T-Cell Large Granular Lymphocytic Leukemia and Coexisting B-Cell Lymphomas: A Study From the Bone Marrow Pathology Group.

Abstract:

Objective:T-cell large granular lymphocytic (T-LGL) leukemia is associated with B-cell lymphomas (BCLs), especially small BCLs. We aimed to explore and expand upon its association with BCLs. Methods:We retrospectively studied clinicopathologic features of T-LGL leukemia patients with coexisting BCL from January 2001 to December 2016. Results:Among 432 patients with T-LGL leukemia, 22 (5.1%) had an associated B-cell non-Hodgkin lymphoma. Thirteen (59%) patients had large and nine (41%) had small BCL. T-LGL leukemia occurred synchronously with BCL in five, preceded BCL in three, and followed BCL in 14 patients. Anemia was the most common cytopenia (68%). Only one patient had a history of rheumatoid arthritis. Conclusion:To our knowledge, this is the first multicenter study looking at the spectrum and incidence of BCLs in patients with T-LGL leukemia and highlights its association with large BCLs (3% of T-LGL leukemias).

journal_name

Am J Clin Pathol

authors

Goyal T,Thakral B,Wang SA,Bueso-Ramos CE,Shi M,Jevremovic D,Morice WG,Zhang QY,George TI,Foucar KK,Bhattacharyya S,Bagg A,Rogers HJ,Bodo J,Durkin L,Hsi ED

doi

10.1093/ajcp/aqx146

subject

Has Abstract

pub_date

2018-01-29 00:00:00

pages

164-171

issue

2

eissn

0002-9173

issn

1943-7722

pii

4818426

journal_volume

149

pub_type

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