Acute Myeloid Leukemia With Myelodysplasia-Related Changes.

Abstract:

OBJECTIVES:Acute myeloid leukemia with myelodysplasia-related changes (AML-MRC) is a heterogeneous disorder defined by morphologic, genetic, or clinical features. Genetic abnormalities associated with AML-MRC are often associated with adverse prognostic features, and many cases are preceded by a myelodysplastic syndrome (MDS) or a myelodysplastic/myeloproliferative neoplasm. METHODS:Although the criteria of 20% or more blasts in blood or bone marrow and multilineage dysplasia affecting 50% or more of cells in two or more of the myeloid lineages seem straightforward for AML-MRC, identification of morphologic dysplasia among observers is not always consistent, and there is morphologic overlap with other leukemic disorders such as acute erythroleukemia. RESULTS:Session 3 of the workshop cases displayed heterogeneity as expected within AML-MRC, yet several cases suggested that recently recognized entities may exist within this category, such as familial MDS/AML predisposition syndromes and rare cases of high-risk AML associated with the cryptic t(5;11)(q35;p15);NUP98-NSD1 that may masquerade as a del(5q). However, most cases of AML-MRC were usually associated with adverse genetic abnormalities, particularly -5/del(5q), -7/del(7q), and/or complex karyotypes. CONCLUSIONS:Whole-genome sequencing and array studies may identify genetic abnormalities, such as those affecting TP53, which may provide prognostic information.

journal_name

Am J Clin Pathol

authors

Vardiman J,Reichard K

doi

10.1309/AJCP58RSMFRHLHHH

subject

Has Abstract

pub_date

2015-07-01 00:00:00

pages

29-43

issue

1

eissn

0002-9173

issn

1943-7722

pii

144/1/29

journal_volume

144

pub_type

杂志文章,评审
  • The reticulocyte. An approach to definition.

    abstract::Experiences of the CAP Survey Program in reticulocyte counts and morphologic identification of reticulocytes from 1971 to 1974 are reviewed. Problems of morphologic identification are reflected in an excessive variance of reticulocyte counts. Statistical sources of variations in counting are identified. The older, ori...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Gilmer PR Jr,Koepke JA

    更新日期:1976-07-01 00:00:00

  • Patient age in Spitz nevus and malignant melanoma: implication of Bayes rule for differential diagnosis.

    abstract::In the differential diagnosis of Spitz nevus vs malignant melanoma, patient age provides a critical piece of clinical information, because Spitz nevi occur mostly in children and melanomas occur mostly in adults. Nevertheless, there is overlap in the age distributions of Spitz nevus and melanoma. The issue to consider...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/E14C-J6KR-D092-DP3M

    authors: Vollmer RT

    更新日期:2004-06-01 00:00:00

  • Esterase activity in erythroleukemia.

    abstract::Specific esterase activity, a property generally ascribed to cells of granulocytic origin, was found in abnormal erythroid precursors obtained from the bone marrows of six patients with untreated erythroleukemia. These erythroblasts also showed nonspecific esterase activity. Neither specific nor nonspecific esterase a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.4.368

    authors: Kass L

    更新日期:1977-04-01 00:00:00

  • Early use of indirect immunofluorescence for the detection of respiratory syncytial virus in HEp-2 cell culture.

    abstract::Respiratory syncytial virus is detected in cell culture by the presence of cytopathic effect. To detect RSV before cytopathic effect is usually seen, slides were evaluated retrospectively from 482 HEp-2 cell cultures on days 2-4 after inoculation. Indirect immunofluorescent staining detected RSV in 57 of 94 cultures t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.1.127

    authors: Bromberg K,Tannis G,Daidone B

    更新日期:1991-07-01 00:00:00

  • Quantitative assessment of the subepithelial collagen band does not increase the accuracy of diagnosis of collagenous colitis.

    abstract::The thickness of eosinophilic band in collagenous colitis (CC) was assessed by 3 methods: histologic estimates (22 observers), conventional measurements using a calibrated micrometric scale (1 observer), and semiautomatic micrometric measurements (1 observer). By the histologic estimate technique, 7.4% of the results ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/K7MH8UCK3MR7Q77L

    authors: Rubio CA,Orrego A,Höög A,Porwitz A,Petersson F,Elmberger G,Glaessgen A,Eriksson E,Kanter L,Jaremko G,Egevad L,Laforga J,Liljefors M,Löfdahl B,Norman P,Larsson O,Wanat R,Wejde J,Zickert P,Björk J,Caini S,Palli D

