Abstract:
:Immunohistochemical analysis of oral lichen-planus-like eruption (LPLE) in graft-versus-host disease (GVHD) using monoclonal antibodies (MoAbs) was performed on five patients after allogeneic bone marrow transplantation (BMT) for leukemia. In the mucosal lesions of LPLE in GVHD, the major population of infiltrated lymphocytes in the areas of upper lamina propria (Lp), basal cell layer (Bc), and epithelium above the basal cell layer (Ep) were T-cells (Leu-1+, Leu-4+) and expressed the phenotype associated with suppressor/cytotoxic T-cells (Leu-2a+) rather than helper/inducer T-cells (Leu-3a+). Some of the infiltrated lymphocytes in the areas of Lp, Bc, and satellite cell necrosis (SCN) bore interleukin-2 (IL-2) receptor. HLA-DR antigen was expressed on keratinocytes in the LPLE lesions. Immunoelectron micrographs showed various degrees of degeneration of keratinocytes to which Leu-2a+ cells attached, whereas those with accidentally attached Leu-3a+ cells preserved normal structures. These findings suggest that cellular immunity mediated by cytotoxic T-cells may play a major role in the pathogenesis of oral LPLE in GVHD.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Fujii H,Ohashi M,Nagura Hdoi
10.1093/ajcp/89.2.177subject
Has Abstractpub_date
1988-02-01 00:00:00pages
177-86issue
2eissn
0002-9173issn
1943-7722journal_volume
89pub_type
杂志文章abstract::A unique case of intramural uterine tumor composed of malignant epithelium and benign smooth muscle, adipose tissue, and cartilage is reported. This tumor, which the authors designated "carcinomesenchymoma," apparently represents an example of a previously unreported variant of mixed müllerian tumor that is composed o...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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abstract::Accurate diagnosis of oral hairy leukoplakia (OHL) is important because it may be an early indicator of undiagnosed HIV infection; moreover, it may be a prognostic indicator. Our purpose was to investigate the histopathologic features of subclinical OHL and to evaluate and support the rationale of detecting subclinica...
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journal_title:American journal of clinical pathology
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更新日期:1983-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1996-10-01 00:00:00
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更新日期:1998-03-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,多中心研究
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更新日期:2008-03-01 00:00:00
abstract::We reviewed the cytologic features of 20 adrenal cortical carcinomas (ACCs; 9 primary and 11 metastatic) from 19 patients and highlighted diagnostic pitfalls. The mean size of primary ACCs was 11.9 cm, and that of metastatic ACCs was 3.0 cm. The metastatic sites were liver, lung, lymph node, soft tissue, and bone. Pri...
journal_title:American journal of clinical pathology
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更新日期:2006-09-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2000-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1995-08-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1987-03-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1977-10-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/104.5.583
更新日期:1995-11-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2010-11-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1984-11-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1978-09-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1995-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1975-06-01 00:00:00
abstract::A 65-year-old man with lower back pain was found to have multiple myeloma. Unique findings in the marrow aspirate smears of this patient were tadpolelike plasma cells and cellular rosettes simulating those seen in neuroblastoma. This case documents yet another facet of the broad morphologic spectrum of neoplastic plas...
journal_title:American journal of clinical pathology
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更新日期:1992-12-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2007-09-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1992-04-01 00:00:00
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更新日期:2001-06-01 00:00:00
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更新日期:2006-03-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2010-08-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2004-04-01 00:00:00