Overexpression of fatty acid synthase in ulcerative colitis.


:Fatty acid synthase is an enzyme that catalyzes the synthesis of long-chain fatty acids. The enzyme expression is minimal in adult tissues and very high in many cancers. Ulcerative colitis is a chronic inflammatory bowel disease that, when long-standing, is associated with an increased risk of colon cancer. The aim of the present study was to establish whether fatty acid synthase levels in the mucosa without dysplasia of patients with long-standing ulcerative colitis were higher than in control subjects. Three groups of patients were selected: 30 with active ulcerative colitis, 30 with ulcerative colitis in remission, and 30 undergoing colonoscopy for colorectal cancer screening, as healthy control subjects. Fatty acid synthase expression was evaluated with immunohistochemical procedures. The enzyme was detected in all patients with active colitis, in most patients with quiescent disease, in both pathologic and normal mucosa, but in only 3 healthy control subjects. Our results suggest that extension of ulcerative colitis is greater than that revealed by common diagnostic techniques.


Am J Clin Pathol


Consolazio A,Alò PL,Rivera M,Iacopini F,Paoluzi OA,Crispino P,Pica R,Paoluzi P




Has Abstract


2006-07-01 00:00:00














  • Malakoplakia of palatine tonsil.

    abstract::This paper's purpose is to document a case of unilateral tonsillar malakoplakia. Escherichia coli was repeatedly cultured from the lesion, and the isolate was studied by expert microbiologists who found no abnormalities in its biologic properties. The course of the lesion was followed by repeated punch biopsies before...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Kalfayan B,Seager GM

    更新日期:1982-09-01 00:00:00

  • Lymph node interdigitating reticulum cell sarcoma.

    abstract::A 67-year-old man presented with a malignant tumor involving abdominal lymph nodes, spleen, liver, and lungs, with associated protracted fever and night sweats. The tumor consisted of large pleomorphic cells, often surrounding microabscesses. Intracytoplasmic S100 protein, surface T6, Leu-3a (T4), and HLA-DR antigens ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Chan WC,Zaatari G

    更新日期:1986-06-01 00:00:00

  • Laboratory diagnosis of inherited protein S deficiency.

    abstract::The authors investigated assays for free protein S (ProS) antigen, total ProS antigen, and ProS crossed immunoelectrophoresis (CIEP) in the diagnosis of type 1 inherited ProS deficiency. Accurate measurement of the hemostatically important free ProS required showing that, on each specimen, precipitation of the C4b-bin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Edson JR,Vogt JM,Huesman DA

    更新日期:1990-08-01 00:00:00

  • Calretinin as a marker for cardiac myxoma. Diagnostic and histogenetic considerations.

    abstract::To study the usefulness of calretinin as an immunohistochemistry marker in the diagnosis of cardiac myxoma (CM) and the origin of myxoma cells, we examined 24 CMs and 9 fetal hearts with immunohistochemical methods on formalin-fixed paraffin-embedded tissues. We compared 24 CMs with 10 mural thrombi, 6 jaw myxomas, an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Terracciano LM,Mhawech P,Suess K,D'Armiento M,Lehmann FS,Jundt G,Moch H,Sauter G,Mihatsch MJ

    更新日期:2000-11-01 00:00:00

  • CD138 (syndecan-1), a plasma cell marker immunohistochemical profile in hematopoietic and nonhematopoietic neoplasms.

    abstract::We evaluated the immunohistochemical profile and specificity of CD138 reactivity in 238 specimens from hematopoietic and nonhematopoietic neoplasms. In 91 bone marrow biopsies, CD138 reactivity was observed for nonneoplastic plasma cells, neoplastic plasma cells in multiple myeloma cases (43/43), and the plasmacytic c...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: O'Connell FP,Pinkus JL,Pinkus GS

    更新日期:2004-02-01 00:00:00

  • The utility of BRAF V600E mutation-specific antibody VE1 for the diagnosis of hairy cell leukemia.

    abstract:OBJECTIVES:BRAF V600E mutation is characteristic of hairy cell leukemia (HCL). A V600E mutation-specific antibody, VE1, has been recently developed. We studied the diagnostic utility of this antibody in HCL and compared it with other B-cell neoplasms. METHODS:VE1 activity was assessed using immunohistochemistry in 90 ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Uppal G,Ly V,Wang ZX,Bajaj R,Solomides CC,Banks PM,Medeiros LJ,Peiper SC,Gong JZ

    更新日期:2015-01-01 00:00:00

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Shetty S,Kulkarni B,Pai N,Mukundan P,Kasatkar P,Ghosh K

    更新日期:2010-07-01 00:00:00

  • Sensitivity, specificity, and reproducibility of four measures of laboratory turnaround time.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Valenstein PN,Emancipator K

    更新日期:1989-04-01 00:00:00

  • Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,多中心研究


    authors: Reddi DM,Lu CM,Fedoriw G,Liu YC,Wang FF,Ely S,Boswell EL,Louissaint A Jr,Arcasoy MO,Goodman BK,Wang E

