CD161 Is Expressed in a Subset of T-Cell Prolymphocytic Leukemia Cases and Is Useful for Disease Follow-up.

Abstract:

OBJECTIVES:CD161 (NKRP1) is a lectin-like receptor present on NK cells and rare T-cell subsets. We have observed CD161 expression in some cases of T-cell prolymphocytic leukemia (T-PLL) and found it to be useful in follow-up and detection of disease after treatment. METHODS:Retrospective review of T-PLL cases with complete flow cytometry data including CD161. RESULTS:We identified 10 cases of T-PLL with flow cytometric evaluation of CD161 available. Six of these cases were positive for CD161 expression. All CD161-positive cases were positive for CD8 with variable CD4 expression, whereas all CD161-negative cases were negative for CD8. In a case with two neoplastic subsets positive and negative for CD8, only the former expressed CD161. CONCLUSIONS:These novel results suggest that CD161 is often aberrantly expressed in a defined subset of T-PLL positive for CD8. We are showing the utility of this immunophenotype in diagnosis and follow-up.

journal_name

Am J Clin Pathol

authors

Gilles SR,Yohe SL,Linden MA,Dolan M,Hirsch B,Grzywacz B

doi

10.1093/ajcp/aqz060

subject

Has Abstract

pub_date

2019-09-09 00:00:00

pages

471-478

issue

4

eissn

0002-9173

issn

1943-7722

pii

5532262

journal_volume

152

pub_type

杂志文章
  • Comparison of the diagnostic values of biopsies of the pleura and cytologic evaluation of pleural fluids.

    abstract::Results of a comparison of the diagnostic efficacy of percutaneous needle biopsy of the parietal pleura with that of cytologic examination of pleural fluid sediment obtained concurrently from 166 patients with benign or cancerous pleural disorders are reported. Of 44 patients with confirmatory evidence of cancer invol...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.1.48

    authors: Frist B,Kahan AV,Koss LG

    更新日期:1979-07-01 00:00:00

  • The defined antigen substrate sphere system with direct immunohistoperoxidase for detection of soluble dengue antigen in sera of patients with dengue hemorrhagic fever.

    abstract::The defined antigen substrate sphere system is a simple method for detecting antigen or antibody in the circulation. The technic is based on the coupling of antigen or antibody with Sepharose 4B beads that have been activated by cyanogen bromide. In this study the activated beads were exposed to dengue antigen in the ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.3.343

    authors: Boonpucknavig S,Bunnag C,Vuttiviroj O,Nimmannitya S

    更新日期:1978-09-01 00:00:00

  • Therapeutic control of oral anticoagulant treatment in The Netherlands.

    abstract::Therapeutic control achieved by an anticoagulant clinic may be assessed by calculation of the proportion of time spent by the patients within the prothrombin time target range aimed for by the clinic. Three calculation methods for such assessment have been described by other investigators. The three methods were compa...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1093/ajcp/90.6.685

    authors: van den Besselaar AM,van der Meer FJ,Gerrits-Drabbe CW

    更新日期:1988-12-01 00:00:00

  • Bone marrow involvement by marginal zone B-cell lymphomas of different types.

    abstract::We compared the morphologic findings of different types of marginal zone B-cell lymphoma (MZL) involving the bone marrow (BM), including 18 splenic (SMZL), 6 extranodal (mucosa-associated lymphoid tissue lymphoma), and 6 nodal cases. The median percentage of BM involvement was 15%, and multiple overlapping patterns of...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HRHQFBFTR8B4LXT4

    authors: Inamdar KV,Medeiros LJ,Jorgensen JL,Amin HM,Schlette EJ

    更新日期:2008-05-01 00:00:00

  • Lymph node interdigitating reticulum cell sarcoma.

    abstract::A 67-year-old man presented with a malignant tumor involving abdominal lymph nodes, spleen, liver, and lungs, with associated protracted fever and night sweats. The tumor consisted of large pleomorphic cells, often surrounding microabscesses. Intracytoplasmic S100 protein, surface T6, Leu-3a (T4), and HLA-DR antigens ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/85.6.739

    authors: Chan WC,Zaatari G

    更新日期:1986-06-01 00:00:00

  • A dissection of the CD45/side scatter "blast gate".

