Profiles of black and Latin-American patients having pernicious anemia. HLA antigens, lymphocytotoxic antibody, anti-parietal cell antibody serum gastrin levels, and ABO blood groups.

Abstract:

:Because of the unusual presentation of pernicious anemia in many black women, a further characterization of this disease among the different racial groups was undertaken. The following were found. (1) Black women under the age of 50 years had a significantly lower prevalence of anti-parietal cell antibody than did "European" and Latin-American patients or even older black women. The disease in the younger black women resembles juvenile pernicious anemia in this respect. Blacks in general had a lower prevalence of anti-parietal cell antibody than did "Europeans" and Latin Americans, though the difference was not statistically significant. A particularly striking finding was that anti-parietal cell antibody occurred much less often than anti-intrinsic factor antibody among black patients. (2) An analysis of all published HLA data for patients of European origin indicated a weak association of pernicious anemia with HLA-B7. However, no antigen association among the black and Latin-American patients studied was found. HLA-DR typing, not previously reported even for whites, also showed no association. (3) Lymphocytotoxic antibody was equally increased in frequency in all racial groups. (4) Serum gastrin levels did not follow a racial pattern; however, women with pernicious anemia had much higher levels than did men. (5) Pernicious anemia was not associated with blood group A.

journal_name

Am J Clin Pathol

authors

Carmel R,Ozturk G,Johnson CS,Tung KS,Terasaki PI

doi

10.1093/ajcp/75.3.291

subject

Has Abstract

pub_date

1981-03-01 00:00:00

pages

291-6

issue

3

eissn

0002-9173

issn

1943-7722

journal_volume

75

pub_type

杂志文章
  • Ectopic poorly differentiated (insular) carcinoma of the thyroid. Report of a case presenting as an anterior mediastinal mass.

    abstract::A case is presented of an anterior mediastinal mass arising in a 64-year-old woman that showed on histologic, immunopathologic, and ultra-structural examination features of a poorly differentiated (insular) thyroid carcinoma. The tumor in this patient most likely arose from ectopically displaced thyroid tissue on the ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/104.4.408

    authors: Dominguez-Malagon H,Guerrero-Medrano J,Suster S

    更新日期:1995-10-01 00:00:00

  • A rapid point-of-care cardiac marker testing strategy facilitates the rapid diagnosis and management of chest pain patients in the emergency department.

    abstract::We compared a rapid, point-of-care multimarker protocol with a single and serial troponin I (TnI)-only protocol in 5,244 patients admitted to the emergency department with chest pain. The diagnosis of acute myocardial infarction (AMI) was based on a doubling myoglobin level accompanied by at least a 50% increase in th...

    journal_title:American journal of clinical pathology

    pub_type: 临床试验,杂志文章,多中心研究

    doi:10.1309/9GGNMURLJWJD88W3

    authors: Straface AL,Myers JH,Kirchick HJ,Blick KE

    更新日期:2008-05-01 00:00:00

  • Analysis of bacterial detection in whole blood-derived platelets by quantitative glucose testing at a university medical center.

    abstract::After the March 2004 implementation of American Association of Blood Banks standards regarding platelet bacterial detection, we began quantitative glucose screening of whole blood-derived platelets (WB-P). The glucose level was measured immediately before component release--often storage day 4 or 5--using the Glucomet...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPVN9OT4GRCSKO

    authors: McKane AV,Ward N,Senn C,Eubanks J,Wessels L,Bowman R

    更新日期:2009-04-01 00:00:00

  • Evaluation of a semiautomated micro-broth dilution system for determing minimum inhibitory concentrations of antimicrobics.

    abstract::This study investigates the dispensing and inoculating characteristics of the MIC-2000 micro-broth dilution system and compares its ability to determine minimum inhibitory concentrations with that of the reference macro-broth dilution method. Micro-well filling showed a coefficient of variation of 6.8%, and micro-well...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.3.374

    authors: Woolfrey BF,Ramadei WA,Quall CO

    更新日期:1980-03-01 00:00:00

  • Comparison of disagreement and amendment rates by tissue type and diagnosis: identifying cases for directed blinded review.

