Correlation of pathologic features with clinical outcome in pediatric adrenocortical neoplasia. A study of a Brazilian population. Brazilian Group for Treatment of Childhood Adrenocortical Tumors.

Abstract:

:Although the relationship between pathologic features and clinical outcome is well established in adult adrenocortical neoplasms, the prognostic value of these features in pediatric adrenocortical neoplasms (PACN) is unclear. In a series of PACNs from 54 Brazilian children, the authors retrospectively investigated the prognostic value of histologic classification, ploidy, proliferative index, and size (as tumor weight or greater diameter). Histologic classification was most predictive of clinical behavior: there were no failures in 11 adenomas, 5 failures in 27 low-grade carcinomas, and 9 failures in 16 high-grade carcinomas (P = .0003). Tumor weight was predictive of failure in tumors weighing > or = 100 versus < 100 g (P = .04), and a trend was found toward failure among tumors measuring > or = 5 cm, as opposed to those < 5 cm (P = .07). Proliferative index was marginally related to failure (P = .05 at < 11% vs. > or = 11% and .07 at < 10% vs. > or = 10%), and ploidy was not significantly predictive of outcome (P = .25). Histologic type and tumor weight were the most reliable predictors of outcome in PACN.

journal_name

Am J Clin Pathol

authors

Bugg MF,Ribeiro RC,Roberson PK,Lloyd RV,Sandrini R,Silva JB,Epelman S,Shapiro DN,Parham DM

doi

10.1093/ajcp/101.5.625

subject

Has Abstract

pub_date

1994-05-01 00:00:00

pages

625-9

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

101

pub_type

杂志文章
  • In-situ and microinvasive adenocarcinoma of the uterine cervix. A clinical, cytologic and histologic study of 14 cases.

    abstract::In-situ and microinvasive adenocarcinoma of the uterine cervix. A clinical, cytologic and histologic study of 14 cases. Am J Clin Pathol 64: 155-70, 1975. The clinicopathologic features of 14 cases of in-situ and microinvasive adenocarcinoma of the cervix, encountered during the period 1961-1974, form the basis of thi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.2.155

    authors: Qizilbash AH

    更新日期:1975-08-01 00:00:00

  • Expression of "myelomonocytic" antigens in mesotheliomas and adenocarcinomas involving the serosal surfaces.

    abstract::Because of the demonstrated efficacy of Leu-M1 as a discriminant between malignant epithelioid mesothelioma (MEM) and adenocarcinomas involving the serosal surfaces (ACSs), the authors assessed the reactivities of related "myelomonocytic" antigens in this context. Paraffin sections from 41 MEMs and 43 ACSs (pulmonary,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.1.18

    authors: Wick MR,Mills SE,Swanson PE

    更新日期:1990-07-01 00:00:00

  • Postmortem bacteriology and pneumonia in a mentally retarded population.

    abstract::Postmortem pathologic and bacteriologic reports were analyzed for 237 deaths occurring at a large institution for the mentally retarded from 1958 to 1973. Bronchopneumonia, aspiration pneumonia, and lipid pneumonia were frequently reported at autopsy, and in a total of 146 cases (61.6%) at least one type of pneumonia ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.2.190

    authors: Polednak AP

    更新日期:1977-02-01 00:00:00

  • The diagnostic utility of the minimal carcinoma triple stain in breast carcinomas.

    abstract::Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPF4O0ADKFMGRJ

    authors: Ross DS,Liu YF,Pipa J,Shin SJ

    更新日期:2013-01-01 00:00:00

  • Evaluation of a new blood culture medium for mycobacteria.

    abstract::This study evaluates the sensitivity and detection time of a new radiometric broth (BACTEC 13A medium, Johnston Laboratories, Towson, MD) designed for direct blood culturing for Mycobacteria. A total of 1,848 blood specimens were cultured in parallel by a new method in which blood was directly inoculated into 13A medi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.3.316

    authors: Strand CL,Epstein C,Verzosa S,Effatt E,Hormozi P,Siddiqi SH

    更新日期:1989-03-01 00:00:00

  • Giant forms of Blastomyces dermatitidis in the pulmonary lesions of blastomycosis. Potential confusion with Coccidioides immitis.

