Myeloid neoplasms secondary to plasma cell myeloma: an intrinsic predisposition or therapy-related phenomenon? A clinicopathologic study of 41 cases and correlation of cytogenetic features with treatment regimens.

Abstract:

:We describe 41 cases of myeloid neoplasms (MNs) secondary to plasma cell myeloma (PCM). The types of MN included myelodysplastic syndrome (MDS) in 34 (82.9%), acute myeloid leukemia (AML) in 4 (9.8%), and myeloproliferative neoplasm (MPN) or MDS/MPN in 3 (7.3%) cases. The latency from treatment to diagnosis of MN ranged from 9 to 384 months, with a median of 60 months. Of 37 cases with cytogenetic studies, complex abnormalities were detected in 22 (59.5%), -5(q)/-7(q) in 4 (10.8%), other abnormalities in 8 (21.6%), and normal karyotype in 3 (8.1%) cases. Complex abnormalities and -5(q)/-7(q) correlated directly with multiple chemotherapeutic regimens, particularly with combined melphalan/cyclophosphamide. Moreover, the features of cytogenetic abnormalities in our series were significantly different from those with concomitant PCM/MN who had significantly lower complex abnormalities. The latency, skewed proportion of MDS, and bias toward complex cytogenetic abnormalities/unbalanced aberrations of chromosomes 5/7 suggested an alkylating mutagenic effect on pathogenesis of secondary MN. Kaplan-Meier survival analysis demonstrated a median survival of 19 months, which was better than that for therapy-related (t)-MDS/AML. In contrast to t-MDS, the survival in our patients appeared to depend on subtypes of MDS as seen in de novo diseases.

journal_name

Am J Clin Pathol

authors

Reddi DM,Lu CM,Fedoriw G,Liu YC,Wang FF,Ely S,Boswell EL,Louissaint A Jr,Arcasoy MO,Goodman BK,Wang E

doi

10.1309/AJCPOP7APGDT9JIU

subject

Has Abstract

pub_date

2012-12-01 00:00:00

pages

855-66

issue

6

eissn

0002-9173

issn

1943-7722

pii

138/6/855

journal_volume

138

pub_type

杂志文章,多中心研究
  • Anaerobiospirillum succiniciproducens. Two case reports.

    abstract::Anaerobiospirillum succiniciproducens is a little-known spiral bacterium. Presented here are two septicemia cases similar in that both occurred in rural northern Virginia, both patients presented with dental infection, and in both cases the organism was first suspected to be Campylobacter. The morphology, motility, bi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/85.1.73

    authors: Park CH,Hixon DL,Endlich JF,O'Connell P,Bradd FT,Mount PM

    更新日期:1986-01-01 00:00:00

  • Strategies for the analysis of oncogene overexpression. Studies of the neu oncogene in breast carcinoma.

    abstract::The development of a consistent strategy for the analysis of oncogene expression at the cellular level is essential for understanding the roles of these genes in the development and progression of human neoplasia. Detection of the neu oncogene products in breast carcinoma was selected as a model for analysis of oncoge...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.2.125

    authors: Naber SP,Tsutsumi Y,Yin S,Zolnay SA,Mobtaker H,Marks PJ,McKenzie SJ,DeLellis RA,Wolfe HJ

    更新日期:1990-08-01 00:00:00

  • The autopsy. Simple thoughts about the public needs and how to address them.

    abstract::Dialogue regarding the autopsy has been sustained largely by medical students and professionals, and by families of deceased patients. Exclusion of the general public may represent a significant reason for the inexorable decline of autopsy rates and politicoeconomic support. Sensitivity to public concerns regarding th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: McManus BM,Wood SM

    更新日期:1996-10-01 00:00:00

  • Automated evaluation of synovial and ascitic fluids with the Advia 2120 hematology analyzer.

    abstract:OBJECTIVES:The purpose of this study was to determine if the Advia 2120 hematology analyzer (Siemens Healthcare Diagnostics, Deerfield, IL) can accurately quantify both WBCs and the proportion of neutrophils from synovial and ascitic body fluids. METHODS:We analyzed 60 samples on the Advia and compared the results wit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP6JIJV7WYMUAK

    authors: Froom P,Diab A,Barak M

    更新日期:2013-12-01 00:00:00

  • Immunohistochemical Expression of Lymphoid Enhancer Binding Factor 1 in CD5-Positive Marginal Zone, Lymphoplasmacytic, and Follicular Lymphomas.