    更新日期:2008-09-01 00:00:00

  • Workload recording by microcomputer.

    abstract::Workload recording as designed by the College of American Pathologists has proven to be an invaluable aid in the assessment of overall laboratory operation. The administrative information derived from the compilation of these workload statistics is utilized to provide effective and these workload statistics is utilize...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.4.469

    authors: Norbut AM,Foulis PR,Mendelow H

    更新日期:1980-10-01 00:00:00

  • Application of adrenocorticotropin assays in a routine clinical laboratory.

    abstract::The radioimmunoassay of ACTH was used in a routine laboratory to localize the site of the lesion in 20 patients with Cushing's syndrome. Eight of the patients had no detectable circulating ACTH and had adrenal tumors removed, 12 had high levels and were diagnosed as having pituitary Cushing's syndrome. Very high level...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.5.618

    authors: Broughton A

    更新日期:1975-11-01 00:00:00

  • Method precision and frequent causes of errors observed in point-of-care glucose testing: a proficiency testing program perspective.

    abstract:OBJECTIVES:Method imprecision, error rates, and explanatory causes that were identified in the Institute for Quality Management in Healthcare point-of-care (POC) glucose proficiency testing (PT) program were assessed in comparison with results obtained from laboratory glucose PT surveys. METHODS:POC and laboratory glu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPP5YS2MVSKBYY

    authors: Aslan B,Stemp J,Yip P,Gun-Munro J

    更新日期:2014-12-01 00:00:00

  • Myelodysplastic syndrome/acute myeloid leukemia with t(3;21)(q26.2;q22) is commonly a therapy-related disease associated with poor outcome.

    abstract::The t(3;21)(q26.2;q22) translocation is rare in cases of myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). We studied 17 patients with MDS/AML associated with t(3;21) and compared them with 17 patients with MDS associated with inv(3) (q21q26.2)/t(3;3)(q21;q26.2), because these entities share 3q26 locus ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPZRRL2DGC2ODA

    authors: Li S,Yin CC,Medeiros LJ,Bueso-Ramos C,Lu G,Lin P

    更新日期:2012-07-01 00:00:00

  • Thyroid bed fine-needle aspiration: experience at a large tertiary care center.

    abstract::Fine-needle aspiration (FNA) of thyroid bed (TB) lesions is a common diagnostic modality in monitoring patients for recurrent cancer after a thyroidectomy. To elucidate the value of TB FNA, we reviewed our experience at The Johns Hopkins Hospital, Baltimore, MD. We identified 57 TB FNA specimens from 50 patients. Of t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPD60AHRUCMDPF

    authors: Bishop JA,Owens CL,Shum CH,Ali SZ

    更新日期:2010-08-01 00:00:00

  • Cytodifferentiated renal tumors occurring with Wilms' tumors of the opposite kidneys: report of two cases.

    abstract::The most common differentiated renal tumor of early childhood is the congenital mesoblastic neophroma. Well-differentiated forms of Wilms' tumor may present a difficult differential diagnosis from these benign neoplasms. The cases of two patients found to have well-differentiated renal neoplasms after being treated fo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/66.2.376

    authors: Hughson MD,Hennigar GR,Othersen HB Jr

    更新日期:1976-08-01 00:00:00

  • Inherited giant platelet disorders. Classification and literature review.

    abstract::Inherited giant platelet disorders are extremely rare. The aim of this article is to review the clinical and laboratory features of this heterogeneous group and to arrive at a working classification. We conducted our literature search using the National Library of Medicine database. A total of 12 clinical entities wer...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/FC4H-LM5V-VCW8-DNJU

    authors: Mhawech P,Saleem A

    更新日期:2000-02-01 00:00:00

  • Quality school: an innovative approach to laboratory quality practices training.

    abstract::The quality management program in the Division of Transfusion Medicine at our institution had evolved to the point that the program generally was perceived to be the sole responsibility of our Quality Unit (which was administratively independent of day-to-day operations). It became clear that this administrative model...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/UHKMFRFTDRJ7MJ58

    authors: Foss ML,Moore SB

    更新日期:2005-10-01 00:00:00

  • T-cell malignancy following B-cell lymphoma in remission.

