Serum prostate-specific antigen and prostate pathology in men having simple prostatectomy.

Abstract:

:Prostate-specific antigen (PSA) is a sensitive and specific serum marker for monitoring disease activity in men with prostatic carcinoma. Despite reports of elevation of levels of this analyte in men with benign prostatic hyperplasia, no information is available correlating the serum levels with the actual prostatic abnormalities in men having prostatectomy for presumed benign disease. In the present investigation, the authors compared preoperative serum PSA levels with prostate disease in 81 men with bladder outlet obstruction. Five pathologic groups were found: incidental high-grade carcinoma (n = 3), low-grade carcinoma (n = 11), acute inflammation (n = 16) with or without chronic inflammation, Prostatic intraepithelial neoplasia (PIN) (n = 25), and benign hyperplasia (n = 26). Serum PSA levels were significantly elevated in both low- and high-grade carcinoma, acute inflammation, and PIN when compared with the patients with benign hyperplasia with and without chronic inflammation. Within the four groups with elevated levels, use of PSA levels could separate only the high-grade cancer patients who were subsequently shown to have metastatic disease. Only one patient with simple hyperplasia had PSA levels in the abnormal range.

journal_name

Am J Clin Pathol

authors

Brawer MK,Rennels MA,Nagle RB,Schifman R,Gaines JA

doi

10.1093/ajcp/92.6.760

subject

Has Abstract

pub_date

1989-12-01 00:00:00

pages

760-4

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

92

pub_type

杂志文章
  • Significance of leukocyte alkaline phosphatase in hairy cell leukemia.

    abstract::Peripheral blood samples of 23 patients who had hairy cell leukemia were examined for leukocyte alkaline phosphatase scores. Leukocyte alkaline phosphatase levels were elevated in seventeen patients (74%), were normal in six (26%), and were not decreased in any patient. The mean leukocyte alkaline phosphatase score wa...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.3.297

    authors: Aiba M,Raffa PP,Katayama I

    更新日期:1980-09-01 00:00:00

  • The Becton Dickinson FocalPoint GS Imaging System: clinical trials demonstrate significantly improved sensitivity for the detection of important cervical lesions.

    abstract::Location-guided screening in cervical cytology offers a potentially significant advance over routine manual screening. A prospective, 2-armed, masked clinical trial of the BD FocalPoint GS Imaging System using SurePath slides (BD Diagnostics-TriPath, Burlington, NC) compared routine manual screening and quality contro...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1309/AJCP8VE7AWBZCVQT

    authors: Wilbur DC,Black-Schaffer WS,Luff RD,Abraham KP,Kemper C,Molina JT,Tench WD

    更新日期:2009-11-01 00:00:00

  • HER2 Gene Protein Assay Is Useful to Determine HER2 Status and Evaluate HER2 Heterogeneity in HER2 Equivocal Breast Cancer.

    abstract:Objectives:Approximately 15% of breast cancers show equivocal human epidermal growth factor receptor 2 (HER2) results on HER2 immunohistochemistry (IHC) and are reflexed for fluorescence in situ hybridization (FISH). However, some cases remain equivocal. In this study, we evaluated these double-equivocal cases by using...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw211

    authors: Hou Y,Nitta H,Li Z

    更新日期:2017-01-01 00:00:00

  • Detection of bacteremia with the BACTEC 16B resin blood culture medium.

    abstract::A new blood culture medium (16B) containing adsorbent and cationic exchange resins has become available for use with the BACTEC instrument (Johnston Laboratories, Towson, MD). Its purpose is to enhance the detection of bacteremia through binding of antimicrobials. The performance of the BACTEC 16B resin medium was com...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.5.643

    authors: DeGirolami PC,Eichelberger K,Siegel J

    更新日期:1984-05-01 00:00:00

  • Microcystic adenoma of the pancreas with myoepithelial cells. A hitherto undescribed morphologic feature.

    abstract::A case of microcystic adenoma (glycogen-rich cystadenoma) of the exocrine pancreas in a 62-year-old white female presenting with adult-onset diabetes mellitus is reported. Clinical, histopathologic, and ultrastructural findings are discussed with particular emphasis on the presence of myoepithelial cells, a morphologi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.1.114

    authors: Nyongo A,Huntrakoon M

    更新日期:1985-07-01 00:00:00

  • Management training for pathology residents. I. Results of a national survey.

