Biomarkers of liver regeneration allow early prediction of hepatic recovery after acute necrosis.

Abstract:

:Acute toxic hepatic necrosis is common and may be fatal. Predicting clinical outcome may be aided by following serum markers that could indicate recovery or may signify massive (substantial) destruction of functional liver mass. Previously, in a published case of chloroform poisoning, we serially assayed serum biomarkers of hepatocellular necrosis (aspartate aminotransferase, alanine aminotransferase, alkaline phosphatase, lactate dehydrogenase) and markers of hepatocellular regeneration (alpha-fetoprotein, retinol-binding protein, gamma-glutamyl transferase, and des-gamma-carboxyprothrombin). We noted a decline in necrotic markers and a synchronous elevation in regenerative markers, which could be suggestive of a favorable outcome in similar cases. We now report 6 Amanita mushroom poisonings with favorable outcome and 2 fatal acetaminophen poisonings in which the same markers were observed. Our results further support our hypothesis that a sustained decline in serum markers of hepatocyte necrosis with a concurrent elevation in regenerative markers could aid in prediction of favorable outcome in patients with acute liver injury.

journal_name

Am J Clin Pathol

authors

Horn KD,Wax P,Schneider SM,Martin TG,Nine JS,Moraca MA,Virji MA,Aronica PA,Rao KN

doi

10.1093/ajcp/112.3.351

subject

Has Abstract

pub_date

1999-09-01 00:00:00

pages

351-7

issue

3

eissn

0002-9173

issn

1943-7722

journal_volume

112

pub_type

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