Immunocytochemical demonstration of neuron-specific enolase (NSE) in human lung cancers.

Abstract:

:An anti-serum against human neuron-specific enolase (NSE), raised in sheep, has been characterized and used for immunocytochemical localization of NSE in paraffin sections of normal tissues and lung cancers. Of the small cell carcinomas (SCC), 69 out of 99 (70%) cases stained with the anti-serum. Maltreated biopsies showed a lower frequency of positive staining (19/39), indicating the importance of well-preserved biopsies. There was no clear difference in the staining between the oat cell and intermediate cell type of SCC. A majority (14 out of 21) of the non-SCC:s (large cell, adenocarcinoma and squamous cell carcinoma) were also stained by the anti-serum. Generally, this staining was weak and it could be blocked by preabsorption of the anti-serum by purified NSE. It is concluded that NSE expression, in conjunction with traditional histology, serves as a useful but not exclusive marker for SCC.

journal_name

Am J Clin Pathol

authors

Bergh J,Esscher T,Steinholtz L,Nilsson K,Påhlman S

doi

10.1093/ajcp/84.1.1

subject

Has Abstract

pub_date

1985-07-01 00:00:00

pages

1-7

issue

1

eissn

0002-9173

issn

1943-7722

journal_volume

84

pub_type

杂志文章
  • Splenic pathology after traumatic injury.

    abstract::Little is known concerning the pathology of spleens removed for traumatic injury. The authors studied the gross and microscopic features of 44 spleens removed for trauma and received at the Surgical Pathology Division of Parkland Memorial Hospital and 10 normal control spleens from the Medical Examiner's Office, Dalla...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.4.474

    authors: Farhi DC,Ashfaq R

    更新日期:1996-04-01 00:00:00

  • Age-related changes in mitogen-induced lymphocyte function from birth to old age.

    abstract::This study examines the relationship between age and mitogen-induced lymphocyte blastogenesis. Lymphocytes were stimulated with PHA; Concanavalin A (Con A), and PWM in 156 normal, healthy subjects ranging in age from birth to 75 years. The findings indicate a gradual but significant decrease in PHA- and Con A-induced ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.2.159

    authors: Hicks MJ,Jones JF,Thies AC,Weigle KA,Minnich LL

    更新日期:1983-08-01 00:00:00

  • Immunophenotypic variations in mantle cell lymphoma.

    abstract::Mantle cell lymphoma (MCL) expresses pan-B-cell antigens and is usually CD5+/CD10-/CD23-/FMC7+. In this study, we evaluated 52 patients with confirmed diagnoses of MCL and identified variant immunophenotypes in 21 patients (19/48 classical and 2/4 variant MCLs), including CD5- in 6 (12%) of 52, CD10+ in 4 (8%) of 50, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPV8LN5ENMZOVY

    authors: Gao J,Peterson L,Nelson B,Goolsby C,Chen YH

    更新日期:2009-11-01 00:00:00

  • Congenital-infantile fibrosarcoma. A clinicopathologic study of 10 cases and molecular detection of the ETV6-NTRK3 fusion transcripts using paraffin-embedded tissues.

    abstract::Congenital-infantile fibrosarcoma (CIFS) is a relatively indolent sarcoma that should be distinguished from more aggressive spindle cell sarcomas of childhood. CIFSs have been found to have a novel recurrent reciprocal translocation t(12;15)(p13;q25) resulting in the gene fusion ETV6-NTRK3 (ETS variant gene 6; neurotr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3H24-E7T7-V37G-AKKQ

    authors: Sheng WQ,Hisaoka M,Okamoto S,Tanaka A,Meis-Kindblom JM,Kindblom LG,Ishida T,Nojima T,Hashimoto H

    更新日期:2001-03-01 00:00:00

  • Heterogenous expression of endothelial cell markers in infantile hemangioendothelioma. Immunohistochemical study of two solitary cases and one multiple one.

    abstract::Three cases of infantile hemangioendothelioma were immunohistochemically studied with the use of antibodies against von Willebrand factor (vWF), Ulex europaeus I lectin (UEA I), vimentin, thrombomodulin (TM), and actin, as endothelial cell (EC) markers. Because of a broad variety of histologic features, the growth pat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/91.6.673

    authors: Yasunaga C,Sueishi K,Ohgami H,Suita S,Kawanami T

    更新日期:1989-06-01 00:00:00

  • Chronic granulomatous disease with leukocytic glucose-6-phosphate dehydrogenase deficiency in a 28-month-old girl.

