A comprehensive evaluation of the performance of duplicate prothrombin time and activated partial thromboplastin time assays.

abstract：:We compared 1-stage clot-based, chromogenic, and immunoassay methods for measuring factor VIII in plasma with a focus on the measurement of elevated levels of factor VIII. The chromogenic assay showed the best interassay imprecision for factor VIII levels near 150 IU/dL. The best correlation was between the 1-stage cl...

journal_title：American journal of clinical pathology

authors： Chandler WL,Ferrell C,Lee J,Tun T,Kha H

更新日期：2003-07-01 00:00:00

abstract：:Bone marrow angiogenesis in patients with idiopathic myelofibrosis (IM) was evaluated by using a quantitative morphometric analysis test system. IM specimens had a significantly higher degree of bone marrow microvessel density (MVD) compared with control specimens. The higher degree of angiogenesis was associated with...

journal_title：American journal of clinical pathology

authors： Ni H,Barosi G,Hoffman R

更新日期：2006-08-01 00:00:00

abstract：:This investigation was designed to improve reference information and to evaluate the influences of sample distribution and age on the derived reference intervals. Specimens from 127 men were collected after a 12- to 14-hour fast and analyzed by 60 different laboratory procedures. Differences in the reference intervals...

journal_title：American journal of clinical pathology

authors： Ash KO,Clark SJ,Sandberg LB,Hunter E,Woodward SC

更新日期：1983-05-01 00:00:00

abstract：:The hematologic status of 265 patients with rheumatoid arthritis was assessed. In the group as a whole, a mild depression in the hemoglobin concentration and mean cell volume (MCV) was associated with an increase in the red blood cell distribution width (RDW), erythrocyte sedimentation rate (ESR), and platelet count. ...

journal_title：American journal of clinical pathology

authors： Baynes RD,Bothwell TH,Bezwoda WR,Gear AJ,Atkinson P

更新日期：1987-02-01 00:00:00

abstract：:The authors describe the case of a 33-year-old man with a solitary cystic lesion of the left distal radius with central radiodensities that radiographically suggested a chondroid matrix. Curettage of the lesion revealed numerous calcospherites with a lamellar structure. This lamellar pattern is thought to be a result ...

journal_title：American journal of clinical pathology

authors： Kragel PJ,Williams J,Garvin DF,Goral AB

更新日期：1989-12-01 00:00:00

abstract：:Determination of breast cancer estrogen receptor (ER) status as a predictor of tumor response to adjuvant endocrine therapy remains a mainstay of breast cancer management. Recent second generation anti-ER antibodies and new epitope retrieval methods have produced paraffin-based immunohistochemical results that correla...

journal_title：American journal of clinical pathology

authors： Nichols GE,Frierson HF Jr,Boyd JC,Hanigan MH

更新日期：1996-09-01 00:00:00

abstract：:Inhibition of anti-Rh29 by erythrocytic stroma in feces was devised as a specific test for fecal occult blood. The sensitivity of this test was equivalent to that of a standard Hemoccult test, namely, 10(8) erythrocytes/g feces. Comparison of results of this test with results of Hemoccult tests of random stool specime...

journal_title：American journal of clinical pathology

authors： Rosenfield RE,Kochwa S,Kaczera Z,Maimon J

更新日期：1979-02-01 00:00:00

abstract：:Serum ferritin, serum iron, and unsaturated iron binding capacity were studied in 64 patients with beta homozygous thalassemia (BHT), 120 patients with beta heterozygous thalassemia, and 46 normal subjects. Incidence of iron overload seen in 32 BHT cases was similar in untransfused and transfused cases. Among heterozy...

journal_title：American journal of clinical pathology

authors： Saraya AK,Kumar R,Choudhry VP,Kailash S,Sehgal AK

更新日期：1985-07-01 00:00:00

abstract：:Immunohistochemistry occasionally is used to determine the lineage of entirely necrotic tumors. However, the sensitivity and specificity of antibodies on necrotic tissue are unknown. To determine the usefulness of immunohistochemistry with necrotic lesions, a series of 24 known tumors consisting of 14 carcinomas, 2 ly...

journal_title：American journal of clinical pathology

authors： Judkins AR,Montone KT,LiVolsi VA,van de Rijn M

更新日期：1998-11-01 00:00:00

abstract：:Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion of the oral mucosa of an unclear pathogenesis. We analyzed the profile of the inflammatory infiltrate in 12 cases of TUGSE by using immunohistochemical analysis and polymerase chain reaction-based repertoire analysis to detect T- and B...

