Abstract:
:A goat anti-serum was prepared against mucinous ovarian cyst fluid and absorbed with normal colon and a variety of normal tissues until the only residual immunoreactivity was directed against colon cancer and ovarian tumor mucin. The set of antigenic determinants defined by this anti-serum has been called COTA, standing for colon-ovarian-tumor-antigen. This highly absorbed anti-serum (anti-COTA) was used for immunohistochemical staining of 42 different tissues in parallel with staining with a goat anti-CEA, which was also highly absorbed. The results suggest that COTA is a highly sensitive and specific antigen for colon carcinoma and may have potential for the early detection of malignant changes predictive of cancer of the colon.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Pant KD,Fenoglio-Preiser CM,Berry CO,Zamora PO,Ram MD,Fulks RM,Rhodes BAdoi
10.1093/ajcp/86.1.1subject
Has Abstractpub_date
1986-07-01 00:00:00pages
1-9issue
1eissn
0002-9173issn
1943-7722journal_volume
86pub_type
杂志文章abstract:OBJECTIVES:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous disorder defined by morphologic, genetic, or clinical features. Genetic abnormalities associated with AML-MRC are often associated with adverse prognostic features, and many cases are preceded by a myelodysplastic syndrom...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/AJCP58RSMFRHLHHH
更新日期:2015-07-01 00:00:00
abstract:Objectives:To examine the relationship between the recently defined Gleason grade groups and prostate cancer-specific mortality. Methods:If the probability of prostate cancer-specific death is symbolized as P(PSD), the probability of biochemical failure is symbolized as P(BF), and the probability of prostate cancer-sp...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqw212
更新日期:2017-03-01 00:00:00
abstract::A case of signet ring cell lymphoma, a rare variant of follicular center cell lymphoma, is presented with a review of 20 other such lymphomas previously reported in the English literature. The histologic, immunocytologic, and electron microscopic features are described with speculation as to the possible relationship ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/81.3.358
更新日期:1984-03-01 00:00:00
abstract::A 76-year-old white man previous diagnosed as having Waldenstrom's macroglobulinemia continued with persistent fevers and sweats for two and a half years. Recently, repeated automated differentials during 11 days of hospitalization failed to note any intracellular inclusions in the RBCs. Blood sent to the Microbiology...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/83.4.520
更新日期:1985-04-01 00:00:00
abstract::Three brands of blood collection tubes were studied for their influence on the prothrombin time (PT) and international sensitivity index (ISI) for 5 commercial thromboplastin reagents. With all reagents, PTs were shorter in Vacutainer (Becton Dickinson Vacutainer Systems, Plymouth, England) samples than in S-Monovette...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/NW194EAMD4WMEHJD
更新日期:2007-05-01 00:00:00
abstract:OBJECTIVES:To describe the histopathologic and immunophenotypic features of a temporary splenic allograft exposed to massive donor-specific antibody (DSA) insult. METHODS:A human cadaveric donor splenic allograft was temporarily transplanted in a highly sensitized patient with the intention of removing DSA before inte...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/aqaa175
更新日期:2020-11-21 00:00:00
abstract::Reducing the rate of avoidable errors is crucial to patient safety. Telephone calls with misunderstood critical results constitute one area in which opportunities for improvement exist. The aviation industry has dealt with this issue by requiring pilots to repeat instructions received from the air traffic controller. ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/9DYM-6R0T-M830-U95Q
更新日期:2004-06-01 00:00:00
abstract::Immunostaining of cell cycle-related antigens, especially Ki-67, DNA polymerase alpha, and proliferating cell nuclear antigen, has become an important method to assess the proliferative activity of tumors. These three nuclear antigens were studied by immunohistochemical analysis of cytologic smears. These smears were ...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/98.2.161
更新日期:1992-08-01 00:00:00
