Mucoid Pseudomonas in cystic fibrosis.

Abstract:

:Pseudomonas aeruginosa is a frequent and virulent pulmonary pathogen in patients with cystic fibrosis. If colonization is not prevented, P aeruginosa becomes permanently established and nearly always mutates into a mucoid strain. The alginate-containing matrix of the mucoid strain is thought to allow the formation of protected microcolonies and provide increased resistance to opsonization, phagocytosis, and destruction by antibiotics. As a result, conversion to the mucoid phenotype is associated with a significant increase in morbidity and mortality. In the microbiology laboratory, mucoid P aeruginosa has a distinct Gram stain and culture appearance that can expedite its identification and facilitate appropriate patient management. Important aspects of the mucoid phenotype are reviewed.

journal_name

Am J Clin Pathol

authors

Pritt B,O'Brien L,Winn W

doi

10.1309/KJRPC7DD5TR9NTDM

subject

Has Abstract

pub_date

2007-07-01 00:00:00

pages

32-4

issue

1

eissn

0002-9173

issn

1943-7722

pii

WG00836670862R88

journal_volume

128

pub_type

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