Analysis of intratumoral heterogeneity and amplification status in breast carcinomas with equivocal (2+) HER-2 immunostaining.

abstract：OBJECTIVES:Peritoneal mesothelial cysts have been reported under various terms, including benign cystic mesothelioma, usually in the form of case reports/series, whereas extraperitoneal cases are rarely reported. Our objective was to report the detailed characteristics of cystic lesions of the serosal cavities. METHOD...

journal_title：American journal of clinical pathology

authors： Karpathiou G,Casteillo F,Dridi M,Peoc'h M

更新日期：2020-12-01 00:00:00

abstract：OBJECTIVES:To investigate the prognostic utility of multifocal extraprostatic extension (EPE) on biochemical recurrence after radical prostatectomy. METHODS:We conducted retrospective analysis of biochemical recurrence and prognostic pathologic variables in 673 men with stage pT3a/pT3b prostate cancer from 2000 to 201...

journal_title：American journal of clinical pathology

authors： Farchoukh L,Laframboise WA,Nelson JB,Bastacky S,Parwani AV,Dhir R

更新日期：2020-03-09 00:00:00

abstract：:Previous studies suggest that low prostate weight is a significant negative prognostic factor for prostate cancer. In the current study, the data for 431 men who underwent radical retropubic prostatectomy between 1990 and 1998 were analyzed for association between prostate weight and various clinical and pathologic pa...

journal_title：American journal of clinical pathology

authors： Davidson DD,Koch MO,Lin H,Jones TD,Biermann K,Cheng L

更新日期：2010-04-01 00:00:00

abstract：:Acute myeloid leukemia (AML) with normal cytogenetics represents approximately 40% to 50% of de novo AML. This heterogeneous AML subgroup constitutes the single largest cytogenetic group with an intermediate prognosis. Previous studies have suggested that the Fms-like tyrosine kinase-3 internal tandem duplication (FLT...

journal_title：American journal of clinical pathology

authors： Rausei-Mills V,Chang KL,Gaal KK,Weiss LM,Huang Q

更新日期：2008-04-01 00:00:00

abstract：OBJECTIVES:Superficial pleomorphic liposarcoma (PL) has a favorable prognosis compared to deeply seated PL. Given developments in the classification of lipomatous neoplasms, we reappraised a series of cases. METHODS:Retrospective clinicopathologic evaluation and genome-wide single-nucleotide polymorphism (SNP) microar...

journal_title：American journal of clinical pathology

authors： Berg SH,Massoud CM,Jackson-Cook C,Boikos SA,Smith SC,Mochel MC

更新日期：2020-08-05 00:00:00

abstract：:Whipple disease is a rare, chronic multisystem disease associated with the recently characterized organism Tropheryma whippelii. Extraintestinal manifestation involving the central nervous system, heart, and joints occasionally occurs. Involvement of the abdominal lymph nodes, especially the mesenteric and periaortic ...

journal_title：American journal of clinical pathology

authors： Alkan S,Beals TF,Schnitzer B

更新日期：2001-12-01 00:00:00

abstract：:Peliosis of the spleen was found in 10 out of 1,200 cases autopsied from 1977 through 1980 in our laboratory. Eight such cases had no peliosis of the liver. Histologically, it was noticed that the parafollicular areas were the most common sites of the lesions, and this feature seemed to be important for the histologic...

journal_title：American journal of clinical pathology

authors： Tada T,Wakabayashi T,Kishimoto H

更新日期：1983-06-01 00:00:00

abstract：OBJECTIVES:To characterize error rates for genetic test orders between medical specialties and in different settings by examining detailed order information. METHODS:We performed a retrospective analysis of a detailed utilization management case database, comprising 2.5 years of data and almost 1,400 genetic test orde...

journal_title：American journal of clinical pathology

authors： Mathias PC,Conta JH,Konnick EQ,Sternen DL,Stasi SM,Cole BL,Astion ML,Dickerson JA

更新日期：2016-08-01 00:00:00

abstract：:Bleeding problems are symptomatic of platelet delta-storage pool diseases (SPDs) such as Hermansky-Pudlak syndrome. Although at present no cure is available for delta-SPD, early diagnosis is of great importance for prophylactic and supportive treatment. This study tested the usefulness of a flow cytometric assay for p...

journal_title：American journal of clinical pathology

authors： Maurer-Spurej E,Pittendreigh C,Wu JK

更新日期：2007-04-01 00:00:00

abstract：:We studied the expression of cytokeratin (CK) 7, CK20, CDX-2, and p16 in 119 cervical adenocarcinomas (65 usual type [50 invasive; 15 in situ], 37 intestinal type [21 invasive; 16 in situ], 10 endometrioid, 5 adenosquamous, and 2 signet-ring carcinomas) in comparison with 55 cases of rectal adenocarcinomas. The percen...