    更新日期:2012-12-01 00:00:00

  • Upregulation of miR-125b, miR-181d, and miR-221 Predicts Poor Prognosis in MGMT Promoter-Unmethylated Glioblastoma Patients.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Chen YY,Ho HL,Lin SC,Ho TD,Hsu CY

    更新日期:2018-03-29 00:00:00

  • Restoration of hemoglobin function in stored EDTA blood. Application in identification of hemoglobin variants with abnormal oxygen affinity.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Sumoza A,Fairbanks VF,Pineda AA

    更新日期:1977-07-01 00:00:00

  • Dual use of E-cadherin and D2-40 immunostaining in unusual meningioma subtypes.

    abstract:OBJECTIVES:Meningiomas usually can be readily diagnosed on H&E alone, although occasionally immunohistochemistry (IHC) confirmation is desirable. Studies exploring the diagnostic utility of either podoplanin (D2-40) or E-cadherin IHC in meningiomas have conflicted, and no studies exist in which the two IHCs have been u...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Mrachek EK,Davis D,Kleinschmidt-DeMasters BK

    更新日期:2015-12-01 00:00:00

  • Fluorescent cytochemical detection of estrogen and progesterone receptors in breast fine-needle aspirates.

    abstract::Estrogen and progesterone receptors were studied in fine-needle aspiration biopsy specimens of 56 patients with primary, recurrent, or metastatic breast carcinoma. The ligands, 17 B-estradiol-6-carboxymethyloxine-bovine serum albumin fluorescein isothiocyanate (FITC-BSA estradiol) and hydroxyprogesterone hemisuccinate...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Masood S

    更新日期:1991-01-01 00:00:00

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    abstract::A 55-year-old man presented with nerve compression and examination of tissue removed by laminectomy, and bone marrow aspiration was diagnostic of multiple myeloma. Protein studies showed a total serum protein of 5.7 g/dL, with a M-component in the fast beta region. The abnormal protein reacted only with anti-lambda an...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Hom BL

    更新日期:1984-11-01 00:00:00

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    abstract::A case of fetal demise and maternal recovery after acetaminophen overdose is presented, to our knowledge the first reported. Fetal liver and maternal serum concentrations indicate overdose to be the cause of fetal death. Maternal disseminated intravascular coagulation (DIC) may have been related to maternal acetaminop...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Haibach H,Akhter JE,Muscato MS,Cary PL,Hoffmann MF

    更新日期:1984-08-01 00:00:00

  • Trapped plasma in the microhematocrit.

    abstract::The amount of trapped plasma in the microhematocrit red blood cell column of samples from 25 normal individuals and 102 patients was investigated. The mean value for the normal individuals was 1.53%, and the mean values for the samples from the patient groups ranged from 1.41% to 1.82%. These groups included patients ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Pearson TC,Guthrie DL

    更新日期:1982-11-01 00:00:00

  • Her2/neu Status Determination in Breast Cancer: A Single Institutional Experience Using a Dual-Testing Approach With Immunohistochemistry and Fluorescence In Situ Hybridization.

    abstract:Objectives:According to current guidelines, either immunohistochemistry (IHC) or in situ hybridization (ISH) can be used to determine human epidermal growth factor receptor 2 (Her2/neu) status in breast carcinoma. While the guidelines explicitly delineate result interpretation, there is no consensus on the most appropr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Solomon JP,Dell'Aquila M,Fadare O,Hasteh F

    更新日期:2017-04-01 00:00:00

  • Usefulness of a monoclonal ERG/FLI1 antibody for immunohistochemical discrimination of Ewing family tumors.

    abstract::Ewing family tumors (EFTs) and prostate carcinomas are characterized by rearrangement of ETS genes, most commonly FLI1 (EFTs) and ERG (prostate carcinomas). Previously, we characterized an antibody against ERG (EPR3864) for detecting ERG-rearranged prostate carcinoma. Because EPR3864 also cross-reacts with FLI1, we ev...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Tomlins SA,Palanisamy N,Brenner JC,Stall JN,Siddiqui J,Thomas DG,Lucas DR,Chinnaiyan AM,Kunju LP

    更新日期:2013-06-01 00:00:00

  • Performance characteristics of nested polymerase chain reaction vs real-time polymerase chain reaction methods for detecting Mycobacterium tuberculosis complex in paraffin-embedded human tissues.

    abstract:OBJECTIVES:Nucleic acid amplification tests on formalin-fixed, paraffin-embedded (FFPE) tissue specimens enable Mycobacterium tuberculosis complex (MTB) detection and rapid tuberculosis diagnosis in the absence of microbiologic culture tests. We aimed to evaluate the efficacy of different polymerase chain reaction (PCR...

    journal_title:American journal of clinical pathology

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    authors: Seo AN,Park HJ,Lee HS,Park JO,Chang HE,Nam KH,Choe G,Park KU

    更新日期:2014-09-01 00:00:00

  • Evaluation of volume and total nucleated cell count as cord blood selection parameters: a receiver operating characteristic curve modeling approach.