    abstract::Typical yeast-phase cells of Blastomyces dermatitidis have a characteristic appearance in tissue sections. Fungal morphologic variation occurs infrequently in the lesions of blastomycosis, yet it can complicate the differential diagnosis, particularly if fresh tissue is not available for microbiologic culture. The aut...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.4.575

    authors: Watts JC,Chandler FW,Mihalov ML,Kammeyer PL,Armin AR

    更新日期:1990-04-01 00:00:00

  • Quantitative evaluation of bone marrow angiogenesis in idiopathic myelofibrosis.

    abstract::Bone marrow angiogenesis in patients with idiopathic myelofibrosis (IM) was evaluated by using a quantitative morphometric analysis test system. IM specimens had a significantly higher degree of bone marrow microvessel density (MVD) compared with control specimens. The higher degree of angiogenesis was associated with...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/4YGK-ED5L-WFW4-AVDV

    authors: Ni H,Barosi G,Hoffman R

    更新日期:2006-08-01 00:00:00

  • The occurrence of an auto-immune hemolytic anemia with anti-U specificity in a patient with myelodysplastic syndrome.

    abstract::A 73-year-old man with myelodysplastic syndrome developed during the course of his illness auto-immune hemolytic anemia. The association between auto-immune hemolysis and myeloproliferative disease is extremely rare. An even more unique finding is the nature of the antibody which demonstrated single specificity agains...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.3.356

    authors: Sacher RA,McGinniss MM,Shashaty GG,Jacobson RJ,Rath CE

    更新日期:1982-03-01 00:00:00

  • Extensively keratinized squamous intraepithelial lesions of the cervix are difficult to grade.

    abstract::We tested the hypothesis that extensively keratinized squamous intraepithelial lesions (SILs) are difficult to grade precisely by identifying 100 Papanicolaou smears with a keratinizing SIL that had been originally judged difficult to grade. Of these, 65 were confirmed as low-grade SIL (LSIL) or high-grade SIL (HSIL) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/RQBN-Y51J-CJTK-P9H5

    authors: Faquin WC,Brown FM,Krane JF,Renshaw AA,Cibas ES

    更新日期:2001-01-01 00:00:00

  • Diagnostic yield from 231 autopsies in a community hospital.

    abstract::Autopsy reports of 231 adult autopsies were examined for clinically unexpected diagnoses. Analysis of data showed that 97 of 188 autopsy diagnoses were clinically unexpected. The diagnosis of pulmonary embolism was clinically the most frequently missed diagnosis relative to its actual occurrence. Also noted was that t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.4.486

    authors: Rao MG,Rangwala AF

    更新日期:1990-04-01 00:00:00

  • Xanthogranulomatous pseudotumor of the vagina: evidence of a local response to an unusual bacterium (mucoid Escherichia coli).

    abstract::Utilization of nonconventional bacterial strains and electron microscopy occasionally may aid in the recognition of unusual microorganisms which fail to be demonstrated by more conventional bacterial stains. We report an unusual case of recurrent vaginal polyps, initially thought by physical examination to represent a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.5.637

    authors: Strate SM,Taylor WE,Forney JP,Silva FG

    更新日期:1983-05-01 00:00:00

  • Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens.

    abstract::We describe 41 cases of myeloid neoplasms (MNs) secondary to plasma cell myeloma (PCM). The types of MN included myelodysplastic syndrome (MDS) in 34 (82.9%), acute myeloid leukemia (AML) in 4 (9.8%), and myeloproliferative neoplasm (MPN) or MDS/MPN in 3 (7.3%) cases. The latency from treatment to diagnosis of MN rang...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1309/AJCPOP7APGDT9JIU

    authors: Reddi DM,Lu CM,Fedoriw G,Liu YC,Wang FF,Ely S,Boswell EL,Louissaint A Jr,Arcasoy MO,Goodman BK,Wang E

    更新日期:2012-12-01 00:00:00

  • A new Mycobacterium species causing diffuse lepromatous leprosy.

    abstract::Mycobacterium leprae causes leprosy. M leprae strains collected worldwide have been genetically clonal, which poorly explains the varying severity and clinical features of the disease. We discovered a new Mycobacterium species from 2 patients who died of diffuse lepromatous leprosy (DLL). The Mycobacterium was purifie...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPP72FJZZRRVMM

    authors: Han XY,Seo YH,Sizer KC,Schoberle T,May GS,Spencer JS,Li W,Nair RG

    更新日期:2008-12-01 00:00:00

  • Screening for dyslipidemia. Practice parameter.

