The development and testing of a laboratory information system-driven tool for pre-sign-out quality assurance of random surgical pathology reports.

abstract：:Estrogen receptor (ER), progesterone receptor (PR), and c-ERBB2 (HER2/neu) are therapeutically and prognostically important markers in the management of breast carcinoma. They are not always analyzed in distant metastatic and locally recurrent breast cancers. We compared immunohistochemical expression in a series of p...

journal_title：American journal of clinical pathology

authors： Idirisinghe PK,Thike AA,Cheok PY,Tse GM,Lui PC,Fook-Chong S,Wong NS,Tan PH

更新日期：2010-03-01 00:00:00

abstract：:Pleomorphic adenoma (or benign mixed tumor) of the breast is a rare benign neoplasm that might be misinterpreted both clinically and pathologically as a malignant tumor. The authors present an additional case of this unusual lesion studied by immunohistochemistry, electron microscopy, and flow cytometry. A 77-year-old...

journal_title：American journal of clinical pathology

authors： Ballance WA,Ro JY,el-Naggar AK,Grignon DJ,Ayala AG,Romsdahl MG

更新日期：1990-06-01 00:00:00

abstract：:HMB45 is a melanoma-specific monoclonal antibody that has found widespread use in diagnostic pathology. Recent reports, however, have suggested that this antibody may cross-react with a small number of carcinomas and other epithelial cells. The authors tested the hypothesis that these latter reports represent examples...

journal_title：American journal of clinical pathology

authors： Bonetti F,Pea M,Martignoni G,Mombello A,Colombari R,Zamboni G,Scarpa A,Piubello Q,Bacchi CE,Gown AM

更新日期：1991-04-01 00:00:00

abstract：OBJECTIVES:Sentinel lymph node (SLN)-based diagnosis in gastric cancers has shown varied sensitivities and false-negative rates in several studies. Application of the reverse transcription-polymerase chain reaction (RT-PCR) in SLN diagnosis has recently been proposed. METHODS:A total of 155 SLNs from 65 patients with ...

journal_title：American journal of clinical pathology

authors： Kwak Y,Nam SK,Shin E,Ahn SH,Lee HE,Park do J,Kim WH,Kim HH,Lee HS

更新日期：2016-05-01 00:00:00

abstract：:We compared the morphologic findings of different types of marginal zone B-cell lymphoma (MZL) involving the bone marrow (BM), including 18 splenic (SMZL), 6 extranodal (mucosa-associated lymphoid tissue lymphoma), and 6 nodal cases. The median percentage of BM involvement was 15%, and multiple overlapping patterns of...

journal_title：American journal of clinical pathology

authors： Inamdar KV,Medeiros LJ,Jorgensen JL,Amin HM,Schlette EJ

更新日期：2008-05-01 00:00:00

abstract：:We investigated the pathologic significance of ductular reactions in chronic liver diseases with respect to cellular senescence. The expression of senescence-associated markers (p16(INK4a) and p21(WAF1/Cip1)), cell proliferation, cell cycle markers (cyclin D and cyclin A), and neural cell adhesion molecule (NCAM) was ...

journal_title：American journal of clinical pathology

authors： Sasaki M,Ikeda H,Yamaguchi J,Miyakoshi M,Sato Y,Nakanuma Y

更新日期：2010-02-01 00:00:00

abstract：:Fifteen cases of low-grade B-cell lymphoma involving unusual extranodal sites have been studied in comparison to cases reported or observed arising in typical mucosa-associated lymphoid tissues. In every case, histopathologic features conformed to those characteristic for lymphomas of mucosa-associated lymphoid tissue...

journal_title：American journal of clinical pathology

authors： Pelstring RJ,Essell JH,Kurtin PJ,Cohen AR,Banks PM

更新日期：1991-12-01 00:00:00

abstract：:The cases of three patients who had clinical courses and hematologic data consistent with plasma-cell leukemia or a terminal leukemic phase of multiple myeloma are presented. A double Bence Jones protein was demonstrated in the urine of two of the patients. Immunoelectrophoresis and immunofluorescence studies demonstr...

journal_title：American journal of clinical pathology

authors： Pedraza MA

更新日期：1975-09-01 00:00:00

abstract：:A method using the RNA polymerase chain reaction technique to diagnose infection retrospectively using single-stranded RNA enteroviruses in paraffin-embedded tissue blocks is reported. This method takes advantage of extreme sequence conservation in the 5' untranslated region of the enteroviral genome and uses two roun...

journal_title：American journal of clinical pathology

authors： Redline RW,Genest DR,Tycko B

更新日期：1991-11-01 00:00:00

abstract：:Fine-needle aspiration (FNA) of thyroid bed (TB) lesions is a common diagnostic modality in monitoring patients for recurrent cancer after a thyroidectomy. To elucidate the value of TB FNA, we reviewed our experience at The Johns Hopkins Hospital, Baltimore, MD. We identified 57 TB FNA specimens from 50 patients. Of t...