journal_title：American journal of clinical pathology

authors： Hirshberg A,Amariglio N,Akrish S,Yahalom R,Rosenbaum H,Okon E,Kaplan I

更新日期：2006-10-01 00:00:00

abstract：:A case of metastatic ameloblastoma of the maxilla with secondary hypercalcemia in a 54-year-old man is presented. After treatment with surgery, chemotherapy, and radiotherapy, the patient was found to have multiple metastases and severe hypercalcemia associated with high levels of parathormone-like substance in the pe...

journal_title：American journal of clinical pathology

authors： Madiedo G,Choi H,Kleinman JG

更新日期：1981-04-01 00:00:00

abstract：:The relationship between immunohistochemically measured membranous expression of erbB-2 oncoprotein and prognosis in breast cancer is controversial, and the relationship between cytoplasmic positivity and prognosis has been minimally investigated. The clinical course of 300 women with infiltrating breast carcinoma, wh...

journal_title：American journal of clinical pathology

authors： Keshgegian AA,Cnaan A

更新日期：1997-10-01 00:00:00

abstract：:Vascular endothelial growth factor (VEGF) is one of the most potent mitogenic, highly specific tumor angiogenic factors, which acts via binding to 2 specific tyrosine kinase receptors. There are few studies analyzing VEGF receptor expression in prostate cancer cells, and results are contradictory. In an immunohistoche...

journal_title：American journal of clinical pathology

authors： Köllermann J,Helpap B

更新日期：2001-07-01 00:00:00

abstract：:A number of genetic abnormalities have been detected in multiple myeloma (MM) using cytogenetic techniques. The prominent abnormalities are deletions of 13q and translocations affecting the IgH locus on 14q32. The recurrence of chromosomal abnormalities in MM suggests a specific role for them concerning its pathogenes...

journal_title：American journal of clinical pathology

authors： Tchinda J,Volpert S,Kropff M,Berdel WE,Kienast J,Meinhardt F,Horst J

更新日期：2004-12-01 00:00:00

abstract：OBJECTIVES:To investigate metastasis associated in colon cancer 1 (MACC1) and MET expression in colorectal adenoma, Tis, early-stage invasive (T1 and T2), and advanced adenocarcinoma with liver metastasis using immunohistochemistry. METHODS:Ninety-three paraffin-embedded colorectal tumor specimens were immunohistochem...

journal_title：American journal of clinical pathology

authors： Ren B,Zakharov V,Yang Q,McMahon L,Yu J,Cao W

更新日期：2013-11-01 00:00:00

abstract：:An automated calcium method based on o-cresolphthalein complexone chemistry and designed to be used in conjunction with the Beckman ASTRA systems (Beckman Instruments, Inc., Brea, CA) was evaluated. Day-to-day reproducibility studies yielded coefficients of variation ranging from 1.2 to 3.1%. Linearity was 5.0-15.5 mg...

journal_title：American journal of clinical pathology

authors： Hartmann AE,Lewis LR

更新日期：1984-08-01 00:00:00

abstract：:Distributions of nine clinical chemistry determinations (serum bilirubin, globulin, creatinine, thyroxine, alkaline phosphatase, hematocrit, aspartate aminotransferase, uric acid, and plasma glucose) were assessed for 1,605 schoolchildren aged 6 to 17 years, in the Cincinati Lipid Research Clinic's Princeton School Di...

journal_title：American journal of clinical pathology

authors： Laskarzewski P,Kelly KA,Mellies MJ,Morrison JA,Khoury P,Tillett S,Glueck CJ

更新日期：1980-10-01 00:00:00

abstract：:In normal subjects, mean platelet volume (MPV) has an inverse, nonlinear relation with platelet count, while platelet volume heterogeneity has a direct, nonlinear relation with MPV. Compared with the reference range established for normal subjects, patients with chronic lymphocytic leukemia, atherosclerotic heart dise...

journal_title：American journal of clinical pathology

authors： Bessman JD,Williams LJ,Gilmer PR Jr

更新日期：1982-08-01 00:00:00

abstract：:To establish the feasibility of immunotyping specimens transported over great distance, the University of Arizona and the Cleveland Clinic exchanged 39 lymphoma cases (26 B-cell, 13 T-cell cases) via air express for phenotyping. They were exchanged with the use of glass slides with adherent snap-frozen sections. The m...

journal_title：American journal of clinical pathology

authors： Grogan TM,Tubbs RR

更新日期：1987-04-01 00:00:00

abstract：:We reviewed the cytologic features of 20 adrenal cortical carcinomas (ACCs; 9 primary and 11 metastatic) from 19 patients and highlighted diagnostic pitfalls. The mean size of primary ACCs was 11.9 cm, and that of metastatic ACCs was 3.0 cm. The metastatic sites were liver, lung, lymph node, soft tissue, and bone. Pri...

