HER2 Gene Protein Assay Is Useful to Determine HER2 Status and Evaluate HER2 Heterogeneity in HER2 Equivocal Breast Cancer.

abstract：:Although the relationship between pathologic features and clinical outcome is well established in adult adrenocortical neoplasms, the prognostic value of these features in pediatric adrenocortical neoplasms (PACN) is unclear. In a series of PACNs from 54 Brazilian children, the authors retrospectively investigated the...

journal_title：American journal of clinical pathology

authors： Bugg MF,Ribeiro RC,Roberson PK,Lloyd RV,Sandrini R,Silva JB,Epelman S,Shapiro DN,Parham DM

更新日期：1994-05-01 00:00:00

abstract：:Anaerobiospirillum succiniciproducens is a little-known spiral bacterium. Presented here are two septicemia cases similar in that both occurred in rural northern Virginia, both patients presented with dental infection, and in both cases the organism was first suspected to be Campylobacter. The morphology, motility, bi...

journal_title：American journal of clinical pathology

authors： Park CH,Hixon DL,Endlich JF,O'Connell P,Bradd FT,Mount PM

更新日期：1986-01-01 00:00:00

abstract：:A method using the RNA polymerase chain reaction technique to diagnose infection retrospectively using single-stranded RNA enteroviruses in paraffin-embedded tissue blocks is reported. This method takes advantage of extreme sequence conservation in the 5' untranslated region of the enteroviral genome and uses two roun...

journal_title：American journal of clinical pathology

authors： Redline RW,Genest DR,Tycko B

更新日期：1991-11-01 00:00:00

abstract：:Diarrheal diseases caused by bacterial pathogens are important causes of morbidity in the United States, and considerable laboratory resources are spent to detect these enteric pathogens. This article reviews recent developments in the detection and identification of Campylobacter spp, enterohemorrhagic Escherichia co...

journal_title：American journal of clinical pathology

authors： Nolte FS

更新日期：1994-04-01 00:00:00

abstract：:In this study, 145 well-differentiated (tubular) carcinomas were divided into two groups: 90 pure tubular carcinomas and 55 which were mixtures in that they contained a component of infiltrating duct carcinoma occupying less than half the tumor. Axillary lymph node metastases developed in 29% of women in the mixed gro...

journal_title：American journal of clinical pathology

authors： Deos PH,Norris HJ

更新日期：1982-07-01 00:00:00

abstract：:We present what, to our knowledge, is the first reported case of nephrogenic metaplasia of the ureter. Nephrogenic metaplasia involves the transitional epithelium of the urinary tract and results in the formation of epithelial tubules, which are histologically similar to renal tubules. Special stains demonstrated both...

journal_title：American journal of clinical pathology

authors： Lugo M,Petersen RO,Elfenbein IB,Stein BS,Duker NJ

更新日期：1983-07-01 00:00:00

abstract：:To determine the diagnostic significance of the kappa/lambda ratio in germinal center (GC) B cells in Hashimoto thyroiditis (HT), we used 4-color flow cytometry to immunophenotype 27 samples (21 patients) of well-characterized HT B-cell clonality was analyzed further by polymerase chain reaction (PCR) of the immunoglo...

journal_title：American journal of clinical pathology

authors： Chen HI,Akpolat I,Mody DR,Lopez-Terrada D,De Leon AP,Luo Y,Jorgensen J,Schwartz MR,Chang CC

更新日期：2006-01-01 00:00:00

abstract：:To assess the diagnostic accuracy of margin evaluation of melanocytic lesions using en face frozen sections compared with standard paraffin-embedded sections, we studied 2 sets of lesions in which en face frozen sections were used for analysis of surgical margins (13 from malignant melanomas [MMs] and 10 from nonmelan...

journal_title：American journal of clinical pathology

authors： Prieto VG,Argenyi ZB,Barnhill RL,Duray PH,Elenitsas R,From L,Guitart J,Horenstein MG,Ming ME,Piepkorn MW,Rabkin MS,Reed JA,Selim MA,Trotter MJ,Johnson MM,Shea CR

更新日期：2003-08-01 00:00:00

abstract：:Two separate courses in clinical pathology were presented to two groups of second-year medical students. The first (large) group was taught by the conventional lecture method; the other (small) group, by a self-instructional method for roughly half of the course, followed by the conventional lecture method for the sec...

journal_title：American journal of clinical pathology

authors： Kao YS,Beeler MF,Strong JP

更新日期：1978-12-01 00:00:00

abstract：:An evaluation of the performance of duplicate prothrombin time (PT) and activated partial thromboplastin time (aPTT) assays was undertaken to develop analytical duplicate performance criteria in order to quantitate the risks associated with singlet versus duplicate procedures. Data were retrospectively collected from ...