    abstract::The professional activities of anatomic and clinical pathologists involve, to a large extent, management issues. To evaluate the management training received by pathology residents, the authors surveyed pathology residency training programs in the United States. Responses were collected from 138 of 187 programs (73.8%...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.5.559

    authors: Brugnara C,Fenton T,Winkelman JW

    更新日期:1994-05-01 00:00:00

  • The equivocally amplified HER2 FISH result on breast core biopsy: indications for further sampling do affect patient management.

    abstract::To our knowledge, there are no universally accepted, evidence-based guidelines for how to resolve the HER2 status of tumors demonstrating equivocal amplification. The present study was based on 17 breast core biopsy specimens demonstrating invasive carcinoma with equivocal HER2 amplification, defined as an HER2/chromo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/KFKDNK8CENVN24VU

    authors: Striebel JM,Bhargava R,Horbinski C,Surti U,Dabbs DJ

    更新日期:2008-03-01 00:00:00

  • Clinical and laboratory efficiency of rapid screening urine cultures by nephelometry.

    abstract::Urine cultures represent 40-50% of specimens processed by hospital clinical microbiology laboratories. An accurate rapid screening method to detect positive urine cultures could greatly improve laboratory efficiency. Three hundred eighty-two unselected urines were screened by nephelometry at 2, 4, and 5 hours of shaki...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.3.305

    authors: Heinz T,Pezzlo M,Thrupp L

    更新日期:1982-03-01 00:00:00

  • An acute myeloproliferative disorder characterized by myelofibrosis and blast cells that express phenotypic properties associated with multiple hematopoietic lineages.

    abstract::The authors investigated the blast cells obtained from two patients with acute myelofibrosis with the use of recently developed immunochemical and ultrastructural markers. They intended to examine the expression of megakaryoblastic, erythroblastic, myeloblastic, and monoblastic properties in these cells. Respectively,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/83.1.114

    authors: Schreeder MT,Prchal JT,Parmley RT,Carroll AJ,Gewirtz AM,Hoffman R

    更新日期:1985-01-01 00:00:00

  • Blue nevus of the lymph node capsule. Report of a new case with review of the literature.

    abstract::This article describes the seventh known case of blue nevus of the lymph node capsule and reviews the previously reported cases. The migration arrest hypothesis as an explanation for the occurrence of this lesion is favored rather than the "benign metastasis" hypothesis. The importance of the recognition of this pheno...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.367

    authors: Lamovec J

    更新日期:1984-03-01 00:00:00

  • Tubular carcinoma of the breast: association with multicentricity, bilaterality, and family history of mammary carcinoma.

    abstract::Seventeen tubular carcinomas occurred among 211 consecutive mastectomies (7.6%). The relative frequencies of multicentric involvement in the ipsilateral breast (56%), history of bilateral mammary cancer (38%) (P less than .01), and family history of mammary cancer in a first-degree relative (40%) (P less than .05) wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.1.25

    authors: Lagios MD,Rose MR,Margolin FR

    更新日期:1980-01-01 00:00:00

  • Are autopsies obsolete?

    abstract::To determine the current frequency of discovering important diagnoses at autopsy, the diagnoses made in all complete or "no head" autopsies during 1994 at a major tertiary care transplantation referral center were retrospectively compared with the diagnoses made antemortem. Of 176 autopsies, 79 (44.9%) revealed 1 or m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/110.2.210

    authors: Nichols L,Aronica P,Babe C

    更新日期:1998-08-01 00:00:00

  • Blood group substances as tumor antigens in the distal colon.

    abstract::Adenocarcinomas of the sigmoid colon and rectum were studied for the presence of blood group substances of the A, B, H system using the method of specific erythrocytic adherence. Of 17 adenocarcinomas studied, eight were found to have reactivity for blood group substances. All eight tumours showing reactivity for bloo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/69.6.594

    authors: Cooper HS,Haesler WE Jr

    更新日期:1978-06-01 00:00:00

  • The effect of bacteremia on automated platelet measurements in neonates.

    abstract::Platelet volume measurements have been used to differentiate consumptive and hypoplastic thrombocytopenia. Since thrombocytopenia is a frequent complication of neonatal sepsis, the authors explored the utility of correlating mean platelet volume (MVP) and platelet distribution width (PDW) with bacteremia. In a sample ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.3.391

    authors: Patrick CH,Lazarchick J

    更新日期:1990-03-01 00:00:00

  • Strict vs lenient criteria for elution testing: comparison of yields between two tertiary care medical centers.