    abstract:OBJECTIVES:Lymphoid enhancer binding factor 1 (LEF1) is expressed in most cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and has shown utility in distinguishing CLL/SLL from other small B-cell lymphomas. LEF1 expression has not been systematically studied in CD5-positive marginal zone lympho...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz207

    authors: Patel N,Durkin L,Bodo J,Hsi ED

    更新日期:2020-04-15 00:00:00

  • In vitro detection of mild inhibitors to factor VIII in hemophilia.

    abstract::Plasma samples from patients with severe classic hemophilia, suspected of having mild inhibitors not detected in the standard Bethesda inhibitor test, were examined in modified Bethesda tests and in a screening test based on the activated partial thromboplastin time (APTT). The APTT test was more sensitive to mild inh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.6.749

    authors: Ewing NP,Kasper CK

    更新日期:1982-06-01 00:00:00

  • Lymphoepithelioma-like carcinoma of the lung with a better prognosis. A clinicopathologic study of 32 cases.

    abstract::The purpose of our study was to clarify the prognosis of lymphoepithelioma-like carcinoma (LELC) of the lung, which is rare. We analyzed the clinicopathologic features of 32 cases of pulmonary LELC and compared the cases with 84 cases of pulmonary non-LELC with available long-term follow-up information. The results sh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/BUAN-BGFW-69U9-C3H8

    authors: Han AJ,Xiong M,Gu YY,Lin SX,Xiong M

    更新日期:2001-06-01 00:00:00

  • Are autopsies obsolete?

    abstract::To determine the current frequency of discovering important diagnoses at autopsy, the diagnoses made in all complete or "no head" autopsies during 1994 at a major tertiary care transplantation referral center were retrospectively compared with the diagnoses made antemortem. Of 176 autopsies, 79 (44.9%) revealed 1 or m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/110.2.210

    authors: Nichols L,Aronica P,Babe C

    更新日期:1998-08-01 00:00:00

  • Myxomatous degeneration of the mitral valve complicated by nonbacterial thrombotic endocarditis with systemic embolization.

    abstract::Myxomatous degeneration of the mitral valve is a disease of unknown etiology that is associated with many ominous complications. A case in which non-bacterial thrombotic endocarditis, superimposed on a myxomatous mitral valve, resulted in systemic embolization to the brain, heart, and kidney is presented. The purpose ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.3.489

    authors: Geyer SJ,Franzini DA

    更新日期:1979-09-01 00:00:00

  • Impact of Laboratory Charge Display Within the Electronic Health Record Across an Entire Academic Medical Center: Results of a Randomized Controlled Trial.

    abstract:Objectives:To determine the impact of systemwide charge display on laboratory utilization. Methods:This was a randomized controlled trial with a baseline period and an intervention period. Tests were randomized to a control arm or an active arm. The maximum allowable Medicare reimbursement rate was displayed for tests...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,随机对照试验

    doi:10.1093/ajcp/aqx110

    authors: Schmidt RL,Colbert-Getz JM,Milne CK,Vargo DJ,Hussong JW,Hoidal JR,Markewitz BA,Walker BS,Kawamoto K

    更新日期:2017-11-20 00:00:00

  • Calculation vs calibration curve for INR determination. Results of an interlaboratory proficiency scheme.

    abstract::We surveyed 271 laboratories participating in a quality assessment program to ascertain whether the use of a calibration curve for determining the international normalized ratio (INR) would improve interlaboratory accuracy and precision. Lyophilized warfarinized samples with INR values assigned through manual calibrat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/111.2.193

    authors: Brien WF,Baskerville JC,Taberner DA,Crawford L

    更新日期:1999-02-01 00:00:00

  • Workload, space, and personnel of clinical chemistry laboratories in teaching hospitals.

    abstract::The resources needed to operate a clinical chemistry laboratory are known only as rough approximations. In order to gather more information about these resources, a 13-page questionnaire was completed by 50 pathology departments of which 38 departments provided adequate information about their clinical chemistry secti...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.6.839

    authors: Elin RJ,Robertson EA,Sever G

    更新日期:1982-12-01 00:00:00

  • Ultraviolet spectrophotometric analysis of barbiturates. Current assessment as an emergency screening procedure.

    abstract::Several laboratory methods are currently available for the detection of barbiturates, but few are suitable for emergency use, The authors evaluated use of an ultraviolet spectrophotometric method as a screening procedure and compared the results with results obtained by other barbiturate methods (colorimetric, gas-li...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/66.5.823

    authors: Schumann GB,Lauenstein K,LeFever D,Henry JB

    更新日期:1976-11-01 00:00:00

  • Acute Myeloid Leukemia With Myelodysplasia-Related Changes.