    abstract::We sought to determine whether a group of cases that was relatively high in disagreements and subsequent amendments could be identified and targeted for blinded review. During a 4-year period, 8,916 surgical pathology and nongynecologic cytology cases were subjected to blinded review; of these, there were 616 disagree...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/DH4U-0KT6-QB01-KR55

    authors: Renshaw AA,Gould EW

    更新日期:2006-11-01 00:00:00

  • In vitro assessment of platelet damage during rotator storage.

    abstract::The measurement of beta-thromboglobulin (BTG) and platelet lactic dehydrogenase (LDH) as markers for alpha-granule release and platelet lysis, respectively, has been reported to correlate with the amount of damage incurred during the preparation and storage of platelet concentrates. We compared the concentrations of t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/79.6.719

    authors: Kalmin ND,Wilson MJ,Liles BA

    更新日期:1983-06-01 00:00:00

  • Bladder Cancer Involving Smooth Muscle of Indeterminate Type or Muscularis Mucosae in Transurethral Biopsy Specimens.

    abstract:OBJECTIVES:Bladder cancers invading the muscularis mucosae (MM) are treated differently from those invading the muscularis propria (MP). However, it may be difficult to determine the type of smooth muscle in transurethral resection (TUR) or biopsy specimens. We aimed to investigate the clinicopathologic features of bla...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa030

    authors: Hwang MJ,Kamat AM,Dinney CP,Czerniak B,Guo CC

    更新日期:2020-07-07 00:00:00

  • Improving patient safety by repeating (read-back) telephone reports of critical information.

    abstract::Reducing the rate of avoidable errors is crucial to patient safety. Telephone calls with misunderstood critical results constitute one area in which opportunities for improvement exist. The aviation industry has dealt with this issue by requiring pilots to repeat instructions received from the air traffic controller. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/9DYM-6R0T-M830-U95Q

    authors: Barenfanger J,Sautter RL,Lang DL,Collins SM,Hacek DM,Peterson LR

    更新日期:2004-06-01 00:00:00

  • EDTA Treatment of Serum Unmasks Complement-Mediated Prozone Inhibition in Human Leukocyte Antigen Antibody Testing.

    abstract:OBJECTIVES:Luminex-based single-antigen bead human leukocyte antigen (HLA) antibody testing is widely used to define HLA antibodies for transplant compatibility. False-negative results can occur with complement-mediated prozone inhibition. This study assessed the effect of EDTA on the assay background reactivity and fl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw116

    authors: Anani WQ,Zeevi A,Lunz JG

    更新日期:2016-09-01 00:00:00

  • A rapid paper-disc test for penicillinase.

    abstract::A practical acidimetric assay for penicillinase production using penicillin and phenol red impregnated in paper discs was developed. Blank discs were first impregnated with buffered penicillin G and, after drying, with 1% phenol red. For use, a disc was added to a bacterial suspension made in saline solution. A yellow...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.4.557

    authors: Tu KK,Jorgensen JH,Stratton CW

    更新日期:1981-04-01 00:00:00

  • Clinical comparison of immunoradiometric assays for intact versus beta-specific human chorionic gonadotropin.

    abstract::Monoclonal immunoradiometric assays (IRMA) for human chorionic gonadotropin (hCG) are available for either intact hCG (IhCG) or beta subunit hCG (beta hCG). The authors evaluated the clinical applications of both methods. Serum samples (N = 180) were divided into the following five clinical groups: Group 1: elevated l...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/93.3.347

    authors: Pardue MG,Taylor EH,London S,Walls RC,Pappas AA

    更新日期:1990-03-01 00:00:00

  • Effects of cigarette smoking on intramyocardial arteries and arterioles in man.

    abstract::Proliferative lesions, which include collagen, elastic fibers and abnormally oriented muscle fibers, were found to develop in intramyocardial arteries more rapidly with age in cigarette smokers than in nonsmokers. The study attempted to determine whether these lesions reduce perfusion pressures in the subendocardial z...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/68.4.493

    authors: Naeye RL,Truong LD

    更新日期:1977-10-01 00:00:00

  • T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group.

    abstract:Objective:T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods:We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,多中心研究

    doi:10.1093/ajcp/aqx146

    authors: Goyal T,Thakral B,Wang SA,Bueso-Ramos CE,Shi M,Jevremovic D,Morice WG,Zhang QY,George TI,Foucar KK,Bhattacharyya S,Bagg A,Rogers HJ,Bodo J,Durkin L,Hsi ED

