Steroid hormone receptor and COX-2 expression in chordoma.

Abstract:

:Reports of sex steroid receptor expression in chordoma suggest that these tumors may be responsive to hormone manipulation therapy. Immunohistochemical stains for estrogen receptor (ER)-alpha, ER-beta, progesterone receptor (PR), androgen receptor (AR), and cyclooxygenase 2 (COX-2), were performed on a tissue microarray containing 21 samples of chordoma. Most chordomas expressed COX-2, ER-beta, and AR, whereas ER-alpha and PR stains were negative in all cases. ER-beta expression did not correlate with AR expression (P = .4142; McNemar test). There were no statistically significant correlations between the expression of any of these markers and anatomic location of tumor, patient sex, patient age, or disease-free survival. Chordomas commonly express COX-2, AR, and ER-beta. These findings may have therapeutic implications concerning the use of agents that inhibit or modulate these signaling molecules.

journal_name

Am J Clin Pathol

authors

Fasig JH,Dupont WD,Olson SJ,Lafleur BJ,Cates JM

doi

10.1309/8T2NPHLK5X5WQ3E7

subject

Has Abstract

pub_date

2007-09-01 00:00:00

pages

375-81

issue

3

eissn

0002-9173

issn

1943-7722

pii

H2556481807H6452

journal_volume

128

pub_type

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