    abstract::A 28-month-old girl, whose parents are first cousins, was hospitalized following a series of severe infections. Results of functional granulocytic tests permitted the diagnosis of chronic granulomatous disease (lack of nitroblue tetrazolium dye reduction, impaired bactericidal activity for Staphylococcus aureus but no...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.2.296

    authors: Corberand J,De Larrard B,Vergnes H,Carrière JP

    更新日期:1978-08-01 00:00:00

  • Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining.

    abstract::Fluorescence in situ hybridization (FISH) and immunohistochemical analysis for assessment of HER-2 status in breast carcinomas are discordant in a significant proportion of cases with equivocal (2+) immunostaining. To evaluate the role of intratumoral heterogeneity and degree of amplification, we performed additional ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/J9VX-ABUG-KC4Y-07DL

    authors: Lewis JT,Ketterling RP,Halling KC,Reynolds C,Jenkins RB,Visscher DW

    更新日期:2005-08-01 00:00:00

  • Usefulness of Dual Immunohistochemistry Staining in Detection of Hairy Cell Leukemia in Bone Marrow.

    abstract:OBJECTIVES:We evaluated efficacy of two dual immunohistochemistry (IHC) staining assays in assessing hairy cell leukemia (HCL) involvement in core biopsies and compared the results with concurrently collected flow cytometric data. METHODS:Overall, 148 patients with HCL (123 male, 25 female; mean age: 59.8 years; range...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqz171

    authors: Gupta GK,Sun X,Yuan CM,Stetler-Stevenson M,Kreitman RJ,Maric I

    更新日期:2020-02-08 00:00:00

  • The effects of under 6 hours of formalin fixation on hormone receptor and HER2 expression in invasive breast cancer: a systematic review.

    abstract:OBJECTIVES:A systematic review of the literature was performed to identify whether minimum formalin fixation time may be reduced for reliable immunohistochemical assessment of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2). METHODS:PubMed, EMBASE, and the Cochra...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCP96YDQSTYBXWU

    authors: Kalkman S,Barentsz MW,van Diest PJ

    更新日期:2014-07-01 00:00:00

  • Suppurative granulomatous lymphadenitis caused by corynebacterium ovis (pseudotuberculosis).

    abstract::A 30-year-old previously healthy man developed cervical adenopathy associated with mild constitutional symptoms. Corynebacterium ovis was isolated in pure culture from lymph node tissue on two separate occasions, and small gram positive organisms were identified in both lymph nodes with tissue gram stain. Histopatholo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.4.486

    authors: Goldberger AC,Lipsky BA,Plorde JJ

    更新日期:1981-10-01 00:00:00

  • Glucose stability in lyophilized chemistry quality control serum. A study of data from the quality assurance service (QAS) program of the College of American Pathologists.

    abstract::Data from 2.5 million glucose analyses on pools of lyophilized human quality control serum were used to evaluate analyte stability in the prereconstitution phase. Input information was from laboratories in Regional Quality Control Programs that use CAP Quality Assurance Service (QAS) data processing. Of 31 pools in us...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Lawson NS,Haven GT,DiSilvio TV,Gilmore BF

    更新日期:1982-10-01 00:00:00

  • Critical values in pediatric surgical pathology: definition, implementation, and reporting in a children's hospital.

    abstract::Timely communication of significant or unexpected findings in surgical pathology can significantly improve patient care. Although surgical pathology critical values have been published, no systematic assessment in pediatric surgical pathology has been published. We surveyed pediatric pathologists and pediatric subspec...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/Y5K829U67GVYDWTU

    authors: Coffin CM,Spilker K,Lowichik A,Zhou H,Nielson K,Erickson L,Pysher TJ

    更新日期:2007-12-01 00:00:00

  • Erosive gastritis as a manifestation of secondary syphilis.

    abstract::In a case of secondary syphilis with gastric involvement, the clinical history and roentgenographic and gastroscopic examiniations initially suggested an infiltrative malignant neoplasm. However, macroscopic and histologic examination of the partial gastrectomy specimen demonstrated an erosive, inflammatory lesion. Su...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/63.6.895

    authors: Butz WC,Watts JC,Rosales-Wuintana S,Hicklin MD

    更新日期:1975-06-01 00:00:00

  • Extramammary Paget disease is characterized by the consistent lack of estrogen and progesterone receptors but frequently expresses androgen receptor.