    更新日期:2018-01-29 00:00:00

  • Mucocele-like tumors of the breast. Cytologic findings in two cases.

    abstract::Mucocele-like tumors of the breast originally were reported by Rosen in 1986 as benign lesions that histologically resembled colloid carcinoma of the breast. The authors document two cases of mucocele-like tumors to illustrate the difficulty in separating these lesions from colloid carcinoma on the basis of fine-needl...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.6.875

    authors: Bhargava V,Miller TR,Cohen MB

    更新日期:1991-06-01 00:00:00

  • Biclonal chronic lymphocytic leukemia.

    abstract::Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/V8AN-A2XP-7TDV-HR0T

    authors: Hsi ED,Hoeltge G,Tubbs RR

    更新日期:2000-06-01 00:00:00

  • Band neutrophil counts are unnecessary for the diagnosis of infection in patients with normal total leukocyte counts.

    abstract::The authors have assessed the clinical value of an "accurate" band count as a correlate to infection in 33 patients with a culture proven bacterial infection and a normal total leukocyte count. Thirty hematologically normal outpatients, presumably with no infections, were selected for the control group. Manual 500 cel...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.5.646

    authors: Ardron MJ,Westengard JC,Dutcher TF

    更新日期:1994-11-01 00:00:00

  • Detection of circulating T-activating enzyme in the serum of a patient having hemolytic-uremic syndrome and disseminated intravascular coagulation.

    abstract::A three-and-a-half-year old boy suffering from streptococcal pneumonia developed hemolytic-uremic syndrome and disseminated intravascular coagulation (DIC). His red blood cells (RBC) were shown to be T- and Tk-activated; serial testing showed his mature RBCs as well as neocytes remained T-activated at 40 days. Anti-T ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.2.244

    authors: Beattie KM,Lewis PE,Briski JE,Strauch BM

    更新日期:1985-08-01 00:00:00

  • Detection of immunophenotypic abnormalities in paraffin-embedded B-lineage non-Hodgkin's lymphomas.

    abstract::The authors analyzed the frequency of immunophenotypic abnormalities in 1,474 cases of routinely fixed, paraffin-embedded B-lineage non-Hodgkin's lymphomas. B-lineage was determined by immunoreactivity for CD20 (L26, 92%); CD45RA (4KB5, an additional 3%) or immunoglobulin (Ig) light chain restriction (remaining 5%). C...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.6.825

    authors: Gelb AB,Rouse RV,Dorfman RF,Warnke RA

    更新日期:1994-12-01 00:00:00

  • A primer on the cost of quality for improvement of laboratory and pathology specimen processes.

    abstract::In today's environment, many laboratories and pathology practices are challenged to maintain or increase their quality while simultaneously lowering their overall costs. The cost of improving specimen processes is related to quality, and we demonstrate that actual costs can be reduced by designing "quality at the sour...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPSMQYAF6X1HUT

    authors: Carlson RO,Amirahmadi F,Hernandez JS

    更新日期:2012-09-01 00:00:00

  • Serum concentrations of allergen-specific IgG antibodies in inhalant allergy: effect of specific immunotherapy.

    abstract::The occurrence of antibodies belonging to IgG class of immunoglobulins with specificity for short ragweed and Bermuda grass in the sera of nonatopic subjects and patients with inhalant allergy (at the time of initial diagnosis, following specific immunotherapy was investigated with an enzyme immunoassay. The intra-ass...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.3.290

    authors: Ali M,Ramanarayanan MP,Nalebuff DJ,Fadal RG,Willoughby JW

    更新日期:1983-09-01 00:00:00

  • Assessment of cervicovaginal smear adequacy. The Bethesda System guidelines and reproducibility.

    abstract::Criteria for assessing adequacy of cervicovaginal smears according to the Bethesda System include cellular composition and quantity, specimen preservation, fixation, and absence of obscuring elements. The reproducibility of adequacy assessment using these parameters was the focus of this study. Specimens were chosen t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.3.354

    authors: Spires SE,Banks ER,Weeks JA,Banks HW,Davey DD

    更新日期:1994-09-01 00:00:00

  • Comparison of two slide tests for detection of group A streptococcal antibodies.

