this study, 2 patient populations, using different elution strategies, were compared to evaluate eluate yields under more and less restrictive conditions. An informative eluate was defined as one in which an antibody that could be clinically significant was detected in the eluate but was not detectable in the plasma at the time of elution testing. The results for 160 direct antiglobulin tests (DATs) and 160 elution studies were evaluated in 71 patients at the adult hospital (lenient criteria). The results for 372 DATs and 43 elution studies were evaluated in 123 patients at the pediatric hospital (strict criteria). The yields from these eluates were 0.6% at the adult hospital (C antibody) vs 2.3% at the pediatric hospital (Jk(a) antibody). Thus, the yield of information from eluate testing is low regardless of the stringency applied to testing. However, considering the cost and time required for testing, more stringent criteria are advised.

journal_name

Am J Clin Pathol

authors

Veeraputhiran MK,Pesek GA,Blackall DP

doi

10.1309/AJCPRVDCKI5CE2CH

subject

Has Abstract

pub_date

2011-09-01 00:00:00

pages

359-63

issue

3

eissn

0002-9173

issn

1943-7722

pii

136/3/359

journal_volume

136

pub_type

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