abstract::The expression of the cell-cycle-associated Ki-67 antigen by MIB-1 monoclonal antibody was retrospectively assessed in 35 surgically resected neuroendocrine tumor specimens of the pancreas embedded in paraffin. The MIB-1 proliferation index was correlated with the classification of the neuroendocrine tumors of the pan...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/109.3.286
更新日期:1998-03-01 00:00:00
abstract:OBJECTIVES:The purpose of this study was to determine if the Advia 2120 hematology analyzer (Siemens Healthcare Diagnostics, Deerfield, IL) can accurately quantify both WBCs and the proportion of neutrophils from synovial and ascitic body fluids. METHODS:We analyzed 60 samples on the Advia and compared the results wit...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCP6JIJV7WYMUAK
更新日期:2013-12-01 00:00:00
abstract::We sought to determine whether a group of cases that was relatively high in disagreements and subsequent amendments could be identified and targeted for blinded review. During a 4-year period, 8,916 surgical pathology and nongynecologic cytology cases were subjected to blinded review; of these, there were 616 disagree...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/DH4U-0KT6-QB01-KR55
更新日期:2006-11-01 00:00:00
abstract::Following normalization of blood glucose levels, a marked change in the MCV and in the calculated hematocrit was observed in five patients with transient severe hyperglycemia. The addition of varied concentrations of glucose to blood samples from healthy volunteers and from patients with microcytic, macrocytic, and no...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/77.5.561
更新日期:1982-05-01 00:00:00
abstract::Progression of follicular lymphoma (FL) to a higher-grade lymphoma occurs in 25% to 60% of cases and frequently indicates a poor prognosis. The transformation is accompanied by alteration in morphologic features and clinical behaviors. Herein, we report a case of FL occurring in a 59-year-old woman with the developmen...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/NKK3FEX2BE5L7EKB
更新日期:2008-01-01 00:00:00
abstract::Critical Path Method (CPM) and Program Evaluation and Review Technique (PERT) are quantitative network planning strategies that facilitate management of projects with many interrelated activities. They determine the minimum time necessary to complete a project and identify which activities are critical to achieving th...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/79.3.353
更新日期:1983-03-01 00:00:00
abstract::Poor core laboratory performance that causes delays in diagnosis and treatment is an impediment to optimal patient care, particularly in high-volume patient care areas such as the emergency department (ED). To evaluate the impact of laboratory performance on patient care outcomes, we obtained data from 11 hospitals re...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/E9QP-VQ6G-2FBV-MJ3B
更新日期:2005-11-01 00:00:00
abstract::The development of a consistent strategy for the analysis of oncogene expression at the cellular level is essential for understanding the roles of these genes in the development and progression of human neoplasia. Detection of the neu oncogene products in breast carcinoma was selected as a model for analysis of oncoge...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/94.2.125
更新日期:1990-08-01 00:00:00
abstract::The authors investigated the blast cells obtained from two patients with acute myelofibrosis with the use of recently developed immunochemical and ultrastructural markers. They intended to examine the expression of megakaryoblastic, erythroblastic, myeloblastic, and monoblastic properties in these cells. Respectively,...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/83.1.114
更新日期:1985-01-01 00:00:00
abstract::From November 1985 to December 1990, 2,552 endomyocardial biopsy specimens from 209 heart transplant patients were studied. Forty-four (21%) patients developed 45 episodes of major human cytomegalovirus infection (HCMV). Human cytomegalovirus infection was primary in 13 of 44 patients. Thirty-one patients developed ep...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
更新日期:1992-08-01 00:00:00
abstract::Diarrheal diseases caused by bacterial pathogens are important causes of morbidity in the United States, and considerable laboratory resources are spent to detect these enteric pathogens. This article reviews recent developments in the detection and identification of Campylobacter spp, enterohemorrhagic Escherichia co...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1994-04-01 00:00:00
