Type II estrogen receptors in the papillary cystic tumor of the pancreas.

Abstract:

:Two cases of papillary cystic tumor (PCT) of the pancreas were investigated for the presence of estrogen receptors (ERs) and progesterone receptors (PgRs). Both PCT and normal pancreas are able to specifically bind 3H-estradiol. This binding almost exclusively results from the presence of high levels of type II ER, whereas type I ERs were absent or present at very low levels. Both normal and neoplastic pancreas studied immunohistochemically for the presence of nuclear ER had negative results. This could be explained assuming that anti-ER antibodies are specific for type I binding sites. In conclusion, the presence of specific estrogen as well as progesterone binding may explain the sex and age predilection of PCT and suggest a possible hormone sensitivity for this tumor.

journal_name

Am J Clin Pathol

authors

Carbone A,Ranelletti FO,Rinelli A,Vecchio FM,Lauriola L,Piantelli M,Capelli A

doi

10.1093/ajcp/92.5.572

subject

Has Abstract

pub_date

1989-11-01 00:00:00

pages

572-6

issue

5

eissn

0002-9173

issn

1943-7722

journal_volume

92

pub_type

杂志文章
  • Proficiency testing for the radioimmunoassay of carcinoembryonic antigen. A one-year report.

    abstract::Forty-three laboratories participated in an interlaboratory testing program offered by the College of American Pathologists for the radioimmunoassay (RIA) of carcinoembryonic antigen (CEA). Thirty correctly reported a sample with 1.9 ng of endogenous CEA per ml as less than 2.5 ng. For samples with added exogenous CEA...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Reynoso G,Keane M,Konopka S

    更新日期:1977-07-01 00:00:00

  • bcl-2 expression by multicolor flow cytometric analysis assists in the diagnosis of follicular lymphoma in lymph node and bone marrow.

    abstract::The expression of bcl-2, CD10, and CD20 was examined by multicolor flow cytometry in 78 samples including lymph node or other tissue biopsy specimens containing follicular lymphoma (FL; n = 17), reactive hyperplasia (RH; n = 28), or other malignant lymphomas (n = 20), as well as bone marrow aspirates (n = 13). The pre...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/820R-476K-Y9G0-3L9A

    authors: Cook JR,Craig FE,Swerdlow SH

    更新日期:2003-01-01 00:00:00

  • The diagnostic value of the serum lactic dehydrogenase determination in the evaluation of unexplained thrombocytosis.

    abstract::Thrombocytosis may reflect a primary myeloproliferative disorder or be a secondary reaction to other pathologic processes. Patients with persistent unexplained thrombocytosis meeting criteria of primary thrombocythemia had elevated levels of serum lactic dehydrogenase, whereas comparable patients with secondary thromb...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/75.6.840

    authors: Budman DR,Lackner H,Berczeller P,Silber R

    更新日期:1981-06-01 00:00:00

  • The surgical pathologist as a diagnostician and consultant.

    abstract::The primary role of the surgical pathologist is to diagnose, and then to transmit this information effectively so that it can be used to guide patient management; therefore, the dual roles of the surgical pathologist as a diagnostician and consultant are inextricable. The diagnostic pathologist determines the nature, ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:

    authors: Hutter RV

    更新日期:1981-03-01 00:00:00

  • An Audit of Repeat Testing at an Academic Medical Center: Consistency of Order Patterns With Recommendations and Potential Cost Savings.

    abstract:Objectives:To evaluate the prevalence of potentially unnecessary repeat testing (PURT) and the associated economic burden for an inpatient population at a large academic medical facility. Methods:We evaluated all inpatient test orders during 2016 for PURT by comparing the intertest times to published recommendations. ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/aqy020

    authors: Hueth KD,Jackson BR,Schmidt RL

    更新日期:2018-05-31 00:00:00

  • Oral lichen planus and chronic hepatitis C: a controversial association.

    abstract::Our aim was to study the possible association between oral lichen planus and chronic hepatitis C in patients from the state of Minas Gerais, Brazil. Two groups of patients were studied: group 1, 50 patients with oral lichen planus evaluated for the presence of chronic hepatitis C; and group 2, 215 patients with chroni...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/HDWCT36P0GMGP40V

    authors: de Mattos Camargo Grossmann S,de Aguiar MC,Teixeira R,do Carmo MA

    更新日期:2007-05-01 00:00:00

  • Automated heart-type fatty acid-binding protein assay for the early diagnosis of acute myocardial infarction.

