Abstract：
:The pattern of spurious red blood cell parameters caused by serum cold agglutinins has been well characterized for the Coulter counters but not the Ortho ELT-8. The pattern consists of a spurious increase in mean corpuscular volume (MCV), a discrepancy between the hemoglobin and the hematocrit, the latter falsely reduced and consequently a MCHC value greater than 36%. Since MCHC rarely exceeds 36% in health or disease, it is an important clue to the spurious nature of the macrocytosis caused by cold agglutinins. The authors have studied five examples of cold agglutinin induced artefact on the Ortho ELT-8 counter. Although a pattern similar to that for the Coulter counters was anticipated, three of the five patients failed to show the characteristics "internal discrepancy" and a MCHC value greater than 36%, despite a marked spurious elevation of MCV. In two of the three patients a classical pattern of cold agglutinin artefact was observed on a Coulter S Plus IV counter with only a modest elevation of MCV. Possible explanations for the observed pattern on the ELT-8 and its implications are discussed.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Solanki DL,Blackburn BCdoi
10.1093/ajcp/83.2.218subject
Has Abstractpub_date
1985-02-01 00:00:00pages
218-22issue
2eissn
0002-9173issn
1943-7722journal_volume
83pub_type
杂志文章abstract：:Acute exacerbations of idiopathic pulmonary fibrosis/cryptogenic fibrosing alveolitis (IPF/CFA) are rare and typically terminal events, but their relationship to underlying patterns of idiopathic interstitial pneumonias is unknown. We reviewed autopsy material from patients who died of diffuse alveolar damage in the c...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/UVAR-MDY8-FE9F-JDKU
更新日期：2003-05-01 00:00:00
abstract：:In situ hybridization for the Y chromosome (Y-ISH) was used to identify residual host cells in the peripheral blood of 51 recipients of sex-mismatched allogeneic marrow not depleted of T cells following conditioning with high-dose cyclophosphamide and total body irradiation (TBI). One patient who rejected the graft sh...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/95.2.201
更新日期：1991-02-01 00:00:00
abstract：:Nine human exocrine pancreatic adenocarcinomas were examined by serial sectioning and double- and triple-labeled immunohistochemical techniques with antibodies against chromogranin A, insulin, islet amyloid polypeptide, glucagon, somatostatin, pancreatic polypeptide, serotonin, pancreastatin, and neuron-specific enola...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/100.3.223
更新日期：1993-09-01 00:00:00
abstract：:Blast-like cells in the cerebrospinal fluid (CSF) of neonates have been identified and previously suggested to be of germinal matrix origin. Twelve additional CSF specimens with blast-like cells collected at the University of Texas Medical Branch, Galveston, between 1985-1992 were analyzed. The cytological features of...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/105.5.544
更新日期：1996-05-01 00:00:00
abstract：:A fatal case of an apparently congenital form of hemophagocytic reticulosis is reported. The onset was manifested by hyperbilirubinemia and hepatosplenomegaly which were present at birth and persisted throughout life. Fever, anemia and pancytopenia developed at 1 month of age and became progressively worse. A splenect...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/65.4.495
更新日期：1976-04-01 00:00:00
abstract：OBJECTIVES:We wished to discover (1) in what circumstances surgeons wished to request frozen sections (FSs) on thyroid nodules having a prior fine needle aspiration (FNA) and the preoperative plan in these cases; (2) what the surgeons did with the information provided by FS and (3) in what types of cases was value adde...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/aqw042
更新日期：2016-05-01 00:00:00
abstract：:We describe 35 peripheral lymph nodes classified as mantle cell/marginal zone B-cell hyperplasia with clear cells using morphologic and immunologic findings. For the purpose of this study, we obtained clinical follow-up information and performed immunoglobulin gene rearrangement studies on paraffin sections by polymer...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/P2M2-JEA3-YYQF-0P38
更新日期：2001-10-01 00:00:00
abstract：:Our purpose was to determine whether the in vitro (or "spiked curve") method for the therapeutic heparin range is an accurate and valid method for heparin monitoring. Many laboratories use the in vitro method for determining the activated partial thromboplastin time (APTT)-based unfractionated heparin (UFH) therapeuti...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCP60ZGXCJKRMJO
更新日期：2011-06-01 00:00:00
abstract：:The expression of bcl-2, CD10, and CD20 was examined by multicolor flow cytometry in 78 samples including lymph node or other tissue biopsy specimens containing follicular lymphoma (FL; n = 17), reactive hyperplasia (RH; n = 28), or other malignant lymphomas (n = 20), as well as bone marrow aspirates (n = 13). The pre...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/820R-476K-Y9G0-3L9A
更新日期：2003-01-01 00:00:00
abstract：Objectives:A report on the multicenter evaluation of the Bruker MALDI Biotyper CA System (MBT-CA; Bruker Daltonics, Billerica, MA) for the identification of clinically important bacteria and yeasts. Methods:In total, 4,399 isolates of medically important bacteria and yeasts were assessed in the MBT-CA. These included ...
