To what extent are free testosterone (FT) values reproducible between the two Washingtons, and can calculated FT be used in lieu of expensive direct measurements?

Abstract:

:Free testosterone (FT) measurement by equilibrium dialysis and liquid chromatography-tandem mass spectroscopy (LCMS/MS) is the "gold standard." We hypothesized that calculated FT values could substitute for measured values; compared FT results reported by Walter Reed Army Medical Center (WRAMC), Washington, DC, with results reported by the Seattle Veterans Affairs Health Care System, Seattle, WA, for 3 patient groups; and evaluated the calculated FT values by gold-standard measurements. Groups 1 and 2 included samples from 54 patients evaluated in Seattle and 94 evaluated at a primary care clinic in Alaska whose samples were analyzed in Seattle, respectively, whose care resulted in ordering an FT measurement. Group 3 included samples from 64 patients evaluated in endocrine WRAMC clinics. Calculated FT values between the 2 facilities demonstrated a strong correlation (R2 = 0.98) for all 212 patients. In a comparison of calculated FT values with measured levels, group 3 had an R2 = 0.93; however, samples with FT values less than 50 pg/mL had a poorer correlation (R2 = 0.45). Calculated FT values may accurately reflect and be substituted in the clinical setting for gold-standard values when levels are more than 50 pg/mL.

journal_name

Am J Clin Pathol

authors

DeVan ML,Bankson DD,Abadie JM

doi

10.1309/6PYTC60ALVQQ59RQ

subject

Has Abstract

pub_date

2008-03-01 00:00:00

pages

459-63

issue

3

eissn

0002-9173

issn

1943-7722

pii

AU364571U6X72150

journal_volume

129

pub_type

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