    abstract:OBJECTIVES:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous disorder defined by morphologic, genetic, or clinical features. Genetic abnormalities associated with AML-MRC are often associated with adverse prognostic features, and many cases are preceded by a myelodysplastic syndrom...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCP58RSMFRHLHHH

    authors: Vardiman J,Reichard K

    更新日期:2015-07-01 00:00:00

  • ABO blood type and longevity.

    abstract::To assess the observation that blood type B might be a marker for longevity, we reviewed the records and determined the ABO blood types of all patients who died in our hospital in 2004. Age was stratified by decade of death, and linear regressions were calculated by ABO percentage. ABO survival curves were compared. I...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPMIHJ6L3RPHZX

    authors: Brecher ME,Hay SN

    更新日期:2011-01-01 00:00:00

  • Ochronosis in the breast.

    abstract::A patient who had masses in the breasts clinically suggestive of neoplasia had fibrous mastopathy and striking deposition of ochronotic pigment within the soft tissue of the breast. The gross appearance and light microscopic features are illustrated. The histochemical features of ochronotic pigment and the difficulty ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.3.349

    authors: Lefer LG,Rosier RP

    更新日期:1979-03-01 00:00:00

  • Alpha1-antitrypsin, protein marker in oral contraceptive-associated hepatic tumors.

    abstract::Tissue specimens from a series of 46 hepatic tumors occurring in young female oral contraceptive users were tested for alpha1-antitrypsin deposition, utilizing immunocytochemical and histochemical methods. In two instances serum alpha1-antitrypsin phenotyping was also performed. Immunoreactive alpha1-antitrypsin depos...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/68.6.736

    authors: Palmer PE,Christopherson WM,Wolfe HJ

    更新日期:1977-12-01 00:00:00

  • Detection of chlamydial cervicitis by Papanicolaou stained smears and culture.

    abstract::The ability of the cervical Papanicolaou (Pap) smear to detect cervicitis associated with Chlamydia trachomatis was investigated. Cultures and cervical cytology samples were obtained from 487 women seen at the Mayo Clinic Department of Obstetrics and Gynecology and at the Sexually Transmitted Disease clinic of the Olm...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.4.421

    authors: Dorman SA,Danos LM,Wilson DJ,Noller KL,Malkasian GD,Goellner JR,Smith TF

    更新日期:1983-04-01 00:00:00

  • Pre-instrumental variables in coagulation testing.

    abstract::A number of variables thought to affect measurement of prothrombin time (PT) and partial thromboplastin time (PTT) were examined in an effort to determine more precisely their effects on these measurements. On the basis of these studies, it is proposed that blood specimens be anticoagulated with one part 3.8% (w./v.) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.5.591

    authors: Koepke JA,Rodgers JL,Ollivier MJ

    更新日期:1975-11-01 00:00:00

  • Aberrations of chromosomes 9 and 17 in bilharzial bladder cancer as detected by fluorescence in situ hybridization.

    abstract::Fluorescence in situ hybridization (FISH), using repetitive alpha satellite probes to chromosomes 9 and 17, was performed on 27 paraffinembedded bladder specimens from 18 Egyptian patients affected with bilharzial carcinoma. Fluorescence in situ hybridization results in the carcinomas and benign mucosa of patients wit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.2.234

    authors: Ghaleb AH,Pizzolo JG,Melamed MR

    更新日期:1996-08-01 00:00:00

  • Evaluation of two commercially available nucleic acid hybridization assays for the detection and typing of human papillomavirus in clinical specimens.

    abstract::Southern blot (Oncor, Gaithersburg, MD) and dot blot (Life Technologies, Gaithersburg, MD) nucleic acid hybridization assays were compared for their ability to detect and type human papillomavirus (HPV) DNA in 50 cervical swab specimens and 11 biopsy specimens. Overall agreement between the two methods was 78.7%. With...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.1.21

    authors: Bartholoma NY,Adelson MD,Forbes BA

    更新日期:1991-01-01 00:00:00

  • Acute hepatitis with periportal confluent necrosis associated with human herpesvirus 6 infection in liver transplant patients.

    abstract:OBJECTIVES:To correlate human herpesvirus 6 (HHV-6) viral load with pathologic features in graft acute hepatitis of unknown origin. METHODS:Liver frozen samples from 26 patients with graft hepatitis of unknown origin were available for HHV-6 DNA quantification. RESULTS:In 10 (38.5%) of 26 liver samples, HHV-6 DNA was...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP0FWI2XAHECBJ

    authors: Buyse S,Roque-Afonso AM,Vaghefi P,Gigou M,Dussaix E,Duclos-Vallée JC,Samuel D,Guettier C

    更新日期:2013-09-01 00:00:00

  • Are en face frozen sections accurate for diagnosing margin status in melanocytic lesions?