journal_title：American journal of clinical pathology
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1093/ajcp/aqw225
更新日期：2017-06-01 00:00:00
abstract：:Non-Hodgkin lymphoma (NHL) is more likely to develop in patients with Hodgkin disease (HD) than in the general population. Although reports of synchronous or metachronous HD and NHL are not uncommon in the literature, the biologic relationship of these 2 malignant neoplasms often is unclear. A larger-than-expected fra...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/W1GW-43HT-793U-F86R
更新日期：2004-05-01 00:00:00
abstract：:Automation was introduced into the clinical microbiology laboratory in the 1960s but initially met with limited success. Today, instruments are an integral part of many clinical laboratories and are used for microbial detection, identification, and susceptibility testing; detection of positive blood cultures; screenin...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：
更新日期：1992-10-01 00:00:00
abstract：OBJECTIVES:Cytogenetics defines disease entities and predicts prognosis in acute myeloid leukemia (AML). Conventional karyotyping provides a comprehensive view of the genome, while fluorescence in situ hybridization (FISH) detects targeted abnormalities. The aim of this study was to compare the utility of karyotyping a...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/AJCPP6LVMQG4LNCK
更新日期：2015-06-01 00:00:00
abstract：OBJECTIVES:Preanalytical factors, such as hemolysis, affect many components of a test panel. Machine learning can be used to recognize these patterns, alerting clinicians and laboratories to potentially erroneous results. In particular, machine learning might identify which cases of elevated potassium from a point-of-c...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/aqaa039
更新日期：2020-07-07 00:00:00
abstract：:A patient with prolymphocytic leukemia was immunophenotyped by whole blood and Ficoll-Hypaque methods. Discordance was noted between the two methods, especially for the HLE1, B1, I2, and T1B monoclonal markers. The disparity in results reflected the use of 15 X 10(6) cells versus 1 X 10(6) cells per reaction tube. Thi...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/91.2.227
更新日期：1989-02-01 00:00:00
abstract：OBJECTIVES:We report a case of a patient with diabetes mellitus and unexpectedly low hemoglobin A1c results associated with paroxysmal nocturnal hemoglobinuria (PNH). We review the impact of shortened RBC half-life on the interpretation of hemoglobin A1c levels. METHODS:Patient history and laboratory test results were...
