Morphonuclear relationship between prostatic intraepithelial neoplasia and cancers as assessed by digital cell image analysis.

Abstract:

:Using digital cell image analysis performed on Feulgen-stained nuclei, the nuclear characteristics of prostatic neoplasia, ranging from benign (benign prostatic hyperplasia [BPH]), through dysplastic (prostatic intraepithelial neoplasia [PIN] 1-3), to carcinoma were studied. Four histopathologic groups were studied: group IA (18 samples) contained BPH, PIN 1, and PIN 2 lesions that were from 9 prostate samples free of cancer. Group IB (23 samples) was identical to group IA, contained also BPH, PIN 1, and PIN 2 lesions, but lesions that were from 7 prostate samples where malignant foci were detected elsewhere. Group II (11 samples) were PIN 3 specimens. Group III (24 samples) were carcinomas. Features of neoplastic nuclei were quantified objectively through morphometric (nuclear size), densitometric (nuclear DNA content), and textural (chromatin organization and heterogeneity) parameters. Cell kinetic parameter, i.e., cell proliferation index, was assessed from the densitometric measurement. The proliferation index was significantly higher in PIN 3 and cancers as compared to BPH, PIN 1, and PIN 2 tissues. Morphonuclear characteristics were also dramatically distinct among the four groups. Indeed, the nuclear size and the hyperchromatism of severe prostatic dysplasia were similar to those of carcinomas, these two lesion types showing mean parameter values that were higher as compared to BPH, PIN 1, and PIN 2 lesions. Finally, benign tissues related to mild or moderate dysplasia taken in histologic material in which cancer was present already share the morphonuclear characteristics of severe dysplasia, although they are nonproliferating.

journal_name

Am J Clin Pathol

authors

Petein M,Michel P,van Velthoven R,Pasteels JL,Brawer MK,Davis JR,Nagle RB,Kiss R

doi

10.1093/ajcp/96.5.628

subject

Has Abstract

pub_date

1991-11-01 00:00:00

pages

628-34

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

96

pub_type

杂志文章
  • Studies of end-stage kidneys. III. Glycogen deposition in interstitial cells of the renal medulla.

    abstract::Examination of kidneys of ten patients with uremia and severe hypertension treated by chronic intermittent hemodialysis revealed a deposition of glycogen within interstitial cells of the renal medulla. This is unlike any described renal distribution of glycogen. Electron microscopic studies performed in one case demon...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.3.400

    authors: Hughson MD,McManus JF,Fitts CT,Williams AV

    更新日期:1979-09-01 00:00:00

  • S-100 protein positive human T-lymphocyte.

    abstract::S-100 protein was detected in a small number of human peripheral T-lymphocytes by a direct immunoperoxidase method with the use of monospecific antibody to S-100 protein. Complemented-mediated lysis using monoclonal antibodies revealed that the S-100+ T-lymphocytes bore OKT3, OKT8, and OKT11 antigens but not OKT4, OKM...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/83.1.69

    authors: Takahashi K,Isobe T,Ohtsuki Y,Sonobe H,Yamaguchi H,Akagi T

    更新日期:1985-01-01 00:00:00

  • Fresh and citrated whole-blood specimens can produce different thromboelastography results in patients on extracorporeal membrane oxygenation.

    abstract:OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPYIQ9JNNSEN4Q

    authors: Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

    更新日期:2013-08-01 00:00:00

  • Bronchoalveolar lavage cytology in pulmonary alveolar proteinosis.

    abstract::Pulmonary alveolar proteinosis (PAP) is an uncommon disease in which alveoli are progressively filled with surfactant-related material. Although a definitive diagnosis is usually made by an open lung biopsy, bronchoalveolar lavage (BAL) cytology may play a decisive role in the clinical work-up of these patients, and, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/106.4.504

    authors: Burkhalter A,Silverman JF,Hopkins MB 3rd,Geisinger KR

    更新日期:1996-10-01 00:00:00

  • Marrow biopsy and survival in multiple myeloma.

    abstract::Pretreatment posterior iliac crest bone marrow biopsies were obtained from 26 multiple myeloma patients. Biopsies were processed in methacrylate. The percentage of myeloma tissue, myeloid tissue, and fat was estimated in each biopsy. In 20 patients who died there was a positive correlation between the percent of myelo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.3.363

    authors: Mahmoud LA,Block MH,Franks JJ,Sayed NM

    更新日期:1983-09-01 00:00:00

  • Tumor-Infiltrating Lymphocytes in Breast Cancer: Evaluating Interobserver Variability, Heterogeneity, and Fidelity of Scoring Core Biopsies.