    abstract::To assess the diagnostic accuracy of margin evaluation of melanocytic lesions using en face frozen sections compared with standard paraffin-embedded sections, we studied 2 sets of lesions in which en face frozen sections were used for analysis of surgical margins (13 from malignant melanomas [MMs] and 10 from nonmelan...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/J1Q0-V35E-UTMV-R193

    authors: Prieto VG,Argenyi ZB,Barnhill RL,Duray PH,Elenitsas R,From L,Guitart J,Horenstein MG,Ming ME,Piepkorn MW,Rabkin MS,Reed JA,Selim MA,Trotter MJ,Johnson MM,Shea CR

    更新日期:2003-08-01 00:00:00

  • Direct and indirect immunofluorescence as a diagnostic adjunct in the interpretation of nonneoplastic medical lung disease.

    abstract::Fresh open lung biopsy material from 57 patients was incubated with fluoresceinated complement and immunoglobulin antisera. An indirect immunofluorescent assay using neonatal lung as substrate was conducted as well. Direct immunofluorescent patterns could be categorized into interalveolar septal capillary deposition, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/EHUQ-HW6K-0G41-E0DX

    authors: Magro CM,Morrison C,Pope-Harman A,Rothrauff SK,Ross P Jr

    更新日期:2003-02-01 00:00:00

  • Secondary CD5+ diffuse large B-cell lymphoma not associated with transformation of chronic lymphocytic leukemia/small lymphocytic lymphoma (Richter syndrome).

    abstract::Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression durin...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP58FETFGLCKKW

    authors: Maeshima AM,Taniguchi H,Nomoto J,Maruyama D,Kim SW,Watanabe T,Kobayashi Y,Tobinai K,Matsuno Y

    更新日期:2009-03-01 00:00:00

  • Neonatal Intensive Care Unit Quality Initiative:  Identifying Preanalytical Variables Contributing to Specimen Hemolysis and Measuring the Impact of Evidence-Based Practice Interventions.

    abstract:OBJECTIVES:Blood specimen hemolysis is a major cause of sample recollection in the neonatal intensive care unit. We aimed to reduce the hemolysis rate from 6.3% at baseline to less than 4% within the 9 months' duration of the study. METHODS:Intravenous infusion of lipid emulsion during sample collection, sample collec...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw086

    authors: Tolan NV,Kaleta EJ,Fang JL,Colby CE,Carey WA,Karon BS,Baumann NA

    更新日期:2016-07-01 00:00:00

  • STAT testing? A guideline for meeting clinician turnaround time requirements. Practice parameter.

    abstract::This practice parameter, developed by the Practice Parameters and Outcomes Measurement Committee of the American Society of Clinical Pathologists (ASCP), is a guideline for the development of reasonable stat lists. Stat testing lists vary according to practice setting. Furthermore, although stat lists exist, extenuati...

    journal_title:American journal of clinical pathology

    pub_type: 指南,杂志文章

    doi:10.1093/ajcp/105.6.671

    authors: Hilborne L,Lee H,Cathcart P

    更新日期:1996-06-01 00:00:00

  • Linking Statistics With Testing Policy to Manage COVID-19 in the Community.

    abstract:OBJECTIVES:To determine the public health surveillance severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) testing volume needed, both for acute infection and seroprevalence. METHODS:Required testing volumes were developed using standard statistical methods based on test analytical performance, disease preval...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa099

    authors: Hilborne LH,Wagner Z,Cabreros I,Brook RH

    更新日期:2020-07-07 00:00:00

  • Reproducibility of mean values of duplicate specimens in the Basic Ligand Assay Survey.

    abstract::Three paired samples were distributed at three--six-month intervals in the Basic Ligand Survey during 1976. The stabilities of mean values obtained by widely used commercial kit procedures and by all methods for eight analytes are reported. Significant improvements in accuracy and long-term precision were identified i...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Haven GT,Hansell JR,Haven MC

    更新日期:1978-09-01 00:00:00

  • Detection of influenza A and B viruses with the Sofia analyzer: a novel, rapid immunofluorescence-based in vitro diagnostic device.

    abstract::This report describes the clinical evaluation of a novel fluorescent immunoassay (FIA), Sofia Influenza A+B FIA (Quidel, San Diego, CA), for the rapid detection and differentiation of influenza A and B viruses. A total of 2,047 subjects provided nasal swabs and nasopharyngeal swabs or aspirates. The overall sensitivit...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1309/AJCP7ZTLJCP3LLMA

    authors: Lewandrowski K,Tamerius J,Menegus M,Olivo PD,Lollar R,Lee-Lewandrowski E

    更新日期:2013-05-01 00:00:00