Lesions indefinite for intraepithelial neoplasia and OLGA staging for gastric atrophy.

Abstract:

:Gastric intraepithelial neoplasia (IEN; formerly dysplasia) is an advanced precancerous lesion. Lesions indefinite for IEN mimic the IEN phenotype but lack some morphologic attributes of IEN. Indefinite for IEN lesions may arise in native foveolae (atypical foveolar hyperproliferation [aFH]) or intestinalized glands (hyperproliferative intestinal metaplasia [HIM]). The clinicopathologic outcome of such lesions is debated. We retrospectively studied the clinicopathologic behavior of 129 consecutive indefinite for IEN lesions (HIM, 98; aFH, 31; median follow-up, 31 months) and correlated outcome with the extent and topography of mucosal atrophy (assessed by OLGA staging) at the initial endoscopy/biopsy. At enrollment, aFH never coexisted with severe/extensive atrophy (all cases were in low-risk OLGA stages [0-II]), whereas HIM was associated with low- and high-risk OLGA stages (0-II, 73; III-IV, 25). At follow-up, IEN was never documented among cases enrolled as aFH, while follow-up endoscopy/biopsy documented 6 neoplastic intraepithelial lesions among 98 cases of HIM (6%, all had high-risk OLGA stages at initial biopsy). OLGA staging can stratify indefinite for IEN lesions into different risk classes, potentially contributing to decisions for a patient-specific follow-up strategy.

journal_name

Am J Clin Pathol

authors

Fassan M,Pizzi M,Farinati F,Nitti D,Zagonel V,Genta RM,Rugge M

doi

10.1309/AJCPEU41HTGXSJDQ

subject

Has Abstract

pub_date

2012-05-01 00:00:00

pages

727-32

issue

5

eissn

0002-9173

issn

1943-7722

pii

137/5/727

journal_volume

137

pub_type

杂志文章
  • Epithelioid angiosarcoma arising in uterine leiomyomas.

    abstract::Primary angiosarcomas of the uterus are exceedingly rare. The authors report a unique case of this entity arising in connection with uterine leiomyomas. The malignant tumor cells showed focally epithelioid features and were immunoreactive for keratin. Electron microscopy and immunohistochemistry confirmed their endoth...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.5.514

    authors: Tallini G,Price FV,Carcangiu ML

    更新日期:1993-11-01 00:00:00

  • AIDS-related lymphoma in Brazil. Histopathology, immunophenotype, and association with Epstein-Barr virus.

    abstract::The occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several type...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.2.230

    authors: Bacchi CE,Bacchi MM,Rabenhorst SH,Soares FA,Fonseca LE Jr,Barbosa HS,Weiss LM,Gown AM

    更新日期:1996-02-01 00:00:00

  • Platelet aggregation induced by antilymphocyte serum. 2. Two modes of the aggregation mechanism.

    abstract::The ability to inhibit the release reaction was found to correlate well with the ability to inhibit aggregation in washed human platelets exposed to antilymphocyte serum (ALS). However, the primary mechanism that contributes to ALS-induced aggregation in unwashed platelets appeared to be different from that found in w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/65.5.680

    authors: Wang TY,Hussey CV,Hause LL,Fobian JE

    更新日期:1976-05-01 00:00:00

  • Effects of chemotherapy (busulfan-hydroxyurea) and interferon-alfa on bone marrow morphologic features in chronic myelogenous leukemia. Histochemical and morphometric study on sequential trephine biopsy specimens with special emphasis on dynamic features.

    abstract::We performed a retrospective clinicopathologic study on sequential biopsy specimens from 90 patients with Philadelphia chromosome-positive chronic myelogenous leukemia to study therapy-specific effects of busulfan (28 patients), hydroxyurea (32 patients), and interferon-alfa (IFN-alfa; 30 patients). Bone marrow specim...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/XMGX-7HQ8-7PLU-LQ9M

    authors: Thiele J,Kvasnicka HM,Schmitt-Graeff A,Bundschuh S,Biermann T,Roessler G,Wasmus M,Diehl V,Zankovich R,Schaefer HE

    更新日期:2000-07-01 00:00:00

  • Effects of drugs on glucose measurements with handheld glucose meters and a portable glucose analyzer.

    abstract::Thirty drugs used primarily in critical care and hospital settings were tested in vitro to observe interference on glucose measurements with 6 hand-held glucose meters and a portable glucose analyzer. Paired differences of glucose measurements between drug-spiked samples and unspiked control samples were calculated to...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/QAW1-X5XW-BVRQ-5LKQ

    authors: Tang Z,Du X,Louie RF,Kost GJ

    更新日期:2000-01-01 00:00:00

  • Double immunostaining of lymph node sections by monoclonal antibodies using phycoerythrin labeling and haptenated reagents.