    abstract::We compared an automated quantitative heart-type fatty acid-binding protein (H-FABP) assay with other cardiac-marker assays to examine its usefulness as an early diagnostic marker of acute myocardial infarction (AMI). Serum samples for cardiac troponin T (cTnT), creatine kinase-MB isozyme (CK-MB), myoglobin, and H-FAB...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP0F6AXRCJMQQG

    authors: Kim Y,Kim H,Kim SY,Lee HK,Kwon HJ,Kim YG,Lee J,Kim HM,So BH

    更新日期:2010-07-01 00:00:00

  • JAK2 mutations across a spectrum of venous thrombosis cases.

    abstract::The JAK2(V617F)mutation is recurrent in polycythemia vera and essential thrombocythemia, which are myeloproliferative neoplasms frequently associated with arterial and venous thromboembolism. It has also been reported as a marker for occult myeloproliferative disorder (MPD) in patients with splanchnic venous thrombosi...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP7VO4HAIZYATP

    authors: Shetty S,Kulkarni B,Pai N,Mukundan P,Kasatkar P,Ghosh K

    更新日期:2010-07-01 00:00:00

  • Medullary thyroid cancer. An immunohistochemical and humoral study using six separate antigens.

    abstract::The authors investigated the humoral and tissue expression of six antigens associated with medullary thyroid cancer (MTC): calcitonin (CT), calcitonin gene-related peptide (CGRP), carcinoembryonic antigen (CEA), neuron-specific enolase (NSE), somatostatin (SRIF), and thyroglobulin (TG). The antigens were studied in th...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/95.3.300

    authors: Pacini F,Basolo F,Elisei R,Fugazzola L,Cola A,Pinchera A

    更新日期:1991-03-01 00:00:00

  • Instability of immunophenotype in plasma cell myeloma.

    abstract::Little information has been reported describing antigen stability in plasma cell myeloma. In this study, the expression frequency and stability of 2 potential therapeutic targets, CD20 and CD52, along with the frequently aberrantly expressed CD56 antigen, were evaluated by flow cytometric analyses in 56 patients with ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/8UVF7YQ1D4D4ETQV

    authors: Cao W,Goolsby CL,Nelson BP,Singhal S,Mehta J,Peterson LC

    更新日期:2008-06-01 00:00:00

  • Erroneously low results due to high nonspecific binding encountered with a radioassay kit that measures true serum vitamin B12.

    abstract::Subsequent to recent disclosures that low serum vitamin B12 results can appear normal using many of the current radioassay methods because of the presence of cobalamin (vitamin B12) analogues in human serum, a number of radioassay kits have become available with modified intrinsic factor preparations and claims of mea...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/74.2.209

    authors: LeFebvre RJ,Virji AS,Mertens BF

    更新日期:1980-08-01 00:00:00

  • The role of fine-needle aspiration biopsy in the management of palpable thyroid nodules.

    abstract::FNAB is the most important advance in the management of thyroid nodules in the past two decades. Dr Mazzaferri has said that finding a thyroid cancer in a thyroid nodule is like finding a needle in a haystack. Fine-needle aspiration biopsy is like applying a strong electromagnet to find that needle. It should be avail...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Greenspan FS

    更新日期:1997-10-01 00:00:00

  • Immunoglobulin inclusions in non-Hodgkin's lymphomas.

    abstract::The occurrence and characteristics of intracellular immunoglobulin inclusions in non-Hodgkin's lymphomas are described. Lymphoma cells from three patients with immunoblastic sarcoma contained classic cytoplasmic, periodic acid-Schiff (PAS)-positive Russell bodies. Immunoperoxidase staining revealed monoclonal IgG (k) ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/69.1.306

    authors: van den Tweel JG,Taylor CR,Parker JW,Lukes RJ

    更新日期:1978-03-01 00:00:00

  • Myelodysplasia in the acquired immune deficiency syndrome.

    abstract::Certain new hematologic findings in eight homosexual or bisexual patients with the acquired immune deficiency syndrome (AIDS) are presented. All eight patients manifested a normochromic, normocytic anemia, and six of eight had granulocytopenia during their hospitalization. The other two had low-normal granulocyte coun...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/84.2.144

    authors: Schneider DR,Picker LJ

    更新日期:1985-08-01 00:00:00

  • Cellular dyscohesion in fine-needle aspiration of breast carcinoma. Prognostic indicator for axillary lymph node metastases?