journal_title：American journal of clinical pathology

authors： Scheer WD,Catrou PG,Lipscomb GE,Boudreau DA

更新日期：1986-04-01 00:00:00

abstract：:A unique case of intramural uterine tumor composed of malignant epithelium and benign smooth muscle, adipose tissue, and cartilage is reported. This tumor, which the authors designated "carcinomesenchymoma," apparently represents an example of a previously unreported variant of mixed müllerian tumor that is composed o...

journal_title：American journal of clinical pathology

authors： Chen KT,Vergon JM

更新日期：1981-05-01 00:00:00

abstract：:Lymphocyte subpopulations were studied in the peripheral blood, lymph nodes, and spleens in a group of 17 patients with untreated Hodgkin's disease. In 12 of 15 cases, diminished absolute levels of T-lymphocytes in the peripheral blood were found; however, this was correlated with total lymphopenia. No direct relation...

journal_title：American journal of clinical pathology

authors： Bukowski RM,Noguchi S,Hewlett JS,Deodhar S

更新日期：1976-01-01 00:00:00

abstract：:Histologic findings in liver biopsy specimens obtained from 88 patients before and one and two years after end-to-end jejunoileal bypass are compared. In addition to the expected fatty changes, mild changes of centrilobular, pericellular fibrosis were present in the initial biopsies in 8.6%; a year later they had beco...

journal_title：American journal of clinical pathology

authors： Marubbio AT Jr,Buchwald H,Schwartz MZ,Varco R

更新日期：1976-10-01 00:00:00

abstract：:The Sysmex R-3000 (TOA Medical Electronics, Kobe, Japan) evaluates maturation of reticulocytes by quantitating the fraction of reticulocytes within low-, middle-, and high-fluorescence intensity regions. We defined the immature reticulocyte fraction (IRF) as the sum of the fraction of high-fluorescence intensity regio...

journal_title：American journal of clinical pathology

authors： Chang CC,Kass L

更新日期：1997-07-01 00:00:00

abstract：:The demonstration of carcinoembryonic antigen (CEA) in serum and in tissue sections may be of value in diagnosis and follow-up of several malignant tumors. Anti-CEA sera, however, cross-react with normal antigens, also present in tumors. The staining patterns of three commercially produced anti-CEA sera were investiga...

journal_title：American journal of clinical pathology

authors： Nap M,ten Hoor KA,Fleuren GJ

更新日期：1983-01-01 00:00:00

abstract：:A girl, aged 2 years, 11 months, who had pain and swelling of the proximal humerus, was found to have osteoblastic osteogenic sarcoma of the humerus. Among 937 consecutive patients with osteogenic sarcoma examined at the Mayo Clinic, she is the youngest child seen, as well as only the sixth child younger than 6 years...

journal_title：American journal of clinical pathology

authors： Siegal GP,Dahlin DC,Sim FH

更新日期：1975-06-01 00:00:00

abstract：:The diagnostic value of glypican 3 (GPC3) immunostaining on needle biopsy specimens has not been well assessed. In this study, 120 liver needle biopsy specimens, including 46 from cirrhotic livers and 74 hepatocellular carcinomas (HCCs), were immunohistochemically examined for expression of GPC3. The results showed st...

journal_title：American journal of clinical pathology

authors： Anatelli F,Chuang ST,Yang XJ,Wang HL

更新日期：2008-08-01 00:00:00

abstract：:Differential characterization of the "reticulum cell" in lymphoreticular neoplasms. Am J Clin Pathol. 64: 171-179, 1975. The term "reticulum cell" is confusing, having been applied to the cells involved in many hematopoietic neoplasms, such as reticulum-cell sarcoma, histiocytic medullary reticulosis, leukemic reticul...

journal_title：American journal of clinical pathology

authors： Yam LT,Tavassoli M,Jacobs P

更新日期：1975-08-01 00:00:00

abstract：:The authors report the clinicopathologic findings in four cases of adult women with rhabdomyosarcomas that originated in the endometrium or cervix, or both. All tumors were pure sarcomas and not components of carcinosarcomas or malignant mixed mesodermal tumors. In two patients, the tumors were typical botryoid embryo...

journal_title：American journal of clinical pathology

authors： Hart WR,Craig JR

更新日期：1978-08-01 00:00:00

abstract：:Mastocytosis, an unusual disorder of bone marrow-derived, clonally transformed hematopoietic progenitor cells, exhibits a broad spectrum of clinical and morphologic features ranging from a self-limiting benign disorder (ie, juvenile cutaneous mastocytosis) to highly aggressive neoplasms like mast cell leukemia. Princi...