    abstract::Double immunostaining of tissue sections by monoclonal antibodies has been performed using, in immunofluorescence, combinations of reagents conjugated with different fluorochromes. These were monoclonal antibodies directly labeled with phycoerythrin (a new red fluorochrome) and haptenated monoclonal antibodies detecte...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/82.1.44

    authors: Pizzolo G,Chilosi M

    更新日期:1984-07-01 00:00:00

  • Predictive values of erythrocyte indices for tests of iron, folic acid, and vitamin B12 deficiency.

    abstract::The probabilities of low transferrin saturation, folic acid, or vitamin B12 levels in association with various erythrocyte indices was determined from the prevalences of these abnormalities and the distributions of the indices among 206 hospitalized and 1,000 ambulatory anemic patients. At mean corpuscular hemoglobin ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/70.5.748

    authors: Griner PF,Oranburg PR

    更新日期:1978-11-01 00:00:00

  • The pathologic and clinical spectrum of anaplastic large cell lymphoma and correlation with ALK gene dysregulation.

    abstract::Anaplastic large cell lymphoma (ALCL) is clinically and pathologically heterogeneous, leading to some difficulty in its diagnosis and acceptance as a specific entity. ALCL can be subdivided into different groups according to histologic features (pleomorphic, monomorphic, small cell predominant, Hodgkin's disease-relat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Kinney MC,Kadin ME

    更新日期:1999-01-01 00:00:00

  • Effects of Implementing the Dual Papanicolaou Test Interpretation of ASC-H and LSIL Following Bethesda 2014.

    abstract:OBJECTIVES:To evaluate the impact of implementing the dual interpretation of atypical squamous cells, cannot exclude high-grade squamous intraepithelial lesion (ASC-H) and low-grade squamous intraepithelial lesion (LSIL) after the Bethesda System 2014 and to compare it with other indeterminate interpretations. METHODS...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqaa069

    authors: Goyal A,Patel AP,Dilcher TL,Alperstein SA

    更新日期:2020-09-08 00:00:00

  • Laboratory prediction of the carrier state in hemophilia B: role of replication of assays.

    abstract::The authors studied the effect of averaging replicated assays of Factor IX coagulation activity and Factor IX antigen on each plasma specimen in improving the ability to detect carriers of hemophilia B. The improvement resulting from this procedure is particularly marked in tests depending on the linear regression of ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/72.6.1000

    authors: Lipworth L,Tiarks CY,Rice CA,Pechet L

    更新日期:1979-12-01 00:00:00

  • Vascular changes of endometrium in early pregnancy.

    abstract::Spiral arteries, from curetted endometrium, of first-trimester pregnancies, were examined in 342 consecutive cases, comprising 150 primigravida and 192 multigravida . Vascular changes, similar to the "acute atherosis ," described at the end of pregnancy in preeclamptic women, were found. Primigravida had a statistical...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.6.702

    authors: Lichtig C,Deutch M,Brandes J

    更新日期:1984-06-01 00:00:00

  • Kinetic latex agglutinometry I. A rapid, quantitative immunologic assay for fibrinogen.

    abstract::A rapid, convenient immunologic assay technic for fibrinogen is reported. Basically a latex agglutination, the assay technic, called kinetic latex agglutinometry, quantitates the increase in light transmission that occurs in a stirred suspension of anti-fibrinogen-coated latex beads after the addition of a plasma or w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/77.4.424

    authors: Babson AL,Opper CA,Crane LJ

    更新日期:1982-04-01 00:00:00

  • Aberrant nuclear p53 expression predicts hemizygous 17p (TP53) deletion in chronic lymphocytic leukemia.

    abstract::Hemizygous TP53 gene deletion is the most important adverse risk factor in chronic lymphocytic leukemia (CLL), but its relationship with p53 protein expression is unclear. We investigated 110 CLL cases and correlated nuclear p53 protein immunoreactivity with TP53 gene deletion status and other CLL-associated genetic r...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPEPX1C7HHFELK

    authors: Chang H,Jiang AM,Qi CX

    更新日期:2010-01-01 00:00:00

  • Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Part II: Correlation between biochemical and immunohistochemical methods and survival.