    abstract::A T-cell malignancy developed in a 64-year-old man with recurrent B-cell lymphoma after one and a half years of remission. Immunophenotypic and DNA analyses confirmed clonality and cell lineage of both lymphoid malignancies. Sequential development of B- and T-cell malignancies in this patient may be an example of bicl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.3.362

    authors: Shimizu K,Hirano M,Maruyama F,Itoh M,Hara K,Ino T,Ezaki K,Kunii A

    更新日期:1989-09-01 00:00:00

  • High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera.

    abstract::We examined the occurrence of JAK2(V617F) and JAK2 exon 12 mutations in a clinical cohort of polycythemia vera (PV) in Taiwan. Of 22 patients with PV, 17 (77%) had the V617F mutation, and all 5 V617F-negative patients (23%) had the exon 12 mutation. We found 3 different exon 12 mutations: 3 N542-E543del, 1 F537-K539de...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPK7KGOWPHYWM0

    authors: Yeh YM,Chen YL,Cheng HY,Su WC,Chow NH,Chen TY,Ho CL

    更新日期:2010-08-01 00:00:00

  • Immunoglobulin inclusions in non-Hodgkin's lymphomas.

    abstract::The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin's lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG (k) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/69.1.306

    authors: van den Tweel JG,Taylor CR,Parker JW,Lukes RJ

    更新日期:1978-03-01 00:00:00

  • The cytopathology of proliferative breast disease. Comparison with features of ductal carcinoma in situ.

    abstract::Epithelial hyperplasia, a component of proliferative breast disease (PBD), is a known risk factor for the development of breast carcinoma. To determine if criteria established for tissue biopsy could be used to more precisely define cytologic criteria for diagnosis of PBD, 37 breast fine-needle aspirates with biopsy d...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.4.438

    authors: Dawson AE,Mulford DK,Sheils LA

    更新日期:1995-04-01 00:00:00

  • Intratumoral genetic heterogeneity in Barrett adenocarcinoma.

    abstract::In 10 cases of Barrett adenocarcinoma, samples from 8 tumor areas (including superficial and deep from peripheral and central areas) and a regional lymph node metastasis were studied for amplification of c-myc, c-erbB-2, and EGFR. We analyzed loss of heterozygosity (LOH) at 3 loci (APC, MCC, and RB) and 2 anonymous mi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/6XY8-FMM5-VVCJ-T3N0

    authors: Owonikoko T,Rees M,Gabbert HE,Sarbia M

    更新日期:2002-04-01 00:00:00

  • Double immunostaining of lymph node sections by monoclonal antibodies using phycoerythrin labeling and haptenated reagents.

    abstract::Double immunostaining of tissue sections by monoclonal antibodies has been performed using, in immunofluorescence, combinations of reagents conjugated with different fluorochromes. These were monoclonal antibodies directly labeled with phycoerythrin (a new red fluorochrome) and haptenated monoclonal antibodies detecte...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.1.44

    authors: Pizzolo G,Chilosi M

    更新日期:1984-07-01 00:00:00

  • mhatomic pathology turnaround times. Use and abuse.

    abstract::Anatomic pathology service is judged by accuracy of diagnosis and rapidity of reporting of that diagnosis to clinicians. Turnaround times have been used in anatomic pathology to show how long it take to produce a tissue report. Rapid tissue diagnosis is important to patients, clinicians, administrators, and anatomic p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Smith MT,Garvin AJ

    更新日期:1996-10-01 00:00:00

  • Pathologic findings of follow-up surgical excision for lobular neoplasia on breast core biopsy performed for calcification.

    abstract::This study aimed to ascertain pathologic findings of surgical follow-up excision (FUE) on patients who had radiologic finding of calcifications and lobular neoplasia (LN) on core biopsy. Breast core biopsy specimens from 2006-2011 with a diagnosis of pure classic-type LN (lobular carcinoma in situ [LCIS] and atypical ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPYG48TUTFIBMR

    authors: Zhao C,Desouki MM,Florea A,Mohammed K,Li X,Dabbs D

    更新日期:2012-07-01 00:00:00

  • Mucocele-like tumors of the breast. Cytologic findings in two cases.

