Abstract:
:In the absence of clinical signs, elevated values of the cardiac isoforms of troponin T (cTnT) and I (cTnI) can be found in the serum samples of some patients with skeletal muscle myopathies; the cause is unclear. We studied the messenger RNA (mRNA) expression of cTnT and cTnI in the skeletal muscles of 24 patients with histologically proven myopathies and in 18 patients in whom a myopathy could be excluded. For cTnT- and cTnI-mRNA determination, we designed specific primer pairs for nested polymerase chain reaction. After amplification, the products were digested with 2 restriction enzymes and visualized. We found cTnT mRNA in 7 skeletal muscle biopsy specimens (6 patients with Duchenne muscular dystrophy, 1 patient with a primary sarcoglycanopathy) and cTnI mRNA in 6 (5 with Duchenne muscular dystrophy, 1 patient with a histologically negative biopsy). The mRNA of the cardiac isoforms, cTnT and cTnI, is expressed in the skeletal muscles of patients with Duchenne muscular dystrophy, but also in some other myopathies. Further studies are needed to show whether the mRNA is translated into the protein, but serum levels of cTnT and cTnI in patients with Duchenne muscular dystrophy would seem to indicate this.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Messner B,Baum H,Fischer P,Quasthoff S,Neumeier Dsubject
Has Abstractpub_date
2000-10-01 00:00:00pages
544-9issue
4eissn
0002-9173issn
1943-7722journal_volume
114pub_type
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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abstract:OBJECTIVES:Mucinous cystic neoplasm of the liver is characterized by neoplastic mucinous and/or biliary epithelium surrounded by ovarian-type stroma. Immunohistochemical studies have shown that the ovarian-type stroma expresses estrogen receptor, suggesting potential hormonal responsiveness. The molecular biology of mu...
journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:2008-12-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1980-04-01 00:00:00
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更新日期:1980-01-01 00:00:00
abstract::The Philadelphia chromosome (Ph) is found in most chronic myelogenous leukemia (CML) patients. The bcr-abl oncoprotein (P210 or P185), the product of the fused bcr-abl gene produced by the Ph, is known to be the major factor in initiation and maintenance of the leukemic state in these types of leukemias. The authors h...
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更新日期:1996-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1992-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1992-03-01 00:00:00
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doi:10.1093/ajcp/aqy020
更新日期:2018-05-31 00:00:00
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journal_title:American journal of clinical pathology
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doi:
更新日期:1990-10-01 00:00:00
abstract::Pathologists are expected to accurately diagnose increasingly smaller breast carcinomas. Correct classification (ie, lobular vs ductal or in situ vs invasive) directly affects subsequent management, especially when the focus is near a surgical margin or present in a needle core biopsy and is further challenging if the...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
doi:10.1309/AJCPF4O0ADKFMGRJ
更新日期:2013-01-01 00:00:00
abstract::During a 6-month period at Walter Reed Army Hospital the monthly attack rate of Staphylococcus aureus bacteremia increased to 3.8 +/- 0.5 (mean +/- SEM) from 2.5 +/- 0.2 cases per 1,000 dispositions for the previous 48 months (P less than 0.05). A predominant phage pattern, designated S, was found in 12 (39%) of 31 ba...
journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1983-05-01 00:00:00
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:1975-10-01 00:00:00
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更新日期:2016-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2019-06-05 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1995-10-01 00:00:00
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更新日期:1996-03-01 00:00:00
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更新日期:1977-03-01 00:00:00