Volumetric erythrocyte macrocytosis induced by hydroxyurea.

Abstract:

:An atypical form of macrocytosis termed volumetric macrocytosis is described. In contrast to the macrocyte associated with megaloblastic anemia and the pseudomacrocyte caused by viscoelastic defects, the volumetric macrocyte is characterized by an increased mean corpuscular volume and a normal cell diameter. The volumetric macrocyte proves to be thicker than the normocytic red blood cell. This large erythrocyte is overhydrated and contains an increased quantity of hemoglobin. The cell has many characteristics in common with the red blood cells of neonates. Volumetric macrocytosis accompanies sustained hydroxyurea therapy and may represent a drug-induced dyserythropoiesis.

journal_name

Am J Clin Pathol

authors

Burns ER,Reed LJ,Wenz B

doi

10.1093/ajcp/85.3.337

subject

Has Abstract

pub_date

1986-03-01 00:00:00

pages

337-41

issue

3

eissn

0002-9173

issn

1943-7722

journal_volume

85

pub_type

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