    abstract::Extramammary Paget disease (EPD) is an uncommon cutaneous malignant neoplasm that arises in areas rich in apocrine glands (perineum, vulva, and axilla). Apocrine gland origin or apocrine differentiation of cells of EPD has been suggested. Estrongen, progesterone, and androgen hormone receptors have been reported to ex...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/P756-XXCB-TV71-U4XV

    authors: Diaz de Leon E,Carcangiu ML,Prieto VG,McCue PA,Burchette JL,To G,Norris BA,Kovatich AJ,Sanchez RL,Krigman HR,Gatalica Z

    更新日期:2000-04-01 00:00:00

  • Modified Plasma-Thrombin Method of Cell Block Preparation for Fine-Needle Aspiration Biopsies in Resource-Limited Settings.

    abstract:Objectives:The plasma-thrombin method is commonly used to make cell blocks from fine-needle aspiration (FNA) samples but requires centrifugation. We describe a modification to this method that does not require centrifugation for use in resource-limited settings. Methods:Pooled fresh plasma is aliquoted into 2-mL Eppen...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqy031

    authors: Aisagbonhi O,Birungi A,Atwine R,Behayo P,Ayebaziwe B,Roberts D,Tambouret R

    更新日期:2018-07-03 00:00:00

  • Comparison of eight kits for the diagnosis of pregnancy.

    abstract::The results obtained with eight pregnancy kits on 735 urines were compared. Overall accuracies were similar and fairly high (93.4 to 95.37%), although only 78.28% of all pregnancies were simultaneously detected by all eight kits. It is suggested that the different performances of each kit could be accounted for not on...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.4.452

    authors: Porres JM,D'Ambra C,Lord D,Garrity F

    更新日期:1975-10-01 00:00:00

  • Serum trypsin inhibitory capacity and pi phenotypes. II. Prevalence of alpha1-antitrypsin deficiency in an allergy population.

    abstract::A series of 138 patients seen consecutively in an adult allergy clinic were studied to determine serum alpha1-antitrypsin (alpha1-AT) levels and protease inhibitor (Pi) phenotypes. These were compared with a control group of 700 healthy young adult blood donors. Both total serum trypsin inhibitory capacity (STIC) and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.3.297

    authors: Ihrig J,Schwartz HJ,Rynbrandt DJ,Kleinerman J

    更新日期:1975-09-01 00:00:00

  • ABO blood type and longevity.

    abstract::To assess the observation that blood type B might be a marker for longevity, we reviewed the records and determined the ABO blood types of all patients who died in our hospital in 2004. Age was stratified by decade of death, and linear regressions were calculated by ABO percentage. ABO survival curves were compared. I...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPMIHJ6L3RPHZX

    authors: Brecher ME,Hay SN

    更新日期:2011-01-01 00:00:00

  • Analysis of bacterial detection in whole blood-derived platelets by quantitative glucose testing at a university medical center.

    abstract::After the March 2004 implementation of American Association of Blood Banks standards regarding platelet bacterial detection, we began quantitative glucose screening of whole blood-derived platelets (WB-P). The glucose level was measured immediately before component release--often storage day 4 or 5--using the Glucomet...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPVN9OT4GRCSKO

    authors: McKane AV,Ward N,Senn C,Eubanks J,Wessels L,Bowman R

    更新日期:2009-04-01 00:00:00

  • The risk of metachronous neoplasia in patients with serrated adenoma.

    abstract::Serrated adenomas are the precursors of at least 5.8% of colorectal cancers; otherwise little is known of their clinical significance in comparison with conventional adenomas and hyperplastic polyps. We compared the risk of metachronous lesions in colorectal serrated adenomas, conventional adenomas, and hyperplastic p...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/VBAG-V3BR-96N2-EQTR

    authors: Lazarus R,Junttila OE,Karttunen TJ,Mäkinen MJ

    更新日期:2005-03-01 00:00:00

  • Theory and applications of the polymerase chain reaction.

    abstract::The polymerase chain reaction (PCR) is a newly developed molecular biology technique that can significantly amplify DNA or RNA. The process consists of repetitive cycles of specific DNA synthesis, defined by short stretches of preselected DNA. With each cycle, there is a doubling of the final, desired DNA product such...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Remick DG,Kunkel SL,Holbrook EA,Hanson CA

    更新日期:1990-04-01 00:00:00

  • Measuring direct thrombin inhibitors with routine and dedicated coagulation assays: which assay is helpful?

    abstract::The use of direct thrombin inhibitors (DTIs) for prophylactic or therapeutic anticoagulation is increasing because of the predictable bioavailability and short half-life of these DTIs. However, in certain situations, indication of the concentration is warranted. We investigated the effects of 3 DTIs (lepirudin, argatr...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPQOD9WFPEYY0H

    authors: Curvers J,van de Kerkhof D,Stroobants AK,van den Dool EJ,Scharnhorst V

    更新日期:2012-10-01 00:00:00

  • Evaluation of a Digene-recommended algorithm for human papillomavirus low-positive results present in a "retest zone".