    abstract::Screening sera for streptococcal antibodies is a useful clinical procedure when recent streptococcal infection requires verification. Presently there are two test kits available that detect five (or more) of the antibodies that may be present. These two screening tests were compared using antistreptolysin O (ASO) and ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.2.218

    authors: Tolliver PR,Roe MH

    更新日期:1979-08-01 00:00:00

  • Impersonal medical care. Role of the pathologist in its evolution.

    abstract::An evaluation of the change in the former close relationship between the patient and his physician, and the contribution of the pathologist to its development, is presented. The effect of these changes on the interest in and care of the patient by all in the hospital in this changing medical scene is decried; the pati...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/64.1.136

    authors: Angrist AA

    更新日期:1975-07-01 00:00:00

  • Hepatoma in siblings with progressive familial cholestatic cirrhosis of childhood.

    abstract::This report describes four siblings affected with familial intrahepatic cholestasis detected in early infancy. In the two male siblings, biliary cirrhosis and fatal hepatocellular carcinoma later developed, whereas the female siblings have had persistent hepatomegaly and recurrent episodes of cholestasis. Sequential b...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.2.172

    authors: Ugarte N,Gonzalez-Crussi F

    更新日期:1981-08-01 00:00:00

  • Double immunostaining of lymph node sections by monoclonal antibodies using phycoerythrin labeling and haptenated reagents.

    abstract::Double immunostaining of tissue sections by monoclonal antibodies has been performed using, in immunofluorescence, combinations of reagents conjugated with different fluorochromes. These were monoclonal antibodies directly labeled with phycoerythrin (a new red fluorochrome) and haptenated monoclonal antibodies detecte...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.1.44

    authors: Pizzolo G,Chilosi M

    更新日期:1984-07-01 00:00:00

  • Psammoma bodies in malignant carcinoid tumor metastases.

    abstract::A clinically and histopathologically well-documented case of malignant carcinoid tumor (with carcinoid syndrome) is described. The presence of numerous psammoma bodies in metastatic carcinoid tumor deposits, confirmed by histochemical and ultrastructural analyses, represents a heretofore unreported finding. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.372

    authors: Caya JG,Tieu TM,Wollenberg NJ,Soergel K,Anderson T

    更新日期:1984-03-01 00:00:00

  • Fresh and citrated whole-blood specimens can produce different thromboelastography results in patients on extracorporeal membrane oxygenation.

    abstract:OBJECTIVES:To compare thromboelastography (TEG) tracings obtained from fresh and citrated whole-blood samples in patients on extracorporeal membrane oxygenation (ECMO) or after cardiopulmonary bypass and in healthy volunteers. METHODS:Samples of fresh and citrated whole blood were analyzed for 25 patients and 4 health...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPYIQ9JNNSEN4Q

    authors: Gilman EA,Koch CD,Santrach PJ,Schears GJ,Karon BS

    更新日期:2013-08-01 00:00:00

  • Essential thrombocythemia with acquired von Willebrand's disease.

    abstract::Two patients with essential thrombocythemia showed a marked decrease in ristocetin-induced platelet aggregation in addition to other aggregation defects during routine aggregation studies for prolonged bleeding times. Further investigation revealed type I von Willebrand's disease (vWD) in one patient and a variant of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/88.1.102

    authors: Raman BK,Sawdyk M,Saeed SM

    更新日期:1987-07-01 00:00:00

  • Distribution and incidence of viridans streptococcal species in routine clinical specimens.

    abstract::Five hundred consecutive isolates of viridans streptococci were identified to the species level in an effort to determine their distribution and incidence in routine clinical specimens. Viridans streptococci accounted for significant percentages of streptococcal isolates from urine, wounds, body fluids, and blood. The...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/80.6.854

    authors: Ruoff KL,Fishman JA,Calderwood SB,Kunz LJ

    更新日期:1983-12-01 00:00:00

  • The stability of clinical chemistry specimens during refrigerated storage for 24 hours.

    abstract::The authors investigated the stability of the tests comprising the SMA-6 and SMA-12 chemistry profiles during overnight refrigerated storage. Several constituents were found to undergo changes that were statistically significant when evaluated by a t test for paired comparisons. A recently published sequential method ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/73.1.91

    authors: Rossing RG,Foster DM

    更新日期:1980-01-01 00:00:00