Abstract:
:Gastric intraepithelial neoplasia (IEN; formerly dysplasia) is an advanced precancerous lesion. Lesions indefinite for IEN mimic the IEN phenotype but lack some morphologic attributes of IEN. Indefinite for IEN lesions may arise in native foveolae (atypical foveolar hyperproliferation [aFH]) or intestinalized glands (hyperproliferative intestinal metaplasia [HIM]). The clinicopathologic outcome of such lesions is debated. We retrospectively studied the clinicopathologic behavior of 129 consecutive indefinite for IEN lesions (HIM, 98; aFH, 31; median follow-up, 31 months) and correlated outcome with the extent and topography of mucosal atrophy (assessed by OLGA staging) at the initial endoscopy/biopsy. At enrollment, aFH never coexisted with severe/extensive atrophy (all cases were in low-risk OLGA stages [0-II]), whereas HIM was associated with low- and high-risk OLGA stages (0-II, 73; III-IV, 25). At follow-up, IEN was never documented among cases enrolled as aFH, while follow-up endoscopy/biopsy documented 6 neoplastic intraepithelial lesions among 98 cases of HIM (6%, all had high-risk OLGA stages at initial biopsy). OLGA staging can stratify indefinite for IEN lesions into different risk classes, potentially contributing to decisions for a patient-specific follow-up strategy.
journal_name
Am J Clin Patholjournal_title
American journal of clinical pathologyauthors
Fassan M,Pizzi M,Farinati F,Nitti D,Zagonel V,Genta RM,Rugge Mdoi
10.1309/AJCPEU41HTGXSJDQsubject
Has Abstractpub_date
2012-05-01 00:00:00pages
727-32issue
5eissn
0002-9173issn
1943-7722pii
137/5/727journal_volume
137pub_type
杂志文章abstract::Primary angiosarcomas of the uterus are exceedingly rare. The authors report a unique case of this entity arising in connection with uterine leiomyomas. The malignant tumor cells showed focally epithelioid features and were immunoreactive for keratin. Electron microscopy and immunohistochemistry confirmed their endoth...
journal_title:American journal of clinical pathology
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abstract::The occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several type...
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journal_title:American journal of clinical pathology
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abstract::Double immunostaining of tissue sections by monoclonal antibodies has been performed using, in immunofluorescence, combinations of reagents conjugated with different fluorochromes. These were monoclonal antibodies directly labeled with phycoerythrin (a new red fluorochrome) and haptenated monoclonal antibodies detecte...
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更新日期:1978-11-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
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更新日期:1999-01-01 00:00:00
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journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/72.6.1000
更新日期:1979-12-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1984-06-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:1982-04-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2010-01-01 00:00:00
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journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/94.3.255
更新日期:1990-09-01 00:00:00
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更新日期:1980-12-01 00:00:00
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更新日期:2013-09-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章
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更新日期:1992-12-01 00:00:00
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journal_title:American journal of clinical pathology
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doi:10.1093/ajcp/101.3.327
更新日期:1994-03-01 00:00:00
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journal_title:American journal of clinical pathology
pub_type: 杂志文章,评审
doi:
更新日期:1995-10-01 00:00:00
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journal_title:American journal of clinical pathology
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更新日期:2006-08-01 00:00:00
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更新日期:1981-09-01 00:00:00
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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journal_title:American journal of clinical pathology
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更新日期:1993-10-01 00:00:00