Age-related changes in mitogen-induced lymphocyte function from birth to old age.

Abstract:

:This study examines the relationship between age and mitogen-induced lymphocyte blastogenesis. Lymphocytes were stimulated with PHA; Concanavalin A (Con A), and PWM in 156 normal, healthy subjects ranging in age from birth to 75 years. The findings indicate a gradual but significant decrease in PHA- and Con A-induced blastogenesis with increasing age. The decrease in Con A and PHA induced in vitro lymphocyte function begins in early childhood and young adulthood, respectively, and continues throughout the age range studied. In addition, there appears to be a decreased range of lymphocyte functional capacity among the 50-75-year-old subjects. The clinical and laboratory implications of these observations are discussed.

journal_name

Am J Clin Pathol

authors

Hicks MJ,Jones JF,Thies AC,Weigle KA,Minnich LL

doi

10.1093/ajcp/80.2.159

subject

Has Abstract

pub_date

1983-08-01 00:00:00

pages

159-63

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

80

pub_type

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