Abstract:
:We compared the morphologic findings of different types of marginal zone B-cell lymphoma (MZL) involving the bone marrow (BM), including 18 splenic (SMZL), 6 extranodal (mucosa-associated lymphoid tissue lymphoma), and 6 nodal cases. The median percentage of BM involvement was 15%, and multiple overlapping patterns of infiltration were observed in all MZL types. The most frequent patterns were nodular (87%) and interstitial (63%). A focal sinusoidal pattern of involvement was found in one third of SMZLs and rarely in MALT lymphoma. Germinal centers (GCs) were uncommon in routinely stained BM biopsy sections and were observed only in SMZL. However, antibodies specific for CD21 and CD23 highlighted follicular dendritic cells in most MZLs of all types. MZLs cannot be distinguished from each other by examining BM sections alone. However, a sinusoidal pattern or presence of GCs is suggestive of SMZL. Furthermore, correlation with the CBC count can further enhance the reliability of diagnosing SMZL.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Inamdar KV,Medeiros LJ,Jorgensen JL,Amin HM,Schlette EJdoi
10.1309/HRHQFBFTR8B4LXT4subject
Has Abstractpub_date
2008-05-01 00:00:00pages
714-22issue
5eissn
0002-9173issn
1943-7722pii
F266578433335718journal_volume
129pub_type
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