Characterization of tissue findings in bone marrow biopsy specimens with small monoclonal B-cell populations.

Abstract:

OBJECTIVES:Bone marrows (BMs) with incidentally identified, small monotypic B-cell populations (MBPs) were evaluated. METHODS:BM aspirates with MBPs representing 5% or less of total events by flow cytometry, less than 5.0 × 10(9)/L B cells in blood, and no history of lymphoma or MBP with a different phenotype from prior lymphoma were selected. Clinical, immunophenotypic, and histologic findings were evaluated. RESULTS:Forty-one of 3,052 BMs had MBPs at 5% or less of total events (median, 1%); 17 were females and 24 were males aged 30 to 87 years (median, 73 years). The MBPs were CD5- in 24, CD5+ resembling chronic lymphocytic leukemia (CLL) in 13, and CD5+ unlike CLL in four. Eighteen of 40 had lymphoid aggregates (LAs) with mostly T cells or a mixture of B and T cells, but three cases had B-cell-rich LAs. CONCLUSIONS:Unlike monoclonal B lymphocytosis in blood, MBPs in BMs were more commonly CD5-. Forty-five percent of BMs had LAs; none were interpreted as lymphoma, although three were suspicious for B-cell lymphoma.

journal_name

Am J Clin Pathol

authors

Nelson BP,Abdul-Nabi A,Goolsby C,Winter J,Peterson L

doi

10.1309/AJCPD5TOBDJU4GKO

subject

Has Abstract

pub_date

2014-05-01 00:00:00

pages

687-96

issue

5

eissn

0002-9173

issn

1943-7722

pii

141/5/687

journal_volume

141

pub_type

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