    abstract::The role of fine-needle aspiration (FNA) in the diagnosis of breast carcinoma is established. We evaluated whether the degree of cellular dyscohesion and the nuclear grade in FNA material of breast carcinomas are reliable prognostic predictors for ipsilateral axillary lymph node metastasis. FNA specimens from 98 women...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/PR6K-7RXQ-NJUD-443Q

    authors: Schiller AB,Tadros TS,Birdsong GG,Grossl NA

    更新日期:2001-02-01 00:00:00

  • Chondroid chordoma. A hyalinized chordoma without cartilaginous differentiation.

    abstract::"Chondroid chordoma" is a controversial and confusing entity that was originally described by Heffelfinger and colleagues as a biphasic malignant neoplasm possessing elements of both chordoma and cartilaginous tissue. Because the premise for this distinction was based strictly on histomorphologic criteria, the light m...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1093/ajcp/103.3.271

    authors: Jeffrey PB,Biava CG,Davis RL

    更新日期:1995-03-01 00:00:00

  • Special commentary: patient safety and the next generation of HPV DNA tests.

    abstract::Human papillomavirus (HPV) testing is more sensitive for the detection of cervical precancer and cancer than cervical cytology. The increased sensitivity of HPV testing and cytology combined ("cotesting") compared to cytology alone permitted professional societies to recommend 3-year screening intervals among the cote...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPRI8XPQUEAA3K

    authors: Kinney W,Stoler MH,Castle PE

    更新日期:2010-08-01 00:00:00

  • CD163 expression is present in cutaneous histiocytomas but not in atypical fibroxanthomas.

    abstract::CD163, a hemoglobin scavenger receptor, is expressed in monocytes and macrophages. Recent work has shown that this marker is specific for neoplasms of histiocytic differentiation. Our aim was to test the ability of CD163 to separate cutaneous histiocytomas from their morphologic mimics. We tested the expression of CD1...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCP88IRBPXQZYIR

    authors: Sachdev R,Robbins J,Kohler S,Vanchinathan V,Schwartz EJ,Sundram UN

    更新日期:2010-06-01 00:00:00

  • Comparative study of spleen pathology in drug abusers with thrombocytopenia related to human immunodeficiency virus infection and in patients with idiopathic thrombocytopenic purpura. A morphometric, immunohistochemical, and ultrastructural study.

    abstract::A morphometric and immunohistochemical study was performed to assess the spleen's alterations in patients with autoimmune thrombocytopenia and in drug abusers with thrombocytopenia (DAT) related to human immunodeficiency virus (HIV) infection. A total of 34 patients were included in the study: 20 DAT patients and 14 w...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/100.6.633

    authors: Marti M,Feliu E,Campo E,Palacin A,Berga L,Casals FJ,Urbano Ispizua A,Cardesa A,Rozman C

    更新日期:1993-12-01 00:00:00

  • Factitious biochemical measurements resulting from hematologic conditions.

    abstract::Factitious laboratory results often lead to unnecessary testing or treatment. This brief review of factitious biochemical results due to preexisting hematologic conditions focuses on the mechanisms underlying the factitious results and suggests ways to prevent them. An observant pathologist identifies these errors, in...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:10.1309/AJCPY9RP5QYTYFWC

    authors: Dalal BI,Brigden ML

    更新日期:2009-02-01 00:00:00

  • The pathologic and clinical spectrum of anaplastic large cell lymphoma and correlation with ALK gene dysregulation.

    abstract::Anaplastic large cell lymphoma (ALCL) is clinically and pathologically heterogeneous, leading to some difficulty in its diagnosis and acceptance as a specific entity. ALCL can be subdivided into different groups according to histologic features (pleomorphic, monomorphic, small cell predominant, Hodgkin's disease-relat...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章,评审

    doi:

    authors: Kinney MC,Kadin ME

    更新日期:1999-01-01 00:00:00

  • The cytopathology of proliferative breast disease. Comparison with features of ductal carcinoma in situ.

    abstract::Epithelial hyperplasia, a component of proliferative breast disease (PBD), is a known risk factor for the development of breast carcinoma. To determine if criteria established for tissue biopsy could be used to more precisely define cytologic criteria for diagnosis of PBD, 37 breast fine-needle aspirates with biopsy d...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/103.4.438

    authors: Dawson AE,Mulford DK,Sheils LA

    更新日期:1995-04-01 00:00:00

  • Prevalence of non-A,non-B hepatitis/hepatitis C virus antibody in human immunoglobulins.

