Abstract:
:The present immunoperoxidase study attempted to localize aldosterone and cortisol in formalin-fixed paraffin-embedded adrenal glands or tumors. Apparently, steroid substances are solubilized during routine tissue processing, and the cytoplasm of adrenal cortical cells is not stained by either antialdosterone or anticortisol antibodies. However, spironolactone bodies react positively with antialdosterone antibody. The presence of aldosterone in the concentric laminations of spironolactone bodies supports the concept that spironolactone bodies are not artifacts. Furthermore, the fact that aldosterone does survive in spironolactone bodies suggests that it is bound in some unusual form. The spironolactone bodies are probably derived from endoplasmic reticulum, and the membranes of endoplasmic reticulum are considered capable of storing steroids. It is likely that during the formation of spironolactone bodies are probably derived from endoplasmic reticulum, and the membranes of endoplasmic reticulum are considered capable of storing steroids. It is likely that during the formation of spironolactone bodies, aldosterone or a few cortisol-like substances are trapped in these laminated concentric bodies.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Hsu SM,Raine L,Martin HFdoi
10.1093/ajcp/75.1.92subject
Has Abstractpub_date
1981-01-01 00:00:00pages
92-5issue
1eissn
0002-9173issn
1943-7722journal_volume
75pub_type
杂志文章abstract::We describe the development and testing of a novel pre-sign-out quality assurance tool for case diagnoses that allows for the random review of a percentage of cases by a second pathologist before case verification and release of the final report. The tool incorporates the ability to record and report levels of diagnos...
journal_title:American journal of clinical pathology
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更新日期:1991-02-01 00:00:00
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pub_type: 杂志文章
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更新日期:1987-09-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1981-06-01 00:00:00
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更新日期:2002-08-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1981-07-01 00:00:00
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更新日期:1997-05-01 00:00:00
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更新日期:2016-05-01 00:00:00
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更新日期:2002-01-01 00:00:00
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更新日期:2010-11-01 00:00:00
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更新日期:1983-11-01 00:00:00
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pub_type: 杂志文章
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更新日期:1983-01-01 00:00:00