journal_title：American journal of clinical pathology

authors： Saad RS,Ismiil N,Dubé V,Nofech-Mozes S,Khalifa MA

更新日期：2009-10-01 00:00:00

abstract：:The authors report the use of cardiac troponin I (cTnI) for the early, noninvasive determination of coronary reperfusion following thrombolytic therapy. Cardiac troponin I, creatine kinase (CK)-MB, and myoglobin concentrations were measured in early serum specimens at 30, 60, and 90 minutes after initiation of therapy...

journal_title：American journal of clinical pathology

authors： Apple FS,Henry TD,Berger CR,Landt YA

更新日期：1996-01-01 00:00:00

abstract：:The characteristics of the normal adult thymus in both sexes were determined in 50 cases of accidental death by a simplified quantitative histologic technic. A table of normal values derived from these findings was used for making comparisons with thymus from autopsies of 50 additional patients suffering terminal illn...

journal_title：American journal of clinical pathology

authors： Smith SM,Ossa-Gomez LJ

更新日期：1981-11-01 00:00:00

abstract：:Hyperparathyroidism may occasionally present as a neck mass resulting from cystic change in a parathyroid adenoma. We report an unusual instance of hyperparathyroidism presenting as a palpable, but asymptomatic hyperplastic parathyroid gland cyst. We conclude that hyperplastic parathyroid glands may undergo cystic deg...

journal_title：American journal of clinical pathology

authors： Fallon MD,Haines JW,Teitelbaum SL

更新日期：1982-01-01 00:00:00

abstract：:Patients with chronic renal failure (CRF) are at increased risk for myocardial events that are difficult to evaluate due to atypical symptoms and chronically elevated protein markers of cardiac damage. This study evaluated cardiac troponin T (cTnT), a sensitive marker of cardiac injury, in patients with CRF without my...

journal_title：American journal of clinical pathology

authors： Frankel WL,Herold DA,Ziegler TW,Fitzgerald RL

更新日期：1996-07-01 00:00:00

abstract：:The development of chemoresistance in a variety of cancers seems related to overexpression of the P-glycoprotein (P-gp) drug pump. Nephroblastoma, the most common malignant renal tumor of childhood, usually is responsive to treatment, and prognosis is favorable in most cases. However, the disease in a subset of patien...

journal_title：American journal of clinical pathology

authors： Camassei FD,Arancia G,Cianfriglia M,Bosman C,Francalanci P,Ravà L,Jenkner A,Donfrancesco A,Boldrini R

更新日期：2002-03-01 00:00:00

abstract：:The participant performances on the College of American Pathologists (CAP) Urine Survey specimens distributed during 1979 and 1980 for pregnancy testing are reviewed. Almost all the reagent methods used by the participants performed well on the negative specimens. Prominent differences in results on the positive speci...

journal_title：American journal of clinical pathology

authors： Biesecker JL,Rippey JH

更新日期：1981-10-01 00:00:00

abstract：:In the absence of clinical signs, elevated values of the cardiac isoforms of troponin T (cTnT) and I (cTnI) can be found in the serum samples of some patients with skeletal muscle myopathies; the cause is unclear. We studied the messenger RNA (mRNA) expression of cTnT and cTnI in the skeletal muscles of 24 patients wi...

journal_title：American journal of clinical pathology

authors： Messner B,Baum H,Fischer P,Quasthoff S,Neumeier D

更新日期：2000-10-01 00:00:00

abstract：:Therapeutic control achieved by an anticoagulant clinic may be assessed by calculation of the proportion of time spent by the patients within the prothrombin time target range aimed for by the clinic. Three calculation methods for such assessment have been described by other investigators. The three methods were compa...

journal_title：American journal of clinical pathology

authors： van den Besselaar AM,van der Meer FJ,Gerrits-Drabbe CW

更新日期：1988-12-01 00:00:00

abstract：:Because of the unusual presentation of pernicious anemia in many black women, a further characterization of this disease among the different racial groups was undertaken. The following were found. (1) Black women under the age of 50 years had a significantly lower prevalence of anti-parietal cell antibody than did "Eu...

journal_title：American journal of clinical pathology

authors： Carmel R,Ozturk G,Johnson CS,Tung KS,Terasaki PI

更新日期：1981-03-01 00:00:00

abstract：:Urine myoglobin concentrations are measured clinically to assess rhabdomyolysis and the related risk of renal damage. We studied urine myoglobin concentrations in vitro to explore the factors affecting stability. Myoglobin was very unstable in urine specimens, especially below pH 6.5, and its immunoreactivity deterior...