    abstract:Objectives:The aims were to evaluate breast cancer (BC) tumor-infiltrating lymphocytes (TILs) interobserver variability, heterogeneity, and the fidelity of scoring TILs in core needle biopsy (CNB). Methods:Matching CNB and two full-face sections (FFSs) of BC cases (n = 100) were independently reviewed by two pathologi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqy069

    authors: Khoury T,Peng X,Yan L,Wang D,Nagrale V

    更新日期:2018-10-01 00:00:00

  • Hepatosplenic gamma/delta T-cell lymphoma in bone marrow. A sinusoidal neoplasm with blastic cytologic features.

    abstract::We report 8 cases of hepatosplenic T-cell lymphoma (HSTCL) involving bone marrow and correlate histologic findings with disease progression. Immunophenotypic analysis demonstrated mature, aberrant gamma/delta T-cell immunophenotypes. Isochromosome 7q was identified in 4 cases; 1 case showed the t(7;14)(q34;q13). Seven...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/BM40-YM6J-9T3X-MH8H

    authors: Vega F,Medeiros LJ,Bueso-Ramos C,Jones D,Lai R,Luthra R,Abruzzo LV

    更新日期:2001-09-01 00:00:00

  • The antimicrobial removal device. A microbiological and clinical evaluation.

    abstract::A parallel study of blood cultured conventionally and following processing in an Antimicrobial Removal Device (ARD) was conducted with patients suspected of being clinically bacteremic. Cultures yielded 205 isolates from 87 clinically bacteremic patients, of whom 28 were receiving antibiotics at the time their culture...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.2.173

    authors: Wright AJ,Thompson RL,McLimans CA,Wilson WR,Washington JA 2nd

    更新日期:1982-08-01 00:00:00

  • Effects of Implementing the Dual Papanicolaou Test Interpretation of ASC-H and LSIL Following Bethesda 2014.

    abstract:OBJECTIVES:To evaluate the impact of implementing the dual interpretation of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and low-grade squamous intraepithelial lesion (LSIL) after the Bethesda System 2014 and to compare it with other indeterminate interpretations. METHODS...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa069

    authors: Goyal A,Patel AP,Dilcher TL,Alperstein SA

    更新日期:2020-09-08 00:00:00

  • T-cell lymphoma after heart transplantation.

    abstract::A 26-year-old woman who had undergone orthotopic heart transplantation because of dilative cardiomyopathy received a triple-drug immunosuppressive regimen (cyclosporine A, azathioprine, and prednisolone). During her relatively frequent episodes of acute rejection, she was treated with methylprednisolone and repeated a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.1.95

    authors: Kemnitz J,Cremer J,Gebel M,Uysal A,Haverich A,Georgii A

    更新日期:1990-07-01 00:00:00

  • Biochemical markers for prediction of chemotherapy-induced cardiotoxicity: systematic review of the literature and recommendations for use.

    abstract::Chemotherapy is a well-established therapeutic approach for several malignancies, but its clinical efficacy is often limited by its related cardiotoxicity, which leads to cardiomyopathy, possibly evolving into heart failure. To detect cardiac damage, the adopted diagnostic approach is the estimation of left ventricula...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPB66LRIIVMQDR

    authors: Dolci A,Dominici R,Cardinale D,Sandri MT,Panteghini M

    更新日期:2008-11-01 00:00:00

  • E-cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters.

    abstract::Our objective was to assess the loss of E-cadherin (EC) as a diagnostic marker or a predictor of prognosis. We stained 276 breast carcinomas with monoclonal antibodies to EC (invasive lobular carcinomas [ILC] and variants, 59; invasive ductal carcinoma and ductal special types [IDC], 204; tubulolobular carcinoma [TLC]...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Qureshi HS,Linden MD,Divine G,Raju UB

    更新日期:2006-03-01 00:00:00

  • Assessment of platelet function on whole blood by multiple electrode aggregometry in high-risk patients with coronary artery disease receiving antiplatelet therapy.

    abstract::This study sought to compare Multiplate impedance platelet aggregometry (IPA) with light transmission aggregometry (LTA) and the PFA-100 for determining the prevalence of residual platelet reactivity (RPR) by the Multiplate IPA in 297 patients with acute coronary syndrome receiving dual antiplatelet therapy. Aggregati...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPTE3K1SGAPOIZ

    authors: Paniccia R,Antonucci E,Maggini N,Romano E,Gori AM,Marcucci R,Prisco D,Abbate R

    更新日期:2009-06-01 00:00:00

  • CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up.