    abstract::In this study, 2 patient populations, using different elution strategies, were compared to evaluate eluate yields under more and less restrictive conditions. An informative eluate was defined as one in which an antibody that could be clinically significant was detected in the eluate but was not detectable in the plasm...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPRVDCKI5CE2CH

    authors: Veeraputhiran MK,Pesek GA,Blackall DP

    更新日期:2011-09-01 00:00:00

  • Immunologic abnormalities and their significance in sinus histiocytosis with massive lymphadenopathy.

    abstract::In a computerized case registry, containing 220 cases of sinus histiocytosis with massive lymphadenopathy (SHML), 23 patients were identified with clinical or routine laboratory findings suggestive or diagnostic of immune dysfunction. We divided the abnormalities into hematologic autoantibodies (nine patients), glomer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.5.515

    authors: Foucar E,Rosai J,Dorfman RF,Eyman JM

    更新日期:1984-11-01 00:00:00

  • Large colorectal adenomas. An approach to pathologic evaluation.

    abstract::Adenomatous polyps are common neoplastic lesions of the large intestine. The risk of carcinoma increases with polyp size. Small polyps are typically totally embedded for histologic examination, but no standard method for sampling large, grossly benign polyps has been established. We reviewed grossly noninvasive adenom...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/804U-LHU1-TJ00-UGAU

    authors: Euscher ED,Niemann TH,Lucas JG,Kurokawa AM,Frankel WL

    更新日期:2001-09-01 00:00:00

  • Blast-like cells in the cerebrospinal fluid of young infants: further characterization of clinical setting, morphology and origin.

    abstract::Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.5.544

    authors: Jaffey PB,Varma SK,DeMay RM,McLucas EJ,Campbell GA

    更新日期:1996-05-01 00:00:00

  • The "diff-if". Use of microcomputer analysis to triage blood specimens for microscopic examination.

    abstract::Increasingly, all automated blood counts are not accompanied by a microscopic white blood cell differential. A popular strategy is to obtain a manual differential if any part of the automated blood count and differential is outside specified limits (the "diff-if" strategy). The authors compared two sets of criteria to...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.2.163

    authors: McClure S,Bates JE,Harrison R,Gilmer PR,Bessman JD

    更新日期:1988-08-01 00:00:00

  • Clinical comparison of immunoradiometric assays for intact versus beta-specific human chorionic gonadotropin.

    abstract::Monoclonal immunoradiometric assays (IRMA) for human chorionic gonadotropin (hCG) are available for either intact hCG (IhCG) or beta subunit hCG (beta hCG). The authors evaluated the clinical applications of both methods. Serum samples (N = 180) were divided into the following five clinical groups: Group 1: elevated l...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.3.347

    authors: Pardue MG,Taylor EH,London S,Walls RC,Pappas AA

    更新日期:1990-03-01 00:00:00

  • DRC antigen expression in B-cell lymphomas.

    abstract::DRC (dendritic reticulum cell) antigen expression was studied in 38 cases of B-cell lymphomas including follicular lymphoma. The results of this study showed DRC-1 to be expressed in 1/3 of small lymphocytic; 3/3 of mantle zone lymphoma (MZL); 10/10 of follicular, small cleaved; 6/7 of follicular, mixed; 1/2 of follic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.4.488

    authors: Mori N,Oka K,Kojima M

    更新日期:1988-04-01 00:00:00

  • Soft agar culture of human transitional cell carcinoma colonies from urine.

    abstract::Soft-agar culture of transitional cell carcinoma colonies from urine, bladder irrigation fluid, and transurethral resection solid tumor specimens demonstrate generally better growth of tumor cell colonies from urine than from irrigation fluid. Growth of tumor colonies from urine was adequate to evaluate presence of tu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.5.690

    authors: Kirkels WJ,Pelgrim OE,Debruyne FM,Vooijs GP,Herman CJ

    更新日期:1982-11-01 00:00:00

  • Improving quality of patient care in an emergency department: a laboratory perspective.