    abstract::Human intravenous immunoglobulins prepared by the cold ethanol fractionation technique of Cohn are considered safe with respect to infectivity. However, there have been several instances of transmission of both hepatitis B and non-A,non-B hepatitis viruses after administration of intravenous immunoglobulins. To determ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/97.1.108

    authors: Dodd LG,McBride JH,Gitnick GL,Howanitz PJ,Rodgerson DO

    更新日期:1992-01-01 00:00:00

  • Concurrent antiglomerular basement membrane antibody and immune complex mediated glomerulonephritis.

    abstract::A teenage male, with Goodpasture's syndrome and serum antiglomerular basement membrane (anti-GBM) antibodies, had a focal proliferative glomerulonephritis with crescents. Immunofluorescence microscopy of his glomeruli using anti-IgG antibodies demonstrated both intense linear GBM staining, and granular subepithelial s...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/78.3.381

    authors: Jennette JC,Lamanna RW,Burnette JP,Wilkman AS,Iskander SS

    更新日期:1982-09-01 00:00:00

  • T-cell lymphoma after heart transplantation.

    abstract::A 26-year-old woman who had undergone orthotopic heart transplantation because of dilative cardiomyopathy received a triple-drug immunosuppressive regimen (cyclosporine A, azathioprine, and prednisolone). During her relatively frequent episodes of acute rejection, she was treated with methylprednisolone and repeated a...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/94.1.95

    authors: Kemnitz J,Cremer J,Gebel M,Uysal A,Haverich A,Georgii A

    更新日期:1990-07-01 00:00:00

  • Incidence of diagnostic change in colorectal polyp specimens after deeper sectioning at 2 different laboratories staffed by the same pathologists.

    abstract:OBJECTIVES:To calculate the incidence of nondiagnostic (ND) colorectal (CR) polyp cases in which deeper tissue sectioning rendered new diagnostic information--particularly adenomas--in 2 laboratories staffed by the same pathologists. METHODS:After initial diagnosis, 100 ND CR polyps from each laboratory were reexamine...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPPXU66QZAZNYN

    authors: Nielsen JA,Lager DJ,Lewin M,Weber JJ,Roberts CA

    更新日期:2013-08-01 00:00:00

  • Evaluation of initial and deeper sections of esophageal biopsy specimens for detection of intestinal metaplasia.

    abstract::There are wide variations in the preparation of histologic sections from endoscopic esophageal biopsy specimens. We evaluated serial step sections from 261 esophageal or gastroesophageal junction biopsies at 4 levels to determine the first level at which goblet cell metaplasia (GCM) was detected. Deeper step sections ...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/MGRX-LQG9-QVRV-VMCG

    authors: Chitkara YK,Eyre CL

    更新日期:2005-06-01 00:00:00

  • Assessment of cervicovaginal smear adequacy. The Bethesda System guidelines and reproducibility.

    abstract::Criteria for assessing adequacy of cervicovaginal smears according to the Bethesda System include cellular composition and quantity, specimen preservation, fixation, and absence of obscuring elements. The reproducibility of adequacy assessment using these parameters was the focus of this study. Specimens were chosen t...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/102.3.354

    authors: Spires SE,Banks ER,Weeks JA,Banks HW,Davey DD

    更新日期:1994-09-01 00:00:00

  • AIDS-related lymphoma in Brazil. Histopathology, immunophenotype, and association with Epstein-Barr virus.

    abstract::The occurrence of malignant lymphoma is an increasingly important cause of morbidity and mortality in AIDS patients. The incidence of AIDS-related lymphoma in some developing countries such as Brazil is increasing as the survival of HIV infection has improved. Although there is a clear association between several type...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1093/ajcp/105.2.230

    authors: Bacchi CE,Bacchi MM,Rabenhorst SH,Soares FA,Fonseca LE Jr,Barbosa HS,Weiss LM,Gown AM

    更新日期:1996-02-01 00:00:00

  • The development and testing of a laboratory information system-driven tool for pre-sign-out quality assurance of random surgical pathology reports.

    abstract::We describe the development and testing of a novel pre-sign-out quality assurance tool for case diagnoses that allows for the random review of a percentage of cases by a second pathologist before case verification and release of the final report. The tool incorporates the ability to record and report levels of diagnos...

    journal_title:American journal of clinical pathology

    pub_type: 杂志文章

    doi:10.1309/AJCPLN9DU9LNXSXA

    authors: Owens SR,Dhir R,Yousem SA,Kelly SM,Piccoli A,Wiehagen L,Lassige K,Parwani AV

    更新日期:2010-06-01 00:00:00