Abstract:
:Coronary artery disease (CAD) is the leading cause of death in the United States. Increasing evidence suggests involvement of inflammation in the atherosclerotic process. We examined cytokines and other inflammatory markers in 865 patients with chest pain in whom coronary angiography revealed no evidence of CAD or CAD with or without concomitant myocardial infarction (MI). We developed a multiplexed immunoassay to simultaneously assess the plasma concentrations of 8 cytokines (interferon gamma, interleukin (IL)-2, IL-4, IL-6, IL-8, IL-10, IL-12, and tumor necrosis factor alpha), IL-2r, and soluble CD40 ligand in the patient groups. Concentrations of C-reactive protein (CRP) and IL-18 also were determined. Significant differences (P < .05) between no CAD and combined CAD groups were found for IL-2, IL-4, IL-6, IL-12, and IL-18. When the no CAD group was compared with the group with CAD with subsequent MI, significant differences were found for proinflammatory markers IL-6 (P pound .001), IL-8 (P = .017), and CRP (P pound .001). Cytokine profiles may have a role in differentiating patients with CAD with MI from those with chest pain due to other disorders and in deciphering the role of inflammation in the pathogenesis of CAD.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Martins TB,Anderson JL,Muhlestein JB,Horne BD,Carlquist JF,Roberts WL,Carlquist JFdoi
10.1309/Q3E6-KF0Q-D3U3-YL6Tsubject
Has Abstractpub_date
2006-06-01 00:00:00pages
906-13issue
6eissn
0002-9173issn
1943-7722pii
Q3E6KF0QD3U3YL6Tjournal_volume
125pub_type
杂志文章abstract::A column chromatographic method for the simultaneous single-eluate isolation of CPK-MB and LDH 1,2 has been evaluated. The method is rapid in that the entire isolation is completed in less than an hour and subsequent analysis can be performed using presently available spectrophotometric methods and reagents without th...
journal_title:American journal of clinical pathology
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更新日期:1976-08-01 00:00:00
abstract::Prostate-specific antigen (PSA) is a sensitive and specific serum marker for monitoring disease activity in men with prostatic carcinoma. Despite reports of elevation of levels of this analyte in men with benign prostatic hyperplasia, no information is available correlating the serum levels with the actual prostatic a...
journal_title:American journal of clinical pathology
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abstract::In a case of secondary syphilis with gastric involvement, the clinical history and roentgenographic and gastroscopic examiniations initially suggested an infiltrative malignant neoplasm. However, macroscopic and histologic examination of the partial gastrectomy specimen demonstrated an erosive, inflammatory lesion. Su...
journal_title:American journal of clinical pathology
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更新日期:1975-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2007-11-01 00:00:00
abstract::A simple assay based on molecular light scattering was developed to detect soluble immune complexes. In this assay the percentage of relative light scattering (%RLS) caused by complexes in buffer containing polyethylene glycol 6000 (PEG) was measured with a laser nephelometer. In low concentrations of PEG (3%-5%), IgG...
journal_title:American journal of clinical pathology
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abstract:OBJECTIVES:To establish an objective, scientific, evidence-based process for planning statistical quality control (SQC) procedures based on quality required for a test, precision and bias observed for a measurement procedure, probabilities of error detection and false rejection for different control rules and numbers o...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
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pub_type: 杂志文章,评审
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1990-04-01 00:00:00
abstract::Although cytology laboratories are mandated to rescreen at least 10% of cervicovaginal smears, there is no uniform national rescreening practice. Follow-up data for 16,188 rescreened cervicovaginal smears were studied and decision analysis was performed to determine an optimal rescreening strategy. High-grade dysplasi...
journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/111.5.601
更新日期:1999-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2020-10-13 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2014-05-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2020-07-07 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1993-10-01 00:00:00
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journal_title:American journal of clinical pathology
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doi:10.1309/AJCP0V0OATKCNAZP
更新日期:2011-11-01 00:00:00
abstract::CD45/side scatter (SS) gating is widely used for isolating blasts by flow cytometry (FC). However, other cells contaminate the "blast gate" (BG); CD45/SS gating is thus imprecise, particularly when there are few blasts. We studied the BG contents in 21 myelodysplastic syndromes (MDSs), 14 myeloproliferative neoplasms ...
journal_title:American journal of clinical pathology
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doi:10.1309/AJCPN4G1IZPABRLH
更新日期:2012-05-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1981-06-01 00:00:00
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abstract::The use of direct thrombin inhibitors (DTIs) for prophylactic or therapeutic anticoagulation is increasing because of the predictable bioavailability and short half-life of these DTIs. However, in certain situations, indication of the concentration is warranted. We investigated the effects of 3 DTIs (lepirudin, argatr...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/73.4.556
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journal_title:American journal of clinical pathology
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abstract::A girl, aged 2 years, 11 months, who had pain and swelling of the proximal humerus, was found to have osteoblastic osteogenic sarcoma of the humerus. Among 937 consecutive patients with osteogenic sarcoma examined at the Mayo Clinic, she is the youngest child seen, as well as only the sixth child younger than 6 years...
journal_title:American journal of clinical pathology
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更新日期:1975-06-01 00:00:00
abstract::To increase transplantation access, particularly in living-donor renal transplantation, efforts have been made to overcome the barrier of ABO incompatibility. In adults, the most successful cases have involved renal transplantation. Although the overall goal of reducing antibodies against donor ABO before and after tr...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/8W4X9H6F8FTLCGYX
更新日期:2006-06-01 00:00:00