    abstract::Screening for serum lipid disorders is recommended by numerous specialty societies to identify patients at risk for coronary heart disease (CHD). The best screening tests will identify patients at highest risk for CHD who would benefit from intervention. This report discusses an appropriate test panel to use as the in...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.4.380

    authors: Hostetter AL

    更新日期:1995-04-01 00:00:00

  • Mucocele-like lesions diagnosed on breast core biopsy: assessment of upgrade rate and need for surgical excision.

    abstract::Mucocele-like lesion (MLL) is a rare mucinous lesion of the breast with highly variable upgrade rates to atypia or malignancy on excision. This spectrum of data has led to differing opinions on the need for surgical excision. We evaluated 50 core biopsy specimens diagnosed as having MLLs and correlated the findings wi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP1D8YLCFFTLOW

    authors: Sutton B,Davion S,Feldman M,Siziopikou K,Mendelson E,Sullivan M

    更新日期:2012-12-01 00:00:00

  • Malignant melanoma. Interaction with coagulation and fibrinolysis pathways in situ.

    abstract::Immunohistochemical techniques applied to fresh frozen sections of metastatic malignant melanoma tissue revealed abundant fibrinogen (or fibrin I) in perivascular areas throughout the tumor connective tissue stroma. Fibrin was readily detected in a focal distribution in the connective tissue around nodules of viable t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.4.516

    authors: Wojtukiewicz MZ,Zacharski LR,Memoli VA,Kisiel W,Kudryk BJ,Rousseau SM,Stump DC

    更新日期:1990-04-01 00:00:00

  • Effects of time, platelet concentration, and sex on the human platelet aggregation response.

    abstract::The platelet aggregation responses induced by adenosine diphosphate (ADP) and collagen were characterized by parameters defining rate and extent of reaction. Values were compared on the basis of platelet concentration, time elapsed between sample collection and test performance, and sex of donors. Rate and extent of a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.3.263

    authors: Roper P,Drewinko B,Hasler D,Johnston D,Hester J,Freireich EJ

    更新日期:1979-03-01 00:00:00

  • Rapid immunocytochemical analysis of acute leukemias.

    abstract::Immunophenotypic analysis of acute leukemias is time consuming and often requires flow cytometric analysis. A 1-hour alkaline phosphatase-labeled streptavidin-biotin immunocytochemical procedure was evaluated as an alternative. Seventeen cases of acute leukemia, including 10 acute lymphocytic (ALL) and 7 acute nonlymp...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.6.876

    authors: Hammer RD,Collins RD,Ebrahimi S,Casey TT

    更新日期:1992-06-01 00:00:00

  • Fine-needle cytology of 292 palpable orbital and eyelid tumors.

    abstract::Fine-needle cytology (FNC) of 292 palpable orbital and eyelid tumors was performed with a 25-gauge (0.5-mm), 3-cm needle and compared with the histopathologic findings in 286 cases. Among these 286 cases, a concordant diagnosis of malignancy and type was achieved in 249 cases (87%). False positive diagnoses were made ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.1.100

    authors: Zajdela A,Vielh P,Schlienger P,Haye C

    更新日期:1990-01-01 00:00:00

  • The effect of bacteremia on automated platelet measurements in neonates.

    abstract::Platelet volume measurements have been used to differentiate consumptive and hypoplastic thrombocytopenia. Since thrombocytopenia is a frequent complication of neonatal sepsis, the authors explored the utility of correlating mean platelet volume (MVP) and platelet distribution width (PDW) with bacteremia. In a sample ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.3.391

    authors: Patrick CH,Lazarchick J

    更新日期:1990-03-01 00:00:00

  • Pulmonary histologic changes in Marfan syndrome: a case series and literature review.

    abstract::Marfan syndrome is one of the most common connective tissue diseases and may manifest with a range of symptoms and pathologic changes. We present a retrospective series of 5 cases of patients with Marfan syndrome and pulmonary pathology. Patients were young to middle-aged adults with absent or minimal smoking historie...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCP79SNDHGKQFIN

    authors: Dyhdalo K,Farver C

    更新日期:2011-12-01 00:00:00

  • Comparison of anti-estrogen receptor antibodies SP1, 6F11, and 1D5 in breast cancer: lower 1D5 sensitivity but questionable clinical implications.

    abstract::We compared the anti-estrogen receptors (ER) SP1, 6F11, and 1D5 antibodies in breast carcinoma cases with different ranges of positive cells to evaluate whether this could generate different therapies for patients. We selected 66 cases of breast cancer, each of which was immunostained with the 3 antibodies. 1D5 was le...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPLX0QJROV2IJG

    authors: Bogina G,Zamboni G,Sapino A,Bortesi L,Marconi M,Lunardi G,Coati F,Massocco A,Molinaro L,Pegoraro C,Venturini M

