Analytic inaccuracy resulting from hematology specimen characteristics. Three cases of clinically misleading artifacts affecting white blood cell and platelet counts.

abstract：:Although acute myeloid leukemias (AMLs) cytochemically negative for myeloperoxidase are now well recognized, myeloid surface antigen-negative AMLs are rare. The morphologic, cytochemical, immunologic, and cytogenetic or molecular features of such cases are described in four adults aged 19 to 60 years. All had AML with...

journal_title：American journal of clinical pathology

authors： Arber DA,Glackin C,Lowe G,Medeiros LJ,Slovak ML

更新日期：1997-01-01 00:00:00

abstract：:A case of metastatic ameloblastoma of the maxilla with secondary hypercalcemia in a 54-year-old man is presented. After treatment with surgery, chemotherapy, and radiotherapy, the patient was found to have multiple metastases and severe hypercalcemia associated with high levels of parathormone-like substance in the pe...

journal_title：American journal of clinical pathology

authors： Madiedo G,Choi H,Kleinman JG

更新日期：1981-04-01 00:00:00

abstract：OBJECTIVES:Bladder cancers invading the muscularis mucosae (MM) are treated differently from those invading the muscularis propria (MP). However, it may be difficult to determine the type of smooth muscle in transurethral resection (TUR) or biopsy specimens. We aimed to investigate the clinicopathologic features of bla...

journal_title：American journal of clinical pathology

authors： Hwang MJ,Kamat AM,Dinney CP,Czerniak B,Guo CC

更新日期：2020-07-07 00:00:00

abstract：OBJECTIVES:Assess support for the effectiveness of two separate practices, restrictive transfusion strategy and computerized physician order entry/clinical decision support (CPOE/CDS) tools, in decreasing RBC transfusions in adult surgical and nonsurgical patients. METHODS:Following the Centers for Disease Control and...

journal_title：American journal of clinical pathology

authors： Derzon JH,Clarke N,Alford A,Gross I,Shander A,Thurer R

更新日期：2019-10-07 00:00:00

abstract：Objectives:To curtail inappropriate plasma transfusions, we instituted clinical decision support as an alert upon order entry if the patient's recent international normalized ratio (INR) was 1.7 or less. Methods:The alert was suppressed for massive transfusion and within operative or apheresis settings. The plasma ord...

journal_title：American journal of clinical pathology

authors： Shah N,Baker SA,Spain D,Shieh L,Shepard J,Hadhazy E,Maggio P,Goodnough LT

更新日期：2017-08-01 00:00:00

abstract：:Cell counter-based formulas have been used in the differential diagnosis of microcytic anemia. The measurement of RBC subpopulations is now available on the Sysmex XE 5000 analyzer (Sysmex, Kobe, Japan). We describe the new formulas: % microcytic - % hypochromic; and % microcytic - % hypochromic - red cell distributio...

journal_title：American journal of clinical pathology

authors： Urrechaga E,Borque L,Escanero JF

更新日期：2011-03-01 00:00:00

abstract：:A method using the RNA polymerase chain reaction technique to diagnose infection retrospectively using single-stranded RNA enteroviruses in paraffin-embedded tissue blocks is reported. This method takes advantage of extreme sequence conservation in the 5' untranslated region of the enteroviral genome and uses two roun...

journal_title：American journal of clinical pathology

authors： Redline RW,Genest DR,Tycko B

更新日期：1991-11-01 00:00:00

abstract：:A new blood culture medium (16B) containing adsorbent and cationic exchange resins has become available for use with the BACTEC instrument (Johnston Laboratories, Towson, MD). Its purpose is to enhance the detection of bacteremia through binding of antimicrobials. The performance of the BACTEC 16B resin medium was com...

journal_title：American journal of clinical pathology

authors： DeGirolami PC,Eichelberger K,Siegel J

更新日期：1984-05-01 00:00:00

abstract：:Postmortem pathologic and bacteriologic reports were analyzed for 237 deaths occurring at a large institution for the mentally retarded from 1958 to 1973. Bronchopneumonia, aspiration pneumonia, and lipid pneumonia were frequently reported at autopsy, and in a total of 146 cases (61.6%) at least one type of pneumonia ...

journal_title：American journal of clinical pathology

authors： Polednak AP

更新日期：1977-02-01 00:00:00

abstract：:The clinical, light microscopic, and immunohistochemical features of 14 sinonasal malignant melanomas were studied to show their diverse morphologic appearance and distinction from therapeutically more amenable neoplasms that occur in this region. The tumors arose in 6 men and 8 women (median age, 70 years). Eleven pa...