    abstract::CD45/side scatter (SS) gating is widely used for isolating blasts by flow cytometry (FC). However, other cells contaminate the "blast gate" (BG); CD45/SS gating is thus imprecise, particularly when there are few blasts. We studied the BG contents in 21 myelodysplastic syndromes (MDSs), 14 myeloproliferative neoplasms ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPN4G1IZPABRLH

    authors: Harrington AM,Olteanu H,Kroft SH

    更新日期:2012-05-01 00:00:00

  • Immunoblastic lymphoma of T-cell type in a chronically immunosuppressed renal transplant recipient.

    abstract::A case of non-Hodgkin's lymphoma of T-cell type occurring in a renal transplant recipient is described. This lymphoma was classified as large cell, immunoblastic type and presented as a mediastinal mass, although it was demonstrated to be disseminated at autopsy two weeks later. Lymphoma cells expressed the immunologi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.2.280

    authors: Griffith RC,Saha BK,Janney CM,Ratner L,Brunt EM,Gajl-Peczalska KJ,Hanto DW

    更新日期:1990-02-01 00:00:00

  • Recurrent adult myofibromatosis. A case report.

    abstract::Myofibromatosis generally is regarded as a fibrous proliferative disease of neonates and children that, even when multicentric, has an excellent prognosis and a propensity for spontaneous involution. Reported is a case of solitary, locally recurrent myofibromatosis in the ear canal of an adult patient. It was initiall...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.6.810

    authors: Hogan SF,Salassa JR

    更新日期:1992-06-01 00:00:00

  • Theory and applications of the polymerase chain reaction.

    abstract::The polymerase chain reaction (PCR) is a newly developed molecular biology technique that can significantly amplify DNA or RNA. The process consists of repetitive cycles of specific DNA synthesis, defined by short stretches of preselected DNA. With each cycle, there is a doubling of the final, desired DNA product such...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Remick DG,Kunkel SL,Holbrook EA,Hanson CA

    更新日期:1990-04-01 00:00:00

  • Simplified neutrophil hexose monophosphate shunt assay on whole blood.

    abstract::Neutrophil function was determined in resting and phagocytic cells by an assay of hexose monophosphate shunt activity performed on small volumes of whole blood. This new micromethod clearly differentiated between zymosan-stimulated and unstimulated hexose monophosphate shunt activity. Furthermore, the whole blood micr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.1.88

    authors: King JW,McCall CE

    更新日期:1980-07-01 00:00:00

  • Computer-assisted work station timing analysis of instrument labor efficiency.

    abstract::Labor use ratings assigned to instruments by the Workload Recording Method (WRM) do not change with batch size or walk-away time use. The authors evaluated the effect of both on the labor use of the analyzers Paramax B6100 (Baxter Paramax, Irvine, CA) and Ektachem 700 (Eastman Kodak, Rochester, NY) by timing all worke...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.5.743

    authors: McClellan GA,Nipper HC,Horn MJ,Burris WD,Hodges K,Monaco S,Cox RS Jr

    更新日期:1991-05-01 00:00:00

  • Spironolactone bodies. An immunoperoxidase study with biochemical correlation.

    abstract::The present immunoperoxidase study attempted to localize aldosterone and cortisol in formalin-fixed paraffin-embedded adrenal glands or tumors. Apparently, steroid substances are solubilized during routine tissue processing, and the cytoplasm of adrenal cortical cells is not stained by either antialdosterone or antico...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.1.92

    authors: Hsu SM,Raine L,Martin HF

    更新日期:1981-01-01 00:00:00

  • High percentage of JAK2 exon 12 mutation in Asian patients with polycythemia vera.

    abstract::We examined the occurrence of JAK2(V617F) and JAK2 exon 12 mutations in a clinical cohort of polycythemia vera (PV) in Taiwan. Of 22 patients with PV, 17 (77%) had the V617F mutation, and all 5 V617F-negative patients (23%) had the exon 12 mutation. We found 3 different exon 12 mutations: 3 N542-E543del, 1 F537-K539de...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPK7KGOWPHYWM0

    authors: Yeh YM,Chen YL,Cheng HY,Su WC,Chow NH,Chen TY,Ho CL

    更新日期:2010-08-01 00:00:00

  • Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful?