abstract::Management by Objectives (MBO) is results-oriented, participatory management, which is appropriate for the current era of keen competition for resources. MBO was installed in the author's institution in clinical laboratory divisions meeting prerequisites and fit the system to the local management environment. The resu...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/86.6.738
更新日期:1986-12-01 00:00:00
abstract:OBJECTIVES:α1-Antitrypsin (AAT) deficiency is associated with an increased risk for lung and liver disease. Identification of AAT deficiency as the underlying cause of these diseases is important in correct patient management. METHODS:AAT deficiency is commonly diagnosed by demonstrating low concentrations of AAT foll...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPR7EIQS8PIMLV
更新日期:2014-05-01 00:00:00
abstract::Fixed lymphoma tissues from 11 patients seropositive for human T-cell leukemia virus type I (HTLV-I) antibodies were analyzed for proviral sequences by the polymerase chain reaction. Typical adult T-cell leukemia/lymphomas (ATLLs) from nine patients were positive for HTLV-I sequences. In contrast, one of two lymphomas...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/95.4.536
更新日期:1991-04-01 00:00:00
abstract::The efficacy of a noninvasive hemoglobin monitoring device (Astrin, Sysmex, Kobe, Japan) was evaluated for healthy volunteers and for patients with hematologic disorders. At the same time, the effects of WBC counts on noninvasive monitoring were studied by clinical evaluation and in ex vivo experiments. The hemoglobin...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/61AN-J1XV-3MW8-78YP
更新日期:2004-01-01 00:00:00
abstract:OBJECTIVES:A systematic review of the literature was performed to identify whether minimum formalin fixation time may be reduced for reliable immunohistochemical assessment of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). METHODS:PubMed, EMBASE, and the Cochra...
journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:10.1309/AJCP96YDQSTYBXWU
更新日期:2014-07-01 00:00:00
abstract::The performance of the Coulter STKS (Coulter, Hialeah, FL) was evaluated in a busy computerized teaching hospital laboratory. The STKS was compared with a Coulter S Plus IV and manually performed 400 white blood-cell differentials. The measured blood-count parameters (i.e., white blood cells [WBCs], red blood cells [R...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/95.2.207
更新日期:1991-02-01 00:00:00
abstract::To evaluate the etiologic role of human papillomavirus (HPV) in oral carcinogenesis, DNA samples were purified from 103 oral squamous cell carcinoma (OSCC) and 30 normal oral mucosal (NOM) specimens. A nested polymerase chain reaction, DNA sequencing, and gene-chip HPV typing were used to identify multiple HPV types i...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/C5P6-NUQ2-NW6L-CTBP
更新日期:2003-12-01 00:00:00
abstract:OBJECTIVES:To determine the impact of implementing p16 Lower Anogenital Squamous Terminology Standardization Project for HPV-Associated Lesions (LAST) guidelines, we compared p16 use and follow-up data before and after implementation of the guidelines. METHODS:We reviewed all cervical biopsy specimens diagnosed by two...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPUXLP7XD8OQYY
更新日期:2015-12-01 00:00:00
abstract::Anatomic pathology service is judged by accuracy of diagnosis and rapidity of reporting of that diagnosis to clinicians. Turnaround times have been used in anatomic pathology to show how long it take to produce a tissue report. Rapid tissue diagnosis is important to patients, clinicians, administrators, and anatomic p...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:
更新日期:1996-10-01 00:00:00
abstract::The major histocompatibility complex probably plays a crucial role in the efficacy of the cellular immune response against virally infected cervical diseases. Therefore, the allele-specific histocompatibility-related leukocyte antigens (HLA) class I and II expression on normal (n = 10), premalignant (n = 25), and mali...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/101.1.5
更新日期:1994-01-01 00:00:00
abstract::The authors describe 11 patients with non-Hodgkin's lymphoma arising in the nasal cavity or paranasal sinuses. Seven were men and four were women. The median age of the women was 76 years; the median age of the men was 45 years. The most common presenting symptoms were nasal obstruction and unilateral facial swelling....
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1093/ajcp/81.6.721
更新日期:1984-06-01 00:00:00