journal_title：American journal of clinical pathology

authors： Horny HP

更新日期：2009-09-01 00:00:00

abstract：:Determination of HER-2/neu oncogene amplification has become clinically important in the present management of breast cancer and may have important applications in other areas of clinical oncology and scientific research. In situ hybridization is an extremely accurate and sensitive technique for assessing amplificatio...

journal_title：American journal of clinical pathology

authors： Gupta D,Middleton LP,Whitaker MJ,Abrams J

更新日期：2003-03-01 00:00:00

abstract：:Serum bicarbonate testing has been reported to be inaccurate in several clinical studies. This prompted a search for systemic errors in bicarbonate testing devices, which has been inconclusive. The effect on serum bicarbonate level measurement of partially filling plain red-top (clot) vacutainer tubes was studied in h...

journal_title：American journal of clinical pathology

authors： Herr RD,Swanson T

更新日期：1992-02-01 00:00:00

abstract：OBJECTIVES:Cytogenetics defines disease entities and predicts prognosis in acute myeloid leukemia (AML). Conventional karyotyping provides a comprehensive view of the genome, while fluorescence in situ hybridization (FISH) detects targeted abnormalities. The aim of this study was to compare the utility of karyotyping a...

journal_title：American journal of clinical pathology

authors： He R,Wiktor AE,Hanson CA,Ketterling RP,Kurtin PJ,Van Dyke DL,Litzow MR,Howard MT,Reichard KK

更新日期：2015-06-01 00:00:00

abstract：:Platelet satellitism (PS), the phenomenon of platelet rosetting around polymorphonuclear neutrophils (PMN), which is observed in ethylenediamineetetraacetic acid (EDTA)-anticoagulated blood at room temperature, is caused by the presence of IgG autoantibodies in the serum. Fourteen patients with PS were studied, and th...

journal_title：American journal of clinical pathology

authors： Bizzaro N,Goldschmeding R,von dem Borne AE

更新日期：1995-06-01 00:00:00

abstract：:An automated fluorescent immunoassay system (FIAX) was compared with complement fixation (CF) for measuring antibodies to cytomegalovirus (CMV) and herpes simplex virus (HSV) in clinical specimens. Compared with CF the specificity of FIAX (ability to detect a negative titer) was 95% for CMV and 92% for HSV. The sensit...

journal_title：American journal of clinical pathology

authors： Friedman HM,Tustin NB,Hitchings MM,Plotkin SA

更新日期：1981-09-01 00:00:00

abstract：:A 3-year-old girl of Navajo heritage had intractable diarrhea beginning at 4 days of age and resulting in long-term hyperalimentation. Investigation before multivisceral transplantation included biopsies of the rectum, stomach, duodenum, and liver. The diagnosis of microvillus inclusion disease was established by docu...

journal_title：American journal of clinical pathology

authors： Schofield DE,Agostini RM Jr,Yunis EJ

更新日期：1992-07-01 00:00:00

abstract：:Inhibition of anti-Rh29 by erythrocytic stroma in feces was devised as a specific test for fecal occult blood. The sensitivity of this test was equivalent to that of a standard Hemoccult test, namely, 10(8) erythrocytes/g feces. Comparison of results of this test with results of Hemoccult tests of random stool specime...

journal_title：American journal of clinical pathology

authors： Rosenfield RE,Kochwa S,Kaczera Z,Maimon J

更新日期：1979-02-01 00:00:00

abstract：:In the laboratory evaluation of platelet disorders, there are a number of situations in which determining the capacity of platelets to synthesize thromboxane is of diagnostic value. An assay for thromboxane production is required for the diagnosis of cyclooxygenase and thromboxane synthetase defects and is useful in d...

journal_title：American journal of clinical pathology

authors： Connor AM,Laposata M

更新日期：1988-02-01 00:00:00

abstract：:The authors report on the cytologic features of six cases of poorly differentiated "insular" carcinoma (IC) of the thyroid, a recently described variety of thyroid tumor intermediate between well-differentiated and anaplastic neoplasms. It is characterized by trabecular and/or alveolar growth patterns, merging with fo...

journal_title：American journal of clinical pathology

authors： Pietribiasi F,Sapino A,Papotti M,Bussolati G

更新日期：1990-12-01 00:00:00

abstract：:The authors describe two patients with clinically and histopathologically documented advanced (tumor) stage mycosis fungoides. In each case the large, pleomorphic neoplastic cells lacked the monoclonal antibody-defined cell surface antigens commonly associated with immature and mature T-cells, i.e., T11, Leu-1, T3, T4...

journal_title：American journal of clinical pathology

authors： Wieczorek R,Suhrland M,Ramsay D,Reed ML,Knowles DM 2nd

更新日期：1986-07-01 00:00:00