Abstract:
:The prognostic value of DNA ploidy and proliferative index (PI) are well established in many cancers, but their significance in childhood rhabdomyosarcoma (RMS) is unclear. We studied the DNA content and PI of 45 cases of childhood RMS obtained retrospectively. DNA histograms were hyperdiploid in 30 cases (67%), diploid in 6 (13%), tetraploid in 5 (11%), polyploid in 3 (7%), and nonclassifiable in 1 (2%). The 5-year overall survival rate by ploidy was 60% (3/5) in tetraploid, 57% (17/30) in hyperdiploid, and 0% in diploid and polyploid cases (P = .000002). The 5-year overall survival by a PI less than or greater than 19% was 62% (13/21) and 21% (5/24), respectively (P = .006). In multivariate analysis, DNA ploidy (P = .001) was an important independent prognostic factor. DNA content in childhood RMS is an important variable in predicting prognosis. DNA hyperdiploid and tetraploid rhabdomyosarcomas had a favorable prognosis, while DNA diploid and polyploid tumors had a poor prognosis.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
San Miguel-Fraile P,Carrillo-Gijón R,Rodriguez-Peralto JL,Badiola IAdoi
10.1309/3DD8-0UC4-DDJ0-JMT2subject
Has Abstractpub_date
2004-03-01 00:00:00pages
358-65issue
3eissn
0002-9173issn
1943-7722journal_volume
121pub_type
杂志文章abstract::Acute exacerbations of idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis (IPF/CFA) are rare and typically terminal events, but their relationship to underlying patterns of idiopathic interstitial pneumonias is unknown. We reviewed autopsy material from patients who died of diffuse alveolar damage in the c...
journal_title:American journal of clinical pathology
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更新日期:1992-07-01 00:00:00
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更新日期:1994-12-01 00:00:00
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更新日期:1986-11-01 00:00:00
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更新日期:1994-07-01 00:00:00
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更新日期:2019-07-05 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1987-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1983-06-01 00:00:00
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更新日期:1982-11-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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