journal_title：American journal of clinical pathology

authors： Franquemont DW,Mills SE

更新日期：1991-12-01 00:00:00

abstract：:In diagnostic pathology, decision-making skills are used to match the facts of a particular case to a diagnostic category. Ideally the diagnosis is established with "beyond a reasonable doubt" certainty, but substantial uncertainty orfrank diagnostic error can afflict the diagnostic process for a variety of reasons. M...

journal_title：American journal of clinical pathology

authors： Foucar E

更新日期：2001-12-01 00:00:00

abstract：:The Department of Laboratory Medicine, University of Washington, has explored various management of organizational approaches over the past seven years. The Centralized Processing Area supported by a computerized information system has evolved from these efforts. Despite a decrease in U.W. hospital usage since 1968-69...

journal_title：American journal of clinical pathology

authors： Nussbaum B,Minckler T,Roby R,Ackerman E

更新日期：1977-02-01 00:00:00

abstract：:Three policies for decreasing unnecessary cerebrospinal fluid (CSF) management Venereal Disease Research Laboratory (VDRL) tests were compared. The first policy attempted to educate physicians about the use of serologic tests for diagnosing neurosyphilis but allowed the CSF VDRL to be performed either as a screening t...

journal_title：American journal of clinical pathology

authors： Albright RE Jr,Christenson RH,Emlet JL,Graham CB 3rd,Estevez EG,Wilson ML,Reller LB,Schneider KA

更新日期：1991-03-01 00:00:00

abstract：:Subsequent to recent disclosures that low serum vitamin B12 results can appear normal using many of the current radioassay methods because of the presence of cobalamin (vitamin B12) analogues in human serum, a number of radioassay kits have become available with modified intrinsic factor preparations and claims of mea...

journal_title：American journal of clinical pathology

authors： LeFebvre RJ,Virji AS,Mertens BF

更新日期：1980-08-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is one of the most potent mitogenic, highly specific tumor angiogenic factors, which acts via binding to 2 specific tyrosine kinase receptors. There are few studies analyzing VEGF receptor expression in prostate cancer cells, and results are contradictory. In an immunohistoche...

journal_title：American journal of clinical pathology

authors： Köllermann J,Helpap B

更新日期：2001-07-01 00:00:00

abstract：:The overall performances of several enzyme reagent kits for alkaline phosphatase, creatine kinase, lactic dehydrogenase, and aspartate aminotransferase were evaluated using an ABA-100 Bichromatic Analyzer. Interassay precision using this instrument with commercial reagents compared well with published data for similar...

journal_title：American journal of clinical pathology

authors： Beckala HR,Agrell J,Forsman RW,Homburger HA

更新日期：1979-08-01 00:00:00

abstract：:To investigate the issue of clonality in Richter's syndrome, phenotypic, molecular genetic, and cytogenetic studies were performed on tumor tissue from a patient with concurrent chronic lymphocytic leukemia and diffuse large cell lymphoma in a single lymph node specimen. The tumor was biphenotypic for immunoglobulin (...

journal_title：American journal of clinical pathology

authors： Nakamine H,Masih AS,Sanger WG,Wickert RS,Mitchell DW,Armitage JO,Weisenburger DD

更新日期：1992-05-01 00:00:00

abstract：:Four media, Eagle's minimal essential medium with 10% fetal bovine serum (MEM/FBS), tryptic soy broth (TSB), 2-SP, and 4-SP, were compared for their ability to maintain the viability of Chlamydia trachomatis at 4 degrees C, -20 degrees C, -70 degrees C, and -176 degrees C (liquid nitrogen) over a 1-week period. 2-SP m...

journal_title：American journal of clinical pathology

authors： Aarnaes SL,Peterson EM,De La Maza LM

更新日期：1984-02-01 00:00:00

abstract：OBJECTIVES:BRAF V600E mutation is characteristic of hairy cell leukemia (HCL). A V600E mutation-specific antibody, VE1, has been recently developed. We studied the diagnostic utility of this antibody in HCL and compared it with other B-cell neoplasms. METHODS:VE1 activity was assessed using immunohistochemistry in 90 ...

journal_title：American journal of clinical pathology

authors： Uppal G,Ly V,Wang ZX,Bajaj R,Solomides CC,Banks PM,Medeiros LJ,Peiper SC,Gong JZ

更新日期：2015-01-01 00:00:00

abstract：OBJECTIVES:Solid tumor metastases to the pancreas are rare, and only limited literature on the topic is available. In this retrospective study, we reviewed 107 cases of solid tumor metastases to the pancreas diagnosed by fine-needle aspiration (FNA) from 2005 to 2019. METHODS:Information including the patients' clinic...