journal_title：American journal of clinical pathology

authors： Bishop JA,Owens CL,Shum CH,Ali SZ

更新日期：2010-08-01 00:00:00

abstract：:Serum creatine kinase (CK) was measured in 515 healthy white women and 28 obligate carriers for Duchenne muscular dystrophy. There was substantial overlap between the control and carrier populations. To analyze the impact of the degree of overlap, the predictive value of a CK result was determined by (1) using sensiti...

journal_title：American journal of clinical pathology

authors： Gruemer HD,Miller WG,Chinchilli VM,Leshner RT,Blasco PA,Hassler CR,Nance WE

更新日期：1985-11-01 00:00:00

abstract：:Hydatidiform moles can be subclassified based on their ploidy. In general, complete moles are diploid, and partial moles are triploid. The standard method for the determination of DNA content is flow cytometric analysis. In this study, the authors investigated whether static cytometric analysis with the CAS 200 Image ...

journal_title：American journal of clinical pathology

authors： Barclay ID,Dabbagh L,Babiak J,Poppema S

更新日期：1993-10-01 00:00:00

abstract：:Two non-Hodgkin's lymphomas, one a follicular mixed cell type and the other a diffuse large cell type (Working Formulation), appeared 7 and 12 years, respectively, after the initial histopathologic diagnosis of Hodgkin's disease (nodular sclerosis) in an elderly male. The clinicopathologic implications of non-Hodgkin'...

journal_title：American journal of clinical pathology

authors： Shimizu K,Hara K,Kunii A

更新日期：1986-09-01 00:00:00

abstract：:Neuroendocrine tumors comprise a family of neoplasms with a wide range of morphologic, functional, and behavioral characteristics. Their diagnosis depends on the recognition of characteristic morphologic features and on the presence of markers indicative of neuroendocrine differentiation. Neuroendocrine tumors can be ...

journal_title：American journal of clinical pathology

authors： DeLellis RA

更新日期：2001-06-01 00:00:00

abstract：:The blood counts and lactic dehydrogenase values of eight patients with thrombotic thrombocytopenic purpura (TTP) were reviewed in relation to the clinical course. Three of the eight patients died. In these patients, the hemoglobin was significantly lower and the LDH higher at the time of presentation than that of the...

journal_title：American journal of clinical pathology

authors： Crowley JP,Metzger JB,L'Europa RA

更新日期：1983-11-01 00:00:00

abstract：OBJECTIVES:B-lymphoblastic leukemia (B-LBL) arising in patients with chronic lymphocytic leukemia (CLL) is exceedingly rare and poorly characterized. METHODS:We describe four patients with CLL and concurrent or subsequent B-LBL diagnosed by morphologic, immunophenotypic, cytogenetic, and molecular analysis and reviewe...

journal_title：American journal of clinical pathology

authors： Chakhachiro Z,Yin CC,Abruzzo LV,Aladily TN,Barron LL,Banks HE,Thomas DA,Keating M,Medeiros LJ,Huh YO

更新日期：2015-08-01 00:00:00

abstract：:Monoclonal immunoradiometric assays (IRMA) for human chorionic gonadotropin (hCG) are available for either intact hCG (IhCG) or beta subunit hCG (beta hCG). The authors evaluated the clinical applications of both methods. Serum samples (N = 180) were divided into the following five clinical groups: Group 1: elevated l...

journal_title：American journal of clinical pathology

authors： Pardue MG,Taylor EH,London S,Walls RC,Pappas AA

更新日期：1990-03-01 00:00:00

abstract：:Determination of urinary homovanillic acid (HVA) is an important analysis to establish the diagnosis and prognosis of neuroblastoma. A method is presented for the determination of this metabolite of dopamine using its reaction with 1-nitroso-2-naphthol and nitrous acid. The method has shown a sensitivity, specificity,...

journal_title：American journal of clinical pathology

authors： Rothstein A

更新日期：1987-05-01 00:00:00

abstract：:A three-and-a-half-year old boy suffering from streptococcal pneumonia developed hemolytic-uremic syndrome and disseminated intravascular coagulation (DIC). His red blood cells (RBC) were shown to be T- and Tk-activated; serial testing showed his mature RBCs as well as neocytes remained T-activated at 40 days. Anti-T ...

journal_title：American journal of clinical pathology

authors： Beattie KM,Lewis PE,Briski JE,Strauch BM

更新日期：1985-08-01 00:00:00

abstract：:A 63-year-old white man had simultaneous onset of the Guillain-Barré syndrome and the nephrotic syndrome, three weeks after having an upper respiratory tract infection. Many granular casts were noticed in the urine sediment. Renal biopsy specimens showed early membranous glomerulonephritis and acute interstitial nephr...

