COTA (colon-ovarian tumor antigen). An immunohistochemical study.

Abstract:

:A goat anti-serum was prepared against mucinous ovarian cyst fluid and absorbed with normal colon and a variety of normal tissues until the only residual immunoreactivity was directed against colon cancer and ovarian tumor mucin. The set of antigenic determinants defined by this anti-serum has been called COTA, standing for colon-ovarian-tumor-antigen. This highly absorbed anti-serum (anti-COTA) was used for immunohistochemical staining of 42 different tissues in parallel with staining with a goat anti-CEA, which was also highly absorbed. The results suggest that COTA is a highly sensitive and specific antigen for colon carcinoma and may have potential for the early detection of malignant changes predictive of cancer of the colon.

journal_name

Am J Clin Pathol

authors

Pant KD,Fenoglio-Preiser CM,Berry CO,Zamora PO,Ram MD,Fulks RM,Rhodes BA

doi

10.1093/ajcp/86.1.1

subject

Has Abstract

pub_date

1986-07-01 00:00:00

pages

1-9

issue

1

eissn

0002-9173

issn

1943-7722

journal_volume

86

pub_type

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