    abstract::The use of direct thrombin inhibitors (DTIs) for prophylactic or therapeutic anticoagulation is increasing because of the predictable bioavailability and short half-life of these DTIs. However, in certain situations, indication of the concentration is warranted. We investigated the effects of 3 DTIs (lepirudin, argatr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQOD9WFPEYY0H

    authors: Curvers J,van de Kerkhof D,Stroobants AK,van den Dool EJ,Scharnhorst V

    更新日期:2012-10-01 00:00:00

  • Peliosis of the spleen.

    abstract::Peliosis of the spleen was found in 10 out of 1,200 cases autopsied from 1977 through 1980 in our laboratory. Eight such cases had no peliosis of the liver. Histologically, it was noticed that the parafollicular areas were the most common sites of the lesions, and this feature seemed to be important for the histologic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.6.708

    authors: Tada T,Wakabayashi T,Kishimoto H

    更新日期:1983-06-01 00:00:00

  • Direct and indirect immunofluorescence as a diagnostic adjunct in the interpretation of nonneoplastic medical lung disease.

    abstract::Fresh open lung biopsy material from 57 patients was incubated with fluoresceinated complement and immunoglobulin antisera. An indirect immunofluorescent assay using neonatal lung as substrate was conducted as well. Direct immunofluorescent patterns could be categorized into interalveolar septal capillary deposition, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/EHUQ-HW6K-0G41-E0DX

    authors: Magro CM,Morrison C,Pope-Harman A,Rothrauff SK,Ross P Jr

    更新日期:2003-02-01 00:00:00

  • COTA (colon-ovarian tumor antigen). An immunohistochemical study.

    abstract::A goat anti-serum was prepared against mucinous ovarian cyst fluid and absorbed with normal colon and a variety of normal tissues until the only residual immunoreactivity was directed against colon cancer and ovarian tumor mucin. The set of antigenic determinants defined by this anti-serum has been called COTA, standi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/86.1.1

    authors: Pant KD,Fenoglio-Preiser CM,Berry CO,Zamora PO,Ram MD,Fulks RM,Rhodes BA

    更新日期:1986-07-01 00:00:00

  • Comparison of an enzyme immunoassay to an indirect fluorescent immunoassay for the detection of antinuclear antibodies.

    abstract::The standard method for detecting antinuclear antibodies (ANAs) is by immunofluorescence assay (IFA), a method that is labor intensive and subjective. In an attempt to overcome these limitations, several commercial enzyme immunoassays (EIAs) have been developed. We report the results of our evaluation of the ANA Micro...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/111.4.503

    authors: Reisner BS,DiBlasi J,Goel N

    更新日期:1999-04-01 00:00:00

  • Diagnostic sensitivity of polymerase chain reaction and Southern blot hybridization for the detection of human papillomavirus DNA in biopsy specimens from cervical lesions.

    abstract::Human papillomaviruses (HPVs) are associated with benign and malignant neoplasms of the cervix. One of the criteria for their etiologic role requires an assessment of whether virtually all or only a small fraction of lesions contain viral genomes. DNA preparations from colposcopically directed punch biopsies of cervic...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.5.638

    authors: Tham KM,Chow VT,Singh P,Tock EP,Ching KC,Lim-Tan SK,Sng IT,Bernard HU

    更新日期:1991-05-01 00:00:00

  • Repeat thyroid nodule fine-needle aspiration in patients with initial benign cytologic results.

    abstract::Fine-needle aspiration (FNA) is the standard of care for the initial workup of thyroid nodules, but there is no consensus algorithm to manage patients with benign results. We examined performance characteristics of initial and repeat satisfactory FNAs for all 402 patients who underwent thyroid surgery during a recent ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/4AXL-DMN1-JRPM-TX5P

    authors: Flanagan MB,Ohori NP,Carty SE,Hunt JL

    更新日期:2006-05-01 00:00:00

  • Septicemia caused by Pseudomonas paucimobilis.

    abstract::A case of septicemia caused by Pseudomonas paucimobilis is reported. This represents the first definitive case of disease produced by this yellow-pigmented, nonfermentative bacillus. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.5.882

    authors: Slotnick IJ,Hall J,Sacks H

    更新日期:1979-11-01 00:00:00

  • Transferrin loss into the urine with hypochromic, microcytic anemia.

    abstract::Anemia developing during the course of chronic renal disease is a frequent complication often necessitating periodic transfusion therapy. A number of etiologic factors have been implicated, including decreased production of erythropoietin; decreased erythrocyte life span secondary to uremia and splenomegaly; increased...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.1.73

    authors: Hancock DE,Onstad JW,Wolf PL

    更新日期:1976-01-01 00:00:00

  • Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers.