    abstract:OBJECTIVES:CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. METHODS:Retrospective review of T-PLL cases with com...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz060

    authors: Gilles SR,Yohe SL,Linden MA,Dolan M,Hirsch B,Grzywacz B

    更新日期:2019-09-09 00:00:00

  • Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma.

    abstract::HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas. However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity. In ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPK6QHNNOEMJIM

    authors: Chan OT,Chen ZM,Chung F,Kawachi K,Phan DC,Himmelfarb E,Lin F,Perry A,Wang HL

    更新日期:2010-12-01 00:00:00

  • Quantitation of hypertensive nephrosclerosis on an objective rational scale of measure in adults and children.

    abstract::The development of a precise, mathematical relationship between blood pressure and renal microvascular abnormalities would be highly desirable. Such a relationship would require that abnormalities be quantitative on a rational scale. The dominant abnormality in nephrosclerosis occurs in arcuate and cortical arteries o...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/85.3.312

    authors: Tracy RE,Mercante DE,Moncada A,Berenson G

    更新日期:1986-03-01 00:00:00

  • Prognostic significance of DNA ploidy and proliferative index (MIB-1 index) in childhood rhabdomyosarcoma.

    abstract::The prognostic value of DNA ploidy and proliferative index (PI) are well established in many cancers, but their significance in childhood rhabdomyosarcoma (RMS) is unclear. We studied the DNA content and PI of 45 cases of childhood RMS obtained retrospectively. DNA histograms were hyperdiploid in 30 cases (67%), diplo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3DD8-0UC4-DDJ0-JMT2

    authors: San Miguel-Fraile P,Carrillo-Gijón R,Rodriguez-Peralto JL,Badiola IA

    更新日期:2004-03-01 00:00:00

  • Peroxidase activity in circulating mast cells in blast crisis of chronic granulocytic leukemia. Comparative studies with basophils and cutaneous mast cells.

    abstract::Although the hematopoietic origin of mast cells is very probable, the cell from which they originate is still a matter of speculation. The description of "transitional basophil/mast cells" in myeloproliferative disorders has suggested a common origin for basophils and mast cells. In a case of mast cell transformation ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.2.212

    authors: Gabriel LC,Escribano LM,Marie JP,Zittoun R,Navarro JL

    更新日期:1986-08-01 00:00:00

  • Variation in human blood high-density lipoprotein response to oral vitamin E megadosage.

    abstract::In a preliminary attempt to distinguish random intrinsic and methodologic variations of blood lipid levels from any that have possibly been induced by ingestion of vitamin E, blood samples were analyzed in duplicate for lipids several times before and during oral vitamin E administration. Three of eight subjects showe...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.2.165

    authors: Muckle TJ,Nazir DJ

    更新日期:1989-02-01 00:00:00

  • Number of Intratumoral T Lymphocytes Is Associated With Lymph Node Size, Lymph Node Harvest, and Outcome in Node-Negative Colon Cancer.

    abstract:OBJECTIVES:We postulated that lymph node (LN) harvest and LN size are influenced by immunologic effects. METHODS:To investigate this hypothesis, we performed a retrospective analysis of 170 node-negative colon cancer cases to evaluate the density of intratumoral T lymphocytes (ITLs). CD3- and CD8-positive T cells were...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw074

    authors: Märkl B,Wieberneit J,Kretsinger H,Mayr P,Anthuber M,Arnholdt HM,Schenkirsch G

    更新日期:2016-06-01 00:00:00

  • Primary osteomyelitis due to an anaerobic microorganism.

    abstract::Primary osteomyelitis in a teen-aged boy that mimicked Ewing's tumor radiologically showed small Gram-negative rods on the original smear. The organism isolated was an obligately anaerobic bacterium, finally identified as Clostridium sphenoides. This finding underlines the need for microbiologic analysis of orthopedic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.3.385

    authors: Isenberg HD,Lavine LS,Painter BG,Rubins WH,Berkman JI

    更新日期:1975-09-01 00:00:00

  • Glycol methacrylate embedding of renal biopsy specimens for light microscopy.

    abstract::Thirty-five consecutive renal biopsy specimens were evaluated by light histology using paraffin and glycol methacrylate embedding. The clarity of the renal structures was found to be much better, and the renal lesions better defined, using glycol methyacrylate embedding. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.5.655

    authors: Agodoa LC,Striker GE,Chi E

    更新日期:1975-11-01 00:00:00

  • Effects of chemotherapy (busulfan-hydroxyurea) and interferon-alfa on bone marrow morphologic features in chronic myelogenous leukemia. Histochemical and morphometric study on sequential trephine biopsy specimens with special emphasis on dynamic features.

