Immunohistochemical characterization of renal amyloidosis.

Abstract:

:Forty-five renal biopsies with amyloidosis were studied by light microscopy with Congo red staining and action of potassium permanganate and by immunofluorescence with antihuman tissue A component antiserum antilight and heavy chains of immunoglobulins antisera. The patients were classified on the basis of concordance between immunohistochemical characterization by immunofluorescence and the results of Congo red staining after potassium permanganate treatment. Thus, 37 of 45 cases (82%) were classified by immunohistochemical characterization (15 with AL amyloidosis and 22 with AA amyloidosis) when the amyloid type could be hypothetized in only 31 of these cases (66%) on the basis of clinical criteria. This study suggests that the association of these two technics is more reliable than clinical data alone in distinguishing between AA and AL amyloidosis.

journal_name

Am J Clin Pathol

authors

Noel LH,Droz D,Ganeval D

doi

10.1093/ajcp/87.6.756

subject

Has Abstract

pub_date

1987-06-01 00:00:00

pages

756-61

issue

6

eissn

0002-9173

issn

1943-7722

journal_volume

87

pub_type

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