Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient.

Abstract:

:A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologic profile of a mature, activated cytotoxic/suppressor T-lymphocyte. T-cell receptor gene rearrangement and karyotypic studies confirmed a clonal T-cell genotype. Molecular studies failed to demonstrate any association with Epstein-Barr virus or human T-cell lymphotropic virus type I or type II. Pathogenesis of lymphomas in this clinical setting is discussed.

journal_name

Am J Clin Pathol

authors

Griffith RC,Saha BK,Janney CM,Ratner L,Brunt EM,Gajl-Peczalska KJ,Hanto DW

doi

10.1093/ajcp/93.2.280

subject

Has Abstract

pub_date

1990-02-01 00:00:00

pages

280-5

issue

2

eissn

0002-9173

issn

1943-7722

journal_volume

93

pub_type

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