    abstract::One hundred eighty-three patients with endometrial carcinoma had both immunohistochemical and biochemical analysis of estrogen receptor (ER) and progesterone receptor (PR) content of the tumor. Biochemical analysis was done on a homogenate of uterine curettings; immunohistochemical stainings were done on formalin-fixe...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.3.255

    authors: Chambers JT,Carcangiu ML,Voynick IM,Schwartz PE

    更新日期:1990-09-01 00:00:00

  • Immunohistochemistry of Warthin's tumor.

    abstract::This study describes results of fresh-frozen immunohistochemistry applied to two typical Warthin's tumors. Polyclonal follicular center cell staining and an apparent reduction in the number of T-lymphocytes were found. These observations tend to support the concept that the lymphoid infiltrate in Warthin's tumor repre...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.6.795

    authors: Tubbs RR,Sheibani K,Weiss RA,Lee V,Sebek BA,Valenzuela R

    更新日期:1980-12-01 00:00:00

  • Physicians' and nurses' satisfaction with the clinical laboratory service of Gondar University Hospital, northwest Ethiopia.

    abstract:OBJECTIVES:To assess physicians' and nurses' satisfaction with the service provided by the laboratory at Gondar University Hospital. METHODS:We conducted a cross-sectional study involving 196 nurses and physicians. RESULTS:Overall level of satisfaction was 51.1% for nurses and 51.5% for physicians. Lack of consistenc...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPU1PLVOIN5JQI

    authors: Addis Z,Birhan W,Derseh D,Sahle B,Gizaw N

    更新日期:2013-09-01 00:00:00

  • Multiple myeloma with tadpolelike cells and rosette formation.

    abstract::A 65-year-old man with lower back pain was found to have multiple myeloma. Unique findings in the marrow aspirate smears of this patient were tadpolelike plasma cells and cellular rosettes simulating those seen in neuroblastoma. This case documents yet another facet of the broad morphologic spectrum of neoplastic plas...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/98.6.630

    authors: Wong KF,Chan JK,Chu YC

    更新日期:1992-12-01 00:00:00

  • Misleading hepatitis C serology following administration of intravenous immunoglobulin.

    abstract::Intravenous immunoglobulin (IVIG) is a blood derivative that is being evaluated for the prevention and treatment of numerous disorders. Recent studies have suggested beneficial effects from the prophylactic administration of IVIG to very-low-birth-weight neonates. A disadvantage of such therapy is misleading infectiou...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/101.3.327

    authors: Nixon RR,Smith SA,Johnson RL,Pillers DA

    更新日期:1994-03-01 00:00:00

  • Clinical and economic performance criteria for intraarterial and extraarterial blood gas monitors, with comparison with in vitro testing.

    abstract::The frequency with which blood gas measurements should be obtained is controversial because laboratory-based blood gas analyzers impose blood loss, delay, and cost on each measurement. Point-of-care analyzers eliminate the delay factor, but blood loss and cost factors remain. Optode microsensing can be adopted readily...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Shapiro BA

    更新日期:1995-10-01 00:00:00

  • Lack of HER2 overexpression and amplification in small intestinal adenocarcinoma.

    abstract::HER2 overexpression and amplification have been studied as a therapeutic and prognostic target in a number of human cancers, including esophageal, gastric, and colorectal adenocarcinomas. However, HER2 status has not been well investigated in primary small intestinal adenocarcinoma, probably because of its rarity. In ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPK6QHNNOEMJIM

    authors: Chan OT,Chen ZM,Chung F,Kawachi K,Phan DC,Himmelfarb E,Lin F,Perry A,Wang HL

    更新日期:2010-12-01 00:00:00

  • Biclonal chronic lymphocytic leukemia.

    abstract::Chronic lymphocytic leukemia (CLL) is well characterized clinically and immunophenotypically. Demonstration of a monotypic CD19+, CD5+ B-cell population is central to the diagnosis. We report 2 cases of biclonal CLL. Two elderly men were encountered with an absolute lymphocytosis consisting of the typical CD5+, CD19+,...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/V8AN-A2XP-7TDV-HR0T

    authors: Hsi ED,Hoeltge G,Tubbs RR

    更新日期:2000-06-01 00:00:00

  • Signet ring cell lymphoma. A report of a case and review of the literature.

    abstract::A case of signet ring cell lymphoma, a rare variant of follicular center cell lymphoma, is presented with a review of 20 other such lymphomas previously reported in the English literature. The histologic, immunocytologic, and electron microscopic features are described with speculation as to the possible relationship ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/81.3.358

    authors: Silberman S,Fresco R,Steinecker PH

    更新日期:1984-03-01 00:00:00

  • Comparison of evaluations for hormone receptors in breast carcinoma using two manual and three automated immunohistochemical assays.