journal_title：American journal of clinical pathology

authors： Chen-Levy Z,Wener MH,Toivola B,Daum P,Reyes M,Fine JS

更新日期：2005-03-01 00:00:00

abstract：:The cytopathologic findings of 196 cases of cancer of the breast were correlated with the hormonal receptor levels. The strict cytologic criteria that allow a positive diagnosis to be used as bases for definitive treatment include adequate cellularity, lack of cohesion, and nuclear abnormalities, including increased n...

journal_title：American journal of clinical pathology

authors： Kern WH

更新日期：1982-12-01 00:00:00

abstract：:Annual ampicillin susceptibility rates for Haemophilus influenzae isolates at the St. Paul-Ramsey Medical Center gradually decreased from 100% in 1974 to 83.3% in 1980 and then remained stable at 88.90%. Penicillin susceptibility rates were similar to those for ampicillin. Ampicillin rates were source dependent: eye 9...

journal_title：American journal of clinical pathology

authors： Woolfrey BF,Lally RT,Ireland GK,Quall CO,Ederer MN

更新日期：1984-09-01 00:00:00

abstract：:Two monoclonal antibodies, UCD/AB 6.11 and UCD/PR 10.11, were evaluated for their patterns of immunohistochemical reactivity in a survey of paraffin-embedded human tissues by the avidin-biotin-immunoperoxidase technique. By two-dimensional immunoblotting, UCD/AB 6.11 reacts with keratin number 18 and UCD/PR 10.11 iden...

journal_title：American journal of clinical pathology

authors： Chan R,Edwards BF,Hu R,Rossitto PV,Min BH,Lund JK,Cardiff RD

更新日期：1988-04-01 00:00:00

abstract：:The measurement of beta-thromboglobulin (BTG) and platelet lactic dehydrogenase (LDH) as markers for alpha-granule release and platelet lysis, respectively, has been reported to correlate with the amount of damage incurred during the preparation and storage of platelet concentrates. We compared the concentrations of t...

journal_title：American journal of clinical pathology

authors： Kalmin ND,Wilson MJ,Liles BA

更新日期：1983-06-01 00:00:00

abstract：:Cellular and humoral immunity combine to determine the outcome following exposure to hepatitis virus and are implicated in the proposed pathogenetic mechanism for acute and chronic hepatitis. Although antibody to HBsAg is found in virtually all following recovery from hepatitis B, a cell-mediated response to HBsAg can...

journal_title：American journal of clinical pathology

authors： Lee WM

更新日期：1976-05-01 00:00:00

abstract：:Allergic adenoiditis is defined as the presence of numerous brightly fluorescent IgE mast cells (FIEMC) demonstrated in formalin-fixed adenoid tissue by the trypsin-immunofluorescent method. A prospective study of 606 routinely accessioned cases seen during a 39-month period revealed 98 positive cases. Correlation wit...

journal_title：American journal of clinical pathology

authors： Loesel LS

更新日期：1984-02-01 00:00:00

abstract：:Hepatitis C virus (HCV) infection may be complicated by non-Hodgkin's lymphoma. We describe eight cases of B-cell extranodal non-Hodgkin's lymphoma occurring during the course of chronic HCV-related hepatic disease (low-grade of mucosa-associated lymphoid tissue [MALT]-type; diffuse large cell; Burkitt; diffuse small ...

journal_title：American journal of clinical pathology

authors： Ascoli V,Lo Coco F,Artini M,Levrero M,Martelli M,Negro F

更新日期：1998-05-01 00:00:00

abstract：:The authors quantified creatine kinase MB (CK-MB) isoenzyme activity and mass in the serum of 81 uremic and 20 nonuremic (control) patients who had no clinical or electrocardiographic evidence of acute myocardial infarction. CK-MB was quantified by three methods: electrophoresis, the QuiCK-MB (International Immunoassa...

journal_title：American journal of clinical pathology

authors： Medeiros LJ,Schotte D,Gerson B

更新日期：1987-01-01 00:00:00

abstract：:Giant lymph node hyperplasia is uncommon in children and is exceptionally rare in infancy. The authors report a case of giant lymph node hyperplasia that presented as a right supraclavicular mass in an asymptomatic two-month-old female infant. Clinically, the mass was thought to be either a lipoma or a cystic hygroma,...

journal_title：American journal of clinical pathology

authors： Hunt SJ,Anderson WD

更新日期：1989-03-01 00:00:00

abstract：:Three policies for decreasing unnecessary cerebrospinal fluid (CSF) management Venereal Disease Research Laboratory (VDRL) tests were compared. The first policy attempted to educate physicians about the use of serologic tests for diagnosing neurosyphilis but allowed the CSF VDRL to be performed either as a screening t...

journal_title：American journal of clinical pathology

authors： Albright RE Jr,Christenson RH,Emlet JL,Graham CB 3rd,Estevez EG,Wilson ML,Reller LB,Schneider KA

更新日期：1991-03-01 00:00:00