Abstract:
OBJECTIVES:Bone marrows (BMs) with incidentally identified, small monotypic B-cell populations (MBPs) were evaluated. METHODS:BM aspirates with MBPs representing 5% or less of total events by flow cytometry, less than 5.0 × 10(9)/L B cells in blood, and no history of lymphoma or MBP with a different phenotype from prior lymphoma were selected. Clinical, immunophenotypic, and histologic findings were evaluated. RESULTS:Forty-one of 3,052 BMs had MBPs at 5% or less of total events (median, 1%); 17 were females and 24 were males aged 30 to 87 years (median, 73 years). The MBPs were CD5- in 24, CD5+ resembling chronic lymphocytic leukemia (CLL) in 13, and CD5+ unlike CLL in four. Eighteen of 40 had lymphoid aggregates (LAs) with mostly T cells or a mixture of B and T cells, but three cases had B-cell-rich LAs. CONCLUSIONS:Unlike monoclonal B lymphocytosis in blood, MBPs in BMs were more commonly CD5-. Forty-five percent of BMs had LAs; none were interpreted as lymphoma, although three were suspicious for B-cell lymphoma.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Nelson BP,Abdul-Nabi A,Goolsby C,Winter J,Peterson Ldoi
10.1309/AJCPD5TOBDJU4GKOsubject
Has Abstractpub_date
2014-05-01 00:00:00pages
687-96issue
5eissn
0002-9173issn
1943-7722pii
141/5/687journal_volume
141pub_type
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journal_title:American journal of clinical pathology
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更新日期:2006-05-01 00:00:00