    abstract::Mucocele-like tumors of the breast originally were reported by Rosen in 1986 as benign lesions that histologically resembled colloid carcinoma of the breast. The authors document two cases of mucocele-like tumors to illustrate the difficulty in separating these lesions from colloid carcinoma on the basis of fine-needl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.6.875

    authors: Bhargava V,Miller TR,Cohen MB

    更新日期:1991-06-01 00:00:00

  • Adrenocortical cytopathology.

    abstract::Cytopathologic smears and/or imprints of human adrenal cortex (9 cases) and its disorders were examined, including adrenocortical nodule (3 cases), adrenocortical adenoma (23 cases), carcinoma (8 cases), and renal cell carcinoma (6 cases). Immunocytochemistry directed against 3 beta-hydroxysteroid dehydrogenase and ad...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/104.2.161

    authors: Sasano H,Shizawa S,Nagura H

    更新日期:1995-08-01 00:00:00

  • Evaluation of a semiautomated micro-broth dilution system for determing minimum inhibitory concentrations of antimicrobics.

    abstract::This study investigates the dispensing and inoculating characteristics of the MIC-2000 micro-broth dilution system and compares its ability to determine minimum inhibitory concentrations with that of the reference macro-broth dilution method. Micro-well filling showed a coefficient of variation of 6.8%, and micro-well...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.3.374

    authors: Woolfrey BF,Ramadei WA,Quall CO

    更新日期:1980-03-01 00:00:00

  • Evaluation of two commercial tests for human immunodeficiency virus antigens in culture supernatant fluid.

    abstract::Two commercial enzyme-linked immunosorbent assays (EIAs) for human immunodeficiency virus (HIV) antigens were evaluated for sensitivity and reproducibility by use of supernatant fluid from cell cultures of peripheral mononuclear cells of 18 patients with acquired immunodeficiency syndrome (AIDS) and 12 asymptomatic HI...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/89.6.788

    authors: Jackson JB,Sannerud K,Rhame FS,Balfour HH Jr

    更新日期:1988-06-01 00:00:00

  • Group-specific component (Gc) alleles among Haitian immigrants.

    abstract::Gc allele frequencies were determined in Haitian immigrants, a group at high risk for AIDS. Gc2, an allele associated with disease resistance, is infrequent in this group; Gc1f is frequent. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/90.3.371

    authors: Wenk RE,Russo F

    更新日期:1988-09-01 00:00:00

  • Psammoma bodies in malignant carcinoid tumor metastases.

    abstract::A clinically and histopathologically well-documented case of malignant carcinoid tumor (with carcinoid syndrome) is described. The presence of numerous psammoma bodies in metastatic carcinoid tumor deposits, confirmed by histochemical and ultrastructural analyses, represents a heretofore unreported finding. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.372

    authors: Caya JG,Tieu TM,Wollenberg NJ,Soergel K,Anderson T

    更新日期:1984-03-01 00:00:00

  • Regional alveolar damage (RAD). A localized counterpart of diffuse alveolar damage.

    abstract::Diffuse alveolar damage (DAD) is usually considered a generalized lung process. During five years the authors observed 83 patients with generalized DAD in 827 adult autopsies (10.1%) and 10 patients with identical, but localized, lesions. The authors propose the term regional alveolar damage (RAD) to designate localiz...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/92.1.10

    authors: Yazdy AM,Tomashefski JF Jr,Yagan R,Kleinerman J

    更新日期:1989-07-01 00:00:00

  • Application of 3-D Delta check graphs to HbA1c quality control and HbA1c utilization.

    abstract::Delta checking is a laboratory information system (LIS)-based tool that detects patient and laboratory quality control errors. By using hemoglobin A1c (HbA1c) data, we developed a novel approach to summarizing and presenting patient Delta values to address limitations of current Delta check algorithms. Delta values we...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/VM6FVF6GGCYYJ9BV

    authors: Tran DV,Cembrowski GS,Lee T,Higgins TN

    更新日期:2008-08-01 00:00:00

  • Hypoglycorrhachia and coxsackie B3 meningoencephalitis.

    abstract::The case of a 3-week-old infant with Coxsackie B3 meningoencephalitis is discussed. Hypoglycorrhachia and neutrophils in the cerebrospinal fluid characterized the first ten days of her illness. Coxsackie B3 should be added to the list of enteroviruses that can cause hypoglycorrhachia during infections of the central n...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.6.947

    authors: Chesney PJ,Quennec P,Clark C

    更新日期:1978-12-01 00:00:00