Abstract:
:Traumatic ulcerative granuloma with stromal eosinophilia (TUGSE) is a benign lesion of the oral mucosa of an unclear pathogenesis. We analyzed the profile of the inflammatory infiltrate in 12 cases of TUGSE by using immunohistochemical analysis and polymerase chain reaction-based repertoire analysis to detect T- and B-cell receptor gene rearrangements. The inflammatory infiltrate consisted in most cases of B and T lymphocytes, macrophages, abundant eosinophils, and large atypical cells. In 5 cases, CD30+ cells were found. Spectratyping analysis displayed a polyclonal rearrangement of the T-cell receptor g gene in 6 cases and oligoclonality in 5 cases. Monoclonality was observed in 1 case that also fulfilled histologic criteria for lymphoma. Healing was uneventful in all cases, including the one suspected of being lymphoma, with no recurrences in more than 2 years'follow-up. TUGSE can be regarded reactive. Some cases, however, may harbor a dominant clonal T-cell population; in these cases, long-term follow-up is mandatory.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Hirshberg A,Amariglio N,Akrish S,Yahalom R,Rosenbaum H,Okon E,Kaplan Idoi
10.1309/AFHA406GBT0N2Y64subject
Has Abstractpub_date
2006-10-01 00:00:00pages
522-9issue
4eissn
0002-9173issn
1943-7722pii
AFHA406GBT0N2Y64journal_volume
126pub_type
杂志文章abstract::Immunohistochemistry occasionally is used to determine the lineage of entirely necrotic tumors. However, the sensitivity and specificity of antibodies on necrotic tissue are unknown. To determine the usefulness of immunohistochemistry with necrotic lesions, a series of 24 known tumors consisting of 14 carcinomas, 2 ly...
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journal_title:American journal of clinical pathology
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更新日期:1981-03-01 00:00:00
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更新日期:1990-06-01 00:00:00
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更新日期:1991-09-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1978-03-01 00:00:00
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更新日期:1991-05-01 00:00:00
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更新日期:1978-06-01 00:00:00
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journal_title:American journal of clinical pathology
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pub_type: 临床试验,杂志文章,随机对照试验
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更新日期:1978-09-01 00:00:00
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