journal_title：American journal of clinical pathology

authors： Ren R,Guo M,Sneige N,Moran CA,Gong Y

更新日期：2006-09-01 00:00:00

abstract：OBJECTIVES:MDM2 gene amplification is associated with well-differentiated (WDL) and dedifferentiated liposarcomas (DDL). Using fluorescent in situ hybridization (FISH), we sought to characterize various patterns of MDM2 amplification among the morphologic spectrum of liposarcoma. METHODS:Forty-six cases of liposarcoma...

journal_title：American journal of clinical pathology

authors： Ware PL,Snow AN,Gvalani M,Pettenati MJ,Qasem SA

更新日期：2014-03-01 00:00:00

abstract：:Several adulterants are used to mask tests for abused drugs in urine. Adulterants such as "Klear" and "Whizzies" contain potassium nitrite, and "Urine Luck" contains pyridinium chlorochromate (PCC). The presence of these adulterants cannot be detected by routine specimen integrity checks (pH, specific gravity, and tem...

journal_title：American journal of clinical pathology

authors： Dasgupta A,Wahed A,Wells A

更新日期：2002-02-01 00:00:00

abstract：:A 63-year-old white man had simultaneous onset of the Guillain-Barré syndrome and the nephrotic syndrome, three weeks after having an upper respiratory tract infection. Many granular casts were noticed in the urine sediment. Renal biopsy specimens showed early membranous glomerulonephritis and acute interstitial nephr...

journal_title：American journal of clinical pathology

authors： Talamo TS,Borochovitz D

更新日期：1982-10-01 00:00:00

abstract：:Riedel thyroiditis (RT) is an uncommon form of chronic thyroiditis in which the thyroid gland is replaced by fibrous tissue. The etiologic mechanisms underlying RT are unclear: the prevailing view is that it is part of a generalized fibroinflammatory process also involving other organs. The clinical manifestations of ...

journal_title：American journal of clinical pathology

authors： Papi G,LiVolsi VA

更新日期：2004-06-01 00:00:00

abstract：:Two separate courses in clinical pathology were presented to two groups of second-year medical students. The first (large) group was taught by the conventional lecture method; the other (small) group, by a self-instructional method for roughly half of the course, followed by the conventional lecture method for the sec...

journal_title：American journal of clinical pathology

authors： Kao YS,Beeler MF,Strong JP

更新日期：1978-12-01 00:00:00

abstract：:A column chromatographic method for the simultaneous single-eluate isolation of CPK-MB and LDH 1,2 has been evaluated. The method is rapid in that the entire isolation is completed in less than an hour and subsequent analysis can be performed using presently available spectrophotometric methods and reagents without th...

journal_title：American journal of clinical pathology

authors： Lederer WH,Gerstbrein HL,McClintock WC

更新日期：1976-08-01 00:00:00

abstract：:Two cases of Actinomyces viscosus infection of the lungs were seen in nonimmunosuppressed patients. One patient had a peripheral actinomycotic lung mass resembling a tumor. Both patients responded to a long course of penicillin therapy. Reports of A. viscosus infections are rare, although the organism colonizes the mo...

journal_title：American journal of clinical pathology

authors： Eng RH,Corrado ML,Cleri D,Cherubin C,Goldstein EJ

更新日期：1981-01-01 00:00:00

abstract：:Colorectal cancer with microsatellite instability (MSI) may occur sporadically or be inherited in cases of hereditary nonpolyposis colorectal cancer (HNPCC) syndrome. However, there is no consensus as to which patients must be tested and how to test MSI. In this study, MSI was tested by immunohistochemical analysis an...

journal_title：American journal of clinical pathology

authors： Bouzourene H,Taminelli L,Chaubert P,Monnerat C,Seelentag W,Sandmeier D,Andrejevic S,Matter M,Bosman F,Benhattar J

更新日期：2006-06-01 00:00:00

abstract：:Blastomycosis generally results from inhalation of Blastomyces dermatitidis conidia following exposure to contaminated soil in an endemic area. Primary infections commonly involve the lungs, although secondary dissemination to other body sites may occur. We describe 2 cases of osseous blastomycosis in people living ou...

journal_title：American journal of clinical pathology

authors： Veligandla SR,Hinrichs SH,Rupp ME,Lien EA,Neff JR,Iwen PC

更新日期：2002-10-01 00:00:00

abstract：:Immunohistochemical (IHC) assays using the monoclonal antibodies (MoAbs) B72.3 and B6.2, recognizing two distinct and independently expressed breast tumor-associated antigens (BTAAs), recently have been shown to significantly improve the accuracy of cytodiagnosis of breast nodules by fine-needle aspiration (FNA). To e...

journal_title：American journal of clinical pathology

authors： Mottolese M,Bigotti G,Coli A,Vitucci C,Natali PG

更新日期：1991-08-01 00:00:00