    abstract::We performed a retrospective clinicopathologic study on sequential biopsy specimens from 90 patients with Philadelphia chromosome-positive chronic myelogenous leukemia to study therapy-specific effects of busulfan (28 patients), hydroxyurea (32 patients), and interferon-alfa (IFN-alfa; 30 patients). Bone marrow specim...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/XMGX-7HQ8-7PLU-LQ9M

    authors: Thiele J,Kvasnicka HM,Schmitt-Graeff A,Bundschuh S,Biermann T,Roessler G,Wasmus M,Diehl V,Zankovich R,Schaefer HE

    更新日期:2000-07-01 00:00:00

  • Delayed diagnosis of osseous blastomycosis in two patients following environmental exposure in nonendemic areas.

    abstract::Blastomycosis generally results from inhalation of Blastomyces dermatitidis conidia following exposure to contaminated soil in an endemic area. Primary infections commonly involve the lungs, although secondary dissemination to other body sites may occur. We describe 2 cases of osseous blastomycosis in people living ou...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/JEJ0-3N98-C3G8-21DE

    authors: Veligandla SR,Hinrichs SH,Rupp ME,Lien EA,Neff JR,Iwen PC

    更新日期:2002-10-01 00:00:00

  • The data warehouse as a foundation for population-based reference intervals.

    abstract::The volume of data contained in a data warehouse represents a potential resource to provide the basis for detailed and specific reference intervals. Routine chemistry panel testing data were derived from an outreach laboratory patient population of 438,180 people and then screened by multiple data filters to identify ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/W8J8-5AG4-WDG6-JGJ9

    authors: Bock BJ,Dolan CT,Miller GC,Fitter WF,Hartsell BD,Crowson AN,Sheehan WW,Williams JD

    更新日期:2003-11-01 00:00:00

  • Mastocytosis: an unusual clonal disorder of bone marrow-derived hematopoietic progenitor cells.

    abstract::Mastocytosis, an unusual disorder of bone marrow-derived, clonally transformed hematopoietic progenitor cells, exhibits a broad spectrum of clinical and morphologic features ranging from a self-limiting benign disorder (ie, juvenile cutaneous mastocytosis) to highly aggressive neoplasms like mast cell leukemia. Princi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPPXHMN5CJOXHZ

    authors: Horny HP

    更新日期:2009-09-01 00:00:00

  • Evaluation of the Yellow IRIS. An automated method for urinalysis.

    abstract::The authors evaluated the Yellow IRIS automated urinalysis instrument (International Remote Imaging Systems, Chatsworth, CA 91311) in terms of its analytic performance as well as its ease of use. The Yellow IRIS is a system using automated intelligence microscopy (AIM), coupled with a dipstick reader and specific grav...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.5.661

    authors: Roe CE,Carlson DA,Daigneault RW,Statland BE

    更新日期:1986-11-01 00:00:00

  • Within-day fluctuations in serum bile-acid concentrations among normal control subjects and patients with hepatic disease.

    abstract::Under carefully controlled conditions in a clinical research ward, conjugated primary bile-acid concentrations were measured by a 125I-radioimmunoassay every eight hours for four days in seven healthy control subjects and ten patients with hepatic disease (five with cirrhosis, three with primary biliary cirrhosis and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.2.196

    authors: Engelking LR,Dasher CA,Hirschowitz BI

    更新日期:1980-02-01 00:00:00

  • Breast carcinoma simulating fibroadenoma or fibrocystic change by fine-needle aspiration. A study of 16 cases.

    abstract::The cytologic features of fine-needle aspiration specimens from 16 breast carcinomas that closely simulated benign lesions were analyzed and compared to smears from fibroadenomas and fibrocystic change. No combination of features was found that accurately separated all benign and malignant cases. Many nuclei with disc...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/98.2.155

    authors: Rogers LA,Lee KR

    更新日期:1992-08-01 00:00:00

  • Expression of "myelomonocytic" antigens in mesotheliomas and adenocarcinomas involving the serosal surfaces.

    abstract::Because of the demonstrated efficacy of Leu-M1 as a discriminant between malignant epithelioid mesothelioma (MEM) and adenocarcinomas involving the serosal surfaces (ACSs), the authors assessed the reactivities of related "myelomonocytic" antigens in this context. Paraffin sections from 41 MEMs and 43 ACSs (pulmonary,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.1.18

    authors: Wick MR,Mills SE,Swanson PE

    更新日期:1990-07-01 00:00:00