    abstract::The aims of this study were to compare the quality of immunohistochemical assays of estrogen receptor (ER) and progesterone receptor (PR) and to compare the intermethod variability of assays from different manufacturers. immunohistochemical staining was entrusted to the following laboratories in Japan: Kyowa Medex, de...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/4D1A04NCDK96WFY7

    authors: Arihiro K,Umemura S,Kurosumi M,Moriya T,Oyama T,Yamashita H,Umekita Y,Komoike Y,Shimizu C,Fukushima H,Kajiwara H,Akiyama F

    更新日期:2007-03-01 00:00:00

  • Effects of storage time and exogenous protease inhibitors on plasma protein levels.

    abstract::Plasma biomarker analysis requires intact unbiased starting material. We analyzed the effects on plasma protein profiles of protease inhibitor cocktails and preprocessing storage. Plasma from 12 healthy subjects collected with and without protease inhibitors was prepared immediately and after 2 hours of room temperatu...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/3WM7-XJ7R-D8BC-LNKX

    authors: Ayache S,Panelli M,Marincola FM,Stroncek DF

    更新日期:2006-08-01 00:00:00

  • Type II estrogen receptors in the papillary cystic tumor of the pancreas.

    abstract::Two cases of papillary cystic tumor (PCT) of the pancreas were investigated for the presence of estrogen receptors (ERs) and progesterone receptors (PgRs). Both PCT and normal pancreas are able to specifically bind 3H-estradiol. This binding almost exclusively results from the presence of high levels of type II ER, wh...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/92.5.572

    authors: Carbone A,Ranelletti FO,Rinelli A,Vecchio FM,Lauriola L,Piantelli M,Capelli A

    更新日期:1989-11-01 00:00:00

  • Comparison of complement fixation and fluorescent immunoassay (FIAX) for measuring antibodies to cytomegalovirus and herpes simplex virus.

    abstract::An automated fluorescent immunoassay system (FIAX) was compared with complement fixation (CF) for measuring antibodies to cytomegalovirus (CMV) and herpes simplex virus (HSV) in clinical specimens. Compared with CF the specificity of FIAX (ability to detect a negative titer) was 95% for CMV and 92% for HSV. The sensit...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/76.3.305

    authors: Friedman HM,Tustin NB,Hitchings MM,Plotkin SA

    更新日期:1981-09-01 00:00:00

  • Gleason Grading, Biochemical Failure, and Prostate Cancer-Specific Death.

    abstract:Objectives:To examine the relationship between the recently defined Gleason grade groups and prostate cancer-specific mortality. Methods:If the probability of prostate cancer-specific death is symbolized as P(PSD), the probability of biochemical failure is symbolized as P(BF), and the probability of prostate cancer-sp...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqw212

    authors: Vollmer RT

    更新日期:2017-03-01 00:00:00

  • Localization of Hantaan viral envelope glycoproteins by monoclonal antibodies in renal tissues from patients with Korean hemorrhagic fever H.

    abstract::The role of viruses in several renal diseases is not documented clearly. The authors attempted to localize envelope glycoproteins of Hantaan virus in biopsy specimens from patients with Korean hemorrhagic fever (KHF) as evidence of direct viral invasion of renal tissues. The authors studied sequential sections of kidn...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.4.398

    authors: Kim S,Kang ET,Kim YG,Han JS,Lee JS,Kim YI,Hall WC,Dalrymple JM,Peters CJ

    更新日期:1993-10-01 00:00:00

  • Catalase-negative listeria monocytogenes causing meningitis in an adult. Clinical and laboratory features.

    abstract::A 63-year-old previously healthy woman presented with acute meningitis. Cultures of the cerebrospinal fluid yielded a serotype 1/2a isolate of Listeria monocytogenes that was biochemically typical in all respects, other than the reproducible lack of catalase production. During therapy, the patient developed oculomotor...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/96.1.130

    authors: Swartz MA,Welch DF,Narayanan RP,Greenfield RA

    更新日期:1991-07-01 00:00:00

  • DNA analysis (ploidy) of molar pregnancies with image analysis on paraffin tissue sections.

    abstract::Hydatidiform moles can be subclassified based on their ploidy. In general, complete moles are diploid, and partial moles are triploid. The standard method for the determination of DNA content is flow cytometric analysis. In this study, the authors investigated whether static cytometric analysis with the CAS 200 Image ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.4.451

    authors: Barclay ID,Dabbagh L,Babiak J,Poppema S

    更新日期:1993-10-01 00:00:00