Regional alveolar damage (RAD). A localized counterpart of diffuse alveolar damage.

Abstract:

:Diffuse alveolar damage (DAD) is usually considered a generalized lung process. During five years the authors observed 83 patients with generalized DAD in 827 adult autopsies (10.1%) and 10 patients with identical, but localized, lesions. The authors propose the term regional alveolar damage (RAD) to designate localized "DAD." RAD was unilateral in six patients and most frequently involved the upper lobe. All ten patients had chronic systemic diseases and presented with life-threatening illnesses. The probable causes of RAD were multifactorial and included hypotensive shock, septicemia, pneumonia, hyperoxia, and pancreatitis. All patients developed respiratory failure, requiring supplemental oxygen and, in nine patients, mechanical ventilation. Chest roentgenograms revealed alveolar or combined alveolar and interstitial infiltrates that corresponded to the lesions found at autopsy. The reasons for localization of RAD within the lung are unclear, but the presence of proliferative lesions and frequent involvement of the upper lobe suggests that RAD is not simply an early phase of DAD and implicates additional pathogenetic factors.

journal_name

Am J Clin Pathol

authors

Yazdy AM,Tomashefski JF Jr,Yagan R,Kleinerman J

doi

10.1093/ajcp/92.1.10

subject

Has Abstract

pub_date

1989-07-01 00:00:00

pages

10-5

issue

1

eissn

0002-9173

issn

1943-7722

journal_volume

92

pub_type

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