    abstract::An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers. Of the small cell carcinomas (SCC), 69 out of 99 (70%) cases stained with the anti-serum. Maltreated biopsies s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.1.1

    authors: Bergh J,Esscher T,Steinholtz L,Nilsson K,Påhlman S

    更新日期:1985-07-01 00:00:00

  • Total laboratory automation can help eliminate the laboratory as a factor in emergency department length of stay.

    abstract::We obtained data on laboratory turnaround time (TAT) and emergency department (ED) length of stay (LOS). We correlated potassium test TAT outlier percentage (TAT-OP) with ED LOS and found that for each outlier percentage (potassium result > 40 minutes), a projected impact on ED LOS was approximately 2.8 additional min...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3J5P-9VJR-UP4U-5RU5

    authors: Holland LL,Smith LL,Blick KE

    更新日期:2006-05-01 00:00:00

  • Asymptomatic Patient Testing After 10:1 Pooling Using the Xpert Xpress SARS-CoV-2 Assay.

    abstract:OBJECTIVES:Pool testing for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) preserves testing resources at the risk of missing specimens through specimen dilution. METHODS:To determine whether SARS-CoV-2 specimens would be missed after 10:1 pooling, we identified 10 specimens with midrange (ie, 25-34 cycl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa273

    authors: Procop GW,Tuohy M,Ramsey C,Rhoads DD,Rubin BP,Figler R

    更新日期:2021-01-05 00:00:00

  • Histopathology of Human Donor Spleen Utilized as a Desensitization Tool Before Intestinal Transplantation.

    abstract:OBJECTIVES:To describe the histopathologic and immunophenotypic features of a temporary splenic allograft exposed to massive donor-specific antibody (DSA) insult. METHODS:A human cadaveric donor splenic allograft was temporarily transplanted in a highly sensitized patient with the intention of removing DSA before inte...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa175

    authors: Gaitonde S,Hassan M,Mehta V,Benedetti E,Tzvetanov I,Lichvar A,Pirzada S,Setty S

    更新日期:2020-11-21 00:00:00

  • Fine-needle aspiration cytologic diagnosis of Kikuchi's lymphadenitis. A report of 27 cases.

    abstract::Kikuchi's lymphadenitis is a self-limiting condition typically affecting young patients. Surgical biopsy is unnecessary if a firm diagnosis can be rendered by fine-needle aspiration cytology (FNAC). The authors report the FNAC findings for 27 cases, including 24 female and 3 male patients aged 12 to 43 years. Histolog...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.4.454

    authors: Tsang WY,Chan JK

    更新日期:1994-10-01 00:00:00

  • Dual isotope Schilling test for measuring absorption of food-bound and free vitamin B12 simultaneously.

    abstract::A prototype food-bound vitamin B12 (food-B12) absorption test has been developed in which 57Co-B12 was incorporated in vitro into egg yolk (yolk-B12) and served to volunteers in 50-g cooked portions together with toast and coffee for breakfast. Six hours later, 1 mg nonlabeled B12 was given intramuscularly and 24-hour...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.4.490

    authors: Doscherholmen A,Silvis S,McMahon J

    更新日期:1983-10-01 00:00:00

  • Incidental medullary thyroid carcinoma in sporadic hyperparathyroidism. An expansion of the concept of C-cell hyperplasia.

    abstract::Two patients with sporadic primary hyperparathyroidism were found to harbor tiny medullary thyroid carcinomas. In addition, parafollicular-cell hyperplasia was recognized in one of these thyroids by the use of immunoperoxidase stain to localize calcitonin. The possible relationships between these lesions are discussed...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/71.5.595

    authors: Livolsi VA,Feind CR

    更新日期:1979-05-01 00:00:00

  • The detection of platelet antibodies using a modified platelet immunofluorescence test.

    abstract::The development of sensitive immunofluorescent technics for the detection of platelet antibodies has stimulated renewed interest in the field of platelet immunology. However, the analysis of multispecific sera containing both HLA and platelet-specific antibodies requires cumbersome absorption technics and relatively l...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.6.839

    authors: Boisvert A,MacPherson BR

    更新日期:1983-12-01 00:00:00