Blood group substances as tumor antigens in the distal colon.

Abstract:

:Adenocarcinomas of the sigmoid colon and rectum were studied for the presence of blood group substances of the A, B, H system using the method of specific erythrocytic adherence. Of 17 adenocarcinomas studied, eight were found to have reactivity for blood group substances. All eight tumours showing reactivity for blood group substances were from patients of the blood group type A, whereas no blood group substances reactivity could be found in any of the adenocarcinomas from patients of the B blood group type. The epithelial cells of the entire colon contain blood group substances in the fetal period; however, shortly after parturition the epithelial cells of the distal colon and rectum rapidly lose the substances. The reappearance of the substances in adenocarcinomas of the distal colon suggests that these neoplastic cells are expressing certain characteristics of fetal colonic epithelial cells.

journal_name

Am J Clin Pathol

authors

Cooper HS,Haesler WE Jr

doi

10.1093/ajcp/69.6.594

subject

Has Abstract

pub_date

1978-06-01 00:00:00

pages

594-8

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

69

pub_type

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