    abstract::The objective of the study was to evaluate the current standard practice of using volume and total nucleated cell (TNC) count for the selection of cord blood (CB) units for cryopreservation and further transplantation. Data on 794 CB units whose CD34+ cell content was determined by flow cytometry were analyzed by usin...

    journal_title:American journal of clinical pathology

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    authors: Jaime-Pérez JC,Monreal-Robles R,Rodríguez-Romo LN,Mancías-Guerra C,Herrera-Garza JL,Gómez-Almaguer D

    更新日期:2011-11-01 00:00:00

  • The determination of reference values for hematologic parameters using results obtained from patient populations.

    abstract::Reference values for hematologic parameters are determined using data from patient populations of a whole year. As a consequence, the authors are not dependent on a limited selected population and can determine reference values for all age and sex groups. It turns out that from the possible compilation technics the ga...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Swaanenburg JC,Rutten WP,Holdrinet AC,van Strik R

    更新日期:1987-08-01 00:00:00

  • Cytologic features of poorly differentiated 'insular' carcinoma of the thyroid, as revealed by fine-needle aspiration biopsy.

    abstract::The authors report on the cytologic features of six cases of poorly differentiated "insular" carcinoma (IC) of the thyroid, a recently described variety of thyroid tumor intermediate between well-differentiated and anaplastic neoplasms. It is characterized by trabecular and/or alveolar growth patterns, merging with fo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Pietribiasi F,Sapino A,Papotti M,Bussolati G

    更新日期:1990-12-01 00:00:00

  • Lack of validity of standard corrections for white blood cell counts of blood-contaminated cerebrospinal fluid in infants.

    abstract::An evaluation of the validity in infants of standard computations for the correction of white cell counts in blood-contaminated cerebrospinal fluid (traumatic lumbar puncture) was undertaken. In 39 infants with significant blood contamination (greater than 10(4) red blood cells/microL) and no evidence of bacterial men...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Novak RW

    更新日期:1984-07-01 00:00:00

  • Sporadic medullary carcinoma of the colon: a clinicopathologic comparison with nonhereditary poorly differentiated enteric-type adenocarcinoma and neuroendocrine colorectal carcinoma.

    abstract::We studied 68 sporadic colorectal carcinomas (CRCs) with medullary features (MCRCs) and compared them with 35 poorly differentiated purely "enteric" CRCs (ECRCs) and 15 purely neuroendocrine carcinomas (NECs) of grades II and III, all in patients lacking a family history of CRC. Potential clinicopathologic differences...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Wick MR,Vitsky JL,Ritter JH,Swanson PE,Mills SE

    更新日期:2005-01-01 00:00:00

  • Quantification of medical and operational factors determining central versus satellite laboratory testing of blood gases.

    abstract::Blood gas measurements performed at the central laboratory and at a satellite laboratory of Brigham and Women's Hospital were studied to determine the differences in quality, turnaround time (TAT), and cost. The quality in both laboratories, as determined by results on proficiency and quality control samples, satisfac...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Winkelman JW,Wybenga DR

    更新日期:1994-07-01 00:00:00

  • Plasma-cell leukemia with unusual immunoglobulin abnormalities.

    abstract::The cases of three patients who had clinical courses and hematologic data consistent with plasma-cell leukemia or a terminal leukemic phase of multiple myeloma are presented. A double Bence Jones protein was demonstrated in the urine of two of the patients. Immunoelectrophoresis and immunofluorescence studies demonstr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Pedraza MA

    更新日期:1975-09-01 00:00:00

  • Tubular carcinoma of the breast: association with multicentricity, bilaterality, and family history of mammary carcinoma.

    abstract::Seventeen tubular carcinomas occurred among 211 consecutive mastectomies (7.6%). The relative frequencies of multicentric involvement in the ipsilateral breast (56%), history of bilateral mammary cancer (38%) (P less than .01), and family history of mammary cancer in a first-degree relative (40%) (P less than .05) wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Lagios MD,Rose MR,Margolin FR

    更新日期:1980-01-01 00:00:00

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    abstract::Statin is a 57 kDa nuclear protein exclusively found in noncycling cells. Its expression in hematolymphoid cells had not been examined previously. The authors studied statin immunoreactivity in nonneoplastic lymphoid tissues from 26 lymph nodes, 3 tonsils, and 2 spleens. Statin was detected primarily in small lymphoid...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Trudel MA,Oligny L,Caplan S,Caplan C,Schipper HM,Wang E

    更新日期:1994-04-01 00:00:00

  • Economic impact of a computer-based centralized organization in a clinical laboratory.

    abstract::The Department of Laboratory Medicine, University of Washington, has explored various management of organizational approaches over the past seven years. The Centralized Processing Area supported by a computerized information system has evolved from these efforts. Despite a decrease in U.W. hospital usage since 1968-69...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章


    authors: Nussbaum B,Minckler T,Roby R,Ackerman E

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  • Special commentary: patient safety and the next generation of HPV DNA tests.

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    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审


    authors: Kinney W,Stoler MH,Castle PE

    更新日期:2010-08-01 00:00:00