    更新日期:2012-11-01 00:00:00

  • Comparison of complement fixation and fluorescent immunoassay (FIAX) for measuring antibodies to cytomegalovirus and herpes simplex virus.

    abstract::An automated fluorescent immunoassay system (FIAX) was compared with complement fixation (CF) for measuring antibodies to cytomegalovirus (CMV) and herpes simplex virus (HSV) in clinical specimens. Compared with CF the specificity of FIAX (ability to detect a negative titer) was 95% for CMV and 92% for HSV. The sensit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.3.305

    authors: Friedman HM,Tustin NB,Hitchings MM,Plotkin SA

    更新日期:1981-09-01 00:00:00

  • Suppurative granulomatous lymphadenitis caused by corynebacterium ovis (pseudotuberculosis).

    abstract::A 30-year-old previously healthy man developed cervical adenopathy associated with mild constitutional symptoms. Corynebacterium ovis was isolated in pure culture from lymph node tissue on two separate occasions, and small gram positive organisms were identified in both lymph nodes with tissue gram stain. Histopatholo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.4.486

    authors: Goldberger AC,Lipsky BA,Plorde JJ

    更新日期:1981-10-01 00:00:00

  • Fresh and citrated whole-blood specimens can produce different thromboelastography results in patients on extracorporeal membrane oxygenation.

    abstract:OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPYIQ9JNNSEN4Q

    authors: Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

    更新日期:2013-08-01 00:00:00

  • Serum uric acid.

    abstract::Data from the 1977 College of American Pathologists (CAP) Comprehensive Chemistry Survey and other programs have been analyzed in an interlaboratory comparison of the measurements of serum uric acid. The majority of clinical laboratories utilize some form of phosphotungstic acid (PTA) oxidation-reduction technic for t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Geisinger KR,Batsakis JG,Bauer RC

    更新日期:1979-08-01 00:00:00

  • Catalase-negative listeria monocytogenes causing meningitis in an adult. Clinical and laboratory features.

    abstract::A 63-year-old previously healthy woman presented with acute meningitis. Cultures of the cerebrospinal fluid yielded a serotype 1/2a isolate of Listeria monocytogenes that was biochemically typical in all respects, other than the reproducible lack of catalase production. During therapy, the patient developed oculomotor...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.1.130

    authors: Swartz MA,Welch DF,Narayanan RP,Greenfield RA

    更新日期:1991-07-01 00:00:00

  • Clinical and laboratory efficiency of rapid screening urine cultures by nephelometry.

    abstract::Urine cultures represent 40-50% of specimens processed by hospital clinical microbiology laboratories. An accurate rapid screening method to detect positive urine cultures could greatly improve laboratory efficiency. Three hundred eighty-two unselected urines were screened by nephelometry at 2, 4, and 5 hours of shaki...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.3.305

    authors: Heinz T,Pezzlo M,Thrupp L

    更新日期:1982-03-01 00:00:00

  • Automated immunohistochemical assay for estrogen receptor status in breast cancer using monoclonal antibody CC4-5 on the Ventana ES.

    abstract::Determination of breast cancer estrogen receptor (ER) status as a predictor of tumor response to adjuvant endocrine therapy remains a mainstay of breast cancer management. Recent second generation anti-ER antibodies and new epitope retrieval methods have produced paraffin-based immunohistochemical results that correla...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.3.332

    authors: Nichols GE,Frierson HF Jr,Boyd JC,Hanigan MH

    更新日期:1996-09-01 00:00:00

  • Conventional karyotyping and fluorescence in situ hybridization: an effective utilization strategy in diagnostic adult acute myeloid leukemia.

    abstract:OBJECTIVES:Cytogenetics defines disease entities and predicts prognosis in acute myeloid leukemia (AML). Conventional karyotyping provides a comprehensive view of the genome, while fluorescence in situ hybridization (FISH) detects targeted abnormalities. The aim of this study was to compare the utility of karyotyping a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPP6LVMQG4LNCK

    authors: He R,Wiktor AE,Hanson CA,Ketterling RP,Kurtin PJ,Van Dyke DL,Litzow MR,Howard MT,Reichard KK

    更新日期:2015-06-01 00:00:00