Abstract:
:Previous reports have indicated that patients with severe acute respiratory syndrome (SARS)-associated coronavirus infection could develop atypical pneumonia with fulminant pulmonary edema. However, the target cells of SARS viral infection have not been characterized in detail. We report the pathologic findings of the lung in 3 cases of SARS. Chest radiographs at 2 to 3 weeks of infection revealed an atypical pneumonia with pulmonary consolidation, a clinical characteristic of SARS infection. The presence of the SARS virus was determined by nested reverse transcription-polymerase chain reaction (RT-PCR), and the infected cells were identified by in situ hybridization in open-lung biopsy and postmortem necropsy specimens. Expression of SARS virus-encoded RNA was detected in all 3 cases by RT-PCR, and the SARS viral signal was localized in pneumocytes by using in situ hybridization.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Chow KC,Hsiao CH,Lin TY,Chen CL,Chiou SHdoi
10.1309/C0ED-U0RA-QBTX-BHCEsubject
Has Abstractpub_date
2004-04-01 00:00:00pages
574-80issue
4eissn
0002-9173issn
1943-7722journal_volume
121pub_type
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journal_title:American journal of clinical pathology
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更新日期:2003-12-01 00:00:00
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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