    abstract::The Digene Hybrid Capture 2 (hc2) high-risk human papillomavirus (HPV) DNA test (Digene, Gaithersburg, MD) is widely used for triage of women with atypical squamous cells of undetermined significance. Results in a "retest zone" (weakly positive tests) are repeated up to 2 times according to the Digene-recommended algo...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/4WCPTUV506HLP06P

    authors: Muldrew KL,Beqaj SH,Han J,Lum SH,Clinard V,Schultenover SJ,Tang YW

    更新日期:2007-01-01 00:00:00

  • Primary osteosarcoma of bone. Clinicopathologic investigation of 243 cases, with necropsy studies in 54.

    abstract::Two hundred forty-three patients who had pathologically verified primary osteosarcomas of bone, treated at The University of Texas System Cancer Center, M. D. Anderson Hospital and Tumor Institute over a 24-year period, form the basis of this study. These cases provide a basis for comparison of those patients currentl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/67.5.427

    authors: Uribe-Botero G,Russell WO,Sutow WW,Martin RG

    更新日期:1977-05-01 00:00:00

  • Tinea Pedis caused by Trichophyton violaceum.

    abstract::This, to authors' knowledge, is the first report in the United States of Tinea pedis caused by Trichophyton violaceum in a recent Southeast Asian immigrant. Because of the recent entry into this country of refugees from an area of the world where T. violaceum is endemic, this anthropophilic dermatophyte may become a s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.1.110

    authors: Fusaro RM,Miller NG,Kelly D

    更新日期:1983-07-01 00:00:00

  • Comparison of complement fixation and fluorescent immunoassay (FIAX) for measuring antibodies to cytomegalovirus and herpes simplex virus.

    abstract::An automated fluorescent immunoassay system (FIAX) was compared with complement fixation (CF) for measuring antibodies to cytomegalovirus (CMV) and herpes simplex virus (HSV) in clinical specimens. Compared with CF the specificity of FIAX (ability to detect a negative titer) was 95% for CMV and 92% for HSV. The sensit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.3.305

    authors: Friedman HM,Tustin NB,Hitchings MM,Plotkin SA

    更新日期:1981-09-01 00:00:00

  • Forty Postmortem Examinations in COVID-19 Patients.

    abstract:OBJECTIVES:Although diffuse alveolar damage, a subtype of acute lung injury (ALI), is the most common microscopic pattern in coronavirus disease 2019 (COVID-19), other pathologic patterns have been described. The aim of the study was to review autopsies from COVID-19 decedents to evaluate the spectrum of pathology and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa156

    authors: De Michele S,Sun Y,Yilmaz MM,Katsyv I,Salvatore M,Dzierba AL,Marboe CC,Brodie D,Patel NM,Garcia CK,Saqi A

    更新日期:2020-11-04 00:00:00

  • Results of multiparameter studies of T-cell lymphoid neoplasms.

    abstract::By application of combined structural and functional analyses, most lymphoid neoplasms may be categorized as of T- or B-cell origin. T lymphocyte neoplasms include types of acute and chronic lymphocytic leukemias, certain cutaneous and node-based lymphomas, and lymphomas of thymocytes (convoluted lymphocytic lymphomas...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Collins RD,Waldron JA,Glick AD

    更新日期:1979-10-01 00:00:00

  • Immunohistochemical characterization of renal amyloidosis.

    abstract::Forty-five renal biopsies with amyloidosis were studied by light microscopy with Congo red staining and action of potassium permanganate and by immunofluorescence with antihuman tissue A component antiserum antilight and heavy chains of immunoglobulins antisera. The patients were classified on the basis of concordance...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/87.6.756

    authors: Noel LH,Droz D,Ganeval D

    更新日期:1987-06-01 00:00:00

  • E-cadherin status in breast cancer correlates with histologic type but does not correlate with established prognostic parameters.

    abstract::Our objective was to assess the loss of E-cadherin (EC) as a diagnostic marker or a predictor of prognosis. We stained 276 breast carcinomas with monoclonal antibodies to EC (invasive lobular carcinomas [ILC] and variants, 59; invasive ductal carcinoma and ductal special types [IDC], 204; tubulolobular carcinoma [TLC]...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Qureshi HS,Linden MD,Divine G,Raju UB

    更新日期:2006-03-01 00:00:00