journal_title：American journal of clinical pathology

authors： Talamo TS,Borochovitz D

更新日期：1982-10-01 00:00:00

abstract：:By studying more than 1,200 patients with cutaneous melanoma and long-term follow-up, I examined the relationship between solar elastosis and age at diagnosis of melanoma, key features of melanoma, and the outcome of overall survival in melanoma. I found that melanomas with elastosis were diagnosed significantly later...

journal_title：American journal of clinical pathology

authors： Vollmer RT

更新日期：2007-08-01 00:00:00

abstract：OBJECTIVES:To examine Hedgehog signaling in cutaneous fibrosing disorders for which effective approved therapies are lacking, expand our knowledge of pathophysiology, and explore the rationale for targeted inhibition. METHODS:Stain intensity and percentage of cells staining for Sonic hedgehog (Shh), Indian hedgehog (I...

journal_title：American journal of clinical pathology

authors： Goyal A,Linskey KR,Kay J,Duncan LM,Nazarian RM

更新日期：2016-12-01 00:00:00

abstract：:Few cases of secondary CD5+ diffuse large B-cell lymphoma (DLBCL) that are not Richter syndrome have been reported previously. We report 9 cases of non-Richter syndrome secondary CD5+ DLBCL. Among 529 cases of DLBCL, 38 (7.2%) were CD5+ DLBCL, including 9 of secondary CD5+ DLBCL. Five cases gained CD5 expression durin...

journal_title：American journal of clinical pathology

authors： Maeshima AM,Taniguchi H,Nomoto J,Maruyama D,Kim SW,Watanabe T,Kobayashi Y,Tobinai K,Matsuno Y

更新日期：2009-03-01 00:00:00

abstract：:Several authors have suggested that a plausible mechanism for variation in reported mean corpuscular volume (MCV) and hematocrit values for Hematology Survey Specimens may be due to the presence of hyperglycemia in the suspending matrix of the specimens, resulting in cell swelling due to an osmotic matrix effect. The ...

journal_title：American journal of clinical pathology

authors： Savage RA

更新日期：1983-10-01 00:00:00

abstract：:Using digital cell image analysis performed on Feulgen-stained nuclei, the nuclear characteristics of prostatic neoplasia, ranging from benign (benign prostatic hyperplasia [BPH]), through dysplastic (prostatic intraepithelial neoplasia [PIN] 1-3), to carcinoma were studied. Four histopathologic groups were studied: g...

journal_title：American journal of clinical pathology

authors： Petein M,Michel P,van Velthoven R,Pasteels JL,Brawer MK,Davis JR,Nagle RB,Kiss R

更新日期：1991-11-01 00:00:00

abstract：:The API-20 Enteric Strip has been proposed to have the capacity to differentiate the nonfermentative gram-negative bacilli. This multitest strip serves as the basis of an evolving system, which first provided a Register, then a Selector, and more recently a computer Index. Twenty-three strains of Pseudomonas aeruginos...

journal_title：American journal of clinical pathology

authors： Morris MJ,Young VM,Moody MR

更新日期：1978-01-01 00:00:00

abstract：:Factor V Leiden (FVR506Q) is a genetic defect in the factor V (FV) molecule that confers resistance to proteolysis by activated protein C (APC) and is the most common abnormality detected in patients studied for hereditary thrombophilia. The initial screening test for this abnormality was a comparison of the activated...

journal_title：American journal of clinical pathology

authors： Akhtar MS,Blair AJ,King TC,Sweeney JD

更新日期：1998-04-01 00:00:00

abstract：:The amount of trapped plasma in the microhematocrit red blood cell column of samples from 25 normal individuals and 102 patients was investigated. The mean value for the normal individuals was 1.53%, and the mean values for the samples from the patient groups ranged from 1.41% to 1.82%. These groups included patients ...

journal_title：American journal of clinical pathology

authors： Pearson TC,Guthrie DL

更新日期：1982-11-01 00:00:00

abstract：:An on-line computer-assisted pathology encoding and reportying system (CAPER) has been developed by the Department of Pathology and Laboratory of Computer Science of the Massachusetts General Hospital for a department of surgical pathology that processes more than 25,000 specimens yearly. CAPER performs clerical funct...

journal_title：American journal of clinical pathology

authors： Aller RD,Robboy SJ,Poitras JW,Altshuler BS,Cameron M,Prior MC,Miao S,Barnett GO

更新日期：1977-12-01 00:00:00

abstract：:A flow cytometric technic was developed to detect platelet surface-bound immunoglobulin in patients with thrombocytopenia. Elevated platelet surface IgG and/or IgM was detected in 90.9% of patients with immune thrombocytopenia purpura (ITP). False positive results occurred in 9.3% of patients with nonimmune thrombocyt...

journal_title：American journal of clinical pathology

authors： Rosenfeld CS,Nichols G,Bodensteiner DC

更新日期：1987-04-01 00:00:00