journal_title：American journal of clinical pathology
pub_type： 杂志文章,评审
doi：10.1309/AJCPTK1HPR2KULJU
更新日期：2014-08-01 00:00:00
abstract：:Anaplastic thyroid carcinomas usually pose no problems in histologic diagnosis because of the obvious invasive growth, high cellularity, and frank anaplasia. Two cases of a variant of anaplastic thyroid carcinoma with peculiar gross and histologic features closely mimicking those of Riedel's thyroiditis are described ...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/105.4.388
更新日期：1996-04-01 00:00:00
abstract：:Peripheral blood mononuclear cells from pemphigus vulgaris and bullous pemphigoid patients produced antiepithelial antibodies in a pokeweed mitogen-stimulated in vitro cell culture system. Antiintercellular substance (ICS) antibodies were detected in supernatants of cell cultures from four of four pemphigus vulgaris p...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/81.5.586
更新日期：1984-05-01 00:00:00
abstract：:Transbronchoscopic biopsies of lung (transbronchial) or bronchus (endobronchial) have a high diagnostic of yield when performed by a single expert bronchoscopist or a small group of expert bronchoscopists. This procedure's diagnostic yield was evaluated in a general hospital where biopsies are performed by a diverse g...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/72.6.926
更新日期：1979-12-01 00:00:00
abstract：:The ongoing collaborative relationship between a pathology department and the vendor of its laboratory information system is vitally important because of the strategic importance of the laboratory information system in managing the information product of the department. Laboratory information system vendors are value-...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/97.3.363
更新日期：1992-03-01 00:00:00
abstract：:In-situ and microinvasive adenocarcinoma of the uterine cervix. A clinical, cytologic and histologic study of 14 cases. Am J Clin Pathol 64: 155-70, 1975. The clinicopathologic features of 14 cases of in-situ and microinvasive adenocarcinoma of the cervix, encountered during the period 1961-1974, form the basis of thi...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/64.2.155
更新日期：1975-08-01 00:00:00
abstract：:A 55-year-old man presented with nerve compression and examination of tissue removed by laminectomy, and bone marrow aspiration was diagnostic of multiple myeloma. Protein studies showed a total serum protein of 5.7 g/dL, with a M-component in the fast beta region. The abnormal protein reacted only with anti-lambda an...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：
更新日期：1984-11-01 00:00:00
abstract：:The authors investigated assays for free protein S (ProS) antigen, total ProS antigen, and ProS crossed immunoelectrophoresis (CIEP) in the diagnosis of type 1 inherited ProS deficiency. Accurate measurement of the hemostatically important free ProS required showing that, on each specimen, precipitation of the C4b-bin...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/94.2.176
更新日期：1990-08-01 00:00:00
abstract：:The uptake and storage of 5-hydroxytryptamine by human platelets from normal donors and patients with the carcinoid syndrome are reported. When platelets were incubated in the presence of 3H-5-hydroxytryptamine (50 microM), an initial phase of rapid uptake was observed until 5-hydroxytryptamine levels of 1--2 microgra...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/70.4.628
更新日期：1978-10-01 00:00:00
abstract：:Cellular proliferation is being evaluated as an independent prognostic indicator in a variety of tumors, including non-Hodgkin's lymphomas (NHL). Although the labeling index (LI), using either tritiated thymidine or monoclonal antibodies to bromodeoxyuridine, is considered to be the gold standard of cell kinetic measu...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/99.6.668
更新日期：1993-06-01 00:00:00
abstract：:A 76-year-old white man previous diagnosed as having Waldenstrom's macroglobulinemia continued with persistent fevers and sweats for two and a half years. Recently, repeated automated differentials during 11 days of hospitalization failed to note any intracellular inclusions in the RBCs. Blood sent to the Microbiology...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/83.4.520
更新日期：1985-04-01 00:00:00
abstract：:By electrophoresis, prealbumin is seen as a discrete band anodic to the albumin fraction. Cases of duplicate bands in the prealbumin region have been described previously in serum, cerebrospinal fluid, and urine, and have had an association with varied clinical entities. The authors describe a novel association of sev...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/101.4.475
更新日期：1994-04-01 00:00:00
abstract：:A parallel study of blood cultured conventionally and following processing in an Antimicrobial Removal Device (ARD) was conducted with patients suspected of being clinically bacteremic. Cultures yielded 205 isolates from 87 clinically bacteremic patients, of whom 28 were receiving antibiotics at the time their culture...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/78.2.173
更新日期：1982-08-01 00:00:00
abstract：:Criteria for assessing adequacy of cervicovaginal smears according to the Bethesda System include cellular composition and quantity, specimen preservation, fixation, and absence of obscuring elements. The reproducibility of adequacy assessment using these parameters was the focus of this study. Specimens were chosen t...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1093/ajcp/102.3.354
更新日期：1994-09-01 00:00:00
abstract：:We compared the morphologic findings of different types of marginal zone B-cell lymphoma (MZL) involving the bone marrow (BM), including 18 splenic (SMZL), 6 extranodal (mucosa-associated lymphoid tissue lymphoma), and 6 nodal cases. The median percentage of BM involvement was 15%, and multiple overlapping patterns of...
journal_title：American journal of clinical pathology
pub_type： 杂志文章
doi：10.1309/HRHQFBFTR8B4LXT4
更新日期：2008-05-01 00:00:00