journal_title：American journal of clinical pathology

authors： Hou T,Stewart JM,Lee JH,Gan Q

更新日期：2020-10-13 00:00:00

abstract：:Although some studies have examined the expression of aberrant markers such as CD2, CD7, CD10, CD13, CD33, and CD34 on B cells in chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL), a uniform multiparametric analysis of the frequency of expression of these markers using stringent criteria is lacking. By...

journal_title：American journal of clinical pathology

authors： Kampalath B,Barcos MP,Stewart C

更新日期：2003-06-01 00:00:00

abstract：Objectives:The aims were to evaluate breast cancer (BC) tumor-infiltrating lymphocytes (TILs) interobserver variability, heterogeneity, and the fidelity of scoring TILs in core needle biopsy (CNB). Methods:Matching CNB and two full-face sections (FFSs) of BC cases (n = 100) were independently reviewed by two pathologi...

journal_title：American journal of clinical pathology

authors： Khoury T,Peng X,Yan L,Wang D,Nagrale V

更新日期：2018-10-01 00:00:00

abstract：:Platelet aggregation studies are usually performed in either electrical impedance or optical systems and the release reaction assessed by quantitating adenosine triphosphate (ATP) from luminesence produced by the firefly luciferin-luciferase system. In evaluating the results of such studies, attention is paid to a var...

journal_title：American journal of clinical pathology

authors： Sweeney JD,Labuzetta JW,Fitzpatrick JE

更新日期：1988-05-01 00:00:00

abstract：:The most commonly used fixative in effusion cytology is formalin. In the present study, the immunocytochemical properties of formalin-fixed and alcohol-fixed specimens were compared to evaluate the usefulness of alcohol-fixed cytocentrifuged preparations for routine cytologic diagnosis. A total of 269 effusion samples...

journal_title：American journal of clinical pathology

authors： Ikeda K,Tate G,Suzuki T,Mitsuya T

更新日期：2011-12-01 00:00:00

abstract：:Fine-needle aspiration (FNA) is the standard of care for the initial workup of thyroid nodules, but there is no consensus algorithm to manage patients with benign results. We examined performance characteristics of initial and repeat satisfactory FNAs for all 402 patients who underwent thyroid surgery during a recent ...

journal_title：American journal of clinical pathology

authors： Flanagan MB,Ohori NP,Carty SE,Hunt JL

更新日期：2006-05-01 00:00:00

abstract：:Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of ...

journal_title：American journal of clinical pathology

authors： Raman BK,Sawdyk M,Saeed SM

更新日期：1987-07-01 00:00:00

abstract：:The authors have examined the sensitivity and detection efficiency of the three peroxidase methods that currently have the widest application in diagnostic immunohistochemistry: the peroxidase-antiperoxidase (PAP), the avidin-biotin complex (ABC), and the labeled avidin-biotin (LAB) methods. Sensitivity was evaluated ...

journal_title：American journal of clinical pathology

authors： Elias JM,Margiotta M,Gaborc D

更新日期：1989-07-01 00:00:00

abstract：:Anaplastic large cell lymphoma (ALCL) is clinically and pathologically heterogeneous, leading to some difficulty in its diagnosis and acceptance as a specific entity. ALCL can be subdivided into different groups according to histologic features (pleomorphic, monomorphic, small cell predominant, Hodgkin's disease-relat...

journal_title：American journal of clinical pathology

authors： Kinney MC,Kadin ME

更新日期：1999-01-01 00:00:00

abstract：:Immunohistochemical analysis of oral lichen-planus-like eruption (LPLE) in graft-versus-host disease (GVHD) using monoclonal antibodies (MoAbs) was performed on five patients after allogeneic bone marrow transplantation (BMT) for leukemia. In the mucosal lesions of LPLE in GVHD, the major population of infiltrated lym...

journal_title：American journal of clinical pathology

authors： Fujii H,Ohashi M,Nagura H

更新日期：1988-02-01 00:00:00

abstract：:Prostate-specific antigen (PSA) is a sensitive and specific serum marker for monitoring disease activity in men with prostatic carcinoma. Despite reports of elevation of levels of this analyte in men with benign prostatic hyperplasia, no information is available correlating the serum levels with the actual prostatic a...

journal_title：American journal of clinical pathology

authors： Brawer MK,Rennels MA,Nagle RB,Schifman R,Gaines JA

更新日期：1989-12-01 00:00:00