    abstract::The purpose of our study was to improve the quality of care in an emergency department (ED) as measured by length of stay (LOS), total turnaround time (TAT) for laboratory result reporting, and the blood culture contamination rate. Data were included for patients who had at least 1 of 5 laboratory tests performed as p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DGXYTH0VNTTQRQHD

    authors: Sheppard C,Franks N,Nolte F,Fantz C

    更新日期:2008-10-01 00:00:00

  • Evaluation of commercial enzyme reagent kits by use of a semiautomated chemistry analyzer.

    abstract::The overall performances of several enzyme reagent kits for alkaline phosphatase, creatine kinase, lactic dehydrogenase, and aspartate aminotransferase were evaluated using an ABA-100 Bichromatic Analyzer. Interassay precision using this instrument with commercial reagents compared well with published data for similar...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.2.151

    authors: Beckala HR,Agrell J,Forsman RW,Homburger HA

    更新日期:1979-08-01 00:00:00

  • Hepatitis B (surface) antigen testing by radioimmunoassaymexperience in a very large volunteer donor population.

    abstract::The results of hepatitis B surface antigen (HBs-Ag) testing in a large volunteer blood donor population are described. Counterelectrophoresis and three versions of solid-phase radioimmunoassay technic are compared and evaluated. Initial results suggested that the radioimmunoassay technic are compared and evaluated. In...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/63.6.847

    authors: Dodd RY,Ni LY,Mallin WS,Greenwalt TJ

    更新日期:1975-06-01 00:00:00

  • Distribution of Lipiodol and evidence for tumor necrosis in hepatocellular carcinoma.

    abstract::To study the distribution and thromboembolic effect of Ultrafluid Lipiodol, 15 surgically removed hepatocellular carcinomas with selective intraarterial Lipiodol injection 7 to 10 days before surgery and 15 noninjected controls were studied radiologically and histologically. Tissue blocks were processed with an en blo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.3.405

    authors: Arnold MM,Kreel L,Wallace AC,Li AK

    更新日期:1992-03-01 00:00:00

  • Type II estrogen receptors in the papillary cystic tumor of the pancreas.

    abstract::Two cases of papillary cystic tumor (PCT) of the pancreas were investigated for the presence of estrogen receptors (ERs) and progesterone receptors (PgRs). Both PCT and normal pancreas are able to specifically bind 3H-estradiol. This binding almost exclusively results from the presence of high levels of type II ER, wh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.5.572

    authors: Carbone A,Ranelletti FO,Rinelli A,Vecchio FM,Lauriola L,Piantelli M,Capelli A

    更新日期:1989-11-01 00:00:00

  • MUC4 expression increases progressively in pancreatic intraepithelial neoplasia.

    abstract::Pancreatic adenocarcinoma is believed to develop from histologically identifiable intraductal lesions known as pancreatic intraepithelial neoplasias (PanINs) that undergo a series of architectural, cytologic, and genetic changes, a progression model similar to the adenoma-carcinoma sequence in the colon. The apomucin ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/7Y7N-M1WM-R0YK-M2VA

    authors: Swartz MJ,Batra SK,Varshney GC,Hollingsworth MA,Yeo CJ,Cameron JL,Wilentz RE,Hruban RH,Argani P

    更新日期:2002-05-01 00:00:00

  • Overexpression of fatty acid synthase in ulcerative colitis.

    abstract::Fatty acid synthase is an enzyme that catalyzes the synthesis of long-chain fatty acids. The enzyme expression is minimal in adult tissues and very high in many cancers. Ulcerative colitis is a chronic inflammatory bowel disease that, when long-standing, is associated with an increased risk of colon cancer. The aim of...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/pubvqndnvqkjvc8m

    authors: Consolazio A,Alò PL,Rivera M,Iacopini F,Paoluzi OA,Crispino P,Pica R,Paoluzi P

    更新日期:2006-07-01 00:00:00

  • Detection of trisomy 3 in primary gastric B-cell lymphoma by using chromosome in situ hybridization on paraffin sections.

    abstract::Recent studies in Western populations have shown that trisomy 3 is the most frequent chromosomal abnormality in primary gastric lymphoma (PGL). To study the incidence of trisomy 3 and its implications for the pathogenesis of PGL in Hong Kong, we have applied the technique of chromosome in situ hybridization in 13 case...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/110.3.347

    authors: Zhang Y,Cheung AN,Chan AC,Shen DH,Xu WS,Chung LP,Ho FC

    更新日期:1998-09-01 00:00:00